The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential
Open accessAbstract
The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded proteins in the ER lumen, a condition referred to as ER stress. In response to ER stress, a signal transduction pathway known as the unfolded protein response (UPR) is activated. UPR activation allows the cell to cope with an increased protein-folding demand on the ER. Recent studies have shown that ER stress/UPR activation plays a critical role in lipid metabolism and homeostasis. ER-stress-dependent dysregulation of lipid metabolism may lead to dyslipidemia, insulin resistance, cardiovascular disease, type 2 diabetes, and obesity. In this paper, we examine recent findings illustrating the important role ER stress/UPR signalling pathways play in regulation of lipid metabolism, and how they may lead to dysregulation of lipid homeostasis.
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“The endoplasmic reticulum (ER) stress response (also known as the unfolded protein response [UPR]), a signal transduction pathway that is activated in response to the accumulation of unfolded proteins in the ER, has emerged as a critical regulator of lipid homeostasis in the liver (Basseri and Austin, 2012; Cnop et al…”
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den Brok, M. H., Raaijmakers, T. K., Collado-Camps, E., & Adema, G. J. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.01.012 · Cited by 203
Wang, W., Mao, X., Zhang, R., Zhou, X.-X., Liu, Y., Zhou, H., Jia, J., & Yan, B. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c02769 · Cited by 106
Metabolic injury of hepatocytes promotes progression of NAFLD and AALD
Carvalho-Gontijo, R., Han, C., Zhang, L., Zhang, V., Hosseini, M., Mekeel, K., Schnabl, B., Loomba, R., Karin, M., Brenner, D. A., et al. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1755316 · Cited by 23
Metadata
- Authors
- Basseri, S., & Austin, R. C.
- Venue
- Biochemistry Research International
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-13
- ISSN
- 2090-2247 (ISSN-L)
- 2090-2255
- OpenAlex
- W2010965956
- Cited by
- 254
- References
- 119
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- gold
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