The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Role of STAT3 in Cancer Metastasis and Translational Advances
Open accessAbstract
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor, originally discovered as a transducer of signal from cell surface receptors to the nucleus. It is activated by tyrosine phosphorylation at position 705 leading to its dimerization, nuclear translocation, DNA binding, and activation of gene transcription. Under normal physiological conditions, STAT3 activation is tightly regulated. However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a pivotal role in tumor growth and metastasis. It regulates cellular proliferation, invasion, migration, and angiogenesis that are critical for cancer metastasis. In this paper, we first describe the mechanism of STAT3 regulation followed by how STAT3 is involved in cancer metastasis, then we summarize the various small molecule inhibitors that inhibit STAT3 signaling.
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Cites
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Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 1×
“STAT3 has also been reported to induce expression of hypoxia-inducible factor1α (HIF1α), another key mediator of angiogenesis [80].”
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“…August 2013; Accepted 26 August 2013 Academic Editor: Jeroen T. Buijs Copyright © 2013 Mohammad Zahid Kamran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the…”
BackgroundCancer chemopreventive activity of resveratrol, a natural product derived from grapes
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“Jang and coworkers reported that resveratrol treatment inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and tumorigenesis in a mouse skin cancer model [97].”
BackgroundSTATs in cancer inflammation and immunity: a leading role for STAT3
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A family of cytokine-inducible inhibitors of signalling
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Cited by
Role of STAT3 signaling pathway in breast cancer
Ma, J.-H., Qin, L., & Li, X. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0527-z · Cited by 420
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
Qin, J.-J., Yan, L., Zhang, J., & Zhang, W.-D. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1206-z · Cited by 396
Napabucasin: an update on the first-in-class cancer stemness inhibitor
Hubbard, J. M., & Grothey, A. (2017) · Drugs · doi:10.1007/s40265-017-0759-4 · Cited by 157
Radotinib inhibits multiple myeloma cell proliferation via suppression of STAT3 signaling
Heo, S.-K., Noh, E.-K., Seo, H. J., Lee, Y. J., Koh, S., Min, Y. J., Choi, Y., & Jo, J.-C. (2022) · PLOS ONE · doi:10.1371/journal.pone.0265958 · Cited by 11
Metadata
- Authors
- Kamran, M. Z., Patil, P., & Gude, R. P.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-15
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2036564735
- Cited by
- 393
- References
- 140
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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