The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Production Methods for Hyaluronan
Open accessAbstract
Hyaluronan is a polysaccharide with multiple functions in the human body being involved in creating flexible and protective layers in tissues and in many signalling pathways during embryonic development, wound healing, inflammation, and cancer. Hyaluronan is an important component of active pharmaceutical ingredients for treatment of, for example, arthritis and osteoarthritis, and its commercial value far exceeds that of other microbial extracellular polysaccharides. Traditionally hyaluronan is extracted from animal waste which is a well-established process now. However, biotechnological synthesis of biopolymers provides a wealth of new possibilities. Therefore, genetic/metabolic engineering has been applied in the area of tailor-made hyaluronan synthesis. Another approach is the controlled artificial (in vitro) synthesis of hyaluronan by enzymes. Advantage of using microbial and enzymatic synthesis for hyaluronan production is the simpler downstream processing and a reduced risk of viral contamination. In this paper an overview of the different methods used to produce hyaluronan is presented. Emphasis is on the advancements made in the field of the synthesis of bioengineered hyaluronan.
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Cites
Biomedical applications of biodegradable polymers
Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011) · Journal of Polymer Science Part B: Polymer Physics · doi:10.1002/polb.22259 · Cited by 2,206
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
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The specific interaction of hyaluronic acid with cartilage proteoglycans.
HARDINGHAM, T., & MUIR, H. (1972) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(72)90160-2 · Cited by 645
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Cited by
Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules
Cress, B. F., Englaender, J. A., He, W., Kasper, D., Linhardt, R. J., & Koffas, M. A. G. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12056 · Cited by 282
“All rights reserved organisms (Liu et al., 2011; Cimini et al., 2012; Boeriu et al., 2013).”
BackgroundHyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review
Iaconisi, G. N., Lunetti, P., Gallo, N., Cappello, A. R., Fiermonte, G., Dolce, V., & Capobianco, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210296 · Cited by 258
Serrano-Sevilla, I., Artiga, Á., Mitchell, S. G., De Matteis, L., & de la Fuente, J. M. (2019) · Molecules · doi:10.3390/molecules24142570 · Cited by 148
Hyaluronic acid production by utilizing agro-industrial waste cane molasses
Shukla, P., Anand, S., Srivastava, P., & Mishra, A. (2022) · 3 Biotech · doi:10.1007/s13205-022-03265-5 · Cited by 16
Metadata
- Authors
- Boeriu, C. G., Springer, J., Kooy, F. K., van den Broek, L. A. M., & Eggink, G.
- Venue
- International Journal of Carbohydrate Chemistry
- Publisher
- Wiley
- Published
- 2013-03-05
- Volume
- 2013
- Pages
- 1-14
- ISSN
- 1687-9341 (ISSN-L)
- 1687-935X
- OpenAlex
- W1964925190
- Cited by
- 205
- References
- 5
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Boeriu, C. G., Springer, J., Kooy, F. K., van den Broek, L. A. M., & Eggink, G. (2013). Production Methods for Hyaluronan. International Journal of Carbohydrate Chemistry. https://doi.org/10.1155/2013/624967
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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