Transfer of Maternal Immunity to Newborns of Diabetic Mothers
Open accessAbstract
This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum.
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Stach et al. and França et al. demonstrated an increased rate of IgG transfer in hyperglycemic mothers.
“Stach et al. (98) demonstrated an increased rate of IgG transfer in hyperglycemic mothers for all antigens they studied (GBS, Klebsiella LPS, and Pseudomonas LPS), as did França et al. (114).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [114]
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Self-citationde Queiroz, A. A., França, E. L., Hara, C. C. P., Honorio, M. D. S., Fagundes, D. L. G., Calderon, I. D. M. P., & Honório‐França, A. C. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1400004 · Cited by 5 · see citing works
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Correlation between Melatonin and Colostral Regulatory T Cells in Giardia lamblia Infection
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Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential
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Self-citation
- Authors
- França, E. L., Calderon, I. D. M. P., Vieira, E. L., Morceli, G., & Honorio-França, A. C.
- Affiliations
- Universidade Federal de Mato Grosso (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- Institute of Biological and Health Science, Federal University of Mato Grosso, 78600-000 Barra do Garças, MT, Brazil
- Venue
- Clinical and Developmental Immunology
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-7
- ISSN
- 1740-2522 (ISSN-L)
- 1740-2530
- PMC
- PMC3444004
- OpenAlex
- W2150101348
- Cited by
- 60
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 11 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical and Developmental Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
- Fundação de Amparo à Pesquisa do Estado de Mato Grosso (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (475739/2011-6, 475826/2010-8, 299032/2010, 2011/18045-5, 2009/01188-8, 2008/09187-8)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- maternal-fetal antibody transfer, maternal diabetes, colostrum immunoglobulins, phagocytic activity, superoxide release, phagocytosis, bactericidal activity, enteropathogenic Escherichia coli, mononuclear phagocytes, neonatal immunity
- MeSH terms
- Adolescent, Adult, Colostrum, Cross-Sectional Studies, Diabetes Mellitus, Female, Fetal Blood, Humans, Hyperglycemia, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunity, Maternally-Acquired, Infant, Newborn, Phagocytes, Pregnancy, Pregnancy in Diabetics, Superoxides, Young Adult
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