Plasma Brain-Derived Neurotrophic Factor as a Biomarker for the Main Types of Mild Neurocognitive Disorders and Treatment Efficacy: A Preliminary Study
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Decreased levels of brain-derived neurotrophic factor (BDNF) are assumed to play a crucial role in the pathophysiology of mild neurocognitive disorders (MNCDs). In this study, we compared plasma BDNF levels (at baseline and after two months of treatment with escitalopram) in patients with the main types of MNCDs and normal controls. 21 patients met the DSM-5 diagnostic criteria for possible MNCD due to Alzheimer’s disease (MNCD-AD); 22 patients fulfilled the diagnostic criteria for subcortical vascular MNCD (ScVMNCD) according to Frisoni et al. (2002) and neuroimaging-supported probable diagnosis of vascular MNCD according to DSM-5; 16 subjects entered control group. At baseline, we detected lower BDNF levels in both MNCD groups, which was significant only in subjects with MNCD-AD. Moreover, plasma BDNF level of 21160 pg/mL showed high sensitivity (94%) to discriminate patients with MNCD-AD. Decreased plasma BDNF highly correlated with the severity of memory impairment and total MMSE score in MNCD-AD group. Escitalopram treatment in patients with MNCD-AD or ScVMNCD led to an increase of plasma BDNF concentrations and as a result to a decrease of cognitive, depressive, and anxiety symptom severity. In conclusion, plasma BDNF might be a reliable biomarker for the validation of MNCD-AD diagnosis and treatment efficacy.
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BDNF levels are reduced in plasma of patients with mild cognitive impairment and Alzheimer's disease.
“BDNF levels are also reduced in plasma of patients with mild cognitive impairment (MCI) [140] and AD [141].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [140]
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[BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF): NEUROBIOLOGY AND MARKER VALUE IN NEUROPSYCHIATRY].
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
- Authors
- Levada, O. A., Cherednichenko, N. V., Trailin, A. V., & Troyan, A. S.
- Affiliations
- Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine (UA)
- Corresponding author
- Levada, Oleg A.
- Venue
- Disease Markers
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 0278-0240 (ISSN-L)
- 1875-8630
- PMC
- PMC4997080
- OpenAlex
- W2511128911
- Cited by
- 28
- References
- 36
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 2
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Disease Markers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- brain-derived neurotrophic factor, plasma BDNF, mild neurocognitive disorder, Alzheimer's disease, subcortical vascular dementia, biomarkers, escitalopram, treatment efficacy, memory impairment, depression, anxiety, cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Diagnosis, Differential, Female, Humans, Male, Citalopram, Biomarkers, Case-Control Studies, Selective Serotonin Reuptake Inhibitors, Brain-Derived Neurotrophic Factor, Cognitive Dysfunction
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