Cited by 863Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchRedox biology and oxidative stress

The DOI matches its Crossref record; 138 of the 140 references it cites were found in a registry or an index.

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Open access

Zhao, Yan, Zhao, Baolu·2013·Oxidative Medicine and Cellular Longevity

DOI 10.1155/2013/316523PMC PMC3745981

Open this paper in CoChat — free account Open PDF

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other cognitive functions, which eventually leads to a complete incapacity and death. A complicated array of molecular events has been implicated in the pathogenesis of AD. The major pathological characteristics of AD brains are the presence of senile plaques, neurofibrillary tangles, and neuronal loss. Growing evidence has demonstrated that oxidative stress is an important factor contributing to the initiation and progression of AD. However, the mechanisms that lead to the disruption of redox balance and the sources of free radicals remain elusive. The excessive reactive oxygen species may be generated from mechanisms such as mitochondria dysfunction and/or aberrant accumulation of transition metals, while the abnormal accumulation of Abeta and tau proteins appears to promote the redox imbalance. The resulted oxidative stress has been implicated in Abeta- or tau-induced neurotoxicity. In addition, evidence has suggested that oxidative stress may augment the production and aggregation of Abeta and facilitate the phosphorylation and polymerization of tau, thus forming a vicious cycle that promotes the initiation and progression of AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2013/316523

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
Alzheimer’s disease
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
Copper, iron and zinc in Alzheimer's disease senile plaques
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611

Flagged first, then by citations

Show all 140 references

2 of the 140 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

1995, American Journal of Pathology, 146, 357
10.1007/978-0-387-46401-5-8 · DOI
2008, Journal of Nutrition, 138
2012, Frontiers in Bioscience, 4, 794
2004, Diabetes, 53, S130
10.1042/0264-6021:3440461 · DOI

Sorted by citations

Items 701–800 of 863

The neuroprotective effect of eugenol in aluminum chloride-induced Alzheimer's rats: Insights into the role of TLR4/MyD88/NF-kB and NLRP3 inflammasome/gasdermin D signaling pathways
El-Dory, S. T., El-Fattah, A. A. A., Sadik, N. A. H., & Elbaz, E. M. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110885 · Cited by 2
Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer’s disease: phytochemicals as neuroprotective agents
Yadav, B., Gangwar, P., Kumari, K., Yadav, A., Rao, R., Kumar, K., Verma, H., Dhiman, M., & Mantha, A. K. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1835778 · Cited by 2
Brain health across the lifespan and the impact of nutrition, exercise, microbiota, and sleep
Shin, A. C., Haque, Z. F., Galyean, S., Hefner, M., Esmaeili, M., Lawrence, J. J., & Watkins, B. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103245 · Cited by 3
The Role of Renin Angiotensin Aldosterone System in the Progression of Cognitive Dysfunction in Chronic Kidney Disease Patients with Alzheimer’s Disease
Ganesan, V. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96048 · Cited by 2
Clinical evaluation of a novel gallotannin-enriched Galla Rhois extract (GRE) on vital cognitive functions in healthy volunteers: A randomized, double-blind, placebo-controlled study
Heuer, M., Baker, C., Sedlak, M., Woo, K. J., Kee, K. H., & Bagchi, D. (2023) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v13i10.1213 · Cited by 2
Cognitive enhancement and anti-oxidant activities of Thespesia populnea L.: A bio-assay guided study using molecular docking for symptomatic alleviation of Alzheimer's disease
Halim, M. B. A., Metwally, G. F., Abd‐Elrazek, A., Al-Karmalawy, A. A., El-Zoheiry, H. H., Deeb, K. S. E., & Eid, H. H. (2024) · Scientific African · doi:10.1016/j.sciaf.2024.e02501 · Cited by 2
Selenium and Episodic Memory: The Moderating Role of Apolipoprotein E ε4
Kim, S. G., Keum, M., Choe, Y. M., Suh, G., Lee, B. C., Kim, H. S., Lee, J. H., Hwang, J., Yi, D., & Kim, J. W. (2025) · Nutrients · doi:10.3390/nu17030595 · Cited by 3
Mitochondrial Genome Variants and Alzheimer’s Disease
Kozin, M. S., Кулакова, О. Г., Сергеевич, К. И., Semina, E. V., Kakotkin, V. V., Агапов, М. А., & Favorova, O. O. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924603174 · Cited by 2
Kaempferide and Norbergenin avert aluminium chloride-induced amyloid β accumulation and neurocognitive shutdown via oxidative and apoptotic mechanisms
Nalla, S., Ganta, S., Bukke, S. P. N., Bandaru, N., Onohuean, H., & Alagbonsi, A. I. (2025) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320251343687 · Cited by 2
Oxidative Stress, Metabolic Syndrome and Alzheimer’s Disease
Toral-Ríos, D., Carvajal, K., Phillips-Farfán, B. V., Camacho, L., & Campos‐Peña, V. (2016) · Springer eBooks · doi:10.1007/978-3-319-45865-6_23 · Cited by 2
Neuropharmacology in Flux: Molecular Modeling Tools for Understanding Protein Conformational Shifts in Alzheimer’s Disease and Related Disorders
Lushington, G. H., Parker, F. E. S., Lushington, T. H. W., & Wallace, N. M. (2017) · Neuromethods · doi:10.1007/978-1-4939-7404-7_20 · Cited by 2
Whole Blood mRNA Expression Pattern Differentiates AD Patients and Healthy Controls Through Bioinformatics Analysis
Zhu, M., & Wang, L. (2019) · Journal of Biology and Life Science · doi:10.5296/jbls.v10i2.14491 · Cited by 2
A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells
Cheng, C., Zheng, N., Sun, D., Fang, W., Zheng, L., Song, W., & Huang, J. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03073-4 · Cited by 2
Alzheimer’s Disease: An Insightful Review on the Future Trends of the Effective Therapeutics
Hashmi, A., Srivastava, V., Kalam, S. A., & Mishra, D. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102762 · Cited by 2
Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice
Hara, T., Toyama, H., Ohata, Y., Ikeuchi, T., Nakamura, S., Joh, T., & Ohtsubo, K. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac125 · Cited by 2
Identification of Phenolic Profiles and In vitro Antioxidants, Neuroprotective, and Anti-diabetic Activities of Extracts from the Algerian Plant: Calendula monardii Boiss. & Reut
Samai, Z., Toudert, N., Dadda, N., Hamel, T., Zakkad, F., Zerrad, C., Boutemedjet, S., Bensouıcı, C., & Djılanı, S. E. (2023) · Current Enzyme Inhibition · doi:10.2174/1573408019666230810115245 · Cited by 2
Histological and Memory Alterations in an Innovative Alzheimer’s Disease Animal Model by Vanadium Pentoxide Inhalation
Dorado-Martínez, C., Montiel-Flores, E., Ordóñez-Librado, J. L., Gutiérrez-Valdez, A. L., Caballero, C. A. G., Sánchez-Betancourt, J., Erazo, L. R., Tron-Alvarez, R., Rodríguez-Lara, V., & Ávila-Costa, M. R. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230818 · Cited by 3
Synthesis and Evaluation of Aminothiazole Hybrids as Potential Acetylcholinesterase Inhibitors
Soni, A., Kumar, A., Kumar, V., Rawat, R., & Eyüpoğlu, V. (2024) · Asian Journal of Chemistry · doi:10.14233/ajchem.2024.31241 · Cited by 2
Generation of reactive oxygen species and their impact on the health related parameters: A critical review
Khan, N. A. Q. M. U. (2016) · International Journal of Biosciences (IJB) · doi:10.12692/ijb/9.1.303-323 · Cited by 2
Antioxidants in Alzheimer’s Therapy
Obulesu, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816412-9.00003-3 · Cited by 2
WITHDRAWN: Assessment and Validation of Globodera pallida as a Novel In Vivo Model for Studying Alzheimer's Disease
Althobaiti, N. A., Albalawi, A. E., Warnock, N. D., Mccammick, E. M., Alsolais, A., Alkhaibari, A. M., Al-Hazani, T. M. I., Menaa, F., Dalzell, J. J., & Green, B. D. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.05.020 · Cited by 2
Retracted
Investigating the combined effect of copper, zinc, and iron ions on truncated and full-length Aβ peptides: insights from molecular dynamics simulation
Sohrabi, M., Bozorgmehr, M. R., & Momen-Heravi, M. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2301755 · Cited by 1
The Identification of Bioactive Compounds in the Aerial Parts of Agrimonia pilosa and Their Inhibitory Effects on Beta-Amyloid Production and Aggregation
Lee, C. H., Ko, M. S., Kim, Y.-S., Hwang, K. W., & Park, S. (2024) · Separations · doi:10.3390/separations11080243 · Cited by 1
Exploring the Potential of Herbal Compounds as Autophagy Modulators in Alzheimer's Disease: A Comprehensive Review
Yadav, E., Mandal, A. K., Sah, A. K., Poudel, S., Pathak, P., Khalilullah, H., Jaremko, M., Emwas, A.-H. M., Yadav, P. S., & Verma, A. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273298025240905130205 · Cited by 2
BBBoid: A spheroid-based model for investigating blood-brain barrier permeability
Shuvalova, M. L., Dmitrieva, A., Belousov, V. V., & Nosov, G. (2025) · Journal of Cellular Biotechnology · doi:10.1177/23523689251340904 · Cited by 1
Neuroprotective Effects of Vitamin C and Vitamin E on Oxidative Stress in Rats with Scopolamine-Induced Dementia
Muhammad, S. A., Aliyu, A. D., Abolaji, A. O., Jiyah, A., Bulama, I., Ibrahim, A., Abbas, A. Y., Imam, M. U., & Bilbis, L. S. (2025) · Journal of Cellular Neuroscience and Oxidative Stress · doi:10.37212/jcnos.1741523 · Cited by 1
Folate receptor 1 activation suppresses high glucose-induced amyloidogenesis in neurons via STAT3/Nrf2 pathway-dependent mitigation of mitochondrial oxidative stress
Kim, D. H., Jo, H. Y., Oh, Y. J., Lim, J. R., Chae, C. W., Jung, Y. H., Han, H. J., & Lee, H. J. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119074 · Cited by 1
Molecular Mechanisms Underlying the Alleviation of Aβ‐Induced Toxicity by Edible Flower Buds of Hemerocallis citrina in Caenorhabditis elegans
Liu, C., Wang, X., Yang, Y., Li, H., Yang, J., Jiang, H., Guo, L., Lu, Y., Zhang, Z., & Fei, D. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503362 · Cited by 1
Exploring the neuroprotective, antioxidant, and anti-amyloid effects of Ganoderma lucidum compounds in Alzheimer’s disease: insights from experimental and computational approaches
Mia, M., Dutta, A., Hossain, M. M., Adhikari, J., Rahman, M. M., & Shibly, A. Z. (2026) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2026.100706 · Cited by 1
FOXO transcription factors in Alzheimer’s Disease: balancing neuroprotection and neuronal degeneration
Shyam, M., Veronica, A., Wadhwa, J., Sharma, V., Bm, O., Srirangan, P., Venkatesh, R., & Prince, S. E. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12021-4 · Cited by 3
Green synthesis of lemon peel-derived multifunctional carbon dots for Alzheimer's disease with activities of alleviating oxidative stress, inhibiting AChE and Aβ aggregation
Zhu, W.-L., Meng, L., & Shen, L. (2026) · Chemical Physics Letters · doi:10.1016/j.cplett.2026.142910 · Cited by 1
Pharmacological Effects and Molecular Mechanisms of Lignans in the Treatment of Alzheimer’s Disease
Sun, L., Zhu, X., Fan, C., Wang, Y., Chen, Q., Zhang, L., Zhang, Y., & Liu, Y. (2026) · Molecules · doi:10.3390/molecules31152594 · Cited by 1
Contribution of Nucleic Acids in the Pathogenesis of Alzheimer’s Disease
Farooqui, A. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809937-7.00004-5 · Cited by 1
Natural Therapeutics for Alzheimer’s Disease
Dang, S., Mehtani, D., Kaur, A., & Gabrani, R. (2018) · Springer eBooks · doi:10.1007/978-981-13-1123-9_11 · Cited by 1
Frontiers in Clinical Drug Research - Alzheimer Disorders
Atta-ur-rahman, Mavoungou, C., Zimmerman, K. S., Wright, J., Harding, J., Cavallaro, R., Fuso, A., Yoshiyama, Y., Asija, Z., Clifford, A., et al. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816810806801150301 · Cited by 1
Unveiling Nature’s Arsenal: Natural Sources for Drug Discovery in Alzheimer’s Disease
Remya, C., Aiswarya, N., & Dileep, K. V. (2024) · Springer eBooks · doi:10.1007/978-981-99-9183-9_13 · Cited by 1
Understanding Alzheimer’s disease at the chemistry level
Xu, Y., Huang, Z., & Mu, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16140-7.00008-0 · Cited by 1
Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.
Ponce, I. T., Coria-Lucero, C. D., Lacoste, M. G., Vedova, M. C. D., Devia, C. M., Ramírez, D. C., Gomez-Mejiba, S., Delgado, S. M., & Anzulovich, A. C. (2024) · Journal of Cellular Neuroscience and Oxidative Stress · doi:10.37212/jcnos.1460272 · Cited by 1
Key Proteins in Rat Cerebral Cortex: Application of Cornu aspersum Extract as a Neuroprotective Agent in Alzheimer’s Type Dementia
Atanasov, V., Velkova, L. G., Tancheva, L. P., Dolashki, A., Kalfin, R. E., & Dolashka, P. A. (2024) · Molecules · doi:10.3390/molecules29225375 · Cited by 1
La melatonina como un factor promotor de la diferenciación neuronal: implicaciones en el tratamiento de las demencias
Benítez‐King, G., Valdés‐Tovar, M., Maya-Ampudia, V., Jiménez-Rubio, G., Domínguez-Alonso, A., Riquelme, A., Galván‐Arrieta, T., Solís‐Chagoyán, H., Alarcón-Elizalde, S., Moreno, J., et al. (2013) · Salud Mental · doi:10.17711/sm.0185-3325.2013.025 · Cited by 1
Association between periodontitis and Alzheimer′s disease: Does the link exist?
Popat, R., Bhavsar, N., & Popat, P. R. (2016) · Indian Journal of Oral Sciences · doi:10.4103/0976-6944.194202 · Cited by 1
In vitro multiple pharmacological targets of Colutea cilicica Boiss. & Balansa against key enzymes linked to neurodegenerative diseases, diabetes, and hyperpigmentation
Uysal, Ş., Ceylan, R., Aktümsek, A., Güler, G. Ö., & Picot, C. M. N. (2019) · Istanbul Journal of Pharmacy · doi:10.5152/istanbuljpharm.2018.396764 · Cited by 1
Análise da patogênese da doença de Alzheimer: revisão narrativa da literatura
Rodrigues, N. M., Bayão, T. D. S., Thomaz, I. B., & Cardoso, S. A. (2020) · HU Revista · doi:10.34019/1982-8047.2019.v45.25924 · Cited by 2
The Effect of Alkaloid Extracted from Huperzia Phlegmaria on Cognitive Deficits Scopolamine-Induced in Mice
Thu, D. K., Vui, D. T., Huyen, N. T. N., Bình, N. T. T., Huyen, N. T., Yên, N. T., & Tùng, B. T. (2020) · Current Bioactive Compounds · doi:10.2174/1573407216999200520082046 · Cited by 1
COVID-19 and Alzheimer's Disease: A Review of Mechanisms and Pathophysiology
Mohammadkhanizadeh, A., & Karimzadeh, F. (2021) · The Neuroscience Journal of Shefaye Khatam · doi:10.52547/shefa.9.2.151 · Cited by 1
Anti-amnesic effects, cerebral protection, and Acute and sub-chronic toxicity studies of Mitragyna inermis (Rubiaceae) leaves decoction
(2021) · Journal of Chemical Biological and Physical Sciences · doi:10.24214/jcbps.b.11.2.29206 · Cited by 1
Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases
Russell, A. E., Badr, A., Rai, A., Carafice, C., Rai, A., Daily, K. P., Whitham, O. D., Amer, A. O., Brown, C. M., & Dakhlallah, D. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-9205-5_13 · Cited by 1
Cognitive Impairment in Diabetes Mellitus and Its Management by Transcription Factor Nrf2-Mediated Antioxidant Defense System
Zhou, X., Münch, G. W., & Chang, D. (2022) · Biochemistry · doi:10.5772/intechopen.108733 · Cited by 1
Medicinal Cannabis for Alzheimer's Disease
Steiner, G. Z., Coles, M., Jaye, K. M., Metri, N., Butt, A. S., Christofides, K., McPartland, J., Al-Modhefer, Z., Karamacoska, D., Russo, E. B., et al. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5652-1.ch001 · Cited by 1
Olfactory neuronal precursors as a model to analyze the effects of melatonin in Alzheimer's disease.
Santillán-Morales, V., & Benítez‐King, G. (2023) · Melatonin Research · doi:10.32794/mr112500164
Liver Enzymes and Lifestyle
Danielsson, J. (2014) · Tampere University Institutional Repository (Tampere University) · Cited by 1
Effect of Vitamin D Supplementation on the Progression of Alzheimer’s Disease in Rats: A Mechanistic ApproachPreprint
Patel, P., & Shah, J. (2021) · Research Square · doi:10.21203/rs.3.rs-736027/v1 · Cited by 1
Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the LiteraturePreprint
Clark, J., Piccirella, S., Kayed, R., Abate, G., Uberti, D. L., & Kinnon, P. (2021) · Preprints.org · doi:10.20944/preprints202109.0359.v1 · Cited by 1
Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s DiseasePreprint
Deng, H., Gong, Y., Zhang, Q., Wu, D., Liu, A., Li, T., Xiao, Z., Li, Y., Haeri, M., Swerdlow, R. H., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7303622/v1 · Cited by 1
Flavonoids with Novel Nicotinic Activity as Potential Pharmacotherapies to Treat Ethanol- Induced Neurotoxicity
Lutz, J. A. (2014) · UKnowledge (University of Kentucky)
IN VITRO CUSO4 EXPOSURE INDUCES GENOMIC DNA DEGRADATION AND REDUCES ANTIOXIDANT ACTIVITY IN LIVER CELLS: AN IMPORTANT CONTAMINANT IN FOODS
Sekar, D., Pichandi, N., Krishnan, R., Sekar, P., Basam, V., & Janakiraman, K. (2015) · Indo American Journal of Pharmaceutical Research
Deciphering cell signaling rewiring in human disordersPreprint
Kuperstein, I. (2015) · arXiv (Cornell University) · doi:10.48550/arxiv.1512.05234
Alexander Disease and Potential Treatment through the Nrf2-ARE Pathway
Small, A. J. (2014) · Scholars' Bank (University of Oregon)
Síntese de potencial inibidor de acetilcolinesterase para tratamento da Doença de Alzheimer
Chierrito, T. P. C. (2016) · doi:10.11606/t.60.2016.tde-02052016-092044
C URRENT OPINION Inflammation and neurodegenerative disorders: is there still hope for therapeutic intervention?
Baune, B. T. (2015)
ROS regulation of axonal mitochondrial transport
Liao, P. (2016) · Purdue e-Pubs (Purdue University System)
Nutritional strategies in the management of Alzheimer\'s disease: systematic review and meta-analysis
Fernández, S. S. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.89.2016.tde-19102016-165329
Avaliação de efeitos neuroprotetores e comportamentais do tratamento com geleia real em ratos Wistar submetidos à administração intracerebroventicular de estreptozotocina, um modelo da doença de Alzheimer esporádica
Silva, T. G. D. S. E. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2017.tde-25072017-105756
O-GlcNAc Regulation of Mitochondrial Function and Energy Metabolism
Tan, E. P. (2017) · KU ScholarWorks (The University of Kansas)
Microfabrication Approaches for Understanding the Role of Vascular Mechanics in Progressive Diseases
Hald, E. S. (2016) · University of Minnesota Digital Conservancy (University of Minnesota)
Screening and evaluation of natural compounds for therapeutic application in Alzheimer's disease
Nirvanashetty, S. (2024) · Swinburne figshare (Swinburne University of Technology) · doi:10.25916/sut.26278636
Deterioro cognitivo leve tipo amnésico y la enfermedad de Alzheimer: implicaciones de la función ejecutiva y la atención dividida en la marcha
Lopes, E. S. T. (2018) · doi:10.14201/gredos.139759
Characterizing the physicochemical properties of TDP-43 protein and Acetylated Amyloid β peptides to discern its role in neurodegenerative diseases
Adhikari, R. (2019) · Digital Commons - Michigan Tech (Michigan Technological University) · doi:10.37099/mtu.dc.etdr/891
Teste de drogas do metabolismo em modelo transgênico de Drosophila melanogaster para doença de Alzheimer
Filho, R. M. (2019) · doi:10.14393/ufu.te.2019.2193
Ανάλυση γενετικών και βιολογικών δεικτών σε ασθενείς με νόσο Alzheimer
Σταμάτη, Π. (2020) · doi:10.12681/eadd/48041
Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease
Dixit, S. (2017)
Neurological Diseases and Mitochondrial Genes
Deepti, A., & Baby Chakrapani, P. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821974-4.00009-1
Fine Particulate Matter, Neuropathologies, & Dementia
Shaffer, R. M. (2020) · ResearchWorks at the University of Washington (University of Washington)
THE EFFECTS OF OXIDATIVE STRESS ON THE EYES OF SPRAGUE–DAWLEY RATS
Pai, C.-L., Chen, J., Lin, H.-J., & Lin, S. (2021) · Taiwan Veterinary Journal · doi:10.1142/s1682648521500050
The effects of sleep deprivation on spatial memory, dream and hyperphosphorylated tau proteins expression in rats
Ramli, N. (2021) · Universiti Sains Malaysia Institutional Repository (Universiti Sains Malaysia)
Ru(Ii)-P-Cymene Schiff Base Complexes: Synthesis, Characterization, Transfer Hydrogenation Reactions, Antioxidant and Enzyme Inhibitory ActivitiesPreprint
Buldurun, K., Turan, N., Mahmoudi, G., & Bursal, E. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4004785
The traditional Thai remedy Tri-Kesornmas promotes oxidative stress resistance, enhances lifespan, and reduces proteotoxicity in C. elegans
Keowkase, R., Kijmankongkul, N., Sangtian, W., & Sitthithaworn, W. (2022) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2022.120319
Marine Drugs as a Valuable Source of Natural Biomarkers Used in the Treatment of Alzheimer’s Disease
U, U. N. U. D. U. N. (2022) · Open Access Journal of Biogeneric Science and Research · doi:10.46718/jbgsr.2022.10.000253
Alzheimer’s Disease Therapy, and the Effects of Genetic Polymorphisms on Its Efficacy and Safety
Usman, H., & Ghaffar, A. (2021) · Molecular Medicine Communications · doi:10.55627/mmc.001.01.0019
Bertholletia excelsa
Bisht, A., Singh, S. K., & Kaldate, R. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00032-3
Authors' reply
Fuh, J., & Yang, C. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.204.2.163a
Cholinesterase Research
Korábečný, J., & Soukup, O. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-1797-1
Neuroprotective effects of Ficusdalhousie and Melissa parviflora benth against aluminium chloride induced Alzheimer's disease in rat model
Himabindu, K., & Vijayalakshmi, A. V. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns5.9097
Infection-Induced Systemic Inflammation and Dementia
Osafo, N., Dei, S. O., Akwei, N. A., & Yeboah, K. O. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_2
Role of Reactive Oxygen Species in Neurodegenerative Diseases
Tripathy, S., Singh, S., Banerjee, M., & Prakash, A. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815040913122010006
Oxyresveratrol-β-cyclodextrin mitigates intracerebral STZ-induced Alzheimer’s disease via suppression of hippocampal and cortical cognitive impairment and histone deacetylase activity in rats: In silico and In vivo studiesPreprint
Agarwal, T., Manandhar, S., Kumar, H., Famurewa, A. C., Gurram, P. C., Shri, S. R., Mudgal, J., & Pai, K. S. R. (2023) · Research Square · doi:10.21203/rs.3.rs-2547946/v1
To Explore the Mechanism of Alzheimer’s Disease Based on Brain-Gut Axis Theory
聂, 奕. (2023) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2023.132013
Consumo de alimentos segundo o grau de processamento e sua associação com ingestão de nutrientes e cognição em idosos
da Silva, G. M. (2022) · doi:10.47749/t/unicamp.2022.1263760
Güncel Biyokimya Çalışmaları VII
Atıcı, Y., Ökten, Z., Kasebi, S., Arıkan, B. S., Erdem, M., Kıran, T. R., Yağız, A. K., Aktolun, B., Demirağcı, Y. G., Kara, H., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3109
DESIGN, SYNTHESIS, AND BIOLOGICAL ASSESSMENT OF NOVEL N'-(BENZYLIDENE)PROPANEHYDRAZIDES AS MTDL FOR ALZHEIMER’S DISEASE
Kılıç, B. (2024) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1434552
Enhancing Mitochondrial Function: A Novel Therapeutic Target for Alzheimer's Disease
Iqbal, A., Ali, F., Qayyum, A., Arshad, F., Choudhary, S., & Sajid, M. (2024) · Current Drug Therapy · doi:10.2174/0115748855291425240802100148
Role of Papaya Seed in the Management of Antiproliferation: Description, Chemistry and Uses
Hait, M., Kashyap, N. K., Sahu, P., & Pal, D. (2024) · Springer eBooks · doi:10.1007/978-981-97-3014-8_10
AD prevention strategies adapted till present
Naik, R. A., Mir, M. N., Rajpoot, R., Singh, S. R., Singh, K., & Singh, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15540-6.00015-x
Unveiling the complexity of Alzheimer's disease: Introduction and its pathophysiology
Shabir, S., & Singh, M. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15540-6.00012-4
Histopathological and Behavioral Irreversible Damage Derived from Chronic Exposure to Vanadium Pentoxide Is Similar to that Found in Alzheimer’s Disease
Ávila-Costa, M. R., Dorado-Martínez, C., Montiel-Flores, E., Ordóñez-Librado, J. L., Gutiérrez-Valdez, A. L., Caballero, C. A. G., Sánchez-Betancourt, J., Erazo, L. R., Tron-Alvarez, R., Rodríguez-Lara, V., et al. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007924
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
Jawad, M. J., Uthirapathy, S., Altalbawy, F. M. A., Oghenemaro, E. F., Rizaev, J. A., Lal, M., Eldesoqui, M. B., Sharma, N., Pramanik, A., & AL-Hamairy, A. K. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01622-9
Alzheimer's disease: Interventions, preventive, and treatment/alternative medicine and nutritional approaches
ZEIDAN, H. M., & ZEIDAN, I. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21632-9.00008-x
Sex and gender differences in Alzheimer's disease
ZEIDAN, H. M., & ZEIDAN, I. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21632-9.00002-9
AN OVERVIEW FOR PHYTOCHEMICAL ACTIVITIES OF CARICA PAPAYA FRUIT
AHMAD, R., WALEED, R., & HAIDER, M. (2024) · Journal of Physical Biomedical and Biological Sciences · doi:10.64013/jpbab.v2024i1.34 · Cited by 1
The Novel Melatonin Analog Containing Donepezil Fragment Prevents Cognitive Impairments and Associated Oxidative Stress in a Hybrid Rat Model of Melatonin Deficiency and icvAβ1-42
Ivanova, P., Kortenska, L., Angelova, V. T., & Tchekalarova, J. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146553

Authors: Zhao, Y., & Zhao, B.
Affiliations: Harbin Institute of Technology (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Zhao, Yan
Zhao, Baolu
ORCID: Zhao, Yan
Venue: Oxidative Medicine and Cellular Longevity
Publisher: Wiley
Published: 2013
Volume: 2013
Pages: 1-10
ISSN: 1942-0994 (ISSN-L)
1942-0900
DOI: 10.1155/2013/316523
PMC: PMC3745981
OpenAlex: W2141262291
Cited by: 855
References: 140
Citations by year: 2026: 47 · 2025: 61 · 2024: 82 · 2023: 78 · 2022: 80 · 2021: 83 · 2020: 76 · 2019: 71 · 2018: 64 · 2017: 64 · 2016: 53 · 2015: 54 · 2014: 36 · 2013: 5
FWCI: 5.44
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (30930036, 31201338, 30870587, 2009-3-93, 2011DXGJ14, Y200902, 2009147, 2006CB500706)
Weihai Science and Technology Development Program (30930036, 31201338, 30870587, 2009-3-93, 2011DXGJ14, Y200902, 2009147, 2006CB500706)
Harbin Institute of Technology (30930036, 31201338, 30870587, 2009-3-93, 2011DXGJ14, Y200902, 2009147, 2006CB500706)
National Basic Research Program of China (30930036, 31201338, 30870587, 2009-3-93, 2011DXGJ14, Y200902, 2009147, 2006CB500706)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Alzheimer's disease, oxidative stress, redox imbalance, reactive oxygen species, free radicals, mitochondrial dysfunction, amyloid-beta, tau protein, neurofibrillary tangles, amyloid plaques, neurotoxicity, neurodegeneration, dementia
MeSH terms: Alzheimer Disease, Humans, Reactive Oxygen Species, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks