The DOI matches its Crossref record; 155 of the 156 references it cites were found in a registry or an index.
Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Open accessAbstract
Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.
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“This latter class, of which artemisinin is a member, are typically bioactive and therefore potential targets for development as pharmaceuticals (22).”
From Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [22]
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Cites
Sesquiterpenoids Lactones: Benefits to Plants and People
Chadwick, M., Trewin, H., Gawthrop, F., & Wagstaff, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612780 · Cited by 698 · cited 4×
“NF-κB controls the response of other effectors such as cytokines, inflammatory molecules, and cell adhesion molecules [2].”
BackgroundInfluentialThe Artemisia L. Genus: A Review of Bioactive Essential Oils
Abad, M. J., Bedoya, L. M., Ticona, L. A., & Bermejo, P. (2012) · Molecules · doi:10.3390/molecules17032542 · Cited by 620 · cited 1×
“Artemisia species are aromatic plants exploited for their volatile oil [12] and many of them are used all over the world in traditional medicine in order to treat conditions such as fever, malaria, inflammation, ulcer, diabetes, and intestinal worms.”
BackgroundThe Molecular Mechanism of Action of Artemisinin—The Debate Continues
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“Artemisinin also targets the parasite mitochondria or the translationally controlled tumour protein and PfATP6, a parasite-encoded sarcoplasmic-endoplasmic reticulum calciumATPase, which is crucial for the development of the parasite [80].”
BackgroundWhat made sesquiterpene lactones reach cancer clinical trials?
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“Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date.”
BackgroundFerreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532 · cited 1×
“One plant species usually produces one type of sesquiterpene lactones, found chiefly in leaves and flowers in concentrations of 0.01% to 8% dry weight [5, 10].”
BackgroundInfluentialThe Antiviral Activities of Artemisinin and Artesunate
Efferth, T., Romero, M. R., Wolf, D. G., Stamminger, T., Marin, J. J. G., & Marschall, M. (2008) · Clinical Infectious Diseases · doi:10.1086/591195 · Cited by 503 · cited 1×
“Another NF-𝜅B inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-𝜅B mediated reporter gene assay [56, 57].”
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“The 𝛾-lactone ring, usually with an 𝛼-methylene group, is a significant characteristic of SLs.”
BackgroundArtemisinins: their growing importance in medicine
Krishna, S., Bustamante, L. Y., Haynes, R. K., & Staines, H. M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.004 · Cited by 396 · cited 1×
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BackgroundBiologically Active Substances from the GenusArtemisia
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“SLs barrelierin, artemalin, barrelin, and desoxyvulgarin from Artemisia barrelieri also exhibited anti-inflammatory activities [69].”
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“These pleiotropic effects can account for effectiveness of artemisinin compounds in multidrug resistant types of cancer [25].”
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Cited by
Sorted by citations
Items 201–203 of 203
Al‐Halaseh, L. K., Al-Samydai, A. M., Moshawih, S., Alqaraleh, M., Al-Zregat, D. M., Amareen, Z. S., Soub, M. N. A., Abdelhadi, N. N., & Qaraghuli, S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0359068
“The pure compounds showed potent antitumor activity against several cell lines after in vitro studies [34].”
Antiviral potential of African Asteraceae: Traditional knowledge and modern perspectives
Kuete, V. (2026) · Advances in botanical research · doi:10.1016/bs.abr.2026.09.006
Olaifa, K. W., Sagindykova, E., Nusipzhanova, G., Unbayeva, S. I., & Ibrayeva, M. (2026) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-026-01503-x
“…from Central Asian flora include absinthin in Artemisia absin-thium , artemisinin in Artemisia annua (famous for anti-malarial activity), costunolide and others in Inula and Saussurea species, and various guaianolide lactones in Tanacetum and Achillea (yarrow) species (Ivanescu et al. 2015).”
Metadata
- Authors
- Ivanescu, B., Miron, A., & Corciova, A.
- Affiliations
- Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
- ORCID
- Miron, Anca
- Venue
- Journal of Analytical Methods in Chemistry
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-21
- ISSN
- 2090-8865 (ISSN-L)
- 2090-8873
- PMC
- PMC4606394
- OpenAlex
- W1950362769
- Cited by
- 201
- References
- 156
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 34 · 2023: 19 · 2022: 34 · 2021: 21 · 2020: 19 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 4
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Analytical Methods in Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Social Fund (POSDRU/159/1.5/S/136893)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Keywords
- sesquiterpene lactones, Artemisia, eudesmanolides, guaianolides, germacranolides, α-methylene-γ-lactones, biological activity, natural product identification, quantification, extraction and separation, thermolabile compounds, Michael addition
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