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The Effect of Osteopontin on Microglia
Abstract
Osteopontin (OPN) is a proinflammatory cytokine that can be secreted from many cells, including activated macrophages and T-lymphocytes, and is widely distributed in many tissues and cells. OPN, a key factor in tissue repairing and extracellular matrix remodeling after injury, is a constituent of the extracellular matrix of the central nervous system (CNS). Recently, the role of OPN in neurodegenerative diseases has gradually caused widespread concern. Microglia are resident macrophage-like immune cells in CNS and play a vital role in both physiological and pathological conditions, including restoring the integrity of the CNS and promoting the progression of neurodegenerative disorders. Microglia’s major function is to maintain homeostasis and the normal function of the CNS, both during development and in response to CNS injury. Although the functional mechanism of OPN in CNS neurodegenerative diseases has yet to be fully elucidated, most studies suggest that OPN play a role in pathogenesis of neurodegenerative diseases or in neuroprotection by regulating the activation and function of microglia. Here, we summarize the functions of OPN on microglia in response to various stimulations in vitro and in vivo.
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OPN influences PI3K/AKT/mTOR signalling to regulate migration, phagocytosis, and the expression of inflammatory factors in microglia.
“is known to influence PI3K/AKT/mTOR signalling 49 to regulate migration, phagocytosis, and the expression of inflammatory factors in microglia.50”
From Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function (2024) · cites this paper as [50]
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“It has been reported that OPN play a role in neurodegenerative diseases such as multiple sclerosis (MS) [4, 5], Parkinson’s disease (PD) [6, 7], and Alzheimer’s disease (AD) [8, 9].”
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Metadata
- Authors
- Yu, H., Liu, X., & Zhong, Y.
- Affiliations
- Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, China
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-6
- ISSN
- 2314-6133
- 2314-6141
- PMC
- PMC5494082
- Cited by
- 56
- References
- 5
- Language
- en
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