The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala
Open accessAbstract
The neuroprotective effects of 3,6′-disinapoyl sucrose (DISS) from Radix Polygala against glutamate-induced SH-SY5Y neuronal cells injury were evaluated in the present study. SH-SY5Y neuronal cells were pretreated with glutamate (8 mM) for 30 min followed by cotreatment with DISS for 12 h. Cell viability was determined by (3,4,5-dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide (MTT) assay, and apoptosis was confirmed by cell morphology and flow cytometry assay, evaluated with propidium iodide dye. Treatment with DISS (0.6, 6, and 60 μmol/L) increased cell viability dose dependently, inhibited LDH release, and attenuated apoptosis. The mechanisms by which DISS protected neuron cells from glutamate-induced excitotoxicity included the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2. The present findings indicated that DISS exerts neuroprotective effects against glutamate toxicity, which might be of importance and contribute to its clinical efficacy for the treatment of neurodegenerative diseases.
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Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,314
Bonanno, G., Giambelli, R., Raiteri, L., Tiraboschi, E., Zappettini, S., Musazzi, L., Raiteri, M., Racagni, G., & Popoli, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5033-04.2005 · Cited by 234
Zha, H., & Reed, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31482 · Cited by 168
GABA and glutamate systems as therapeutic targets in depression and mood disorders
Kendell, S. F., Krystal, J. H., & Sanacora, G. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.1.153 · Cited by 154
Haque, M. E., Asanuma, M., Higashi, Y., Miyazaki, I., Tanaka, K.-I., & Ogawa, N. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00440-3 · Cited by 153
Hu, Y., Liao, H., Guo, D., Liu, P., Wang, Y., & Rahman, K. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.004 · Cited by 85
Self-citationSun, X.-L., Ito, H., Masuoka, T., Kamei, C., & Hatano, T. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1727 · Cited by 76
Repeated administration of imipramine attenuates glutamatergic transmission in rat frontal cortex
Tokarski, K., Bobula, B., Wabno, J., & Hess, G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.007 · Cited by 65
Gołembiowska, K., & Dziubina, A. (2000) · PubMed · Cited by 65
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Brisch, R., Saniotis, A., Wolf, R., Bielau, H., Bernstein, H.-G., Steiner, J., Bogerts, B., Braun, A. K., Jankowski, Z., Kumaritlake, J., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00047 · Cited by 517
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Metadata
- Authors
- Hu, Y., Li, J., Liu, P., Chen, X., Guo, D.-H., Li, Q.-S., & Rahman, K.
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-5
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- OpenAlex
- W2051413325
- Cited by
- 311
- References
- 13
- FWCI
- 39.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala. https://app.cochat.ai/papers/10.1155/2012/728342
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- Hu, Y., Li, J., Liu, P., Chen, X., Guo, D.-H., Li, Q.-S., & Rahman, K. (2012). Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala. Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2012/728342
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