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Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
Open accessAbstract
To date, the preventive strategy against dementia is still essential due to the rapid growth of its prevalence and the limited therapeutic efficacy. Based on the crucial role of oxidative stress in age-related dementia and the antioxidant and nootropic activities of Moringa oleifera, the enhancement of spatial memory and neuroprotection of M. oleifera leaves extract in animal model of age-related dementia was determined. The possible underlying mechanism was also investigated. Male Wistar rats, weighing 180-220 g, were orally given M. oleifera leaves extract at doses of 100, 200, and 400 mg/kg at a period of 7 days before and 7 days after the intracerebroventricular administration of AF64A bilaterally. Then, they were assessed memory, neuron density, MDA level, and the activities of SOD, CAT, GSH-Px, and AChE in hippocampus. The results showed that the extract improved spatial memory and neurodegeneration in CA1, CA2, CA3, and dentate gyrus of hippocampus together with the decreased MDA level and AChE activity but increased SOD and CAT activities. Therefore, our data suggest that M. oleifera leaves extract is the potential cognitive enhancer and neuroprotectant. The possible mechanism might occur partly via the decreased oxidative stress and the enhanced cholinergic function. However, further explorations concerning active ingredient(s) are still required.
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“Other studies also demonstrated the protective effect of M. oleifera against memory impairment in experimental models of dementia [225,226].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [225]
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Metadata
- Authors
- Sutalangka, C., Wattanathorn, J., Muchimapura, S., & Thukham-mee, W.
- Affiliations
- Khon Kaen University (TH)
- Corresponding author
- Wattanathorn, Jintanaporn
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-9
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3884855
- OpenAlex
- W2149516433
- Cited by
- 131
- References
- 46
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 16 · 2023: 8 · 2022: 15 · 2021: 22 · 2020: 15 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 2
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Higher Education Research Promotion
- National Research University Project of Thailand
- Khon Kaen University
- The National Research Council of Thailand
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Moringa oleifera research and applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- Moringa oleifera, age-related dementia, memory impairment, neurodegeneration, neuroprotection, oxidative stress, antioxidant activity, nootropic activity, spatial memory, hippocampus, acetylcholinesterase, cholinergic activity, lipid peroxidation, superoxide dismutase, catalase, glutathione peroxidase, AF64A, nootropic drugs
- MeSH terms
- Acetylcholinesterase, Aging, Animals, Cell Count, Dementia, Disease Models, Animal, Escape Reaction, Hippocampus, Male, Malondialdehyde, Phytotherapy, Memory, Memory Disorders, Models, Biological, Nerve Degeneration, Neurons, Plant Extracts, Lipid Peroxidation, Biomarkers, Rats, Wistar, Oxidative Stress, Plant Leaves, Moringa oleifera, Rats
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