The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro
Open accessAbstract
Fucoidans are complex sulphated polysaccharides derived from abundant and edible marine algae.Helicobacter pylori is a stomach pathogen that persists in the hostile milieu of the human stomach unless treated with antibiotics. This study aims to provide preliminary data to determine,in vitro, if fucoidans can inhibit the growth of H. pylori and its ability to adhere to gastric epithelial cells (AGS). We analysed the activity of three different fucoidan preparations (Fucus A,Fucus B, and Undaria extracts). Bacterial growth was not arrested or inhibited by the fucoidan preparations supplemented into culture media. All fucoidans, when supplemented into tissue culture media at 1000 µ g mL−1, were toxic to AGS cells and reduced the viable cell count significantly. Fucoidan preparations at 100 µ g mL−1 were shown to significantly reduce the number of adherent H. pylori. These in vitro findings provide the basis for further studies on the clinical use of sulphated polysaccharides as complementary therapeutic agents.
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Cites
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Cited by
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Therapies from Fucoidan: New Developments
Fitton, J. H., Stringer, D. N., Park, A. Y., & Karpiniec, S. S. (2019) · Marine Drugs · doi:10.3390/md17100571 · Cited by 225
Ginger in gastrointestinal disorders: A systematic review of clinical trials
Nikkhah Bodagh, M., Maleki, I., & Hekmatdoost, A. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.807 · Cited by 221
Olsson Möller, U., Beck, I., Rydén, L., & Malmström, M. (2019) · BMC Cancer · doi:10.1186/s12885-019-5648-7 · Cited by 189
Zhao, J., Yin, H., Zhang, G., Li, G., Shang, B., Wang, C., & Chen, L. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.14000 · Cited by 93
Metadata
- Authors
- Chua, E.-G., Verbrugghe, P., Perkins, T. T., & Tay, C.-Y.
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-6
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- OpenAlex
- W1844710519
- Cited by
- 273
- References
- 39
- FWCI
- 48.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chua, E.-G., Verbrugghe, P., Perkins, T. T., & Tay, C.-Y. (2015). Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2015/120981
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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