Changes in Testosterone Levels and Sex Hormone-Binding Globulin Levels in Extremely Obese Men after Bariatric Surgery
Open accessAbstract
Objective.Obesity is a risk factor for hypogonadotropic hypogonadism in men. Weight loss has been shown to improve hypogonadism in obese men. This study evaluated the early changes in sex hormones profile after bariatric surgery.Methods.This is a prospective study including 29 morbidly obese men. Main outcomes were changes in serum levels of total testosterone (TT), free testosterone (cFT), SHBG, estradiol, adiponectin, and leptin at 1 and 6 months after surgery.Results.The mean age of patients was 31 ± 8 years and the mean BMI was 56.8 ± 11.7 kg/m 2. Fifteen patients underwent Roux-en-Y gastric bypass and 14 patients underwent sleeve gastrectomy. At baseline, 22 patients (75.9%) had either low TT levels (<10.4 nmol/L) or low cFT levels (<225 pmol/L). Total testosterone and SHBG levels increased significantly at 1 month after surgery (p≤0.001). At 6 months after surgery, TT and cFT increased significantly (p≤0.001) and 22 patients (75.9%) had normalized TT and cFT levels. There were no changes in estradiol levels at either 1 month or 6 months after surgery.Conclusions. Increases in TT and SHBG levels occurred early at 1 month after bariatric surgery while improvements in cFT levels were observed at 6 months after bariatric surgery.
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Lifestyle modifications, such as losing weight or maintaining weight within the recommended range, along with increasing physical activity, have the potential to increase total testosterone levels and/or reduce signs and symptoms associated with testosterone deficiency in men with testosterone deficiency.
“Men with testosterone deficiency should be counseled that lifestyle modifications, such as losing weight, or maintaining weight within the recommended range, along with increasing physical activity, has the potential to increase total testosterone levels and/or reduce signs and symptoms associated with testosterone deficiency.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [42]
The Introduction says weight loss through diet and exercise improves testosterone levels in obese men. The Discussion reports improved testosterone levels and a lower androgen-deficiency screening score after bariatric surgery in extremely obese men. The paper does not establish that maintaining weight within the recommended range has these effects, or that these findings extend to all men with testosterone deficiency. (LLM, conf=0.84)
Experimental — accuracy not yet measuredBariatric surgery has been reported to reverse reduced testosterone and SHBG concentrations in men with obesity.
“bariatric surgery has been reported to reverse reduced testosterone and SHBG concentrations in men with obesity.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [224]
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Evaluation and Management of Testosterone Deficiency: AUA Guideline
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- Authors
- Boonchaya-anant, P., Laichuthai, N., Suwannasrisuk, P., Houngngam, N., Udomsawaengsup, S., & Snabboon, T.
- Affiliations
- Hormonal and Metabolic Disorders Research Unit, Excellence Center for Diabetes, Hormone, and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
- Thai Red Cross Society (TH)
- Chulalongkorn University (TH)
- ORCID
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-5
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC5048048
- OpenAlex
- W2401783207
- Cited by
- 43
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 5
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- bariatric surgery, testosterone, sex hormone-binding globulin, free testosterone, hypogonadotropic hypogonadism, morbid obesity, Roux-en-Y gastric bypass, sleeve gastrectomy, weight loss, estradiol, adiponectin, leptin
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