The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Oxidative Stress and Epilepsy: Literature Review
Open accessAbstract
Backgrounds. The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy.Objective. A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed.Results/Conclusions. Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.
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Cites
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
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Gene regulation and DNA damage in the ageing human brain
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Inflammation is detrimental for neurogenesis in adult brain
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Inflammation and neurodegenerative diseases
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Mitochondrial dysfunction and oxidative stress: A contributing link to acquired epilepsy?
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Molecular aging in human prefrontal cortex is selective and continuous throughout adult life
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Copper–zinc superoxide dismutase: Why not pH-dependent?
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Disruption of mitochondrial redox circuitry in oxidative stress
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Cited by
Frye, R. E. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.08.134 · Cited by 117
Metadata
- Authors
- Aguiar, C. C. T., Almeida, A. B., Araújo, P. V. P., Abreu, R. N. D. C. D., Chaves, E. M. C., Vale, O. C. D., Macêdo, D. S., Woods, D. J., Fonteles, M. M. D. F., & Vasconcelos, S. M. M.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-12
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2149239016
- Cited by
- 322
- References
- 12
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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