Therapeutic role of functional components in Alliums for preventive chronic disease in human being
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Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016. Allium genus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti‐inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results support Allium genus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.
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PCSO can produce more than fifty metabolites depending on water content and temperature, and allinase enzyme can act on a mixture of MCSO, PCSO, and alliin to produce other molecules such as allyl methane thiosulfinates, methyl methanethiosulfonate, and further corresponding thiosulfinates.
“PCSO can produce more than fifty metabolites depend on water content and temperature as well as allinase enzyme that can act on the mixture of MCSO, PCSO, and alliin to produce other molecules, such as allyl methane thiosulfinates, methyl methanethiosulfonate, and further corresponding thiosulfinates (R-S-S-R′), by which R and R′ are allyl, propyl, and methyls groups [31].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [31]
PCSO, allicin and MCSO are the main odoriferous molecules of freshly milled garlic homogenates.
“S-propyl-cysteine-sulfoxide (PCSO), allicin and S-methyl cysteine-sulfoxide (MCSO) are the main odoriferous molecules of freshly milled garlic homogenates [31].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [31]
Alliin is transformed to allicin by allinase enzyme after cutting garlic and breaking down the parenchyma.
“Alliin, the main cysteine sulfoxide is transformed to allicin by allinase enzyme after cutting off the garlic and breaking down the parenchyma [31].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [31]
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Sorted by citations
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
- Authors
- Zeng, Y., Li, Y., Yang, J., Pu, X., Du, J., Yang, X., Yang, T., & Yang, S.
- Affiliations
- Yunnan Academy of Agricultural Sciences (CN)
- Yuxi Agriculture Vocation-Technical College (CN)
- Corresponding author
- Zeng, Yawen
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 9402849-9402849
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC5316450
- OpenAlex
- W2583555841
- Cited by
- 157
- References
- 146
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 26 · 2023: 16 · 2022: 20 · 2021: 22 · 2020: 23 · 2019: 13 · 2018: 13 · 2017: 5
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Yunnan Provincial Scientific and Technology Department (2014RA060, CARS-05)
- China Agriculture Research System (2014RA060, CARS-05)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Keywords
- Allium, garlic, onion, Allium tuberosum, organosulfur compounds, quercetin, flavonoids, saponins, chronic disease prevention, anticancer activity, cardiovascular disease, anti-inflammatory activity, anti-obesity, antidiabetic activity, antioxidant activity, antimicrobial activity, neuroprotection, immunological effects, functional foods, nutraceuticals, dietary therapy
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