The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Properties and Therapeutic Application of Bromelain: A Review
Open accessAbstract
Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and they contain different enzymatic composition. “Bromelain” refers usually to the “stem bromelain.” Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors.In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death. This paper reviews the important properties and therapeutic applications of bromelain, along with the possible mode of action.
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Osorio, L. L. D. R., Flórez-López, E., & Grande-Tovar, C. D. (2021) · Molecules · doi:10.3390/molecules26020515 · Cited by 367
Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy
Yang, S., & Gao, H. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.004 · Cited by 256
Roselli, V., Pugliese, G., Leuci, R., Brunetti, L., Gambacorta, L., Tufarelli, V., & Piemontese, L. (2024) · Molecules · doi:10.3390/molecules29112682 · Cited by 53
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052465 · Cited by 43
Bromelain enhances digestibility of Spirulina-based fish feed
Sharma, S. A., Surveswaran, S., Arulraj, J., & Velayudhannair, K. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-020-02337-4 · Cited by 15
Metadata
- Authors
- Pavan, R., Jain, S., Shraddha, & Kumar, A.
- Venue
- Biotechnology Research International
- Publisher
- Wiley
- Published
- 2012-12-10
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 2090-3138 (ISSN-L)
- 2090-3146
- OpenAlex
- W2157745445
- Cited by
- 484
- References
- 35
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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