Cited by 157Garlic and Onion StudiesGenomics, phytochemicals, and oxidative stressChemical synthesis and alkaloids

Therapeutic role of functional components in Alliums for preventive chronic disease in human being

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Zeng, Yawen, Li, Yuping, Yang, Jiazhen, Pu, Xiaoying, Du, Juan, Yang, Xiaomeng, Yang, Tao, Yang, Shuming·2017·Evidence-Based Complementary and Alternative Medicine

Abstract

Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016. Allium genus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti‐inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results support Allium genus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.

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Crossref · 10.1155/2017/9402849

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  • PCSO can produce more than fifty metabolites depending on water content and temperature, and allinase enzyme can act on a mixture of MCSO, PCSO, and alliin to produce other molecules such as allyl methane thiosulfinates, methyl methanethiosulfonate, and further corresponding thiosulfinates.

    “PCSO can produce more than fifty metabolites depend on water content and temperature as well as allinase enzyme that can act on the mixture of MCSO, PCSO, and alliin to produce other molecules, such as allyl methane thiosulfinates, methyl methanethiosulfonate, and further corresponding thiosulfinates (R-S-S-R′), by which R and R′ are allyl, propyl, and methyls groups [31].”
  • PCSO, allicin and MCSO are the main odoriferous molecules of freshly milled garlic homogenates.

    “S-propyl-cysteine-sulfoxide (PCSO), allicin and S-methyl cysteine-sulfoxide (MCSO) are the main odoriferous molecules of freshly milled garlic homogenates [31].”
  • Alliin is transformed to allicin by allinase enzyme after cutting garlic and breaking down the parenchyma.

    “Alliin, the main cysteine sulfoxide is transformed to allicin by allinase enzyme after cutting off the garlic and breaking down the parenchyma [31].”

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  1. [15]Li Q. Q. Study on edible plant resources species of Allium L. in China Journal of Anhui Agricultural Sciences 2015 43 13 7 11
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Authors
Zeng, Y., Li, Y., Yang, J., Pu, X., Du, J., Yang, X., Yang, T., & Yang, S.
Affiliations
  • Yunnan Academy of Agricultural Sciences (CN)
  • Yuxi Agriculture Vocation-Technical College (CN)
Corresponding author
Zeng, Yawen
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2017-01
Volume
2017
Issue
1
Pages
9402849-9402849
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
OpenAlex
W2583555841
Cited by
157
References
146
Citations by year
2026: 9 · 2025: 10 · 2024: 26 · 2023: 16 · 2022: 20 · 2021: 22 · 2020: 23 · 2019: 13 · 2018: 13 · 2017: 5
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Yunnan Provincial Scientific and Technology Department (2014RA060, CARS-05)
  • China Agriculture Research System (2014RA060, CARS-05)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
Keywords
Allium, garlic, onion, Allium tuberosum, organosulfur compounds, quercetin, flavonoids, saponins, chronic disease prevention, anticancer activity, cardiovascular disease, anti-inflammatory activity, anti-obesity, antidiabetic activity, antioxidant activity, antimicrobial activity, neuroprotection, immunological effects, functional foods, nutraceuticals, dietary therapy

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