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Cited by 258

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

Open access
Iaconisi, Giorgia Natalia, Lunetti, Paola, Gallo, Nunzia, Cappello, Anna Rita, Fiermonte, Giuseppe, Dolce, Vincenza, Capobianco, Loredana·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms241210296
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Abstract

Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions. Due to its biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, several HA-based biomedical products have been developed. There is an increasing focus on optimizing HA production processes to achieve high-quality, efficient, and cost-effective products. This review discusses HA’s structure, properties, and production through microbial fermentation. Furthermore, it highlights the bioactive applications of HA in emerging sectors of biomedicine.

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Crossref · 10.3390/ijms241210296

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Metadata

Authors
Iaconisi, G. N., Lunetti, P., Gallo, N., Cappello, A. R., Fiermonte, G., Dolce, V., & Capobianco, L.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-06-18
Volume
24
Issue
12
Pages
10296
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms241210296
OpenAlex
W4381166333
Cited by
258
References
115
FWCI
30.91
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review. https://app.cochat.ai/papers/10.3390/ijms241210296
The paper
Iaconisi, G. N., Lunetti, P., Gallo, N., Cappello, A. R., Fiermonte, G., Dolce, V., & Capobianco, L. (2023). Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241210296

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.