The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Cell Adhesion and Long-Term Survival of Transplanted Mesenchymal Stem Cells: A Prerequisite for Cell Therapy
Open accessAbstract
The literature provides abundant evidence that mesenchymal stem cells (MSCs) are an attractive resource for therapeutics and have beneficial effects in regenerating injured tissues due to their self-renewal ability and broad differentiation potential. Although the therapeutic potential of MSCs has been proven in both preclinical and clinical studies, several questions have not yet been addressed. A major limitation to the use of MSCs in clinical applications is their poor viability at the site of injury due to the harsh microenvironment and to anoikis driven by the loss of cell adhesion. To improve the survival of the transplanted MSCs, strategies to regulate apoptotic signaling and enhance cell adhesion have been developed, such as pretreatment with cytokines, growth factors, and antiapoptotic molecules, genetic modifications, and hypoxic preconditioning. More appropriate animal models and a greater understanding of the therapeutic mechanisms of MSCs will be required for their successful clinical application. Nevertheless, the development of stem cell therapies using MSCs has the potential to treat degenerative diseases. This review discusses various approaches to improving MSC survival by inhibiting anoikis.
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1 retracted
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Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Nourian Dehkordi, A., Mirahmadi Babaheydari, F., Chehelgerdi, M., & Raeisi Dehkordi, S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 533
Capella-Monsonís, H., Crum, R. J., Hussey, G. S., & Badylak, S. F. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115347 · Cited by 84
Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. (2022) · Small · doi:10.1002/smll.202104783 · Cited by 81
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Metadata
- Authors
- Lee, S., Choi, E., Cha, M.-J., & Hwang, K.-C.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-9
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2081581508
- Cited by
- 269
- References
- 94
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
