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Cited by 106Muscle metabolism and nutritionDiet and metabolism studiesDiet, Metabolism, and Disease

A High Protein Diet Has No Harmful Effects: A One-Year Crossover Study in Resistance-Trained Males

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Antonio, Jose, Ellerbroek, Anya, Silver, Tobin, Vargas, Leonel, Tamayo, Armando, Buehn, Richard, Peacock, Corey A.·2016·Journal of Nutrition and Metabolism
DOI 10.1155/2016/9104792PMC PMC5078648
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Abstract

The purpose of this investigation was to determine the effects of a high protein diet over a one-year period. Fourteen healthy resistance-trained men completed the study (mean ± SD; age 26.3 ± 3.9 yr; height 178.5 ± 8.4 cm; and average years of training 8.9 ± 3.4 yr). In a randomized crossover design, subjects consumed their habitual or normal diet for 2 months and 4 months and alternated that with a higher protein diet (>3 g/kg/d) for 2 months and 4 months. Thus, on average, each subject was on their normal diet for 6 months and a higher protein diet for 6 months. Body composition was assessed via the Bod Pod ® . Each subject provided approximately 100–168 daily dietary self-reports. During the subjects’ normal eating phase, they consumed (mean ± SD) 29.94 ± 5.65 kcals/kg/day and 2.51 ± 0.69 g/kg/day of protein. This significantly increased ( p < 0.05 ) during the high protein phase to 34.37 ± 5.88 kcals/kg/day and 3.32 ± 0.87 g/kg/day of protein. Our investigation discovered that, in resistance-trained men that consumed a high protein diet (~2.51–3.32 g/kg/d) for one year, there were no harmful effects on measures of blood lipids as well as liver and kidney function. In addition, despite the total increase in energy intake during the high protein phase, subjects did not experience an increase in fat mass.

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  • A one-year crossover study in fourteen healthy resistance-trained men showed that chronic consumption of a high protein diet (average 3.3 g/kg/day) had no harmful effects on kidney or liver function, and no alterations in clinical markers of metabolism and blood lipids.

    “This investigation showed that the chronic consumption of a high protein diet (i.e., for 1 year) had no harmful effects on kidney or liver function. Furthermore, there were no alterations in clinical markers of metabolism and blood lipids.”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [222]

  • A series of controlled investigations spanning up to one year in duration utilizing protein intakes of up to 2.5-3.3 g/kg/day in healthy resistance-trained individuals consistently indicate that increased intakes of protein exert no harmful effect on blood lipids or markers of kidney and liver function.

    “A series of controlled investigations spanning up to one year in duration utilizing protein intakes of up to 2.5–3.3 g/kg/day in healthy resistance-trained individuals consistently indicate that increased intakes of protein exert no harmful effect on blood lipids or markers of kidney and liver function.”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [222]

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  1. [1]Jackson H. Moore O. J. The effect of high protein diets on the remaining kidney of rats Journal of Clinical Investigation 1928 5 3 415 425 10.1172/jci100168 16693802 PMC434720 · DOI
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  5. [5]Tipton K. D. Efficacy and consequences of very-high-protein diets for athletes and exercisers Proceedings of the Nutrition Society 2011 70 2 205 214 10.1017/S0029665111000024 2-s2.0-79955984873 21375795 · DOI
  6. [9]Antonio J. Peacock C. A. Ellerbroek A. Fromhoff B. Silver T. The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals Journal of the International Society of Sports Nutrition 2014 11, article 19 10.1186/1550-2783-11-19 2-s2.0-84900529893 PMC4022420 24834017 · DOI · Paper page
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  9. [13]Grooms K. N. Ommerborn M. J. Pham D. Q. Djoussé L. Clark C. R. Dietary fiber intake and cardiometabolic risks among US adults, NHANES 1999–2010 The American Journal of Medicine 2013 126 12 1059.e4 1067.e4 10.1016/j.amjmed.2013.07.023 2-s2.0-84888089906 24135514 PMC3865784 · DOI
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Cited by

Sorted by citations

Authors
Antonio, J., Ellerbroek, A., Silver, T., Vargas, L., Tamayo, A., Buehn, R., & Peacock, C. A.
Affiliations
  • Exercise and Sport Science Laboratory, Nova Southeastern University, Davie, FL, USA
  • Nova Southeastern University (US)
ORCID
Venue
Journal of Nutrition and Metabolism
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-5
ISSN
  • 2090-0724 (ISSN-L)
  • 2090-0732
DOI
10.1155/2016/9104792
PMC
PMC5078648
OpenAlex
W2530959860
Cited by
106
References
5
Citations by year
2026: 15 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 17 · 2018: 10 · 2017: 8
FWCI
8.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition and Metabolism (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • NSUWorks (Nova Southeastern University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
high-protein diet, resistance-trained men, body composition, fat mass, serum lipids, liver function, renal function, energy intake, dietary protein, long-term dietary effects

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