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Cited by 207Bariatric Surgery and OutcomesHormonal and reproductive studiesBody Contouring and Surgery

Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men

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Hammoud, Ahmad, Gibson, Mark, Hunt, Steven C., Adams, Ted D., Carrell, Douglass T., Kolotkin, Ronette L., Meikle, A. Wayne·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1598PMC PMC2682482
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Abstract

Context: The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated. Objective: The aim of the study was to define the effect of Roux-En-Y gastric bypass surgery on the reproductive hormones and sexual function in obese men. Design and Setting: The cohort was followed for 2 yr at a clinical research center. Patients: Sixty-four severely obese men (22 who had gastric bypass surgery and 42 controls) participated in the study. Intervention(s): Anthropometrics [weight, body mass index (BMI), and percentage body fat] and reproductive hormones were measured. The sexual quality of life was assessed using the Impact of Weight on the Quality Of Life-Lite questionnaire. Main Outcome Measure(s): Reproductive hormones and sexual quality of life were measured. Results: The mean age was 48.9 ± 1.2 yr. At baseline, mean weight was 333.0 ± 7.1 lb, BMI was 46.2 ± 0.9 kg/m2, and total testosterone was 339.9 ± 21.32 ng/dl. BMI correlated positively with estradiol and negatively with total and free testosterone. Indices of dissatisfaction with sexual quality of life correlated positively with measures of obesity. Difficult sexual performance and low sexual desire correlated negatively with free and total testosterone (r = −0.273, P = 0.038; and r = −0.267, P = 0.042, respectively). After 2 yr, the gastric bypass surgery group had a significant decrease in BMI (−16.6 ± 1.2 vs. −0.46 ± 0.51 kg/m2) and estradiol (−8.1 ± 2.4 vs. 1.6 ± 1.4 pg/ml) and had an increase in total testosterone (310.8 ± 47.6 vs. 14.2 ± 15.3 ng/dl) and free testosterone (45.2 ± 5.1 vs. −0.4 ± 3.0 pg/ml). Sexual quality of life was improved after gastric bypass surgery. Conclusion: Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery.

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  • Over the past 10 years, mass spectrometry, particularly liquid chromatography tandem mass spectrometry, has become increasingly adopted because of high throughput, limited sample preparation, and high sensitivity and specificity at low and high testosterone concentrations.

    “However, over the past 10 years, MS, and in particular liquid chromatography tandem mass spectrometry (LC-MS/MS), has become increasingly adopted due to its high throughput, limited requirement for sample preparation, and high sensitivity/specificity at low and high T concentrations.”

    From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [85]

  • In a 2-year prospective controlled study of gastric bypass surgery in 64 men (age 49 years; BMI, 46 kg/m2), 30% weight loss increased testosterone by 10.8 nmol/L and reduced sexual dissatisfaction by 7.5 on a 20-scale questionnaire.

    “In a 2-year prospective controlled study of gastric bypass surgery in 64 men (age 49 years; BMI, 46 kg/m2), 30% weight loss increased testosterone by 10.8 nmol/L (311 ng/dL) and reduced sexual dissatisfaction by 7.5 on a 20-scale questionnaire (27).”

    From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [27]

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Research works printed but not linked: 14

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Authors
Hammoud, A., Gibson, M., Hunt, S. C., Adams, T. D., Carrell, D. T., Kolotkin, R. L., & Meikle, A. W.
Affiliations
  • University of Utah (US)
  • Intermountain Healthcare (US)
  • Duke Medical Center (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-04-01
Volume
94
Issue
4
Pages
1329-1332
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1598
PMC
PMC2682482
OpenAlex
W2150381615
Cited by
207
References
6
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 21 · 2014: 23 · 2013: 22 · 2012: 20
FWCI
17.04
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (Z01DK055006, R01DK055006)
  • National Center for Research Resources (M01RR000064)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Body Contouring and Surgery
Keywords
Roux-en-Y gastric bypass, bariatric surgery, male obesity, sex steroids, testosterone, estradiol, sexual quality of life, sexual function, reproductive hormones, body mass index
MeSH terms
C-Reactive Protein, Estradiol, Follow-Up Studies, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Libido, Male, Obesity, Morbid, Personal Satisfaction, Sexual Behavior, Testosterone, Gastric Bypass, Weight Loss, Body Mass Index

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