Cited by 259Treatment of Major DepressionStress Responses and CortisolTryptophan and brain disorders

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress

Open access

Gold, Phillip W., Machado-Vieira, Rodrigo, Pavlatou, Maria G.·2015·Neural Plasticity

DOI 10.1155/2015/581976PMC PMC4387963

Open this paper in CoChat — free account Open PDF

Abstract

Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities. Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD. The present paper provides an overview on the stress system as a model to understand key pathophysiological paradigms in MDD. These mechanisms involve behavioral, cognitive, and systemic manifestations and are also associated with the mechanisms of action of effective antidepressants. Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. Finally, new strategies for approaching treatment-resistant major depression and potential adverse effects associated with this complex and intricate network are highlighted. The authors used PubMed as the database for this review. Each author extracted relevant data and assessed the methodological quality of each study.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2015/581976

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
Evidence-based health policy—lessons from the Global Burden of Disease Study
Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178
Emotion: Clues from the Brain
LeDoux, J. E. (1995) · Annual Review of Psychology · doi:10.1146/annurev.ps.46.020195.001233 · Cited by 1,646
Mechanisms of emotional arousal and lasting declarative memory.
Cahill, L., & McGaugh, J. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01214-9 · Cited by 1,575
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
Self-citation

Flagged first, then by citations

Show all 53 references

Research works printed but not linked: 4

1994, British Journal of Psychiatry, 165, 16
10.1038/sj/mp/4001032 · DOI
10.1001/jama.267.9.1244 · DOI · Paper page
1992, Emotion and the amygdala, 339

Sorted by citations

Items 101–200 of 257

Repeated electroconvulsive shock produces long-lasting increases in messenger RNA expression of corticotropin-releasing hormone and tyrosine hydroxylase in rat brain. Therapeutic implications.
Brady, L. S., Lynn, A. B., Glowa, J. R., Le, D. Q., & Herkenham, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117444 · Cited by 25
Chronic social isolation in adaptation of HPA axis to heterotypic stress
Gądek-Michalska, A., Bugajski, A. J., Tadeusz, J., Rachwalska, P., & Bugajski, J. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.08.011 · Cited by 25
Enhanced cholinergic-tone during the stress induce a depressive-like state in mice
Fernandes, S. S., Koth, A. P., Parfitt, G. M., Cordeiro, M. F., Peixoto, C. S., Soubhia, A., Moreira, F. P., Wiener, C. D., Oses, J. P., Kaszubowski, E., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.044 · Cited by 26
“Stress is a crucial point in the development of this psychopathology [62].”
Association between depressive disorders and risk of breast cancer recurrence after curative surgery
Chen, S.-J., Chang, C.-H., Chen, K.-C., & Liu, C. (2016) · Medicine · doi:10.1097/md.0000000000004547 · Cited by 22
“After multivariate adjustment, the HR for subsequent recurrence among the depressive disorder cohort was 1.373 (95% confidence interval 1.098–1.716, P=0.005).”
BackgroundInfluential
Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain
Makunts, T., Cohen, I. V., Lee, K. C., & Abagyan, R. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195521 · Cited by 23
Rationale, Relevance, and Limits of Stress-Induced Psychopathology in Rodents as Models for Psychiatry Research: An Introductory Overview
Italia, M., Forastieri, C., Longaretti, A., Battaglioli, E., & Rusconi, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207455 · Cited by 28
“Depending on the stress nature, intensity, duration, but most of all, individual susceptibility under the form of genetic (innate) or epigenetic (acquired) predisposition, it can happen that an individual undertakes maladaptive trajectories, including neuropsychiatric drifts [50,51].”
Background
Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder
Liu, Y., Zhang, B., Zhou, Y., Li, M., Gao, Y. H., Qin, W., Xie, Y., Liu, W., Jing, Y., & Li, J. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115742 · Cited by 22
Trauma infanto juvenil y psicopatología adulta: un estudio empírico
Weil, K., Ramón Florenzano, U., Vitriol, V. G., Carlos Cruz, M., César Carvajal, A., Claudio Fullerton, U., & Muñiz, C. (2004) · Revista médica de Chile · doi:10.4067/s0034-98872004001200007 · Cited by 22
Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease
Chávez-Castillo, M., Nava, M., Ortega, Á., Rojas, M., Núñez, V., Salazar, J. J., Bermúdez, V., & Rojas, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200413144401 · Cited by 21
“brain-mind and the body sharing a bidirectional relationship [7].”
Background
Antidepressant-Like Activities of Hispidol and Decursin in Mice and Analysis of Neurotransmitter Monoamines
Oh, J., Lee, H., Baek, S. C., Lee, J. P., Jeong, G. S., Paik, M., & Kim, H. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03057-4 · Cited by 19
“, major depressive disorder, is a neuropsychological disorder characterized by loss of interest or pleasure, low self-worth, sleep disturbance, and feelings of guilt and fatigue [1].”
The association between substance P and white matter integrity in medication-naive patients with major depressive disorder
Won, E., Kang, J. C., Choi, S., Kim, A., Han, K., Yoon, H., Cho, S.-H., Tae, W., Lee, M.-S., Joe, S.-H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10100-y · Cited by 23
Understanding the Neuroepigenetic Constituents of Suicide Brain
Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17
Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior
Han, M., Zeng, D., Tan, W., Chen, X.-X., Bai, S.-Y., Wu, Q., Chen, Y., Wei, Z., Mei, Y., & Zeng, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01419 · Cited by 21
Peripheral Biomarkers of Inflammation in Depression: Evidence from Animal Models and Clinical Studies
Brás, J. P., Pinto, S. F. T., Almeida, M. I., Prata, J., von Doellinger, O., Coelho, R. C., Barbosa, M. A., & Santos, S. G. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_28 · Cited by 19
Orthopaedic Surgeon Mental Health During the COVID-19 Pandemic
Al-Humadi, S. M., Cáceda, R., Bronson, B. D., Paulus, M., Hong, H., & Muhlrad, S. I. (2021) · Geriatric Orthopaedic Surgery & Rehabilitation · doi:10.1177/21514593211035230 · Cited by 18
“Activation of stress response can lead to changes in normal physiologic processes regulating metabolism, inflammation, coagulation, and autonomic function.(19) These changes can predispose to coronary artery disease, a prothrombotic state, and insulin resistance and cause dysregulation of sleep, appetite, and reproduc…”
Background
Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder
Won, E., Kang, J. C., Kim, A., Choi, S., Han, K., Tae, W., Chang, H. S., Son, K. R., Greenberg, T., Joe, S.-H., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.008 · Cited by 17
Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases
Ramos-Hryb, A. B., Platt, N., Freitas, A. E., Heinrich, I. A., López, M. G., Leal, R. B., Kaster, M. P., & Rodrigues, A. L. S. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02906-1 · Cited by 18
“This relationship can be explained by the neuro-hormonal hypothesis of depression [5], which postulates that depressive symptoms may occur as a consequence of an altered stress response.”
Background
Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action
Reichard, K. L., Newton, K. A., Rivera, Z. M. G., de Menezes, P. M. S., Schattauer, S. S., Land, B. B., & Chavkin, C. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000124 · Cited by 18
Coping with Stress, Executive Functions, and Depressive Symptoms: Focusing on Flexible Responses to Stress
Kato, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143122 · Cited by 18
Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
Ma, H., Wang, W.-P., Xu, S., Wang, L., & Wang, X. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.08.004 · Cited by 16
“), (4) CUMSþvehicle1 (distilled water), (5) CUMSþPHPB (30mg/kg), (6) CUMSþPHPB (100mg/kg), (7) CUMSþFLX (10mg/kg).”
Dance therapy as an intervention for stress and depression: a systematic review and meta-analysis
Christopher, N., Dumaresq, E., & Tamplin, J. (2024) · Body Movement and Dance in Psychotherapy · doi:10.1080/17432979.2024.2377389 · Cited by 16
“…experiences with symptomatic overlap like chronic fatigue, hypervigilance, and medically unexplained pain, etc. (Gros et al., 2012), likely due to their shared biochemistry, such as increased cortisol levels, slower functioning of reproductive hormones, and insulin resistance (Gold et al., 2015).”
Elevated Levels of Serum Exosomes in Patients with Major Depressive Disorder
Yakovlev, A. A., Druzhkova, T. A., Nikolaev, R., Kuznetsova, V. E., Gruzdev, S., Guekht, A. B., & Gulyaeva, N. V. (2019) · Neurochemical Journal · doi:10.1134/s1819712419040044 · Cited by 19
Associations between major depressive and bipolar disorders and eating disorder, PTSD, and comorbid symptom severity in eating disorder patients
Brewerton, T. D., Gavidia, I., Suro, G., & Perlman, M. M. (2023) · European Eating Disorders Review · doi:10.1002/erv.3035 · Cited by 19
Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment
Głombik, K., Ślusarczyk, J., Trojan, E., Chamera, K., Budziszewska, B., Lasoń, W., & Basta‐Kaim, A. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.12.005 · Cited by 16
Insomnia and depression: How much is the overlap?
Gupta, R. M., Victor, R., & Garg, S. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_461_18 · Cited by 15
“Since, stress-diathesis theory has been implicated in both depression and insomnia, effect of stress must be discussed here.[35,36] Insomnia itself may be a stressful situation that could activate stress circuitry or vice versa.”
Background
Uso de Práticas Integrativas e Complementares em Saúde no tratamento da depressão
Schwambach, L. B., & Carnielli‐Queiroz, L. (2023) · Physis Revista de Saúde Coletiva · doi:10.1590/s0103-7331202333077 · Cited by 15
Neuroinflammation and Neurotoxicity Contribute to neuroprogression in neurological and psychiatric disorders
Halaris, A. E. (2018) · Future Neurology · doi:10.2217/fnl-2017-0039 · Cited by 14
Dietary Exposure to Excess Saturated Fat During Early Life Alters Hippocampal Gene Expression and Increases Risk for Behavioral Disorders in Adulthood
Page, K., & Anday, E. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.527258 · Cited by 17
Physiological linkage in pregnancy: Couples’ cortisol, negative conflict behavior, and postpartum depression
Khaled, M., Corner, G. W., Morris, A. R., Havaldar, S., Luo, E., & Saxbe, D. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108075 · Cited by 16
Neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression.
Kiani, A. K., Maltese, P. E., Dautaj, A., Paolacci, S., Kurti, D., Picotti, P. M., & Bertelli, M. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i13-s.10536 · Cited by 16
“Major depressive disorder (MDD) is the fourth main cause of disability worldwide, according to the World Health Organization (1).”
BackgroundInfluential
Identifying patients with major depressive disorder based on tryptophan hydroxylase-2 methylation using machine learning algorithms
Fan, R. G., Hua, T., Shen, T., Jiao, Z., Yue, Q., Chen, B., & Xu, Z. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114258 · Cited by 16
Psychosocial stress inhibits additional stress-induced hyperexpression of NO synthases and IL-1β in brain structures
Gądek-Michalska, A., Tadeusz, J., Rachwalska, P., & Bugajski, J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.09.003 · Cited by 14
3D FRN-ResNet: An Automated Major Depressive Disorder Structural Magnetic Resonance Imaging Data Identification Framework
Jialin, H., Huang, Y., Ye, J., Wang, J., Xu, X., Wu, Y., Li, Y., Zhao, J., Li, R., Kang, J., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.912283 · Cited by 13
“Moreover, in the Wrapper model, Guyon et al. (2002) proposed a support vector machine-based recursive feature elimination (RFE-SVM) algorithm for gene sequence feature selection.”
Method
Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems
Lin, M., Li, H., Zhao, Y. H., Cai, E., Zhu, H., Gao, Y., Liu, S., Yang, H., Zhang, L., Tang, G., et al. (2017) · Molecules · doi:10.3390/molecules22040565 · Cited by 13
“is considered as one of the leading public health problem and has a lifetime prevalence of approximately 15%~17% in the world today [4,4,4].”
Background
Wine-Derived Phenolic Metabolites in the Digestive and Brain Function
Zorraquín‐Peña, I., Esteban‐Fernández, A., de Llano, D. G., Bartolomé, B., & Moreno-Arribas, M. V. (2019) · Beverages · doi:10.3390/beverages5010007 · Cited by 13
The potential of microRNAs as putative biomarkers in major depressive disorder and suicidal behavior
Serafini, G., Trabucco, A., Corsini, G. P., Escelsior, A., Amerio, A., Aguglia, A., Nasrallah, H. A., & Amore, M. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100035 · Cited by 14
Sleep as a Major Determinant for Mental Health Outcomes in Elite Australian Football League (AFL) Athletes
Facer‐Childs, E. R., Mascaro, L., HOFFMAN, D., MANSFIELD, D., DRUMMOND, S. P. A., & Rajaratnam, S. M. W. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002825 · Cited by 14
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder
Mingoti, M. E. D., Bertollo, A. G., de Oliveira, T., & Ignácio, Z. M. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_8 · Cited by 12
Blebbistatin, a Myosin II Inhibitor, Exerts Antidepressant-Like Activity and Suppresses Detrusor Overactivity in an Animal Model of Depression Coexisting with Overactive Bladder
Wróbel, A., Doboszewska, U., Rechberger, E., Bańczerowska‐Górska, M., Czuczwar, P., Poleszak, E., Dudka, J., Właź, P., Miotła, P., Wlaźlak, E., et al. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9948-5 · Cited by 12
SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine
Marinescu, I. P., Marinescu, D., Mogoantă, L., Efrem, I. C., & Stovicek, P. O. (2021) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.4.03 · Cited by 13
“At the same time, depression favors prothrombotic status, inflammation and oxidative stress, mechanisms that in the context of SARS-CoV-2 infection induce a severe evolution, with a high risk of death [151].”
Background
Butyrate- and Beta-Hydroxybutyrate-Mediated Effects of Interventions with Pro- and Prebiotics, Fasting, and Caloric Restrictions on Depression: A Systematic Review and Meta-Analysis
Breuling, M., Tomeva, E., Ivanović, N., & Haslberger, A. G. (2024) · Life · doi:10.3390/life14070787 · Cited by 11
“The scientific interest in the pathology of depression has increased during the last decades due to the rising prevalence of this disorder [1–3].”
Background
Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells
Zhao, J., Peng, L., Zheng, W., Wang, R., Zhang, L., Yang, J., & Chen, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922795 · Cited by 11
“In brain, ROS generated by glucocorticoid exposure will finally induce apoptotic neuronal cell death, which appears to be a key mechanism for the development of depression [15,18].”
Background
Quetiapine effect on depressive-like behaviors, oxidative balance, and inflammation in serum of rats submitted to chronic stress
Grolli, R. E., Bertollo, A. G., Behenck, J. P., Borba, L. A., Plissari, M. E., Soares, S. J. B., Mânica, A., Joaquim, L. D. S., Petronilho, F. C., Quevedo, J., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02406-8 · Cited by 12
Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress
van der Gronde, T., Los, L., Herremans, A. H. J., Oosting, R. S., Zorzanelli, R., & Pieters, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00412 · Cited by 12
“Patients with melancholic depression, a subtype based on symptoms, were thought to respond better to TCAs than atypical patients (hence the name) (20, 27, 31, 32), but other researchers could not replicate this finding (33–36).”
BackgroundInfluential
Effect of Musa sapientum stem extract on animal models of depression
Dubey, A., Reddy, A. J., Handu, S. S., Mediratta, P. K., Shukla, R., & Ahmed, Q. (2016) · Pharmacognosy Research · doi:10.4103/0974-8490.188876 · Cited by 12
“Severe stress produces depression‐like pictures associated with disruption of this counter‐regulatory stress system.[16] The antidepressant‐like property of MSSE was evaluated by applying FST and tail suspension test (TST), the commonly used models for behavioral despair in the experimental models.”
Method
Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway
Xia, Q., Wang, H., Yin, H., & Yang, Z. R. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0326-z · Cited by 11
Central injection of abscisic acid attenuates mood disorders induced by subchronic stress in male mice
Shabani, M., Ranjbar, H., Soti, M., & Naderi, R. (2022) · Brain and Behavior · doi:10.1002/brb3.2796 · Cited by 10
Unraveling the complex interplay of immunometabolic systems that contribute to the neuroprogression of psychiatric disorders
Halaris, A. E., & Leonard, B. E. (2019) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2019.05.005 · Cited by 11
The potential anti-depressant properties of dexmedetomidine infusion: a review of mechanistic, preclinical, and clinical evidence
Al‐Alawi, M., Brietzke, E. M., Carvalhal, A., & Soares, C. N. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0001 · Cited by 10
“Although the interpretation of plasma levels is a complex matter, NE kinetic analysis has demonstrated increased NE in extravascular and vascular compartments of depressed patients when compared to healthy controls, though similar rates of NE clearance fromplasma alsowere found in both groups (Gold et al. 1988; Stahl…”
BackgroundResult
Identifying High-Risk Factors of Depression in Middle-Aged Persons with a Novel Sons and Spouses Bayesian Network Model
Costello, F. J., Kim, C. G., Kang, C. M., & Lee, K. C. (2020) · Healthcare · doi:10.3390/healthcare8040562 · Cited by 10
“Moreover, depression has been shown to intrude on fundamental biological processes that are used for regulating certain bodily functions, such as sleep and appetite [7].”
Background
TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory
Hung, Y.-F., & Hsueh, Y. (2021) · iScience · doi:10.1016/j.isci.2021.102384 · Cited by 10
Regulation of the stress response by social buffering: A review across species
Avellaneda, M. A., & Kamenetzky, G. (2021) · Revista Interamericana de Psicología/Interamerican Journal of Psychology · doi:10.30849/ripijp.v55i1.1439 · Cited by 14
“For example, chronic stress has been linked to depression (Dinan, 1994; Gold et al., 2015; Redinbaugh et al., 1995), immunological deficiencies (Yada & Tort, 2016), cardiovascular alterations (Cohen et al., 2015) and inflammatory diseases (LeResche & Dworkin, 2002).”
Background
Cortisol-dependent impairment of dendrite plasticity in human dopaminergic neurons derived from hiPSCs is restored by ketamine: Relevance for major depressive disorders.
Cavalleri, L., Dassieni, I., Marcotto, G. S., Zoli, M., Pich, E. M., & Collo, G. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104049 · Cited by 9
“…depression via a complex peripheral/central interaction that involves the HPA axis, the autonomic nervous system and several central limbic structures whose neurons express glucocorticoid receptors (McEwen and Gianaros, 2011; Gold et al., 2015; Anderson et al., 2016, Barfield and Gourley, 2018).”
Serum Interleukin-6 is Not Linked with Sleep-Quality, Restless Legs Syndrome, and Depression, But with 6-Month Survival in Hematological Malignancies
Chandra, S., Gupta, V., Chandra, H., Dhyani, M., Kotwal, A., Verma, S. K., & Gupta, R. M. (2018) · Journal of Neurosciences in Rural Practice · doi:10.4103/jnrp.jnrp_159_18 · Cited by 9
Conversion disorder/functional neurological disorder – a narrative review on current research into its pathological mechanism
Ratcliff, J., & Feltz-Cornelis, C. M. V. D. (2020) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2020.03.004 · Cited by 10
An invisible villain: high perceived stress, its associated factors, and possible consequences in a population-based survey in southern Brazil
Demenech, L. M., Fernandes, S. S., Paulitsch, R. G., & Dumith, S. C. (2021) · Trends in Psychiatry and Psychotherapy · doi:10.47626/2237-6089-2021-0228 · Cited by 14
The scalp prefrontal–limbic functional connectivity moderates stress‐related rumination effects on stress recovery
Luo, Y., Li, J., Zhang, Y., & Pan, W. (2023) · Psychophysiology · doi:10.1111/psyp.14462 · Cited by 9
Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress
Smith, A., Bisby, J. A., Dercon, Q., Bevan, A., Kigar, S. L., Lynall, M.-E., Dalgleish, T., Hitchcock, C., & Nord, C. L. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02840-z · Cited by 10
“This is mediated by physiological responses to stress: exposure to a highly arousing, negative event activates stress responses governed by the hypothalamic-pituitary-adrenal (HPA) axis [33, 34].”
Background
Sexual Rehabilitation After Gynaecological Cancers
Graziottin, A., Lukasiewicz, M., & Serafini, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-43193-2_27 · Cited by 8
Morphine Exposure Causes to Enhance Depression-like Behaviour in Confront with Chronic Stress in Adult Male Offspring Rat
Torkaman‐Boutorabi, A., Seifi, F., Akbarabadi, A., Toolee, H., Sadat‐Shirazi, M., Vousooghi, N., & Zarrindast, M. (2018) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.155 · Cited by 8
A Review of Device-Free Indoor Positioning for Home-Based Care of the Aged: Techniques and Technologies
Chen, G., Cheng, L., Shao, R., Wang, Q., & Wang‎, S. (2022) · Computer Modeling in Engineering & Sciences · doi:10.32604/cmes.2023.024901 · Cited by 8
Evaluation of thiol/disulfide homeostasis in patients with a first episode of major depressive disorder
Karaaslan, Ö., Hacımusalar, Y., Bal, C., & Ercan, M. (2019) · Medical Science and Discovery · doi:10.17546/msd.488247 · Cited by 8
“4 Medical Science and Discovery, 2019; 6(1):1-7 Discussion”
BackgroundInfluential
Depresion en pacientes con alteraciones del tiroides
Radanović-Grgurić, L., Filaković, P., Barkić, J., Mandic´, N., Karner, I., & Smoje, J. (2003) · The European journal of psychiatry (edición en español) · doi:10.4321/s1579-699x2003000300001 · Cited by 8
Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo
Schiller, M., Wilson, G. C., Keitsch, S., Soddemann, M., Wilker, B., Edwards, M. J., Scherbaum, N., & Gulbins, E. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03026-8 · Cited by 7
“Corticosterone-induced stress is a well-established, well-documented, and frequently reported model of stress for inducing depression-like symptoms in mice in vivo [8, 20, 23, 24, 35, 38, 42, 48, 56, 58].”
Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice
de Aquino, G. Â., de Sousa, C. N. S., Medeiros, I. D. S., de Almeida, J. C., Filho, F. M. S. C., Júnior, M. A. S., & Vasconcelos, S. M. M. (2021) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2021-0056 · Cited by 7
Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens
Ma, Y., Kochunov, P. V., Kvarta, M. D., LeGates, T. A., Adhikari, B. M., Chiappelli, J., van der Vaart, A. D., Goldwaser, E. L., Bruce, H. A., Hatch, K. S., et al. (2023) · Psychological Medicine · doi:10.1017/s0033291723002866 · Cited by 7
Peripheral blood GILZ mRNA levels in depression and following electroconvulsive therapy
Ryan, K. M., & McLoughlin, D. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.234 · Cited by 7
Crossmodal Audiovisual Emotional Integration in Depression: An Event-Related Potential Study
Lu, T., Yang, J., Zhang, X., Guo, Z., Li, S., Yang, W., Chen, Y., & Wu, N. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.694665 · Cited by 8
“The interaction between emotion and group was not significant, F(2, 80) = 1.”
BackgroundMethodInfluential
Effect of electroconvulsive therapy on the oxidative metabolism in major depressive disorder
Şahin, Ş. K., Aybastı, Ö., Elboğa, G., & Altındağ, A. (2017) · Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi) · doi:10.17826/cutf.323838 · Cited by 7
The associations among the stress symptoms, depressive symptoms, anxiety symptoms and insomnia symptoms in depressed patients after the first COVID-19 outbreak was initially controlled in China: A prospective cohort study
Guo, J., Zhao, Y., Wang, J., Fang, L., Liu, S., Luo, X., Tang, C., Li, E., Lv, Z., Xu, Y. J., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.021 · Cited by 7
Obesity and Depression: Shared Pathophysiology and Translational Implications
Huet, L., Delgado, I., Aouizerate, B., Castanon, N., & Capuron, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00016-0 · Cited by 8
Behavioral and neuroimmune characterization of resilience to social stress: rewarding effects of cocaine.
Ródenas-González, F., Blanco-Gandía, M. D. C., López, J. M., & Rodríguez-Arias, M. (2020) · Adicciones · doi:10.20882/adicciones.1348 · Cited by 8
The Effect of Anxiety and Nutritional Habits on the Body Distortion of Athletes.
Ramírez-Goerke, M. I., Tornero-Aguilera, J. F., Martín-Rodríguez, A., & Clemente-Suárez, V. J. (2025) · Nutrients · doi:10.3390/nu17040682 · Cited by 6
“Insulin resistance and inflammation can cause anxiety [47], and whole grains decrease inflammatory biomarkers [48] and influence the postprandial glucose metabolism [49–51], which could affect insulin sensitivity.”
Winter is coming: Seasonality and the acoustic startle reflex
Armbruster, D., Brocke, B., & Strobel, A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.038 · Cited by 7
“melancholic depression have been argued to be caused by different dysregulations in a number of interlinked neurobiological systems [12].”
Background
Childhood depression and oxidative stress
Miniksar, D. Y., & Göçmen, A. Y. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00518-1 · Cited by 7
Psychiatric Illness Is Common in Elderly Fracture Patients
Gitajn, I., Titus, A., Mastrangelo, S., Ali, S., Sparks, M. B., & Jevsevar, D. (2019) · Journal of Orthopaedics and Trauma · doi:10.1097/bot.0000000000001371 · Cited by 5
Selected nitrostyrene compounds demonstrate potent activity in chronic lymphocytic leukaemia cells, including those with poor prognostic markers
Bright, S. A., Byrne, A., Vandenberghe, E., Browne, P., McElligott, A. M., Meegan, M. J., & Williams, D. C. (2019) · Oncology Reports · doi:10.3892/or.2019.7068 · Cited by 6
“symptoms of depression, anxiety and several other psychological illnesses (9,10).”
Background
Ethnopharmacological Profile, Phytochemistry and Therapeutic Potential of Aegle marmelos L. for the Treatment of Neurological Disorders
Sharma, A., Gugulothu, D. B., Virmani, T., Sharma, A., Kumar, G., Singh, K., Jain, D., Bhuia, M. S., Chowdhury, R., Ahammed, N. T., et al. (2025) · Journal of Nutrition and Metabolism · doi:10.1155/jnme/2275526 · Cited by 5
Psychosexual Issues and Quality of Life after Oncologic Pelvic Surgery, with Focus on Cervical Cancer
Graziottin, A., & Lukasiewicz, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-29191-8_9 · Cited by 5
Low Circulating Levels of GR, FKBP5, and SGK1 in Medicated Patients With Depression Are Not Altered by Electroconvulsive Therapy
Ryan, K. M., Poelz, L., & McLoughlin, D. M. (2019) · Journal of Ect · doi:10.1097/yct.0000000000000633 · Cited by 5
Depression Detection via User Behavior and Tweets
Ji, N., Bouazizi, M., & Ohtsuki, T. O. (2023) · Globecom · doi:10.1109/globecom54140.2023.10437866 · Cited by 4
“Depression seriously affects the normal life of patients [1] and nearly 15% of patients with depression choose to commit suicide [2].”
Background
Effects of brain estrogen receptor on depression and its mechanism of action
Wen, Y., Gao, K., Tong, G., Meng, X., Pan, M., Wang, Y., Meng, D., Zheng, Y., & Yue, G.-X. (2024) · Guidelines and Standards of Chinese Medicine · doi:10.1097/gscm.0000000000000026 · Cited by 4
“Considerable research indicated that NE level in the peripheral plasma of depression patients is apparently higher than in normal people [10,11] , which is possibly due to the suppression of peripheral NE by central nervous NE.”
Biological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects
Escudero, G. E., Martini, N., Jori, K., Jori, N., Maresca, N. R., Laino, C. H., Naso, L. G., Williams, P. A. M., & Ferrer, E. G. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2016.1160900 · Cited by 4
A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking
Barker, D., Nugent, N. R., Delgado, J. R., Knopik, V. S., Brown, L. K., Lally, M., & McGeary, J. E. (2017) · AIDS Care · doi:10.1080/09540121.2017.1291898 · Cited by 4
The Role of Stress and Glucocorticoids in Pathogeny of Age-Related Neuropsychiatric Disorders
Ivanovitch, G. V. (2018) · Journal of Geriatric Medicine and Gerontology · doi:10.23937/2469-5858/1510054 · Cited by 5
“In addition, depressive illness is age-related, being more frequent in the intermediate age categories [10].”
Pharmacological management of treatment resistant depression: a clinical review
Kennedy, N., & McDonough, M. (2003) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700007473 · Cited by 4
Understanding How Mental Health Influences IBD Outcomes: A Review of Potential Culprit Biological Mechanisms
Abdelbadiee, S., Yoon, G., Pearman, K., Kumar, A., & Harvey, P. (2025) · Biomedicines · doi:10.3390/biomedicines13122916 · Cited by 3
“A trademark characteristic of depression is thought to be a pro-inflammatory state, alongside hypercortisolism [29,30].”
A circuit-based framework for depression: Reshaping the pathological attractor
Yuan, Z., Quan, J., Cui, Y., & Luo, M. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.009 · Cited by 5
A DISFAGIA NO ENVELHECIMENTO ASSOCIADA A DESNUTRIÇÃO E DESENCADEAMENTO DE TRANSTORNOS MENTAIS
Capelari, S., & Budni, J. (2019) · Inova Saúde · doi:10.18616/inova.v9i1.3588 · Cited by 3
Modulating Neuroplasticity: Lessons Learned from Antidepressants and Emerging Novel Therapeutics
Yates, C. G., Kruse, J. L., Price, J. B., Robertson, A. A. B., & Tye, S. J. (2021) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-021-00249-9 · Cited by 3
The Neurochemistry of Stress: the Chemistry of the Stress Response and Stress Vulnerability
Gulyaeva, N. V. (2018) · Neurochemical Journal · doi:10.1134/s1819712418020058 · Cited by 3
Allostatic Load and Physical Frailty Increase the Risk of Depression Recurrence in Middle-Aged and Older Adults: A Prospective Cohort Study
Zhao, B., Qi, X., Xia, J., Li, X., Hui, J., Gou, Y., Wei, W., Pan, C., He, D., Feng, J., et al. (2025) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2025.07.009 · Cited by 3
Allostatic load in major depressive disorder: An in-patient clinical study
Finlay, S., Suvarna, B., Adegboye, O. A., Rudd, D., McDERMOTT, B. M., Westphal, S., Guest, P. C., Meyer-Lotz, G., Dobrowolny, H., Bahn, S., et al. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107653 · Cited by 2
The influence of psychosocial stress on functional connectivity and neuroendocrine markers in adolescents with depressive and comorbid anxiety disorders: a study protocol
Jacob, R., Otto, A., Jarvers, I., Kandsperger, S., Ecker, A., Schleicher, D., Malloni, W. M., Neumann, I. D., & Brunner, R. M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07689-0 · Cited by 2
“In parallel, CORT—the end product of HPA axis acti-vation—has been widely studied as a biomarker of stress-related psychopathology [27].”
Leveraging low-cost app-based step count data to assess depression and anxiety in university students: A cross-sectional mobile health study
Huang, J., Zhang, Y., Zhou, D., Li, X., Li, H., Lian, B., Cai, W., Cao, L., Liu, J., Xu, F., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120880 · Cited by 2
Correlation between clinical features of acute episode of major depressive disorder and hypothalamic-pituitary-adrenal axis (HPA) function: a cross-sectional study
Liu, L., Zhou, M., Yang, X., & Lin, D. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07926-0 · Cited by 2
“This preliminarily confirms that MDD is a complex psychiatric disorder with a highly heterogeneous pathophysiology [61, 62].”
Global and regional level association between depression and glycemic control in type 2 diabetes mellitus: A systematic review and meta-analysis
Narra, B., Lakshmi, N. R. A., Ramasamy, N., Kaviprawin, M., Jyrwa, S., Awadhiya, O., Khan, F., Padhi, B. K., & Gandhi, A. P. (2026) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry_467_25 · Cited by 3
“[68] elucidated this mechanism, linking chronic hypercortisolemia in depression to increased adiposity and impaired glucose homeostasis.”
Prevalence and determinants of depression in patients with epilepsy during the COVID-19 pandemic
Sehlo, M. G., Mohamed, W. S., Youssef, U. M., Lotfi, S. E., & El-deen, G. M. S. (2022) · Middle East Current Psychiatry · doi:10.1186/s43045-022-00190-4 · Cited by 2
“(serotonin and norepinephrine) [8], and anatomical abnormalities (prefrontal cortex and paralimbic structures) [9], also the social burden of the epilepsy itself on the patients.”
Background
Depression and poor sleep: neglected prevalent issues among adult epileptic patients
Fathy, S. E., AbdAllah, A., El-Maghawry, H. A., Ali, L. I., & Helal, R. Y. (2024) · Middle East Current Psychiatry · doi:10.1186/s43045-024-00391-z · Cited by 2
Investigation of monoaminergic system mediated antidepressant action of Musa paradisiaca using various experimental models
Galani, V. (2018) · Pharmacy & Pharmacology International Journal · doi:10.15406/ppij.2018.06.00188 · Cited by 2

Authors: Gold, P. W., Machado-Vieira, R., & Pavlatou, M. G.
Affiliations: National Institutes of Health (US)
National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Corresponding author: Gold, Phillip W.
ORCID: Pavlatou, Maria G.
Venue: Neural Plasticity
Publisher: Hindawi Limited
Published: 2015
Volume: 2015
Pages: 1-11
ISSN: 1687-5443 (ISSN-L)
2090-5904
DOI: 10.1155/2015/581976
PMC: PMC4387963
OpenAlex: W2055457894
Cited by: 259
References: 53
Citations by year: 2026: 12 · 2025: 12 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 26 · 2020: 24 · 2019: 24 · 2018: 27 · 2017: 29 · 2016: 20 · 2015: 6
FWCI: 3.43
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Neural Plasticity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, stress system, neurobiology of stress, depression pathophysiology, antidepressant mechanism, depression subtypes, inflammation, insulin resistance, oxidative stress, hypercoagulability, treatment-resistant depression, antidepressant side effects
MeSH terms: Animals, Brain, Depressive Disorder, Homeostasis, Humans, Inflammation, Neuronal Plasticity, Stress, Physiological, Stress, Psychological, Oxidative Stress, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks