Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases
Open accessAbstract
Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson’s disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls. Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P<0.001) and a higher BDNF concentration in patients affected by PD (P=0.045). Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P=0.009) and L-DOPA (P<0.001) and significant reductions in patients taking benzodiazepines (P=0.020). In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects.
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In both PD patients and animal PD models, decreased level of BDNF was found in the nigrostriatal pathway.
“Since, in both PD patients and animal PD models, decreased level of BDNF was found in the nigrostriatal pathway, it has been hypothesized that BDNF may serve as a therapeutic agent.”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [61]
Serum BDNF levels are increased in Parkinson's disease patients, especially in moderate to severe stages of the disease.
“some reports describe that the BDNF levels in serum are increased in PD patients, especially in moderate to severe stages of the disease [167, 168].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [167]
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
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“Changes in BDNF signalling is relevant to a range of human neuronal and psychiatric disorders 30 , as well as to biological systems involved in the stress response 31 .”
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“A recent neuroimaging study implicated a role for BDNF in cognitive decline in LOAD patients [48], although AD genetic association studies of BDNF yielded conflicting results [44,49].”
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- Authors
- Ventriglia, M., Zanardini, R., Bonomini, C., Zanetti, O., Volpe, D., Pasqualetti, P., Gennarelli, M., & Bocchio-Chiavetto, L.
- Affiliations
- Fatebenefratelli Hospital (IT)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Ospedale San Raffaele Arcangelo (IT)
- Neuropsychopharmacology Unit, IRCCS “S. Giovanni di Dio” Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3760208
- OpenAlex
- W1995069132
- Cited by
- 189
- References
- 62
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 9 · 2023: 21 · 2022: 12 · 2021: 17 · 2020: 25 · 2019: 14 · 2018: 21 · 2017: 10 · 2016: 24 · 2015: 13 · 2014: 4
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
- Funders
- Fondazione Cariplo
- Ministero della Salute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- brain-derived neurotrophic factor, serum BDNF, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, dementia with Lewy bodies, vascular dementia, neurodegenerative diseases, mood stabilizers, antiepileptic drugs, L-DOPA, benzodiazepines
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Anticonvulsants, Benzodiazepines, Female, Humans, Male, Middle Aged, Parkinson Disease, Dementia, Vascular, Brain-Derived Neurotrophic Factor, Lewy Body Disease, Frontotemporal Dementia
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