Cited by 60Gestational Diabetes Research and ManagementNeonatal and Maternal InfectionsInfant Nutrition and Health

Transfer of Maternal Immunity to Newborns of Diabetic Mothers

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França, Eduardo Luzía, Calderon, Iracema de Mattos Paranhos, Vieira, Elisa Lima, Morceli, Glilciane, Honorio-França, Adenilda Cristina·2012·Clinical and Developmental Immunology

Abstract

This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum.

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  1. [46]Oliveira AMDM Da Cunha CC Penha-Silva N Abdallah VOS Jorge PT Interference of the blood glucose control in the transition between phases I and II of lactogenesis in patients with type 1 diabetes mellitus Arquivos Brasileiros de Endocrinologia e Metabologia 2008 52 3 473 481 2-s2.0-44949190596 18506272

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Authors
França, E. L., Calderon, I. D. M. P., Vieira, E. L., Morceli, G., & Honorio-França, A. C.
Affiliations
  • Universidade Federal de Mato Grosso (BR)
  • Universidade Estadual Paulista (Unesp) (BR)
  • Institute of Biological and Health Science, Federal University of Mato Grosso, 78600-000 Barra do Garças, MT, Brazil
Venue
Clinical and Developmental Immunology
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-7
ISSN
  • 1740-2522 (ISSN-L)
  • 1740-2530
OpenAlex
W2150101348
Cited by
60
References
46
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 11 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 1
FWCI
6.95
Type
journal article
Language
en
Open access
Locations
  • Clinical and Developmental Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
  • Fundação de Amparo à Pesquisa do Estado de Mato Grosso (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
maternal-fetal antibody transfer, maternal diabetes, colostrum immunoglobulins, phagocytic activity, superoxide release, phagocytosis, bactericidal activity, enteropathogenic Escherichia coli, mononuclear phagocytes, neonatal immunity
MeSH terms
Adolescent, Adult, Colostrum, Cross-Sectional Studies, Diabetes Mellitus, Female, Fetal Blood, Humans, Hyperglycemia, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunity, Maternally-Acquired, Infant, Newborn, Phagocytes, Pregnancy, Pregnancy in Diabetics, Superoxides, Young Adult

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