Cited by 203Sesquiterpenes and Asteraceae StudiesPhytochemistry and Biological ActivitiesPlant chemical constituents analysis

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Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis

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Ivanescu, Bianca, Miron, Anca, Corciova, Andreia·2015·Journal of Analytical Methods in Chemistry

DOI 10.1155/2015/247685PMC PMC4606394

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Abstract

Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

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Sesquiterpenoids Lactones: Benefits to Plants and People
Chadwick, M., Trewin, H., Gawthrop, F., & Wagstaff, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612780 · Cited by 698 · cited 4×
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BackgroundInfluential
The Artemisia L. Genus: A Review of Bioactive Essential Oils
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Background
The Molecular Mechanism of Action of Artemisinin—The Debate Continues
O’Neill, P. M., Barton, V., & Ward, S. A. (2010) · Molecules · doi:10.3390/molecules15031705 · Cited by 618 · cited 1×
“Artemisinin also targets the parasite mitochondria or the translationally controlled tumour protein and PfATP6, a parasite-encoded sarcoplasmic-endoplasmic reticulum calciumATPase, which is crucial for the development of the parasite [80].”
Background
What made sesquiterpene lactones reach cancer clinical trials?
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“Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date.”
Background
Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer
Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532 · cited 1×
“One plant species usually produces one type of sesquiterpene lactones, found chiefly in leaves and flowers in concentrations of 0.01% to 8% dry weight [5, 10].”
BackgroundInfluential
The Antiviral Activities of Artemisinin and Artesunate
Efferth, T., Romero, M. R., Wolf, D. G., Stamminger, T., Marin, J. J. G., & Marschall, M. (2008) · Clinical Infectious Diseases · doi:10.1086/591195 · Cited by 503 · cited 1×
“Another NF-𝜅B inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-𝜅B mediated reporter gene assay [56, 57].”
Method
Molecular Modes of Action of Artesunate in Tumor Cell Lines
Efferth, T., Sauerbrey, A., Olbrich, A., Gebhart, E., Rauch, P., Weber, H. O., Hengstler, J. G., Halatsch, M., Volm, M., Tew, K. D., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.382 · Cited by 431 · cited 1×
“The 𝛾-lactone ring, usually with an 𝛼-methylene group, is a significant characteristic of SLs.”
Background
Artemisinins: their growing importance in medicine
Krishna, S., Bustamante, L. Y., Haynes, R. K., & Staines, H. M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.004 · Cited by 396 · cited 1×
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Background
Biologically Active Substances from the GenusArtemisia
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“SLs barrelierin, artemalin, barrelin, and desoxyvulgarin from Artemisia barrelieri also exhibited anti-inflammatory activities [69].”
Background
Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
Crespo-Ortiz, M. D. P., & Wei, M. Q. (2011) · BioMed Research International · doi:10.1155/2012/247597 · Cited by 384 · cited 1×
“These pleiotropic effects can account for effectiveness of artemisinin compounds in multidrug resistant types of cancer [25].”
Background
Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity
Stashenko, E. E., Jaramillo, B. E., & Martı́nez, J. R. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.10.058 · Cited by 326 · cited 3×
“The extraction methods of SLs may include common procedures, such as extraction using shaker, sonication process, reflux extraction, or Soxhlet extraction, but also less handy methods, like supercritical fluid extraction (SFE) and microwave-assisted extraction (MAE).”
Method
Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant
Pandey, M. M., Rastogi, S., & Rawat, A. K. S. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.12.033 · Cited by 272 · cited 1×
“Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent.”
Background
Isolation of Artemisinin (Qinghaosu) from Artemisia annua Growing in the United States
Klayman, D. L., Lin, A. J., Acton, N., Scovill, J. P., Hoch, J. M., Milhous, W. K., Theoharides, A. D., & Dobek, A. S. (1984) · Journal of Natural Products · doi:10.1021/np50034a027 · Cited by 251 · cited 1×
“annua leaves with petroleum ether followed by column chromatography of the extract over silica gel and elution with a chloroform-ethyl acetate mixture [109].”
Method
Microwave-assisted extraction of artemisinin from Artemisia annua L
Jin-yu, H., Han, W., Huang, S.-D., Xue, B., & Xiu, D. (2002) · Separation and Purification Technology · doi:10.1016/s1383-5866(02)00043-6 · Cited by 249 · cited 1×
“Optimal extraction conditions were extraction time 12 minutes, vegetal particles diameter 0,125mm, and solvent/plant ratio higher than 11 [112].”
Method
Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB
Siedle, B., García‐Piñeres, A., Murillo, R., Schulte‐Mönting, J., Castro, V., Rüngeler, P., Klaas, C. A., Costa, F. B. D., Kisiel, W., & Merfort, I. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049937r · Cited by 248 · cited 1×
“In an extensive study comprising over 100 sesquiterpene lactones, researchers established that guaianolides are most potent inhibitors of NF-κB and their efficacy is due mostly to the α,β-unsaturated carbonyl group [45].”
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an “in vitro” replicative system
Romero, M. R., Efferth, T., Serrano, M. A., Castaño, B., Macı́as, R. I. R., Briz, Ó., & Marı́n, J. J. G. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.07.005 · Cited by 233 · cited 1×
“Several in vitro studies showed that artemisinin has antiviral effect on hepatitis B and C viruses [92, 93], a range of human herpes viruses (human cytomegalovirus, herpes simplex virus type 1, and EpsteinBarr virus) [94–96], influenza virus A [97], and a bovine viral diarrhea virus [98] in the low micromolar range.”
Background
Anti-malarial agent artesunate inhibits TNF- -induced production of proinflammatory cytokines via inhibition of NF- B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes
Xu, H., He, Y., Yang, X., Liang, L., Zhan, Z., Ye, Y., Yang, X., Lian, F., & Sun, L. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem014 · Cited by 222 · cited 1×
“Artesunate is therapeutically relevant to inflammatory responses of microglial cells [52] and inhibits production of interleukin IL-1β, IL-6, and IL-8 in human rheumatoid arthritis through NF-κB inhibition [53].”
Background
Fungicidal activity of natural and synthetic sesquiterpene lactone analogs
Wedge, D. E., Galindo, J. C. G., & Macías, F. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00008-x · Cited by 213 · cited 1×
“Also, nonpolar or weakly polar compounds were more bioactive and sesquiterpene lactones of a guaianolide structure had the greatest antifungal potency [91].”
Background
Sesquiterpene lactones as drugs with multiple targets in cancer treatment
Kreuger, M. R. O., Grootjans, S., Biavatti, M. W., Vandenabeele, P., & D'Herde, K. G. M. A. (2012) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328356cad9 · Cited by 213
Effects of arbuscular mycorrhiza and phosphorus application on artemisinin concentration in Artemisia annua L.
Kapoor, R., Chaudhary, V., & Bhatnagar, A. K. (2007) · Mycorrhiza · doi:10.1007/s00572-007-0135-4 · Cited by 211
The history of qing hao in the Chinese materia medica
Hsü, E. (2006) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2005.09.020 · Cited by 199 · cited 1×
“They are classified depending on their carboxylic skeleton into the following main groups: germacranolides (10-membered rings), the largest group and biogenetic precursors of the majority of sesquiterpene lactones; eudesmanolides and eremophilanolides (6/6-bicyclic compounds); and guaianolides,…”
BackgroundInfluential
Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE 2 .Ki Mice Fed a High-Fat Diet
Abderrazak, A., Couchie, D., Mahmood, D. F. D., Elhage, R., Vindis, C., Laffargue, M., Mateo, V., Büchele, B., Ayala, M. R., Gaafary, M. E., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013730 · Cited by 177
Artesunate in the treatment of metastatic uveal melanoma - first experiences
Berger, T. G., Dieckmann, D., Efferth, T., Schultz, E. S., Funk, J.-O., Baur, A. S., & Schuler, G. (2005) · Oncology Reports · doi:10.3892/or.14.6.1599 · Cited by 176 · cited 1×
“The most common SLs in Artemisia species are guaianolides, eudesmanolides, and germacranolides.”
Background
Artesunate as a Potent Antiviral Agent in a Patient with Late Drug‐Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation
Shapira, M. Y., Resnick, I. B., Chou, S., Neumann, A. U., Lurain, N. S., Stamminger, T., Caplan, O., Saleh, N., Efferth, T., Marschall, M., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587106 · Cited by 157 · cited 1×
“Artesunate was used successfully for reducing the number of CMV (human herpes virus 5) in an immunosuppressed child without traceable toxicity [99].”
Method
Determination of artemisinin in Artemisia sieberi and anticoccidial effects of the plant extract in broiler chickens
Arab, H. A., Rahbari, S., Rassouli, A., Moslemi, M. H., & Khosravirad, F. (2006) · Tropical Animal Health and Production · doi:10.1007/s11250-006-4390-8 · Cited by 153 · cited 1×
“The presence of artemisinin in Artemisia sieberi and Artemisia scoparia in small quantities was also reported [21, 22].”
Background
Structure-Activity Relationships of Sesquiterpene Lactones
Schmidt, T. J. (2006) · Studies in natural products chemistry · doi:10.1016/s1572-5995(06)80030-x · Cited by 150 · cited 2×
“The αMγL acts as aMichael acceptor and reacts with nucleophiles (sulfhydryl or amino groups) in enzymes, transcription factors, and other proteins, alkylating them irreversibly [8, 14].”
Background
The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo
Kaptein, S. J. F., Efferth, T., Leis, M., Rechter, S., Auerochs, S., Kalmer, M., Bruggeman, C. A., Vink, C., Stamminger, T., & Marschall, M. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.10.003 · Cited by 148 · cited 1×
“Another NF-𝜅B inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-𝜅B mediated reporter gene assay [56, 57].”
Method
Sesquiterpene lactones: Adverse health effects and toxicity mechanisms
Amorim, M. H. R., da Costa, R. M. G., Lopes, C., & Bastos, M. M. S. M. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.813905 · Cited by 146
The Gastric Cytoprotective Effect of Several Sesquiterpene Lactones
Giordano, Ó. S., Guerreiro, E., Pestchanker, M. J., Guzmán, J. A., Pastor, D., & Guardia, T. (1990) · Journal of Natural Products · doi:10.1021/np50070a004 · Cited by 140 · cited 2×
“Desacetoxymatricarin did not show cytoprotective activity, suggesting that the presence of the alpha-methylene-gamma-lactone moiety is a requirement for the antiulcerogenic activity [71].”
BackgroundMethod
Efficacy of artemisinin in experimental visceral leishmaniasis
Sen, R., Ganguly, S., Saha, P., & Chatterjee, M. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.03.008 · Cited by 135 · cited 3×
“In in vivo studies on mouse model, treatment with artemisinin led to a significant reduction in splenic weight, a significant inhibition of parasites and a restoration of cytokines such as interferon-𝛾 and interleukin2 (IL-2) [84].”
BackgroundInfluential
Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids
Jesus-Gonzalez, L. D., & Weathers, P. J. (2003) · Plant Cell Reports · doi:10.1007/s00299-003-0587-8 · Cited by 133
Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin
Efferth, T., Herrmann, F., Tahrani, A., & Wink, M. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.06.008 · Cited by 128 · cited 1×
“However, other bioactive compounds in Artemisia annua contribute to the overall activity of extracts: SLs arteannuin B and artemisitene, but also scopoletin and 1,8-cineole [23].”
Background
Biology, Genome Evolution, Biotechnological Issues and Research Including Applied Perspectives in Artemisia (Asteraceae)
Vallès, J., Garcia, S., Hidalgo, O., Martín, J., Pellicer, J., Sanz, M., & Garnatje, T. (2011) · Advances in botanical research · doi:10.1016/b978-0-12-385851-1.00015-9 · Cited by 122
Antiviral Effect of Artemisinin from Artemisia annua against a Model Member of the Flaviviridae Family, the Bovine Viral Diarrhoea Virus (BVDV)
Romero, M. R., Serrano, M. A., Vallejo, M., Efferth, T., Alvarez, M., & Marı́n, J. J. G. (2006) · Planta Medica · doi:10.1055/s-2006-947198 · Cited by 122 · cited 1×
“Several in vitro studies showed that artemisinin has antiviral effect on hepatitis B and C viruses [92, 93], a range of human herpes viruses (human cytomegalovirus, herpes simplex virus type 1, and EpsteinBarr virus) [94–96], influenza virus A [97], and a bovine viral diarrhea virus [98] in the low micromolar range.”
Background
Trichome Dynamics and Artemisinin Accumulation during Development and Senescence of Artemisia annua Leaves
Lommen, W. J., Schenk, E., Bouwmeester, H. J., & Verstappen, F. W. (2006) · Planta Medica · doi:10.1055/s-2005-916202 · Cited by 119 · cited 1×
“Detection methods applied in sesquiterpene lactones analysis include GC-MS [141], GCECD, and GC-FID [139].”
Method
Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial
Zu-yi, Z. (2008) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20080206 · Cited by 118 · cited 1×
“A clinical trial in 120 patients with advanced non-small cell lung cancer tested the effect of artesunate in combinationwith traditional chemotherapeutic drugs [26].”
Background
Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar
Bilia, A. R., de Magalhães, P. M., Bergonzi, M. C., & Vincieri, F. F. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.01.008 · Cited by 115 · cited 1×
“1465 [151] and artemisinin m/z 305 [153], [M + H] in case of artecaninm/z 279.”
Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo
Zhang, C. Z., Zhang, H., Yun, J., Chen, G. G., & Lai, P. B. S. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.002 · Cited by 115 · cited 1×
“The 𝛾-lactone ring, usually with an 𝛼-methylene group, is a significant characteristic of SLs.”
Background
New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives
Christen, P., & Veuthey, J. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013371563 · Cited by 114 · cited 2×
“Pressure had no noticeable influence on the recovery of artemisinin, whatever the solvent used, but a higher temperature significantly favoured artemisinin extraction, particularly in water [114].”
Background
First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers.
Jansen, F. H., Adoubi, I., Comoe, K., Cnodder, T. D., Jansen, N., Tschulakow, A., & Efferth, T. (2011) · PubMed · Cited by 112
Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide
Köhler, M., Haerdi, W., Christen, P., & Veuthey, J. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)00403-2 · Cited by 93 · cited 7×
“The analysis of artemisinin by GC-FID is made via major degradation products, unlike HPLC-ELSD [138].”
BackgroundMethodInfluential
Global yield isotherms and kinetic of artemisinin extraction from Artemisia annua L leaves using supercritical carbon dioxide
Quispe‐Condori, S., Sánchez, D., Foglio, M. A., Rosa, P. D. T. V. E., Zetzl, C., Brunner, G. H., & Meireles, M. A. A. (2005) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2005.03.003 · Cited by 92 · cited 1×
“25% ethanol as cosolvent to the supercritical fluid extraction with CO 2 , the artemisinin extraction yields were substantially improved [115, 116].”
Background
Considerations on the Mechanism of Action of Artemisinin Antimalarials: Part 1 - The 'Carbon Radical' and 'Heme' Hypotheses
Haynes, R. K., Cheu, K., N’Da, D. D., Coghi, P. S., & Monti, D. (2014) · Infectious Disorders - Drug Targets · doi:10.2174/1871526513666131129155708 · Cited by 88
Natural sesquiterpenoids
Fraga, B. M. (2011) · Natural Product Reports · doi:10.1039/c1np00046b · Cited by 84
A colorimetric field method to assess the authenticity of drugs sold as the antimalarial artesunate
Green, M. D., Mount, D. L., Wirtz, R. A., & White, N. J. (2000) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(00)00360-5 · Cited by 81 · cited 1×
“Just like artemisinin, determination of artesunate is challenging because it has not a distinct chromophore and presents a peroxide bridge which absorbs at lower wavelengths [114, 124].”
Background
New sesquiterpene–monoterpene lactone, artemisolide, isolated from Artemisia argyi
Kim, J. H., Kim, H., Jeon, S. B., Son, K., Kim, E. H., Kang, S. K., Sung, N., & Kwon, B. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)01315-1 · Cited by 81 · cited 1×
“Another cytotoxic compound produced by Artemisia argyi is artemisolide (Figure 1), sesquiterpene lactone with a cyclopropane ring which exhibits in vitro activity against human acute lymphoblastic leukaemia Molt-4, promyelocytic leukaemia HL60, and SW620 colon cancer cell lines [38].”
Background
Case report of a laryngeal squamous cell carcinoma treated with artesunate
Singh, N., & Verma, K. (2002) · Archive of oncology · doi:10.2298/aoo0204279s · Cited by 79 · cited 1×
“For some compounds, individual clinical cases were reported: artemether oral treatmentwas used in a patientwith pituitary macroadenoma [28], and artesunate was used in laryngeal squamous cell carcinoma [29] and metastatic uveal melanoma [30] with good results and lack of side effects.”
Background
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin
Paeshuyse, J., Coelmont, L., Vliegen, I., hemel, J. V., Vandenkerckhove, J., Peys, E., Sas, B., Clercq, E. D., & Neyts, J. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.014 · Cited by 76 · cited 1×
“Several in vitro studies showed that artemisinin has antiviral effect on hepatitis B and C viruses [92, 93], a range of human herpes viruses (human cytomegalovirus, herpes simplex virus type 1, and EpsteinBarr virus) [94–96], influenza virus A [97], and a bovine viral diarrhea virus [98] in the low micromolar range.”
Background
Case Report of a Pituitary Macroadenoma Treated With Artemether
Singh, N. P., & Panwar, V. K. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735406295311 · Cited by 76 · cited 1×
“For some compounds, individual clinical cases were reported: artemether oral treatmentwas used in a patientwith pituitary macroadenoma [28], and artesunate was used in laryngeal squamous cell carcinoma [29] and metastatic uveal melanoma [30] with good results and lack of side effects.”
Background
Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity
Tan, L., Chen, H., Wei, N., Mei, X., Zhang, S., Liu, D., Gao, Y., Shu-fang, B., Liu, X., & Zhou, Y.-X. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.11.004 · Cited by 75 · cited 1×
“Moreover, in a mouse model of contact hypersensitivity, topical administration of artemisinin produced anti-inflammatory and immunomodulatory effects [47].”
Background
A comparative study of mist and bubble column reactors in the in vitro production of artemisinin
Kim, Y., Wyslouzil, B. E., & Weathers, P. J. (2001) · Plant Cell Reports · doi:10.1007/s002990100342 · Cited by 75 · cited 1×
“An example is that of artemisinin extracted with toluene from the vegetal product in [134] and subjected to a process of alkaline hydrolysis at 50C for 45 minutes.”
Method
Direct analysis of artemisinin from Artemisia annua L. using high-performance liquid chromatography with evaporative light scattering detector, and gas chromatography with flame ionization detector
Peng, C. A., Ferreira, J., & Wood, A. J. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.043 · Cited by 74 · cited 4×
“HPLC is the most commonly used technique for the quantification of artemisinin and its derivatives in plants, using detection methods like UV detection (HPLC-UV) or diode array detection (HPLC-DAD), mass spectrometry (HPLC-MS), HPLC/tandemmass spectrometry (LC/MS/MS), evaporative light scattering detector (HPLC-ELSD),…”
BackgroundMethodInfluential
NO inhibitory guaianolide-derived terpenoids from Artemisia argyi
Wang, S., Li, J., Sun, J. L., Zeng, K., Cui, J., Jiang, Y., & Tu, P. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.12.005 · Cited by 71 · cited 1×
“The chloroform extract was repeatedly fractioned and the resulting subfractions were purified by semipreparative HPLC to afford artemisinin A and isoartemisolide [120].”
Method
An effective method for fast determination of artemisinin in Artemisia annua L. by high performance liquid chromatography with evaporative light scattering detection
Liu, C., Zhou, H.-Y., & Zhao, Y. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.08.038 · Cited by 69 · cited 3×
“On the other hand, its sensitivity is lower than other detection methods, such as ECD and MS [113, 138, 139].”
BackgroundMethod
Natural sesquiterpenoids
Fraga, B. M. (2008) · Natural Product Reports · doi:10.1039/b806216c · Cited by 67
Immunosuppressive activity of a molecule isolated from Artemisia annua on DTH responses compared with cyclosporin A
Noori, S., Naderi, G., Hassan, Z. M., Habibi, Z., Bathaie, S. Z., & Hashemi, S. M. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.05.003 · Cited by 65 · cited 1×
“Both artemisinin and dihydroartemisinin suppress delayed hypersensitivity to sheep blood cells in mice, manifesting immunosuppressive action [49, 50].”
Background
Review : Role of mast cells in gastrointestinal mucosal defense
Penissi, A. B., Rudolph, M. I., & Piezzi, R. (2003) · Biocell · doi:10.32604/biocell.2003.27.163 · Cited by 62 · cited 1×
“Thus, it is believed that stabilization of mast cells may be a key mechanism in the protection of gastrointestinal tract from injury [73, 74].”
Background
Ethanol modified supercritical fluids extraction of scopoletin and artemisinin from Artemisia annua L.
TZENG, T., Lin, Y., Jong, T., & Chang, C. (2007) · Separation and Purification Technology · doi:10.1016/j.seppur.2007.01.010 · Cited by 62 · cited 1×
“25% ethanol as cosolvent to the supercritical fluid extraction with CO 2 , the artemisinin extraction yields were substantially improved [115, 116].”
Background
Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method
Green, M. D., Mount, D. L., & Wirtz, R. A. (2001) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2001.00793.x · Cited by 61 · cited 2×
“This compound was diazo-coupled with the same diazonium Fast Red TR salt, producing a yellow colour in 5 minutes [132].”
BackgroundMethod
Anti-Helicobacter pylori Potential of Artemisinin and Its Derivatives
Goswami, S., Bhakuni, R. S., Chinniah, A., Pal, A., Kar, S. K., & Das, P. K. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00407-12 · Cited by 61
Anti-tumor effects of dihydroartemisinin on human osteosarcoma
Ji, Y., Zhang, Y.-C., Pei, L., Shi, L., Yan, J., & Ma, X.-H. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0716-6 · Cited by 61 · cited 1×
“The 𝛾-lactone ring, usually with an 𝛼-methylene group, is a significant characteristic of SLs.”
Background
Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells
Lee, I., Ryu, D.-K., Lim, J., Cho, S., Kang, B. Y., & Choi, H. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.034 · Cited by 60 · cited 1×
“Artesunate is therapeutically relevant to inflammatory responses of microglial cells [52] and inhibits production of interleukin IL-1β, IL-6, and IL-8 in human rheumatoid arthritis through NF-κB inhibition [53].”
Background
Analysis of Artemisinin in Artemisia annua L. by LC-MS with Selected Ion Monitoring
Wang, M., Park, C., Wu, Q., & Simon, J. E. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051061p · Cited by 59
Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum
Ortet, R., Prado, S., Mouray, E., & Thomas, O. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.09.022 · Cited by 59 · cited 1×
“The antimalarial activity may be attributed to the exomethylene group of the lactone function [81].”
Background
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas, C. G., Ward, S. A., & Edwards, G. (1992) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(92)80355-t · Cited by 58 · cited 1×
“Thus, it is necessary to have an intermediate step in which by treatment with acids or bases they are transformed into more reactive compounds, such as enolate/carboxylates or α,β-unsaturated decalones, and then reaction with certain reagents to form colored compounds or to bleach, depending on concentration [122, 127…”
Background
Dimeric Guaianolides and Sesquiterpenoids from Artemisia anomala
Wen, J., Shi, H., Xu, Z., Chang, H., Jia, C., Zan, K., Jiang, Y., & Tu, P. (2009) · Journal of Natural Products · doi:10.1021/np900462u · Cited by 58 · cited 1×
“Other anti-inflammatory sesquiterpene lactones mentioned in the literature are dimeric guaianolides from Artemisia anomala [67], and those isolated from Artemisia khorassanica Podl.”
Background
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts
Naesens, L. M. J., Bonnafous, P., Agut, H., & Clercq, E. D. (2006) · Journal of Clinical Virology · doi:10.1016/s1386-6532(06)70015-4 · Cited by 57 · cited 1×
“Another NF-𝜅B inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-𝜅B mediated reporter gene assay [56, 57].”
Method
Application of precolumn reaction to high-performance liquid chromatography of qinghaosu in animal plasma
Shishan, Z., & Mei-Yi, Z. (1986) · Analytical Chemistry · doi:10.1021/ac00293a006 · Cited by 56 · cited 1×
“Thus, it is necessary to have an intermediate step in which by treatment with acids or bases they are transformed into more reactive compounds, such as enolate/carboxylates or α,β-unsaturated decalones, and then reaction with certain reagents to form colored compounds or to bleach, depending on concentration [122, 127…”
Background
Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa
Lee, S. H., Lee, M.-Y., Kang, H., Han, D. C., Son, K., Yang, D. C., Sung, N., Lee, C. W., Kim, H. M., & Kwon, B. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2003.08.008 · Cited by 56 · cited 1×
“They inhibit tumor growth in mouse xenograft models and in human tumour xenograft [37].”
Background
Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis
Zhu, X., Yang, L., Li, Y. J., Zhang, D., Chen, Y., Kostecká, P., Kmonı́èková, E., & Zídek, Z. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71016-8 · Cited by 55 · cited 3×
“Arteannuin B also inhibited lipopolysaccharide- (LPS-) induced in vitro production of nitric oxide (NO) and secretion of cytokines (VEGF, IL-1b, IL-6, and TNF-α) [54].”
BackgroundMethodInfluential
Hypoglycemic properties of some preparations and compounds from Artemisia ludoviciana Nutt
Anaya‐Eugenio, G. D., Rivero‐Cruz, I., Rivera‐Chávez, J., & Mata, R. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.05.051 · Cited by 53 · cited 1×
“One of the compounds was the known guaianolide ludartin which manifested significant hypoglycemic effect on its own [103].”
Background
Tehranolide inhibits proliferation of MCF-7 human breast cancer cells by inducing G0/G1 arrest and apoptosis
Noori, S., & Hassan, Z. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.026 · Cited by 53 · cited 1×
“Tehranolide selectively inhibits proliferation of breast cancer cells through cell cycle arrest and apoptosis [43] and also modifies the immune responses and increases antitumor immunity [44].”
Background
A comparison of low-dose cyclophosphamide treatment with artemisinin treatment in reducing the number of regulatory T cells in murine breast cancer model
Langroudi, L., Hassan, Z. M., Ebtekar, M., Mahdavi, M., Pakravan, N., & Noori, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.005 · Cited by 53 · cited 1×
“Artemisinin diminishes the number of regulatory T cells in murine breast cancer model [51].”
Background
In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents
Gravett, A. M., Liu, W. M., Krishna, S., Chan, W., Haynes, R. K., Wilson, N., & Dalgleish, A. G. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1355-4 · Cited by 52 · cited 1×
“The antimalarial drug artemisinin and its derivatives are very potent anticancer compounds, highly selective on cancer cells with almost no side effects on normal cells and a broad spectrum of action: leukaemia, colon, melanoma, osteosarcoma, pancreas, breast, ovarian, prostate, hepatic, renal, central nervous system,…”
Background
Sesquiterpene Lactones and Their Derivatives Inhibit High Glucose-Induced NF-κB Activation and MCP-1 and TGF-β1 Expression in Rat Mesangial Cells
Jia, Q.-Q., Wang, J., Long, J., Zhao, Y. D., Chen, S., Zhai, J., Wei, L.-B., Zhang, Q., Chen, Y., & Long, H. (2013) · Molecules · doi:10.3390/molecules181013061 · Cited by 52 · cited 1×
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
Method
The Artemisia L. Genus
Martínez, M. J. A., Bedoya, L. M., Ticona, L. A., & Bermejo, P. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-59514-0.00002-x · Cited by 51
Antiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua
Foglio, M. A., Dias, P. C., Antônio, M. A., Possenti, A., Rodrigues, R. A. F., da Silva, É. F., Rehder, V. L. G., & de Carvalho, J. E. (2002) · Planta Medica · doi:10.1055/s-2002-32570 · Cited by 49 · cited 1×
“Previous treatment with indomethacin, a cyclooxygenase inhibitor, blocked the antiulcerogenic activity of compounds on ethanol-induced ulcer, suggesting that the activity is the consequence of an increase in prostaglandin synthesis [76].”
Background
Effect of ultrasound on the extraction of artemisinin from Artemisia annua
Briars, R., & Paniwnyk, L. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.06.043 · Cited by 48 · cited 1×
“After HPLC analysis it was observed that ultrasonic extraction at lower temperature is better than at a higher temperature, also improving the purity [110].”
Background
Determination of Artemisinin in Artemisia annua L. by Reversed Phase HPLC
Qian, G., Yang, Y., & Ren, Q. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200048890 · Cited by 46
Vulgarone B, the Antifungal Constituent in the Steam-Distilled Fraction of Artemisia douglasiana
Meepagala, K. M., Kuhajek, J. M., Sturtz, G., & Wedge, D. E. (2003) · Journal of Chemical Ecology · doi:10.1023/a:1024842009802 · Cited by 45
Simultaneous densitometric determination of artemisinin, artemisinic acid and arteannuin‐B in Artemisia annua using reversed‐phase thin layer chromatography
Bhandari, P., Gupta, A. P., Singh, B., & Kaul, V. K. (2005) · Journal of Separation Science · doi:10.1002/jssc.200500198 · Cited by 45 · cited 1×
“2% trifluoroacetic acid in water/acetonitrile (35 : 65, v/v), derivatization with anisaldehyde reagent in acidic medium, and densitometric determination at 426 nm in absorptionreflectance mode [144].”
Method
THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OFTRYPANOSOMA CRUZI
Brengio, S. D., Belmonte, S. A., Guerreiro, E., Giordano, Ó. S., Pietrobon, E. O., & Sosa, M. A. (2000) · Journal of Parasitology · doi:10.1645/0022-3395(2000)086[0407:tsldda]2.0.co;2 · Cited by 45 · cited 1×
“After removing impurities by treatment with lead tetraacetate solution, the filtrate was extracted three times with chloroform and the resulting extract was chromatographed with ethyl acetate-hexane (1 : 9) to yield dehydroleucodine [71, 100].”
Method
Hairy roots induction and artemisinin analysis in Artemisia dubia and Artemisia indica
Mannan, A., Shaheen, N., Arshad, W., Qureshi, R. A., Zia, M., & Mirza, B. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i18.59272 · Cited by 41
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: A new therapeutic target?
Jiménez, V., Kemmerling, U., Paredes, R., Maya, J. D., Sosa, M. A., & Galanti, N. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.06.005 · Cited by 40 · cited 1×
“Chagas disease or American Trypanosomiasis is caused by the flagellated protozoan parasite Trypanosoma cruzi and is one of the world’s neglected tropical diseases [83].”
Background
Susceptibility of Pneumocystis carinii to artemisinin in vitro
Merali, S., & Meshnick, S. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.6.1225 · Cited by 40 · cited 1×
“Artemisinin and its derivatives showed antifungal properties against Pneumocystis carinii in vitro [89, 90].”
Background
Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Artemisia amygdalina Decne
Lone, S. H., Bhat, K. A., Naseer, S., Rather, R. A., Khuroo, M. A., & Tasduq, S. A. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.09.027 · Cited by 40 · cited 1×
“Yet, other factors can influence the potency of SLs: number of alkylating groups, lipophilicity, molecular geometry and size, chemical environment, other functional groups neighboring the 𝛼M𝛾L, and the target sulfhydryl [2, 5].”
Background
Inhibitors of the LPS-induced NF-?B activation from
Jin, H. Z., Lee, J.-H., LEE, D., HONG, Y., KIM, Y., & LEE, J. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.06.034 · Cited by 39 · cited 2×
“(iv )i nj ec tio n vo lu m e: 1μ L [1 58 ]”
Background
Sesquiterpene lactone fraction fromArtemisia khorassanicainhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB
Emami, S. A., Rabe, S. Z. T., Iranshahi, M., Ahi, A., & Mahmoudi, M. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923971003677808 · Cited by 39 · cited 1×
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
Method
Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages
Ryu, J., Lee, H. J., Jeong, Y. S., Ryu, S. Y., & Han, Y. N. (1998) · Archives of Pharmacal Research · doi:10.1007/bf02974648 · Cited by 39
Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori
Vega, A. E., Wendel, G. H., María, A., & Pelzer, L. E. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.04.051 · Cited by 37 · cited 2×
“As mentioned earlier, artemisinin and dehydroleucodine show strong antimicrobial activity againstHelicobacter pylori, the major cause of chronic gastritis and peptic ulcer [77, 78].”
Background
Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana
Guardia, T., Juárez, A., Guerreiro, E., Guzmán, J. A., & Pelzer, L. E. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00211-3 · Cited by 36 · cited 2×
“The sesquiterpene lactone also inhibited inflammation in the granuloma test, probably by interfering with transcription factors, such as NF-κB and cytokines [59].”
Background
Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase‐9 expression via a protein kinase Cδ/p38/extracellular signal‐regulated kinase pathway in phorbol myristate acetate‐induced THP‐1 macrophages
Wang, Y., Huang, Z., Wang, C., Wang, L., Meng, S., Zhang, Y., Chen, T., & Fan, Y. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05454.x · Cited by 35 · cited 1×
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
Method
Artemisolide fromArtemisia asiatica: Nuclear Factor-κB (NF-κB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages
Reddy, A. M., Lee, J., Seo, J. H., Kim, B. H., Chung, E. Y., Ryu, S. Y., Kim, Y. S., Lee, C.-K., Min, K. R., & Kim, Y. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02969271 · Cited by 34 · cited 1×
“Another NF-κB inhibitor, artemisolide, was isolated from Artemisia asiatica by activity-guided fractionation using the NF-κB mediated reporter gene assay [56, 57].”
Method
A comparison of gas chromatography and high performance liquid chromatography for artemisinin analyses
Ferreira, J., Charles, D. J., Wood, K. V., Janick, J., & Simon, J. E. (1994) · Phytochemical Analysis · doi:10.1002/pca.2800050306 · Cited by 34
Tehranolide molecule modulates the immune response, reduce regulatory T cell and inhibits tumor growth in vivo
Noori, S., Taghikhani, M., Hassan, Z. M., Allameh, A., & Mostafaei, A. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.01.007 · Cited by 33 · cited 1×
“Since these methods are difficult, time consuming, and expensive, we have also chosen to present some analysis methods that are cheaper and available to all laboratories, such as spectrophotometric techniques (UV-Vis) and TLC.”
Method
Antiulcerogenic activity of crude ethanol extract and some fractions obtained from aerial parts of Artemisia annua L.
Dias, P. C., Foglio, M. A., Possenti, A., Nogueira, D. C. F., & de Carvalho, J. E. (2001) · Phytotherapy Research · doi:10.1002/ptr.758 · Cited by 33 · cited 1×
“For the medium polarity fraction, it was demonstrated that the active compounds of Artemisia annua act by increasing the prostaglandin levels in the gastric mucosa [75].”
Background
Antibacterial effects of vulgarone B from Artemisia iwayomogi alone and in combination with oxacillin
Chung, E. Y., Byun, Y. H., Shin, E. J., Chung, H. S., Lee, Y. H., & Shin, S. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-2208-8 · Cited by 32
Bioactivity of Sesquiterpenes: Compounds that Protect from Alcohol-Induced Gastric Mucosal Lesions and Oxidative Damage
Repetto, M. G., & Boveris, A. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791383992 · Cited by 31 · cited 1×
“Sesquiterpene lactones of the guaianolide and eudesmanolide types are considered to be of interest in treatment of gastric and peptic ulcers because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage [70].”
Background
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Alejos-Gonzalez, F., Qu, G., Zhou, L.-L., Saravitz, C. H., Shurtleff, J. L., & Xie, D.-Y. (2011) · Planta · doi:10.1007/s00425-011-1430-z · Cited by 31 · cited 2×
“In the case of MS analysis, generally using ESI positive ionisation mode, the pseudo-molecular ions are in the form [M + Na], [M + H], [2M + Na], [2M + K], and [M + NH4] [148, 152].”
Method
Preparation and Characterization of Solid Dispersions of Artemether by Freeze-Dried Method
Ansari, M. T., Hussain, A., Nadeem, S., Majeed, H., Saeed-ul-Hassan, S., Tariq, I., Mahmood, Q., Khan, A. K., & Murtaza, G. (2015) · BioMed Research International · doi:10.1155/2015/109563 · Cited by 30
Pharmacokinetic and Pharmacodynamic Profiles of Rapid-Acting Artemisinins in the Antimalarial Therapy
Li, Q., Weina, P. J., & Milhous, W. K. (2007) · Current Drug Therapy · doi:10.2174/157488507781695649 · Cited by 30 · cited 1×
“Some disadvantages of artemisinin, such as low solubility, short plasma half-life, and poor bioavailability [19], were surpassed by the semisynthetic or fully synthetic derivatives, such as artesunate, artemether, dihydroartemisinin, and artemisone.”
Background
A quantum chemical and chemometric study of sesquiterpene lactones with cytotoxicity against tumor cells
Arantes, F. F. P., Barbosa, L. C. A., Maltha, C. R. A., Demuner, A. J., Fidêncio, P. H., & Carneiro, J. W. D. M. (2011) · Journal of Chemometrics · doi:10.1002/cem.1385 · Cited by 30
In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb
Martins, A., Mignon, R., Bastos, M., Batista, D., Neng, N. R., Nogueira, J. M. F., Vizetto‐Duarte, C., Custódio, L. M. B., Varela, J. C. S., & Rauter, A. P. (2014) · Phytotherapy Research · doi:10.1002/ptr.5133 · Cited by 29
Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea
Natividad, G. M., Broadley, K. J., Kariuki, B. M., Kidd, E. J., Ford, W. R., & Simons, C. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.042 · Cited by 29 · cited 2×
“Yomogin was separated through repeated recrystallization with methanol and its structure was confirmed by X-ray crystallography [62].”
BackgroundMethod
Affordable and sensitive determination of artemisinin in Artemisia annua L. by gas chromatography with electron-capture detection
Liu, S., Tian, N., Liu, Z., Huang, J., Li, J., & Ferreira, J. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.089 · Cited by 29
Artemisia annua L.: evidence of sesquiterpene lactones’ fraction antinociceptive activity
Favero, F. D. F., Grando, R., Nonato, F. R., Sousa, I. M. D. O., Queiroz, N. D. C. A., Longato, G. B., Zafred, R. R. T., de Carvalho, J. E., Spindola, H. M., & Foglio, M. A. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-266 · Cited by 28
A spectrophotometric assay for quantification of artemisinin
Bharati, A., & Sabat, S. C. (2010) · Talanta · doi:10.1016/j.talanta.2010.06.015 · Cited by 27 · cited 1×
“The reaction is completed in 15 minutes and the reaction product is stable for 5 hours [123].”
Background
Highly Oxygenated Guaianolides fromArtemisia dubia
Huang, Z., Pei, Y., Liu, C.-M., Lin, S. H., Tang, J., Huang, D., Song, T.-F., Lu, L.-H., Gao, Y., & Zhang, W. (2010) · Planta Medica · doi:10.1055/s-0030-1249957 · Cited by 27 · cited 1×
“Eight highly oxygenated guaianolides, named artemdubolides A–H, were isolated from Artemisia dubia and two of them manifested reduced cytotoxicity on human colon carcinoma Colo205 and human melanoma MDA-MB-435 cells in vitro [42].”
Background
Growth-inhibiting effects of seco-tanapartholides identified in Artemisia princeps var. orientalis whole plant on human intestinal bacteria
Cho, S.-H., Na, Y.-E., & Ahn, Y. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.01998.x · Cited by 27 · cited 1×
“casei) and Escherichia coli [86].”
Quality of Artesunate Tablets Sold in Pharmacies in Kumasi, Ghana
Ofori-Kwakye, K., Asantewaa, Y., & Gaye, O. (2008) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v7i4.14704 · Cited by 27
Yomogin Inhibits the Degranulation of Mast Cells and the Production of the Nitric Oxide in Activated RAW 264.7 Cells
Ryu, S., Oak, M.-H., & Kim, K.-M. (2000) · Planta Medica · doi:10.1055/s-0029-1243124 · Cited by 27 · cited 1×
“7 cells by suppressing i-NOS enzyme expression [60] and blocks the degranulation ofmast cells by inhibiting the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner [61].”
Background
Artemisolide is a typical inhibitor of IκB kinase β targeting cysteine-179 residue and down-regulates NF-κB-dependent TNF-α expression in LPS-activated macrophages
Kim, B. H., Lee, J., Seo, J. H., Lee, H. Y., Ryu, S. Y., Ahn, B. W., Lee, C., Hwang, B. Y., Han, S., & Kim, Y. S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.069 · Cited by 25
Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica
ZENG, Y.-T., Jiang, J., Lao, H., Guo, J., LUN, Y.-N., & Yang, M. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3012 · Cited by 24 · cited 1×
“The aerial parts of Artemisia amygdalina Decne produce significant amounts of ludartin, a highly cytotoxic guaianolide, also found in Artemisia indica [34].”
Background
Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages
Kim, H. G., Yang, J. H., Han, E. H., Choi, J. H., Khanal, T., Jeong, M. H., Jeong, T. C., & Jeong, H. G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.02.017 · Cited by 23 · cited 1×
“decreased PMA-induced COX-2 expression and PGE 2 production, as well as COX-2 promoter-driven luciferase activity in a dose-dependent manner [48].”
Background
Determination of Artemisinin in Selected Artemisia L. Species of Turkey by Reversed Phase HPLC
Erdemolu, N., & Kartal, M. (2007) · Cited by 23
ANALYSIS OF ARTEMISININ ISOLATED FROM Artemisia Annua L. BY TLC AND HPLC
Ghafouri, H., Sariri, R., Naghavi, M. R., Aryakia, E., Dolatyari, A., Fazeli, S. A. S., Ramazani, H., & Farahmand, Z. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2012.685916 · Cited by 22 · cited 1×
“It was observed that after derivatization the extinction coefficient increased 30–40 times [136].”
Background
An amperometric sensor based on hemin adsorbed on silica gel modified with titanium oxide for electrocatalytic reduction and quantification of artemisinin
Reys, J. R. M., Lima, P., Cioletti, A. G., Ribeiro, A. S., DEABREU, F., Goulart, M. O. F., & Kubota, L. T. (2008) · Talanta · doi:10.1016/j.talanta.2008.07.043 · Cited by 21 · cited 1×
“developed a feasible alternative method that uses an amperometric detector based on hemin adsorbed on silica gel modified for quantification of artemisinin [146].”
Method
An improved extraction procedure for the rapid, quantitative high-performance liquid chromatographic estimation of the main eleutherosides (b and e) inEleutherococcus senticosus (eleuthero)
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Background
Quantitative HPTLC Analysis of Artemisinin in Dried Artemisia annua L.: A Practical Approach
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Method
Artemisia scoparia – A new source of artemisinin
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Method
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Background
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Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
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Method
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Background
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Background
QUANTIFICATION OF SANTONIN FROM ARTEMISIA PALLENS WALL BY HPTLC
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Authors: Ivanescu, B., Miron, A., & Corciova, A.
Affiliations: Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
Grigore T. Popa University of Medicine and Pharmacy (RO)
Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700150 Iasi, Romania
ORCID: Miron, Anca
Venue: Journal of Analytical Methods in Chemistry
Publisher: Wiley
Published: 2015
Volume: 2015
Pages: 1-21
ISSN: 2090-8865 (ISSN-L)
2090-8873
DOI: 10.1155/2015/247685
PMC: PMC4606394
OpenAlex: W1950362769
Cited by: 201
References: 156
Citations by year: 2026: 18 · 2025: 20 · 2024: 34 · 2023: 19 · 2022: 34 · 2021: 21 · 2020: 19 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 4
FWCI: 0.81
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Journal of Analytical Methods in Chemistry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: European Social Fund (POSDRU/159/1.5/S/136893)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
Keywords: sesquiterpene lactones, Artemisia, eudesmanolides, guaianolides, germacranolides, α-methylene-γ-lactones, biological activity, natural product identification, quantification, extraction and separation, thermolabile compounds, Michael addition

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Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis

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