RELATIONSHIP BETWEEN BMI, TOTAL TESTOSTERONE, SEX HORMONE-BINDING-GLOBULIN, LEPTIN, INSULIN AND INSULIN RESISTANCE IN OBESE MEN
Abstract
The objective of this work was to evaluate the relationship between sex steroid hormones, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Anthropometrical indexes, total testosterone (Tt), free testosterone (fT), estradiol (E), sex hormone-binding-globulin (SHBG), glucemia, insulin and leptin were measured in 77 men, with ages between 20 and 60 years. According to their body mass index (BMI), subjects were grouped into three categories: normal body weight ( 30 kg/m2). Insulin resistance index was obtained by the homeostasis assessment model for insulin resistance (HOMA-IR). Total testosterone and SHBG concentrations were lower in the obese group compared with normal and overweight subjects (p < 0.05). The mean insulin concentration was significantly higher in the obese group compared with the other groups (p < 0.05). T was negatively correlated with the BMI (r = -0.447; p < .01), WC (r = -0.464); p < .01, leptin (r = -0.382; p < .01), insulin (r = -0.391; p < 0.01) and also with the HOMA-IR (r = -0.416; p < 0.01). The SHBG negatively and significantly correlated with BMI (r = -0.334; p < 0.01) and WC index (= -0.322; p < 0.01), as well with insulin levels (r = -0.313; p < 0.01) and insulin resistance (= -0.266; p < 0.05). Our results shows that in a sample of men, Tt and SHBG concentrations proportionally diminished with both the increase of BMI and insulin resistance index.
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A consistent finding is the negative association between SHBG and BMI.
“A consistent finding is the negative association between SHBG and BMI [86, 87].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [86]
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- Authors
- Osuna C., J. A., Gómez-Pérez, R., Arata-Bellabarba, G., & Villaroel, V.
- Affiliations
- Universidad de Los Andes (VE)
- Venue
- Archives of Andrology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 52
- Issue
- 5
- Pages
- 355-361
- ISSN
- 0148-5016 (ISSN-L)
- OpenAlex
- W2162557413
- Cited by
- 183
- References
- 38
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 16 · 2012: 10
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, men, body mass index, total testosterone, sex hormone-binding globulin, leptin, insulin, insulin resistance, HOMA-IR, waist circumference, sex hormones, estradiol
- MeSH terms
- Adipose Tissue, Adult, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index, Leptin
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