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Cited by 43Food Science and Nutritional StudiesSARS-CoV-2 and COVID-19 ResearchMedicinal Plant Research

Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature

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Parisi, Giuseppe Fabio, Carota, Giuseppe, Castruccio Castracani, Carlo, Spampinato, Mariarita, Manti, Sara, Papale, Maria, Di Rosa, Michelino, Barbagallo, Ignazio +1 more·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms22052465PMC PMC7957644
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Abstract

In recent years, there has been a growth in scientific interest in nutraceuticals, which are those nutrients in foods that have beneficial effects on health. Nutraceuticals can be extracted, used for food supplements, or added to foods. There has long been interest in the antiviral properties of nutraceuticals, which are especially topical in the context of the ongoing COVID-19 pandemic. Therefore, the purpose of this review is to evaluate the main nutraceuticals to which antiviral roles have been attributed (either by direct action on viruses or by modulating the immune system), with a focus on the pediatric population. Furthermore, the possible applications of these substances against SARS-CoV-2 will be considered.

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  • The use of natural compounds has been recommended in the recent health emergency of the COVID-19 pandemic.

    “the use of natural compounds has been recommended in the recent health emergency of the COVID-19 pandemic [18].”

    From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [18]

    The Conclusions (page unavailable) discuss possible use of nutraceuticals during the COVID-19 pandemic and say their use “could still be suggested,” especially in children. The claim overstates this tentative position as an established recommendation; the paper also says specific clinical evidence is lacking. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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  1. [2]Ackermann M. Verleden S.E. Kuehnel M. Haverich A. Welte T. Laenger F. Vanstapel A. Werlein C. Stark H. Tzankov A. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 N. Engl. J. Med. 2020 383 120 128 10.1056/NEJMoa2015432 32437596 PMC7412750 · DOI · Paper page
  2. [3]Parisi G.F. Brindisi G. Indolfi C. Diaferio L. Marchese G. Ghiglioni D.G. Zicari A.M. Miraglia Del Giudice M. Upper airway involvement in pediatric COVID-19 Pediatric Allergy Immunol. 2020 31 Suppl. 26 85 88 10.1111/pai.13356 PMC7753446 33236430 · DOI
  3. [4]Mehta P. McAuley D.F. Brown M. Sanchez E. Tattersall R.S. Manson J.J. Hlh Across Speciality Collaboration U.K. COVID-19: Consider cytokine storm syndromes and immunosuppression Lancet 2020 395 1033 1034 10.1016/S0140-6736(20)30628-0 32192578 PMC7270045 · DOI · Paper page
  4. [5]Chen G. Wu D. Guo W. Cao Y. Huang D. Wang H. Wang T. Zhang X. Chen H. Yu H. Clinical and immunological features of severe and moderate coronavirus disease 2019 J. Clin. Investig. 2020 130 2620 2629 10.1172/JCI137244 32217835 PMC7190990 · DOI · Paper page
  5. [6]Laforge M. Elbim C. Frere C. Hemadi M. Massaad C. Nuss P. Benoliel J.J. Becker C. Tissue damage from neutrophil-induced oxidative stress in COVID-19 Nat. Rev. Immunol. 2020 20 515 516 10.1038/s41577-020-0407-1 32728221 PMC7388427 · DOI
  6. [7]Cecchini R. Cecchini A.L. SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression Med. Hypotheses 2020 143 110102 10.1016/j.mehy.2020.110102 32721799 PMC7357498 · DOI
  7. [8]Kircheis R. Haasbach E. Lueftenegger D. Heyken W.T. Ocker M. Planz O. NF-kappaB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients Front. Immunol. 2020 11 598444 10.3389/fimmu.2020.598444 33362782 PMC7759159 · DOI
  8. [9]Kandasamy M. NF-kappaB signalling as a pharmacological target in COVID-19: Potential roles for IKKbeta inhibitors Naunyn Schmiedebergs Arch. Pharmacol. 2021 10.1007/s00210-020-02035-5 33394134 PMC7780215 · DOI
  9. [10]Carcaterra M. Caruso C. Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory Med. Hypotheses 2020 110412 10.1016/j.mehy.2020.110412 33308936 PMC7681037 · DOI
  10. [11]Olagnier D. Farahani E. Thyrsted J. Blay-Cadanet J. Herengt A. Idorn M. Hait A. Hernaez B. Knudsen A. Iversen M.B. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate Nat. Commun. 2020 11 4938 10.1038/s41467-020-18764-3 33009401 PMC7532469 · DOI
  11. [12]Liguoro I. Pilotto C. Bonanni M. Ferrari M.E. Pusiol A. Nocerino A. Vidal E. Cogo P. SARS-COV-2 infection in children and newborns: A systematic review Eur. J. Pediatrics 2020 179 1029 1046 10.1007/s00431-020-03684-7 32424745 PMC7234446 · DOI
  12. [13]Lu X. Zhang L. Du H. Zhang J. Li Y.Y. Qu J. Zhang W. Wang Y. Bao S. Li Y. Chinese Pediatric Novel Coronavirus Study, T., SARS-CoV-2 Infection in Children N. Engl. J. Med. 2020 382 1663 1665 10.1056/NEJMc2005073 32187458 PMC7121177 · DOI
  13. [14]Castagnoli R. Votto M. Licari A. Brambilla I. Bruno R. Perlini S. Rovida F. Baldanti F. Marseglia G.L. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review JAMA Pediatrics 2020 174 882 889 10.1001/jamapediatrics.2020.1467 32320004 · DOI · Paper page
  14. [15]Diaferio L. Parisi G.F. Brindisi G. Indolfi C. Marchese G. Ghiglioni D.G. Zicari A.M. Marseglia G.L. Miraglia Del Giudice M. Cross-sectional survey on impact of paediatric COVID-19 among Italian paediatricians: Report from the SIAIP rhino-sinusitis and conjunctivitis committee Ital. J. Pediatrics 2020 46 146 10.1186/s13052-020-00906-4 PMC7538039 33023616 · DOI
  15. [16]Parisi G.F. Indolfi C. Decimo F. Leonardi S. Miraglia Del Giudice M. COVID-19 Pneumonia in Children: From Etiology to Management Front. Pediatrics 2020 8 616622 10.3389/fped.2020.616622 PMC7767924 33381482 · DOI
  16. [17]Manti S. Licari A. Montagna L. Votto M. Leonardi S. Brambilla I. Castagnoli R. Foiadelli T. Marseglia G.L. Cardinale F. SARS-CoV-2 infection in pediatric population Acta Biomed. 2020 91 e2020003 PMC8023063 33004773
  17. [18]Cardinale F. Ciprandi G. Barberi S. Bernardini R. Caffarelli C. Calvani M. Cavagni G. Galli E. Minasi D. Del Giudice M.M. Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic or immunological diseases during the COVID-19 pandemic Ital. J. Pediatrics 2020 46 84 10.1186/s13052-020-00843-2 PMC7296524 32546234 · DOI
  18. [19]Junaid K. Ejaz H. Abdalla A.E. Abosalif K.O.A. Ullah M.I. Yasmeen H. Younas S. Hamam S.S.M. Rehman A. Effective Immune Functions of Micronutrients against SARS-CoV-2 Nutrients 2020 12 2992 10.3390/nu12102992 PMC7599934 33003648 · DOI
  19. [20]Corkins M.R. Daniels S.R. de Ferranti S.D. Golden N.H. Kim J.H. Magge S.N. Schwarzenberg S.J. Nutrition in Children and Adolescents Med. Clin. N. Am. 2016 100 1217 1235 10.1016/j.mcna.2016.06.005 27745591 · DOI · Paper page
  20. [21]Yackobovitch-Gavan M. Lebenthal Y. Lazar L. Shalitin S. Demol S. Tenenbaum A. Shamir R. Phillip M. Effect of Nutritional Supplementation on Growth in Short and Lean Prepubertal Children after 1 Year of Intervention J. Pediatrics 2016 179 154 159.e1 10.1016/j.jpeds.2016.08.100 27697330 · DOI
  21. [22]Souyoul S.A. Saussy K.P. Lupo M.P. Nutraceuticals: A Review Dermatol. Ther. 2018 8 5 16 10.1007/s13555-018-0221-x 29411317 PMC5825326 · DOI · Paper page
  22. [23]Rautiainen S. Manson J.E. Lichtenstein A.H. Sesso H.D. Dietary supplements and disease prevention—A global overview Nat. Rev. Endocrinol. 2016 12 407 420 10.1038/nrendo.2016.54 27150288 · DOI
  23. [24]Karim T. Muhit M. Khandaker G. Interventions to prevent respiratory diseases—Nutrition and the developing world Paediatr. Respir. Rev. 2017 22 31 37 10.1016/j.prrv.2016.09.003 27793738 · DOI
  24. [25]Lee B.Y. Shah M. Prevention of influenza in healthy children Expert Rev. Anti-Infect. Ther. 2012 10 1139 1152 10.1586/eri.12.106 23199400 PMC3763239 · DOI
  25. [26]Swanson K.S. Gibson G.R. Hutkins R. Reimer R.A. Reid G. Verbeke K. Scott K.P. Holscher H.D. Azad M.B. Delzenne N.M. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics Nat. Rev. Gastroenterol. Hepatol. 2020 17 687 701 10.1038/s41575-020-0344-2 32826966 PMC7581511 · DOI · Paper page
  26. [27]Pulvirenti G. Parisi G.F. Giallongo A. Papale M. Manti S. Savasta S. Licari A. Marseglia G.L. Leonardi S. Lower Airway Microbiota Front. Pediatrics 2019 7 393 10.3389/fped.2019.00393 PMC6776601 31612122 · DOI
  27. [28]Miraglia Del Giudice M. Parisi G.F. Indolfi C. Manti S. Leonardi S. Decimo F. Ciprandi G. Nasal microbiome in chronic rhinosinusitis Minerva Pediatrics 2020 10.23736/S0026-4946.20.05850-8 32731730 · DOI
  28. [29]Manti S. Parisi G.F. Papale M. Licari A. Salpietro C. Miraglia Del Giudice M. Marseglia G.L. Leonardi S. Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for treatment of upper respiratory tract infections in children: A pilot study on short-term efficacy Ital. J. Pediatrics 2020 46 42 10.1186/s13052-020-0798-4 32245500 PMC7126168 · DOI
  29. [30]Hardy H. Harris J. Lyon E. Beal J. Foey A.D. Probiotics, prebiotics and immunomodulation of gut mucosal defences: Homeostasis and immunopathology Nutrients 2013 5 1869 1912 10.3390/nu5061869 23760057 PMC3725482 · DOI
  30. [31]Wolvers D. Antoine J.M. Myllyluoma E. Schrezenmeir J. Szajewska H. Rijkers G.T. Guidance for substantiating the evidence for beneficial effects of probiotics: Prevention and management of infections by probiotics J. Nutr. 2010 140 698S 712S 10.3945/jn.109.113753 20107143 · DOI · Paper page
  31. [32]Ichinohe T. Pang I.K. Kumamoto Y. Peaper D.R. Ho J.H. Murray T.S. Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection Proc. Natl. Acad. Sci. USA 2011 108 5354 5359 10.1073/pnas.1019378108 21402903 PMC3069176 · DOI · Paper page
  32. [33]Sun Y. O’Riordan M.X. Regulation of bacterial pathogenesis by intestinal short-chain Fatty acids Adv. Appl. Microbiol. 2013 85 93 118 23942149 PMC4029053
  33. [34]Del Giudice M.M. Indolfi C. Parisi G.F. Coronella A. Allegorico A. Maiello N. Probiotics Role in Allergic Illness Curr. Respir. Med. Rev. 2017 13 19 21 10.2174/1573398X13666170821113226 · DOI
  34. [35]Leonardi S. Parisi G. Papale M. Zicari A.M. Olcese R. Licari A. Marseglia G. Ciprandi G. Small airways in children with allergic rhinoconjunctivitis: The potential role of a multicomponent nutraceutical Acta Biomed. 2020 91 350 355 32420972 PMC7569657
  35. [36]Vallianou N. Stratigou T. Christodoulatos G.S. Tsigalou C. Dalamaga M. Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives Curr. Obes. Rep. 2020 9 179 192 10.1007/s13679-020-00379-w 32472285 · DOI
  36. [37]Chakravarty S. Parashar A. Acharyya S. Saccharomyces cerevisiae Sepsis Following Probiotic Therapy in an Infant Indian Pediatrics 2019 56 971 972 10.1007/s13312-019-1655-7 31729330 · DOI
  37. [38]Princess I. Natarajan T. Ghosh S. When good bacteria behave badly: A case report of Bacillus clausii sepsis in an immunocompetant adult Access Microbiol. 2020 2 acmi000097 10.1099/acmi.0.000097 33005864 PMC7523625 · DOI
  38. [39]Giannoni E. Baud D. Agri V.D. Gibson G.R. Reid G. Probiotics and COVID-19 Lancet Gastroenterol. Hepatol. 2020 5 720 721 10.1016/S2468-1253(20)30195-3 PMC7357984 32673603 · DOI
  39. [40]Jayawardena R. Sooriyaarachchi P. Chourdakis M. Jeewandara C. Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on COVID-19: A review Diabetes Metab. Syndr. 2020 14 367 382 10.1016/j.dsx.2020.04.015 32334392 PMC7161532 · DOI
  40. [42]Gianchecchi E. Fierabracci A. Insights on the Effects of Resveratrol and Some of Its Derivatives in Cancer and Autoimmunity: A Molecule with a Dual Activity Antioxidants 2020 9 91 10.3390/antiox9020091 PMC7070243 31978952 · DOI
  41. [43]Docherty J.J. Fu M.M. Stiffler B.S. Limperos R.J. Pokabla C.M. DeLucia A.L. Resveratrol inhibition of herpes simplex virus replication Antiviral Res. 1999 43 145 155 10.1016/S0166-3542(99)00042-X 10551373 · DOI
  42. [44]Docherty J.J. Sweet T.J. Bailey E. Faith S.A. Booth T. Resveratrol inhibition of varicella-zoster virus replication in vitro Antiviral Res. 2006 72 171 177 10.1016/j.antiviral.2006.07.004 16899306 · DOI
  43. [45]Palamara A.T. Nencioni L. Aquilano K. De Chiara G. Hernandez L. Cozzolino F. Ciriolo M.R. Garaci E. Inhibition of influenza A virus replication by resveratrol J. Infect. Dis. 2005 191 1719 1729 10.1086/429694 15838800 · DOI
  44. [46]Berardi V. Ricci F. Castelli M. Galati G. Risuleo G. Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: Potential clinical use J. Exp. Clin. Cancer Res. 2009 28 96 10.1186/1756-9966-28-96 19570215 PMC2710315 · DOI
  45. [47]Kedzierski L. Curtis J.M. Kaminska M. Jodynis-Liebert J. Murias M. In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes Parasitol. Res. 2007 102 91 97 10.1007/s00436-007-0729-y 17763870 · DOI
  46. [48]Lu C.C. Lai H.C. Hsieh S.C. Chen J.K. Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats J. Leukoc Biol. 2008 83 1028 1037 10.1189/jlb.0907647 18174363 · DOI
  47. [49]Docherty J.J. Fu M.M. Tsai M. Resveratrol selectively inhibits Neisseria gonorrhoeae and Neisseria meningitidis J. Antimicrob. Chemother. 2001 47 243 244 10.1093/jac/47.2.243 11157919 · DOI
  48. [50]Yang M. Wei J. Huang T. Lei L. Shen C. Lai J. Yang M. Liu L. Yang Y. Liu G. Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells Phytother. Res. 2020 10.1002/ptr.6916 PMC7753598 33222316 · DOI
  49. [51]Li Y.Q. Li Z.L. Zhao W.J. Wen R.X. Meng Q.W. Zeng Y. Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication Eur. J. Med. Chem. 2006 41 1084 1089 10.1016/j.ejmech.2006.03.024 16875760 PMC7119042 · DOI
  50. [52]Wahedi H.M. Ahmad S. Abbasi S.W. Stilbene-based natural compounds as promising drug candidates against COVID-19 J. Biomol. Struct. Dyn. 2020 1 10 10.1080/07391102.2020.1762743 32345140 · DOI
  51. [53]Ungvari Z. Bagi Z. Feher A. Recchia F.A. Sonntag W.E. Pearson K. de Cabo R. Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 Am. J. Physiol. Heart Circ. Physiol. 2010 299 H18 H24 10.1152/ajpheart.00260.2010 20418481 PMC2904129 · DOI
  52. [54]Ingham R. The optional subject phenomenon in young children’s English: A case study J. Child. Lang. 1992 19 133 151 10.1017/S0305000900013660 1551928 · DOI
  53. [55]Barbagallo I. Marrazzo G. Frigiola A. Zappala A. Li Volti G. Role of carbon monoxide in vascular diseases Curr. Pharm. Biotechnol. 2012 13 787 796 10.2174/138920112800399086 22201604 · DOI
  54. [56]Ahmed S.M. Luo L. Namani A. Wang X.J. Tang X. Nrf2 signaling pathway: Pivotal roles in inflammation Biochim. Biophys. Acta Mol. Basis Dis. 2017 1863 585 597 10.1016/j.bbadis.2016.11.005 27825853 · DOI · Paper page
  55. [58]Ghanim H. Sia C.L. Korzeniewski K. Lohano T. Abuaysheh S. Marumganti A. Chaudhuri A. Dandona P. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal J. Clin. Endocrinol. Metab. 2011 96 1409 1414 10.1210/jc.2010-1812 21289251 PMC3085195 · DOI
  56. [59]Kode A. Rajendrasozhan S. Caito S. Yang S.R. Megson I.L. Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells Am. J. Physiol. Lung Cell Mol. Physiol. 2008 294 L478 L488 10.1152/ajplung.00361.2007 18162601 · DOI · Paper page
  57. [60]Garg A. Garg S. Zaneveld L.J. Singla A.K. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin Phytother. Res. 2001 15 655 669 10.1002/ptr.1074 11746857 · DOI
  58. [61]Parhiz H. Roohbakhsh A. Soltani F. Rezaee R. Iranshahi M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models Phytother. Res. 2015 29 323 331 10.1002/ptr.5256 25394264 · DOI
  59. [62]Dong W. Wei X. Zhang F. Hao J. Huang F. Zhang C. Liang W. A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways Sci. Rep. 2014 4 7237 10.1038/srep07237 25429875 PMC4246350 · DOI
  60. [63]Saha R.K. Takahashi T. Suzuki T. Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase Biol. Pharm. Bull. 2009 32 1188 1192 10.1248/bpb.32.1188 19571383 · DOI
  61. [64]Wu C. Liu Y. Yang Y. Zhang P. Zhong W. Wang Y. Wang Q. Xu Y. Li M. Li X. Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods Acta Pharm. Sin. B 2020 10 766 788 10.1016/j.apsb.2020.02.008 32292689 PMC7102550 · DOI
  62. [65]Bellavite P. Donzelli A. Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits Antioxidants 2020 9 742 10.3390/antiox9080742 PMC7465267 32823497 · DOI · Paper page
  63. [66]Das S. Sarmah S. Lyndem S. Singha Roy A. An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study J. Biomol. Struct. Dyn. 2020 1 11 10.1080/07391102.2020.1763201 PMC7232884 32362245 · DOI
  64. [67]Coppola M. Mondola R. Phytotherapeutics and SARS-CoV-2 infection: Potential role of bioflavonoids Med. Hypotheses 2020 140 109766 10.1016/j.mehy.2020.109766 32353741 PMC7195027 · DOI
  65. [69]Tejada S. Pinya S. Martorell M. Capo X. Tur J.A. Pons A. Sureda A. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus Curr. Med. Chem. 2018 25 4929 4945 10.2174/0929867324666170718104412 28721824 · DOI
  66. [70]Jose R.J. Manuel A. COVID-19 cytokine storm: The interplay between inflammation and coagulation Lancet Respir. Med. 2020 8 e46 e47 10.1016/S2213-2600(20)30216-2 32353251 PMC7185942 · DOI
  67. [71]Kuntic V. Brboric J. Holclajtner-Antunovic I. Uskokovic-Markovic S. Evaluating the bioactive effects of flavonoid hesperidin—A new literature data survey Vojnosanit Pregl. 2014 71 60 65 10.2298/VSP1401060K 24516992 · DOI
  68. [72]Stricker R.B. Fesler M.C. Flattening the Risk: Pre-Exposure Prophylaxis for COVID-19 Infect. Drug Resist. 2020 13 3689 3694 10.2147/IDR.S264831 33116688 PMC7586021 · DOI
  69. [73]Haggag Y.A. El-Ashmawy N.E. Okasha K.M. Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection? Med. Hypotheses 2020 144 109957 10.1016/j.mehy.2020.109957 32531538 PMC7274964 · DOI
  70. [74]Sime P.J. O’Reilly K.M. Fibrosis of the lung and other tissues: New concepts in pathogenesis and treatment Clin. Immunol. 2001 99 308 319 10.1006/clim.2001.5008 11358425 · DOI
  71. [75]Vitiello A. Pelliccia C. Ferrara F. COVID-19 Patients with Pulmonary Fibrotic Tissue: Clinical Pharmacological Rational of Antifibrotic Therapy SN Compr. Clin. Med. 2020 1 4 10.1007/s42399-020-00487-7 32875276 PMC7452615 · DOI
  72. [76]Gonzalez-Gonzalez F.J. Chandel N.S. Jain M. Budinger G.R.S. Reactive oxygen species as signaling molecules in the development of lung fibrosis Transl. Res. 2017 190 61 68 10.1016/j.trsl.2017.09.005 29080401 PMC5730357 · DOI
  73. [77]Zhou Z. Kandhare A.D. Kandhare A.A. Bodhankar S.L. Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways EXCLI J. 2019 18 723 745 31611754 PMC6785776
  74. [78]Leopoldini M. Russo N. Chiodo S. Toscano M. Iron chelation by the powerful antioxidant flavonoid quercetin J. Agric. Food Chem. 2006 54 6343 6351 10.1021/jf060986h 16910729 · DOI
  75. [79]Li Y. Yao J. Han C. Yang J. Chaudhry M.T. Wang S. Liu H. Yin Y. Quercetin, Inflammation and Immunity Nutrients 2016 8 167 10.3390/nu8030167 26999194 PMC4808895 · DOI · Paper page
  76. [80]Choi H.J. Song J.H. Park K.S. Kwon D.H. Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication Eur. J. Pharm. Sci. 2009 37 329 333 10.1016/j.ejps.2009.03.002 19491023 · DOI
  77. [81]Wu W. Li R. Li X. He J. Jiang S. Liu S. Yang J. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry Viruses 2015 8 6 10.3390/v8010006 PMC4728566 26712783 · DOI
  78. [82]Kim C.H. Kim J.E. Song Y.J. Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses Molecules 2020 25 2379 10.3390/molecules25102379 PMC7287991 32443914 · DOI
  79. [83]Debiaggi M. Tateo F. Pagani L. Luini M. Romero E. Effects of propolis flavonoids on virus infectivity and replication Microbiologica 1990 13 207 213 2125682
  80. [84]Yi L. Li Z. Yuan K. Qu X. Chen J. Wang G. Zhang H. Luo H. Zhu L. Jiang P. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells J. Virol. 2004 78 11334 11339 10.1128/JVI.78.20.11334-11339.2004 15452254 PMC521800 · DOI
  81. [85]Derosa G. Maffioli P. D’Angelo A. Di Pierro F. A role for quercetin in coronavirus disease 2019 (COVID-19) Phytother. Res. 2020 10.1002/ptr.6887 33034398 PMC7675685 · DOI
  82. [86]Russo M. Moccia S. Spagnuolo C. Tedesco I. Russo G.L. Roles of flavonoids against coronavirus infection Chem. Biol. Interact. 2020 328 109211 10.1016/j.cbi.2020.109211 32735799 PMC7385538 · DOI
  83. [87]Mani J.S. Johnson J.B. Steel J.C. Broszczak D.A. Neilsen P.M. Walsh K.B. Naiker M. Natural product-derived phytochemicals as potential agents against coronaviruses: A review Virus Res. 2020 284 197989 10.1016/j.virusres.2020.197989 32360300 PMC7190535 · DOI
  84. [88]Orhan I.E. Senol Deniz F.S. Natural Products as Potential Leads against Coronaviruses: Could They be Encouraging Structural Models against SARS-CoV-2? Nat. Prod. Bioprospect. 2020 10 171 186 10.1007/s13659-020-00250-4 32529545 PMC7289229 · DOI
  85. [90]Aucoin M. Cooley K. Saunders P.R. Cardozo V. Remy D. Cramer H. Neyre Abad C. Hannan N. The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review Adv. Integr. Med. 2020 7 247 251 10.1016/j.aimed.2020.07.007 32837891 PMC7392107 · DOI
  86. [91]Valenti P. Antonini G. Lactoferrin: An important host defence against microbial and viral attack Cell Mol. Life Sci. 2005 62 2576 2587 10.1007/s00018-005-5372-0 16261253 PMC11139069 · DOI
  87. [92]Ng T.B. Cheung R.C. Wong J.H. Wang Y. Ip D.T. Wan D.C. Xia J. Antiviral activities of whey proteins Appl. Microbiol. Biotechnol. 2015 99 6997 7008 10.1007/s00253-015-6818-4 26198883 PMC7080083 · DOI
  88. [93]Lang J. Yang N. Deng J. Liu K. Yang P. Zhang G. Jiang C. Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans PLoS ONE 2011 6 e23710 10.1371/journal.pone.0023710 21887302 PMC3161750 · DOI
  89. [94]Wakabayashi H. Oda H. Yamauchi K. Abe F. Lactoferrin for prevention of common viral infections J. Infect. Chemother. 2014 20 666 671 10.1016/j.jiac.2014.08.003 25182867 · DOI
  90. [95]Campione E. Cosio T. Rosa L. Lanna C. Di Girolamo S. Gaziano R. Valenti P. Bianchi L. Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation Int. J. Mol. Sci. 2020 21 4903 10.3390/ijms21144903 PMC7402319 32664543 · DOI
  91. [98]Carita A.C. Fonseca-Santos B. Shultz J.D. Michniak-Kohn B. Chorilli M. Leonardi G.R. Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability Nanomedicine 2020 24 102117 10.1016/j.nano.2019.102117 31676375 · DOI
  92. [100]Sauberlich H.E. Pharmacology of vitamin C Annu. Rev. Nutr. 1994 14 371 391 10.1146/annurev.nu.14.070194.002103 7946525 · DOI
  93. [101]Ames B.N. Shigenaga M.K. Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging Proc. Natl. Acad. Sci. USA 1993 90 7915 7922 10.1073/pnas.90.17.7915 8367443 PMC47258 · DOI · Paper page
  94. [102]Carr A.C. Maggini S. Vitamin C and Immune Function Nutrients 2017 9 1211 10.3390/nu9111211 PMC5707683 29099763 · DOI · Paper page
  95. [103]Englard S. Seifter S. The biochemical functions of ascorbic acid Annu. Rev. Nutr. 1986 6 365 406 10.1146/annurev.nu.06.070186.002053 3015170 · DOI · Paper page
  96. [104]Winterbourn C.C. Vissers M.C. Changes in ascorbate levels on stimulation of human neutrophils Biochim. Biophys. Acta 1983 763 175 179 10.1016/0167-4889(83)90041-1 6615889 · DOI
  97. [105]Oberritter H. Glatthaar B. Moser U. Schmidt K.H. Effect of functional stimulation on ascorbate content in phagocytes under physiological and pathological conditions Int. Arch. Allergy Appl. Immunol. 1986 81 46 50 10.1159/000234106 3744577 · DOI
  98. [106]Rebora A. Dallegri F. Patrone F. Neutrophil dysfunction and repeated infections: Influence of levamisole and ascorbic acid Br. J. Dermatol. 1980 102 49 56 10.1111/j.1365-2133.1980.tb05671.x 7378281 · DOI
  99. [107]Anderson R. Theron A. Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate S. Afr. Med. J. 1979 56 429 433 550365
  100. [108]Molina N. Morandi A.C. Bolin A.P. Otton R. Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes Int. Immunopharmacol. 2014 22 41 50 10.1016/j.intimp.2014.06.026 24975831 · DOI
  101. [109]Tanaka M. Muto N. Gohda E. Yamamoto I. Enhancement by ascorbic acid 2-glucoside or repeated additions of ascorbate of mitogen-induced IgM and IgG productions by human peripheral blood lymphocytes Jpn. J. Pharmacol. 1994 66 451 456 10.1254/jjp.66.451 7723222 · DOI
  102. [110]Furuya A. Uozaki M. Yamasaki H. Arakawa T. Arita M. Koyama A.H. Antiviral effects of ascorbic and dehydroascorbic acids in vitro Int. J. Mol. Med. 2008 22 541 545 18813862
  103. [111]Schwerdt P.R. Schwerdt C.E. Effect of ascorbic acid on rhinovirus replication in WI-38 cells Proc. Soc. Exp. Biol. Med. 1975 148 1237 1243 10.3181/00379727-148-38724 165544 · DOI
  104. [112]Jariwalla R.J. Roomi M.W. Gangapurkar B. Kalinovsky T. Niedzwiecki A. Rath M. Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids Biofactors 2007 31 1 15 10.1002/biof.5520310101 18806304 · DOI
  105. [113]Harakeh S. Jariwalla R.J. NF-kappa B-independent suppression of HIV expression by ascorbic acid AIDS Res. Hum. Retroviruses 1997 13 235 239 10.1089/aid.1997.13.235 9115810 · DOI
  106. [114]Fisher B.J. Kraskauskas D. Martin E.J. Farkas D. Puri P. Massey H.D. Idowu M.O. Brophy D.F. Voelkel N.F. Fowler A.A. 3rd Attenuation of sepsis-induced organ injury in mice by vitamin C JPEN J. Parenter. Enteral. Nutr. 2014 38 825 839 10.1177/0148607113497760 23917525 · DOI
  107. [115]Kim Y. Kim H. Bae S. Choi J. Lim S.Y. Lee N. Kong J.M. Hwang Y.I. Kang J.S. Lee W.J. Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-alpha/beta at the Initial Stage of Influenza A Virus (H3N2) Infection Immune Netw. 2013 13 70 74 10.4110/in.2013.13.2.70 23700397 PMC3659258 · DOI
  108. [116]Madhusudana S.N. Shamsundar R. Seetharaman S. In vitro inactivation of the rabies virus by ascorbic acid Int. J. Infect. Dis. 2004 8 21 25 10.1016/j.ijid.2003.09.002 14690777 · DOI
  109. [117]Gorton H.C. Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections J. Manip. Physiol Ther. 1999 22 530 533 10.1016/S0161-4754(99)70005-9 10543583 · DOI · Paper page
  110. [118]Abobaker A. Alzwi A. Alraied A.H.A. Overview of the possible role of vitamin C in management of COVID-19 Pharmacol. Rep. 2020 72 1517 1528 10.1007/s43440-020-00176-1 33113146 PMC7592143 · DOI
  111. [120]Boretti A. Banik B.K. Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome PharmaNutrition 2020 12 100190 10.1016/j.phanu.2020.100190 32322486 PMC7172861 · DOI
  112. [121]Cai Y. Li Y.F. Tang L.P. Tsoi B. Chen M. Chen H. Chen X.M. Tan R.R. Kurihara H. He R.R. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice Biomed. Res. Int. 2015 2015 675149 10.1155/2015/675149 25710018 PMC4331320 · DOI
  113. [122]Hoang B.X. Shaw G. Fang W. Han B. Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection J. Glob. Antimicrob. Resist. 2020 23 256 262 10.1016/j.jgar.2020.09.025 33065330 PMC7553131 · DOI
  114. [123]Patel V. Dial K. Wu J. Gauthier A.G. Wu W. Lin M. Espey M.G. Thomas D.D. Ashby C.R. Jr. Mantell L.L. Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1 Int. J. Mol. Sci. 2020 21 977 10.3390/ijms21030977 32024151 PMC7037000 · DOI
  115. [124]Horowitz R.I. Freeman P.R. Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials Med. Hypotheses 2020 143 109851 10.1016/j.mehy.2020.109851 32534175 PMC7242962 · DOI
  116. [126]Rodrigues da Silva M. Schapochnik A. Peres Leal M. Esteves J. Bichels Hebeda C. Sandri S. Pavani C. Ratto Tempestini Horliana A.C. Farsky S.H.P. Lino-Dos-Santos-Franco A. Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat PLoS ONE 2018 13 e0205535 10.1371/journal.pone.0205535 30395570 PMC6218022 · DOI
  117. [127]Hemila H. Chalker E. Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: A meta-regression analysis J. Intensive Care 2020 8 15 10.1186/s40560-020-0432-y 32047636 PMC7006137 · DOI
  118. [128]Hernandez A. Papadakos P.J. Torres A. Gonzalez D.A. Vives M. Ferrando C. Baeza J. Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19 Rev. Esp. Anestesiol. Reanim. 2020 67 245 252 10.1016/j.redare.2020.05.002 32303365 PMC7156242 · DOI
  119. [129]Yatim K.M. Lakkis F.G. A brief journey through the immune system Clin. J. Am. Soc. Nephrol. 2015 10 1274 1281 10.2215/CJN.10031014 25845377 PMC4491295 · DOI
  120. [130]Chen Y. Luo G. Yuan J. Wang Y. Yang X. Wang X. Li G. Liu Z. Zhong N. Vitamin C mitigates oxidative stress and tumor necrosis factor-alpha in severe community-acquired pneumonia and LPS-induced macrophages Mediators Inflamm. 2014 2014 426740 10.1155/2014/426740 25253919 PMC4165740 · DOI
  121. [131]Evans R.M. Currie L. Campbell A. The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration Br. J. Nutr. 1982 47 473 482 10.1079/BJN19820059 7082619 · DOI
  122. [132]Boxer L.A. Vanderbilt B. Bonsib S. Jersild R. Yang H.H. Baehner R.L. Enhancement of chemotactic response and microtubule assembly in human leukocytes by ascorbic acid J. Cell Physiol. 1979 100 119 126 10.1002/jcp.1041000112 468916 · DOI
  123. [133]Parker W.H. Rhea E.M. Qu Z.C. Hecker M.R. May J.M. Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton Am. J. Physiol. Cell Physiol. 2016 311 C652 C662 10.1152/ajpcell.00076.2016 27605450 PMC5129753 · DOI
  124. [134]De la Fuente M. Ferrandez M.D. Burgos M.S. Soler A. Prieto A. Miquel J. Immune function in aged women is improved by ingestion of vitamins C and E Can. J. Physiol. Pharmacol. 1998 76 373 380 10.1139/y98-038 9795745 · DOI
  125. [135]Sharma P. Raghavan S.A. Saini R. Dikshit M. Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: Modulatory effect of nitric oxide J. Leukoc. Biol. 2004 75 1070 1078 10.1189/jlb.0903415 15039465 · DOI
  126. [136]Hong J.M. Kim J.H. Kang J.S. Lee W.J. Hwang Y.I. Vitamin C is taken up by human T cells via sodium-dependent vitamin C transporter 2 (SVCT2) and exerts inhibitory effects on the activation of these cells in vitro Anat. Cell Biol. 2016 49 88 98 10.5115/acb.2016.49.2.88 27382510 PMC4927435 · DOI
  127. [137]Huijskens M.J. Walczak M. Sarkar S. Atrafi F. Senden-Gijsbers B.L. Tilanus M.G. Bos G.M. Wieten L. Germeraad W.T. Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy Cytotherapy 2015 17 613 620 10.1016/j.jcyt.2015.01.004 25747742 · DOI
  128. [138]Kasahara H. Kondo T. Nakatsukasa H. Chikuma S. Ito M. Ando M. Kurebayashi Y. Sekiya T. Yamada T. Okamoto S. Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model Int. Immunol. 2017 29 457 469 10.1093/intimm/dxx060 29126272 · DOI
  129. [139]Campbell J.D. Cole M. Bunditrutavorn B. Vella A.T. Ascorbic acid is a potent inhibitor of various forms of T cell apoptosis Cell Immunol. 1999 194 1 5 10.1006/cimm.1999.1485 10357874 · DOI
  130. [140]Cheng R.Z. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med. Drug Discov. 2020 5 100028 10.1016/j.medidd.2020.100028 32328576 PMC7167497 · DOI
  131. [141]Matthay M.A. Aldrich J.M. Gotts J.E. Treatment for severe acute respiratory distress syndrome from COVID-19 Lancet Respir. Med. 2020 8 433 434 10.1016/S2213-2600(20)30127-2 32203709 PMC7118607 · DOI
  132. [142]Pulvirenti G. Parisi G.F. Manti S. Licari A. Miraglia del Giudice M. Salpietro C. Marseglia G.L. Leonardi S. The Immunomodulatory Role of Vitamin D in Respiratory Diseases Curr. Respir. Med. Rev. 2019 15 238 245 10.2174/1573398X15666191114144230 · DOI
  133. [143]Holick M.F. Vitamin D deficiency N. Engl. J. Med. 2007 357 266 281 10.1056/NEJMra070553 17634462 · DOI · Paper page
  134. [144]Baeke F. Takiishi T. Korf H. Gysemans C. Mathieu C. Vitamin D: Modulator of the immune system Curr. Opin. Pharmacol. 2010 10 482 496 10.1016/j.coph.2010.04.001 20427238 · DOI
  135. [145]Von Essen M.R. Kongsbak M. Schjerling P. Olgaard K. Odum N. Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells Nat. Immunol. 2010 11 344 349 10.1038/ni.1851 20208539 · DOI
  136. [146]Berridge M.J. Vitamin D cell signalling in health and disease Biochem. Biophys. Res. Commun. 2015 460 53 71 10.1016/j.bbrc.2015.01.008 25998734 · DOI
  137. [147]Tao S. Zhang H. Xue L. Jiang X. Wang H. Li B. Tian H. Zhang Z. Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner Environ. Toxicol. 2019 34 594 609 10.1002/tox.22726 30698894 · DOI
  138. [148]Yalaki Z. Tasar M.A. Oney H. Gokceoglu A.U. Comparison of Viral Agents and Vitamin D Levels in Children with Acute Bronchiolitis Infection J. Pediatric Infect. 2019 13 E14 E20 10.5578/ced.201903 · DOI
  139. [149]Larkin A. Lassetter J. Vitamin D deficiency and acute lower respiratory infections in children younger than 5 years: Identification and treatment J. Pediatric Health Care 2014 28 572 582 10.1016/j.pedhc.2014.08.013 25441970 PMC7127565 · DOI
  140. [150]Loeb M. Dang A.D. Thiem V.D. Thanabalan V. Wang B. Nguyen N.B. Tran H.T.M. Luong T.M. Singh P. Smieja M. Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial Influenza Other Respir. Viruses 2019 13 176 183 10.1111/irv.12615 30328294 PMC6379634 · DOI
  141. [151]McCartney D.M. Byrne D.G. Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19 Ir. Med. J. 2020 113 58 32268051
  142. [152]Grant W.B. Lahore H. McDonnell S.L. Baggerly C.A. French C.B. Aliano J.L. Bhattoa H.P. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Nutrients 2020 12 988 10.3390/nu12040988 · DOI
  143. [153]Greiller C.L. Martineau A.R. Modulation of the immune response to respiratory viruses by vitamin D Nutrients 2015 7 4240 4270 10.3390/nu7064240 26035247 PMC4488782 · DOI
  144. [155]Gasmi A. Noor S. Tippairote T. Dadar M. Menzel A. Bjorklund G. Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic Clin. Immunol. 2020 215 108409 10.1016/j.clim.2020.108409 32276137 PMC7139252 · DOI
  145. [156]D’Avolio A. Avataneo V. Manca A. Cusato J. De Nicolo A. Lucchini R. Keller F. Cantu M. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 Nutrients 2020 12 1359 10.3390/nu12051359 PMC7285131 32397511 · DOI
  146. [157]Ilie P.C. Stefanescu S. Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality Aging Clin. Exp. Res. 2020 32 1195 1198 10.1007/s40520-020-01570-8 32377965 PMC7202265 · DOI
  147. [158]Laird E. Rhodes J. Kenny R.A. Vitamin D and Inflammation: Potential Implications for Severity of Covid-19 Ir. Med. J. 2020 113 81 32603576
  148. [159]Entrenas Castillo M. Entrenas Costa L.M. Vaquero Barrios J.M. Alcala Diaz J.F. Lopez Miranda J. Bouillon R. Quesada Gomez J.M. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study J. Steroid Biochem. Mol. Biol. 2020 203 105751 10.1016/j.jsbmb.2020.105751 32871238 PMC7456194 · DOI
  149. [160]Caccialanza R. Laviano A. Lobascio F. Montagna E. Bruno R. Ludovisi S. Corsico A.G. Di Sabatino A. Belliato M. Calvi M. Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol Nutrition 2020 74 110835 10.1016/j.nut.2020.110835 32280058 PMC7194616 · DOI
  150. [161]Mendy A. Apewokin S. Wells A.A. Morrow A.L. Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients medRxiv 2020 10.1101/2020.06.25.20137323 · DOI
  151. [162]Hastie C.E. Mackay D.F. Ho F. Celis-Morales C.A. Katikireddi S.V. Niedzwiedz C.L. Jani B.D. Welsh P. Mair F.S. Gray S.R. Vitamin D concentrations and COVID-19 infection in UK Biobank Diabetes Metab. Syndr. 2020 14 561 565 10.1016/j.dsx.2020.04.050 32413819 PMC7204679 · DOI
  152. [163]Liu N. Sun J. Wang X. Zhang T. Zhao M. Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: A systematic review and meta-analysis Int. J. Infect. Dis. 2021 104 58 64 10.1016/j.ijid.2020.12.077 33401034 PMC7833186 · DOI
  153. [164]Yisak H. Ewunetei A. Kefale B. Mamuye M. Teshome F. Ambaw B. Yideg Yitbarek G. Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review Risk Manag. Healthc. Policy 2021 14 31 38 10.2147/RMHP.S291584 33447107 PMC7800698 · DOI
  154. [165]Pereira M. Dantas Damascena A. Galvao Azevedo L.M. de Almeida Oliveira T. da Mota Santana J. Vitamin D deficiency aggravates COVID-19: Systematic review and meta-analysis Crit. Rev. Food Sci. Nutr. 2020 1 9 10.1080/10408398.2020.1841090 33146028 · DOI
  155. [166]Jain A. Chaurasia R. Sengar N.S. Singh M. Mahor S. Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers Sci. Rep. 2020 10 20191 10.1038/s41598-020-77093-z 33214648 PMC7677378 · DOI
  156. [167]Barrea L. Muscogiuri G. Laudisio D. Pugliese G. de Alteriis G. Colao A. Savastano S. Influence of the Mediterranean Diet on 25- Hydroxyvitamin D Levels in Adults Nutrients 2020 12 1439 10.3390/nu12051439 32429342 PMC7284708 · DOI
  157. [168]Dalamaga M. Muscogiuri G. Paganitsa G. Parvouleskou G. Syriou V. Karagkoynis P. Stratigou T. Vallianou N. Christodoulatos G.S. Karampela I. Adherence to the Mediterranean diet is an independent predictor of circulating vitamin D levels in normal weight and non-smoker adults: An observational cross-sectional study Int. J. Food Sci. Nutr. 2021 1 13 10.1080/09637486.2021.1878488 33509003 · DOI
  158. [169]Skrajnowska D. Bobrowska-Korczak B. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms Nutrients 2019 11 2273 10.3390/nu11102273 PMC6835436 31546724 · DOI
  159. [170]Wessels I. Maywald M. Rink L. Zinc as a Gatekeeper of Immune Function Nutrients 2017 9 1286 10.3390/nu9121286 29186856 PMC5748737 · DOI
  160. [171]Suara R.O. Crowe J.E. Jr. Effect of zinc salts on respiratory syncytial virus replication Antimicrob. Agents Chemother. 2004 48 783 790 10.1128/AAC.48.3.783-790.2004 14982765 PMC353050 · DOI
  161. [172]Truong-Tran A.Q. Carter J. Ruffin R. Zalewski P.D. New insights into the role of zinc in the respiratory epithelium Immunol. Cell Biol. 2001 79 170 177 10.1046/j.1440-1711.2001.00986.x 11264713 · DOI
  162. [173]Roscioli E. Jersmann H.P. Lester S. Badiei A. Fon A. Zalewski P. Hodge S. Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD Int. J. Chron. Obstruct. Pulmon. Dis. 2017 12 3503 3510 10.2147/COPD.S149589 29255357 PMC5723110 · DOI
  163. [174]Skalny A.V. Rink L. Ajsuvakova O.P. Aschner M. Gritsenko V.A. Alekseenko S.I. Svistunov A.A. Petrakis D. Spandidos D.A. Aaseth J. Zinc and respiratory tract infections: Perspectives for COVID19 (Review) Int. J. Mol. Med. 2020 46 17 26 10.3892/ijmm.2020.4575 32319538 PMC7255455 · DOI
  164. [175]Woodworth B.A. Zhang S. Tamashiro E. Bhargave G. Palmer J.N. Cohen N.A. Zinc increases ciliary beat frequency in a calcium-dependent manner Am. J. Rhinol. Allergy 2010 24 6 10 10.2500/ajra.2010.24.3379 20109308 · DOI
  165. [176]Te Velthuis A.J. van den Worm S.H. Sims A.C. Baric R.S. Snijder E.J. van Hemert M.J. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture PLoS Pathog. 2010 6 e1001176 10.1371/journal.ppat.1001176 21079686 PMC2973827 · DOI
  166. [177]Kumar A. Kubota Y. Chernov M. Kasuya H. Potential role of zinc supplementation in prophylaxis and treatment of COVID-19 Med. Hypotheses 2020 144 109848 10.1016/j.mehy.2020.109848 32512490 PMC7247509 · DOI
  167. [178]Shittu M.O. Afolami O.I. Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives—A better synergy for future COVID-19 clinical trials Infez. Med. 2020 28 192 197 32335560
  168. [179]Meo S.A. Klonoff D.C. Akram J. Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19 Eur. Rev. Med. Pharmacol. Sci. 2020 24 4539 4547 32373993
  169. [180]Villamor E. Fawzi W.W. Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes Clin. Microbiol. Rev. 2005 18 446 464 10.1128/CMR.18.3.446-464.2005 16020684 PMC1195969 · DOI
  170. [181]Maggini S. Pierre A. Calder P.C. Immune Function and Micronutrient Requirements Change over the Life Course Nutrients 2018 10 1531 10.3390/nu10101531 PMC6212925 30336639 · DOI · Paper page
  171. [182]Blomhoff H.K. Smeland E.B. Erikstein B. Rasmussen A.M. Skrede B. Skjonsberg C. Blomhoff R. Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells J. Biol. Chem. 1992 267 23988 23992 10.1016/S0021-9258(18)35934-9 1429735 · DOI
  172. [183]Smith S.M. Hayes C.E. Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice Proc. Natl. Acad. Sci. USA 1987 84 5878 5882 10.1073/pnas.84.16.5878 3475707 PMC298966 · DOI
  173. [184]Tian Y. Tian Q. Wu Y. Peng X. Chen Y. Li Q. Zhang G. Tian X. Ren L. Luo Z. Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia inhibits the progression of experimental asthma by altering CD4(+)T cell subsets Sci. Rep. 2020 10 4214 10.1038/s41598-020-60665-4 32144294 PMC7060180 · DOI
  174. [185]Schwartz D.M. Farley T.K. Richoz N. Yao C. Shih H.Y. Petermann F. Zhang Y. Sun H.W. Hayes E. Mikami Y. Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology Immunity 2019 50 106 120.e10 10.1016/j.immuni.2018.12.014 30650370 PMC6338086 · DOI
  175. [186]Hoag K.A. Nashold F.E. Goverman J. Hayes C.E. Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells J. Nutr. 2002 132 3736 3739 10.1093/jn/132.12.3736 12468615 · DOI
  176. [187]Huang Z. Liu Y. Qi G. Brand D. Zheng S.G. Role of Vitamin A in the Immune System J. Clin. Med. 2018 7 258 10.3390/jcm7090258 30200565 PMC6162863 · DOI · Paper page
  177. [188]Garbe A. Buck J. Hammerling U. Retinoids are important cofactors in T cell activation J. Exp. Med. 1992 176 109 117 10.1084/jem.176.1.109 1535365 PMC2119299 · DOI
  178. [189]Rahman M.M. Mahalanabis D. Alvarez J.O. Wahed M.A. Islam M.A. Habte D. Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 mo Am. J. Clin. Nutr. 1997 65 144 148 10.1093/ajcn/65.1.144 8988926 · DOI
  179. [190]Awasthi S. Peto R. Read S. Clark S. Pande V. Bundy D. DEVTA (Deworming and Enhanced Vitamin A) Team Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial Lancet 2013 381 1469 1477 10.1016/S0140-6736(12)62125-4 23498849 PMC3647148 · DOI
  180. [192]Hester G.Z. Nickel A.J. Stinchfield P.A. Spaulding A.B. Low Use of Vitamin A in Children Hospitalized for Measles in the United States Pediatric Infect. Dis. J. 2020 39 e45 e46 10.1097/INF.0000000000002574 31990890 · DOI
  181. [193]Strebel P.M. Orenstein W.A. Measles N. Engl. J. Med. 2019 381 349 357 10.1056/NEJMcp1905181 31184814 · DOI
  182. [194]Fawzi W.W. Mbise R. Spiegelman D. Fataki M. Hertzmark E. Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania J. Pediatrics 2000 137 660 667 10.1067/mpd.2000.110136 11060532 · DOI
  183. [195]Imdad A. Yakoob M.Y. Sudfeld C. Haider B.A. Black R.E. Bhutta Z.A. Impact of vitamin A supplementation on infant and childhood mortality BMC Public Health 2011 11 Suppl. 3 S20 10.1186/1471-2458-11-S3-S20 21501438 PMC3231894 · DOI
  184. [196]Mathew J.L. Vitamin A supplementation for prophylaxis or therapy in childhood pneumonia: A systematic review of randomized controlled trials Indian Pediatrics 2010 47 255 261 10.1007/s13312-010-0042-1 20371893 · DOI
  185. [197]Chen H. Zhuo Q. Yuan W. Wang J. Wu T. Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age Cochrane Database Syst. Rev. 2008 CD006090 10.1002/14651858.CD006090.pub2 18254093 PMC11842301 · DOI
  186. [198]Becker P. Maurer B. Schirmacher P. Waldherr R. Parlesak A. Bode C. Seitz H.K. Vitamin A-induced cholestatic hepatitis: A case report Z. Gastroenterol. 2007 45 1063 1066 10.1055/s-2007-963342 17924304 · DOI
  187. [199]Geubel A.P. De Galocsy C. Alves N. Rahier J. Dive C. Liver damage caused by therapeutic vitamin A administration: Estimate of dose-related toxicity in 41 cases Gastroenterology 1991 100 1701 1709 10.1016/0016-5085(91)90672-8 2019375 · DOI
  188. [200]Minuk G.Y. Kelly J.K. Hwang W.S. Vitamin A hepatotoxicity in multiple family members Hepatology 1988 8 272 275 10.1002/hep.1840080214 3356407 · DOI
  189. [201]Fallon M.B. Boyer J.L. Hepatic toxicity of vitamin A and synthetic retinoids J. Gastroenterol. Hepatol. 1990 5 334 342 10.1111/j.1440-1746.1990.tb01635.x 2103414 · DOI
  190. [202]Penniston K.L. Tanumihardjo S.A. The acute and chronic toxic effects of vitamin A Am. J. Clin. Nutr. 2006 83 191 201 10.1093/ajcn/83.2.191 16469975 · DOI
  191. [203]Pecora F. Persico F. Argentiero A. Neglia C. Esposito S. The Role of Micronutrients in Support of the Immune Response against Viral Infections Nutrients 2020 12 3198 10.3390/nu12103198 PMC7589163 33092041 · DOI
  192. [204]Simopoulos A.P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases Exp. Biol. Med. 2008 233 674 688 10.3181/0711-MR-311 18408140 · DOI
  193. [205]Cholewski M. Tomczykowa M. Tomczyk M. A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids Nutrients 2018 10 1662 10.3390/nu10111662 30400360 PMC6267444 · DOI
  194. [206]Gutierrez S. Svahn S.L. Johansson M.E. Effects of Omega-3 Fatty Acids on Immune Cells Int. J. Mol. Sci. 2019 20 5028 10.3390/ijms20205028 31614433 PMC6834330 · DOI
  195. [207]Serhan C.N. Pro-resolving lipid mediators are leads for resolution physiology Nature 2014 510 92 101 10.1038/nature13479 24899309 PMC4263681 · DOI · Paper page
  196. [209]Basil M.C. Levy B.D. Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation Nat. Rev. Immunol. 2016 16 51 67 10.1038/nri.2015.4 26688348 PMC5242505 · DOI
  197. [212]Hasturk H. Kantarci A. Goguet-Surmenian E. Blackwood A. Andry C. Serhan C.N. Van Dyke T.E. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo J. Immunol. 2007 179 7021 7029 10.4049/jimmunol.179.10.7021 17982093 · DOI
  198. [213]Harris W.S. Von Schacky C. The Omega-3 Index: A new risk factor for death from coronary heart disease? Prev. Med. 2004 39 212 220 10.1016/j.ypmed.2004.02.030 15208005 · DOI · Paper page
  199. [214]Imhoff-Kunsch B. Stein A.D. Martorell R. Parra-Cabrera S. Romieu I. Ramakrishnan U. Prenatal docosahexaenoic acid supplementation and infant morbidity: Randomized controlled trial Pediatrics 2011 128 e505 e512 10.1542/peds.2010-1386 21807696 PMC3164093 · DOI
  200. [215]Pastor N. Soler B. Mitmesser S.H. Ferguson P. Lifschitz C. Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life Clin. Pediatrics 2006 45 850 855 10.1177/1073858406289801 17041174 · DOI

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Authors
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S.
Affiliations
  • University of Catania (IT)
  • The Children’s Hospital of Philadelphia (CHOP), Department of Pediatrics, Division of Hematology Leonard and Madlyn Abramson Pediatric Research Center, Philadelphia, PA 19104, USA
  • Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 87 95125 Catania, Italy
Corresponding author
Barbagallo, Ignazio
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-02-28
Volume
22
Issue
5
Pages
2465
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms22052465
PMC
PMC7957644
OpenAlex
W3134275674
Cited by
43
References
14
Citations by year
2026: 2 · 2025: 4 · 2024: 9 · 2023: 2 · 2022: 20 · 2021: 6
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
nutraceuticals, antiviral activity, COVID-19 pandemic, SARS-CoV-2, viral infection prevention, pediatric population, immunomodulation, dietary supplements, dietary nutrients
MeSH terms
COVID-19, SARS-CoV-2, Antiviral Agents, Child, Humans, Virus Diseases, Randomized Controlled Trials as Topic, Dietary Supplements, Probiotics

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