Potential of garlic (Allium sativum) in lowering high blood pressure: Mechanisms of action and clinical relevance
Open accessAbstract
Garlic supplements have shown promise in the treatment of uncontrolled hypertension, lowering blood pressure (BP) by about 10 mmHg systolic and 8 mmHg diastolic, similar to standard BP medication. Aged garlic extract, which contains S-allylcysteine as the bioactive sulfur compound, in particular is standardizable and highly tolerable, with little or no known harmful interaction when taken with other BP-reducing or blood-thinning medication. Here we describe biologically plausible mechanisms of garlic's BP-lowering effect. Garlic-derived polysulfides stimulate the production of the vascular gasotransmitter hydrogen sulfide (H2S) and enhance the regulation of endothelial nitric oxide (NO), which induce smooth muscle cell relaxation, vasodilation, and BP reduction. Several dietary and genetic factors influence the efficiency of the H2S and NO signaling pathways and may contribute to the development of hypertension. Sulfur deficiency might play a part in the etiology of hypertension, and could be alleviated with supplementation of organosulfur compounds derived from garlic.
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Garlic is used as a medicinal plant for controlling blood pressure worldwide.
“Therefore, garlic is used as a medicinal plant for controlling blood pressure worldwide [123].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [123]
Clinical studies reported that low doses of garlic are safe, whereas therapeutic doses might cause mild gastrointestinal disorders, while high doses have been reported to cause liver damage.
“Clinical studies reported that low doses of garlic are safe, whereas therapeutic doses might cause mild gastrointestinal disorders, while high doses have been reported to cause liver damage [82,123,133].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [123]
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2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
Global burden of blood-pressure-related disease, 2001
Lawes, C. M. M., Hoorn, S. V., & Rodgers, A. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60655-8 · Cited by 2,330 · see citing works
Signal transduction by reactive oxygen species
Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322 · see citing works
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Miller, N. H., Hubbard, V. S., Lee, I.-M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437740.48606.d1 · Cited by 2,261 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,232 · see citing works
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
Wang, R. (2012) · Physiological Reviews · doi:10.1152/physrev.00017.2011 · Cited by 1,939 · see citing works
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
Mudd, S. H., Skovby, F., Levy, H. L., Pettigrew, K. D., Wilcken, B. M., Pyeritz, R. E., Andria, G., Boers, G. H. J., Bromberg, I. L., & Cerone, R. (1985) · PubMed · Cited by 1,256 · see citing works
2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Houston Miller, N., Hubbard, V. S., Lee, I.-M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.003 · Cited by 1,160 · see citing works
Intake of Garlic and Its Bioactive Components
Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., & Itakura, Y. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.955s · Cited by 1,052 · see citing works
Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events
O'Donnell, M., Mente, A., Rangarajan, S., McQueen, M. J., Wang, X., Liu, L., Yan, H., Lee, S. F., Mony, P., Devanath, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311889 · Cited by 886 · see citing works
Hydrogen sulfide mediates the vasoactivity of garlic
Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., Darley-Usmar, V. M., Doeller, J. E., & Kraus, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705710104 · Cited by 886 · see citing works
Association of Urinary Sodium and Potassium Excretion with Blood Pressure
Mente, A., O'Donnell, M. J., Rangarajan, S., McQueen, M. J., Poirier, P., Wielgosz, A., Morrison, H., Li, W., Wang, X., Di, C., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311989 · Cited by 858 · see citing works
Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · see citing works
Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801 · see citing works
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Open Access CRIS of the University of Bern · doi:10.7892/boris.41664 · Cited by 742 · see citing works
Free radicals and antioxidants – quo vadis?
Halliwell, B. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.12.002 · Cited by 706 · see citing works
Clarifying the real bioactive constituents of garlic
Amagase, H. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.3.716s · Cited by 680 · see citing works
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
Chen, C.-A., Wang, T.-Y., Varadharaj, S., Reyes, L. A., Hemann, C., Talukder, M. A. H., Chen, Y.-R., Druhan, L. J., & Zweier, J. L. (2010) · Nature · doi:10.1038/nature09599 · Cited by 594 · see citing works
Souberbielle, J., Body, J.-J., Lappe, J. M., Plebani, M., Shoenfeld, Y., Wang, T. J., Bischoff-Ferrari, H. A., Cavalier, E., Ebeling, P. R., Fardellone, P., et al. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.06.009 · Cited by 537 · see citing works
Okonofua, E. C., Simpson, K. N., Jesri, A., Rehman, S. U., Durkalski, V. L., & Egan, B. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000200702.76436.4b · Cited by 527 · see citing works
Historical Perspective on the Use of Garlic
Rivlin, R. S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.951s · Cited by 525 · see citing works
Fagard, R. H., & Cornelissen, V. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282ef6185 · Cited by 480 · see citing works
Physician-Related Barriers to the Effective Management of Uncontrolled Hypertension
Oliveria, S. A., Lapuerta, P., McCarthy, B. D., L'Italien, G. J., Berlowitz, D. R., & Asch, S. M. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.4.413 · Cited by 479 · see citing works
Reactive oxygen species and vascular biology: implications in human hypertension
Touyz, R. M., & Briones, A. M. (2010) · Hypertension Research · doi:10.1038/hr.2010.201 · Cited by 469 · see citing works
Panza, J. A., García, C. E., Kilcoyne, C. M., Quyyumi, A. A., & Cannon, R. O. (1995) · Circulation · doi:10.1161/01.cir.91.6.1732 · Cited by 428 · see citing works
Ames, B. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608757103 · Cited by 411 · see citing works
MacLennan, A. H., Myers, S. P., & Taylor, A. W. (2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00092.x · Cited by 411 · see citing works
Effect of vitamin D on blood pressure: a systematic review and meta-analysis
Witham, M. D., Nadir, M. A., & Struthers, A. D. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832f075b · Cited by 396 · see citing works
Hydrogen Sulfide in Biochemistry and Medicine
Predmore, B. L., Lefer, D. J., & Gojon, G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4612 · Cited by 393 · see citing works
Complex Inhibitory Effects of Nitric Oxide on Autophagy
Sarkar, S., Korolchuk, V. I., Renna, M., Imarisio, S., Fleming, A., Williams, A. J., Garcı́a-Arencibia, M., Rose, C., Luo, S., Underwood, B. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.029 · Cited by 381 · see citing works
Bangalore, S., Messerli, F. H., Wun, C. C., Zuckerman, A., DeMicco, D. A., Kostis, J. B., & LaRosa, J. C. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq328 · Cited by 366 · see citing works
(2011) · PubMed · Cited by 343 · see citing works
Eckel, R. H., Jakicic, J. M., Ard, J. D., Jesus, J. M. D., Miller, N. H., Hubbard, V. S., Lee, I.-M. M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · Cited by 343 · see citing works
The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats
Yan, H., Du, J., & Tang, C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.081 · Cited by 336 · see citing works
Persistent blood pressure increase induced by heavy smoking
Groppelli, A., Giorgi, D. M. A., Omboni, S., Parati, G., & Mancia, G. (1992) · Journal of Hypertension · doi:10.1097/00004872-199205000-00014 · Cited by 325 · see citing works
Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras
Kashfi, K., & Olson, K. R. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.10.019 · Cited by 315 · see citing works
Harris, P. E., & Rees, R. W. (2000) · Complementary Therapies in Medicine · doi:10.1054/ctim.2000.0353 · Cited by 310 · see citing works
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 309 · see citing works
Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease
Christen, W. G., Ajani, U. A., Glynn, R. J., & Hennekens, C. H. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.422 · Cited by 307 · see citing works
Elliott, W. J. (2009) · Yearbook of Cardiology · doi:10.1016/s0145-4145(08)79414-0 · Cited by 297 · see citing works
Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Ogasawara, Y., & Kimura, H. (2011) · Biochemical Journal · doi:10.1042/bj20110841 · Cited by 295 · see citing works
Juraschek, S. P., Güallar, E., Appel, L. J., & Miller, E. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027995 · Cited by 294 · see citing works
Effect of cocoa on blood pressure
Ried, K., Fakler, P., & Stocks, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008893.pub3 · Cited by 278 · see citing works
Self-citationJaime, J., Speckman, J. L., Salas, M., Raggio, G., & Jackson, J. D. (1999) · Europe PMC (PubMed Central) · Cited by 272 · see citing works
Effect of garlic on blood pressure: A systematic review and meta-analysis
Ried, K., Frank, O. R., Stocks, N., Fakler, P., & Sullivan, T. (2008) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-8-13 · Cited by 255 · see citing works
Self-citationUse of Complementary Therapies in Patients With Cardiovascular Disease
Yeh, G. Y., Davis, R. B., & Phillips, R. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.03.051 · Cited by 241 · see citing works
Redox Signaling, Vascular Function, and Hypertension
Lee, M. Y., & Griendling, K. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1986 · Cited by 241 · see citing works
Aged garlic extract reduces blood pressure in hypertensives: a dose–response trial
Ried, K., Frank, O. R., & Stocks, N. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.178 · Cited by 233 · see citing works
Self-citationFinkelstein, J. D., & Martin, J. J. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00138-7 · Cited by 231 · see citing works
McCraty, R., Atkinson, M., & Tomasino, D. (2003) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555303765551589 · Cited by 229 · see citing works
Composition, stability, and bioavailability of garlic products used in a clinical trial
Lawson, L. D., & Gardner, C. D. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050536+ · Cited by 227 · see citing works
Garlic (<i>Allium sativum </i>L.): Adverse effects and drug interactions in humans
Borrelli, F., Capasso, R., & Izzo, A. A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700072 · Cited by 223 · see citing works
The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 216 · see citing works
Clarke, R., Bennett, D., Parish, S., Verhoef, P., Dötsch‐Klerk, M., Lathrop, M. G., Xu, P., Nordestgaard, B. G., Hólm, H., Hopewell, J. C., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001177 · Cited by 207 · see citing works
A Practical Look at the Chemistry and Biology of Hydrogen Sulfide
Olson, K. R. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4401 · Cited by 206 · see citing works
Ried, K. (2016) · Journal of Nutrition · doi:10.3945/jn.114.202192 · Cited by 206 · see citing works
Self-citationMartiniuk, A. L. C., Lee, C., Lawes, C. M. M., Ueshima, H., Suh, I., Lam, T. H., Gu, D., Feigin, V. L., Jamrozik, K. D., Ohkubo, T., et al. (2006) · Journal of Hypertension · doi:10.1097/hjh.0b013e328010775f · Cited by 203 · see citing works
Physical, Chemical, and Biological Properties of S-Allylcysteine, an Amino Acid Derived from Garlic
Kodera, Y., Suzuki, A., Imada, O., Kasuga, S., Sumioka, I., Kanezawa, A., Taru, N., Fujikawa, M., Nagae, S., Masamoto, K., et al. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0106648 · Cited by 199 · see citing works
Molecular Mechanism for H 2 S-Induced Activation of K ATP Channels
Jiang, B., Tang, G., Cao, K., Wu, L., & Wang, R. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2894 · Cited by 197 · see citing works
Ried, K., & Fakler, P. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.11.018 · Cited by 193 · see citing works
Self-citationAnswering the ultimate question “What is the Proximal Cause of Aging?”
Blagosklonny, M. V. (2012) · Aging · doi:10.18632/aging.100525 · Cited by 191 · see citing works
Conen, D., & Bamberg, F. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f97854 · Cited by 190 · see citing works
Ried, K., Frank, O. R., & Stocks, N. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.06.001 · Cited by 185 · see citing works
Self-citationExtracts from the history and medical properties of garlic
Petrovska, B., & Cekovska, S. (2010) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.65321 · Cited by 183 · see citing works
White-coat hypertension as a cause of cardiovascular dysfunction
Glen, S. K., Elliott, H. L., Curzio, J. L., Lees, K. R., & Reid, J. L. (1996) · The Lancet · doi:10.1016/s0140-6736(96)02303-3 · Cited by 179 · see citing works
A tale of two gases: NO and H2S, foes or friends for life?
Kolluru, G. K., Shen, X., & Kevil, C. G. (2013) · Redox Biology · doi:10.1016/j.redox.2013.05.001 · Cited by 168 · see citing works
Zhang, Y., Tang, Z., Ren, Z., Qu, S.-L., Liu, M., Liu, L.-S., & Jiang, Z.-S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01215-12 · Cited by 167 · see citing works
Reinhart, K. M., Coleman, C. I., Teevan, C., Vachhani, P., & White, C. M. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1l319 · Cited by 157 · see citing works
Homocysteine Imbalance: a Pathological Metabolic Marker
Schalinske, K. L., & Smazal, A. L. (2012) · Advances in Nutrition · doi:10.3945/an.112.002758 · Cited by 157 · see citing works
Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia
Weiss, N., Keller, C., Hoffmann, U., & Loscalzo, J. (2002) · Vascular Medicine · doi:10.1191/1358863x02vm428ra · Cited by 156 · see citing works
Mechanisms underlying the antihypertensive effects of garlic bioactives
Shouk, R., Abdou, A., Shetty, K., Sarkar, D., & Eid, A. H. (2014) · Nutrition Research · doi:10.1016/j.nutres.2013.12.005 · Cited by 154 · see citing works
Chuah, S. C., Moore, P. K., & Zhu, Y. Z. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00853.2007 · Cited by 154 · see citing works
Briganti, E. M., McNeil, J. J., Shaw, J. E., Zimmet, P., Chadban, S. J., Atkins, R. C., & Welborn, T. A. (2003) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2003.tb05471.x · Cited by 153 · see citing works
Effect of cocoa on blood pressure
Ried, K., Sullivan, T. R., Fakler, P., Frank, O. R., & Stocks, N. P. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008893.pub2 · Cited by 150 · see citing works
Self-citationA revisit to the natural history of homocystinuria due to cystathionine β-synthase deficiency
Skovby, F., Gaustadnes, M., & Mudd, S. H. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.09.009 · Cited by 147 · see citing works
Self-care and adherence to medication: a survey in the hypertension outpatient clinic
Gohar, F., Greenfield, S., Beevers, D. G., Lip, G. Y. H., & Jolly, K. B. (2008) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-8-4 · Cited by 146 · see citing works
Potential therapeutic effects of functionally active compounds isolated from garlic
Yun, H., Ban, J. O., Park, K., Lee, C. K., Jeong, H., Han, S., & Hong, J. T. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.005 · Cited by 144 · see citing works
Blood as a reactive species generator and redox status regulator during exercise
Nikolaidis, M. G., & Jamurtas, A. Z. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.08.015 · Cited by 136 · see citing works
Aged Garlic Extract May Be Safe for Patients on Warfarin Therapy
Macan, H. R., Uykimpang, R., Alconcel, M., Takasu, J., Razon, R. L., Amagase, H., & Niihara, Y. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.793s · Cited by 131 · see citing works
Budoff, M. J. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.04.012 · Cited by 131 · see citing works
Cohen, R. A., & Adachi, T. K. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.02.001 · Cited by 119 · see citing works
Redox signaling in pathophysiology of hypertension
Majzúnová, M., Dovinová, I., Barančı́k, M., & Chan, J. Y. H. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-69 · Cited by 116 · see citing works
Lawson, L. D., & Wang, Z. J. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001287m · Cited by 115 · see citing works
Linnane, A. W., Kios, M., & Vitetta, L. (2007) · Biogerontology · doi:10.1007/s10522-007-9096-4 · Cited by 114 · see citing works
Aged garlic extract enhances production of nitric oxide
Morihara, N., Sumioka, I., Moriguchi, T., Uda, N., & Kyo, E. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01706-x · Cited by 110 · see citing works
A population-based European cohort study of persistence in newly diagnosed hypertensive patients
Hasford, J., Mimran, A., & Simons, W. R. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001451 · Cited by 109 · see citing works
The great myth of office blood pressure measurement
Myers, M. G. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283577b05 · Cited by 108 · see citing works
Beard, R. S., & Bearden, S. E. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00598.2010 · Cited by 108 · see citing works
Zhao, X., ZHANG, L.-K., ZHANG, C.-Y., Zeng, X., Yan, H., Jin, H., Tang, C., & Du, J. (2008) · Hypertension Research · doi:10.1291/hypres.31.1619 · Cited by 107 · see citing works
Herbs and Natural Supplements: An Evidence‐based Guide
Ernst, E. M. (2010) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2010.01054_3.x · Cited by 106 · see citing works
Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat
Sharifi, A. M., Darabi, R., & Akbarloo, N. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00080-1 · Cited by 99 · see citing works
Al‐Qattan, K. K., Thomson, M., Al-Mutawa'a, S., Alhajeri, D. M., Drobiova, H., & Ali, M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.774s · Cited by 85 · see citing works
Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans
Jones, D. P., Park, Y. H., Gletsu-Miller, N. A., Liang, Y., Yu, T., Accardi, C. J., & Ziegler, T. R. (2010) · Nutrition · doi:10.1016/j.nut.2010.01.014 · Cited by 81 · see citing works
Lowering blood pressure for cardiovascular risk reduction
McInnes, G. T. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000165622.34192.fd · Cited by 77 · see citing works
State of Complementary and Alternative Medicine in Cardiovascular, Lung, and Blood Research
Lin, M. C., Nahin, R. L., Gershwin, M. E., Longhurst, J. C., & Wu, K. K. (2001) · Circulation · doi:10.1161/01.cir.103.16.2038 · Cited by 75 · see citing works
OLSEN, T. K. H. (1999) · Blood Pressure · doi:10.1080/080370599438266 · Cited by 74 · see citing works
Effects of Garlic Preparations on the Gastrointestinal Mucosa
HOSHINO, T., Kashimoto, N., & Kasuga, S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.1109s · Cited by 73 · see citing works
Persistence with antihypertensive medication: Australia‐wide experience, 2004–2006
Simons, L. A., Ortiz, M. S., & Calcino, G. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb01589.x · Cited by 72 · see citing works
Harauma, A., & Moriguchi, T. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.769s · Cited by 71 · see citing works
Garlic in Health, History, and World Cuisine
Moyers, S. B. (1996) · Medical Entomology and Zoology · Cited by 70 · see citing works
Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis
Ingenbleek, Y., & McCully, K. S. (2011) · Nutrition · doi:10.1016/j.nut.2011.04.009 · Cited by 65 · see citing works
Long-term compliance with antihypertensive therapy
Burnier, M. (2000) · Blood Pressure Monitoring · doi:10.1097/00126097-200005001-00006 · Cited by 65 · see citing works
The NO/ONOO-Cycle as the Central Cause of Heart Failure
Pall, M. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122274 · Cited by 65 · see citing works
Bianca, R. D. D. V., Mitidieri, E., Minno, M. N. D. D., Kirkby, N. S., Warner, T. D., Minno, G. D., Cirino, G., & Sorrentino, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309049110 · Cited by 64 · see citing works
Vasodilatory responsiveness to adenosine triphosphate in ageing humans
Kirby, B. S., Crecelius, A. R., Voyles, W. F., & Dinenno, F. A. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197814 · Cited by 60 · see citing works
Al‐Qattan, K. K., Khan, I., Alnaqeeb, M. A., & Ali, M. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00087-5 · Cited by 56 · see citing works
The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction
Predmore, B. L., Alendy, M. J., Ahmed, K. I., Leeuwenburgh, C., & Julian, D. A. (2010) · AGE · doi:10.1007/s11357-010-9150-z · Cited by 54 · see citing works
Tayama, J., Munakata, M., YOSHINAGA, K., & Toyota, T. (2006) · Hypertension Research · doi:10.1291/hypres.29.403 · Cited by 53 · see citing works
Cohen, D. L., & Denker, M. G. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s33087 · Cited by 50 · see citing works
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice
Lake-Bruse, K. D., Faraci, F. M., Shesely, E. G., Maeda, N., Sigmund, C. D., Heistad, D. D., & Brown), (. T. T. A. O. K. L. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h770 · Cited by 50 · see citing works
Muda, P., Kampus, P., Zilmer, M., Zilmer, K., Kairane, Č., e, T. R., Fischer, K., & Teesalu, R. (2003) · Journal of Hypertension · doi:10.1097/00004872-200312000-00022 · Cited by 45 · see citing works
Two novel mutations of theFMO3 gene in a proband with trimethylaminuria
Akerman, B. R., Forrest, S. M., Chow, L., Youil, R., Knight, M. A., & Treacy, E. P. (1999) · Human Mutation · doi:10.1002/(sici)1098-1004(1999)13:5 · Cited by 45 · see citing works
Effect of chocolate on blood pressure
Ried, K., Sullivan, T., Fakler, P., Frank, O. R., & Stocks, N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008893 · Cited by 44 · see citing works
Self-citationWeiss, N., Papatheodorou, L., Morihara, N., Hilge, R., & Ide, N. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.10.045 · Cited by 37 · see citing works
Is H 2 S a Stinky Remedy for Atherosclerosis?
Wang, R. T. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.180190 · Cited by 36 · see citing works
Yeh, Y., & Yeh, S. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.745s · Cited by 34 · see citing works
Homocysteine and Endothelial Function in Human Studies
Moat, S. J., & McDowell, I. (2005) · Seminars in Vascular Medicine · doi:10.1055/s-2005-872402 · Cited by 32 · see citing works
Sugiyama, T., & Michel, T. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00767.2009 · Cited by 26 · see citing works
Elliott, W. J. (2007) · Yearbook of Cardiology · doi:10.1016/s0145-4145(08)70011-x · Cited by 23 · see citing works
Trusting numbers: uncertainty and the pathology laboratory
Hutchinson, T. P. (2003) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2003.tb05114.x · Cited by 22 · see citing works
Essential hypertension and its causes: neural and non-neural mechanisms
Zanchetti, A. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f46e3c · Cited by 20 · see citing works
Mangoni, A. A., Zinellu, A., Carru, C., Attia, J., & McEvoy, M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-99 · Cited by 20 · see citing works
Mizrahi, E. H., Noy, S., Sela, B., Fleissig, Y., Arad, M., & Adunsky, A. (2003) · PubMed · Cited by 20 · see citing works
The Bergen Blood Pressure Study
Rune, M., Omvik, P., & Lund‐Johansen, P. (1995) · Journal of Hypertension · doi:10.1097/00004872-199512010-00019 · Cited by 10 · see citing works
Diet and individuality in detoxification
Waring, R. H., Klovrza, L. V., & Harris, R. M. (2007) · Journal of Nutritional & Environmental Medicine · doi:10.1080/13590840701343707 · Cited by 7 · see citing works
Cleansing of the Human Body: A Daily Essential Process
Meletis, C. D. (2001) · Alternative and Complementary Therapies · doi:10.1089/107628001750424517 · Cited by 5 · see citing works
Evidence-based treatment of hypertension: What's the role of angiotensin II receptor blockers?
Hobbs, R. F., Irwin, P., & Rubner, J. (2005) · British Journal of Cardiology · Cited by 4 · see citing works
Lin, M., Nahin, R., Gershwin, M., Longhurst, J. C., & Wu, K. (2001) · The HKU Scholars Hub (University of Hong Kong) · Cited by 4 · see citing works
Is H2S a Stinky Remedy for Atherosclerosis
RuiWang (2009) · Arteriosclerosis Thrombosis and Vascular Biology · Cited by 3 · see citing works
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Research works printed but not linked: 2
- [1]World Heart Federation Fact Sheet: Cardiovascular Disease Risk Factors Geneva World Heart Federation 2012 Available from: http://www.world-heart-federation.org/press/fact-sheets/cardiovascular-disease-risk-factors/ Accessed November 12, 2014
- [102]Chuah SC Moore PK Zhu YZ S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway Am J Physiol Heart Circ Physiol 2007 293 5 H2693 H2701 17766469
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931 · see citing works
Nutraceuticals: A paradigm of proactive medicine
Santini, A., Tenore, G. C., & Novellino, E. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.09.003 · Cited by 294 · see citing works
Non‐pharmacological management of hypertension
Verma, N., Rastogi, S., Chia, Y. C., Siddique, S., Turana, Y., Cheng, H., Sogunuru, G. P., Tay, J. C., Teo, B. W., Wang, T., et al. (2021) · Journal of Clinical Hypertension · doi:10.1111/jch.14236 · Cited by 160 · see citing works
Therapeutic role of functional components in Alliums for preventive chronic disease in human being
Zeng, Y., Li, Y., Yang, J., Pu, X., Du, J., Yang, X., Yang, T., & Yang, S. (2017) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2017/9402849 · Cited by 157 · see citing works
Role of phytochemicals in the management of metabolic syndrome
Cicero, A. F. G., & Colletti, A. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.11.009 · Cited by 151 · see citing works
Ried, K., Travica, N., & Sali, A. (2016) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s93335 · Cited by 145 · see citing works
Self-citationFood and plant bioactives for reducing cardiometabolic disease risk: an evidence based approach
Cicero, A. F. G., Fogacci, F., & Colletti, A. (2017) · Food & Function · doi:10.1039/c7fo00178a · Cited by 142 · see citing works
Natural approaches in metabolic syndrome management
Patti, A. M., Al‐Rasadi, K., Giglio, R. V., Nikolić, D., Mannina, C. M., Castellino, G., Chianetta, R., Banach, M., Cicero, A. F. G., Lippi, G., et al. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.68717 · Cited by 139 · see citing works
Capítulo 1 - Conceituação, Epidemiologia e Prevenção Primária
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160151 · Cited by 140 · see citing works
Verma, T., Aggarwal, A., Dey, P., Chauhan, A. K., Rashid, S., Chen, K., & Sharma, R. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1120377 · Cited by 141 · see citing works
Herbal Medications in Cardiovascular Medicine
Liperoti, R., Vetrano, D. L., Bernabei, R., & Onder, G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.078 · Cited by 122 · see citing works
Ried, K., Travica, N., & Sali, A. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00122 · Cited by 120 · see citing works
Self-citationFunctional relationship of vegetable colors and bioactive compounds: Implications in human health
Sharma, S., Katoch, V., Kumar, S., & Chatterjee, S. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108615 · Cited by 122 · see citing works
Borghi, C., & Cicero, A. F. G. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12902 · Cited by 113 · see citing works
Vegetable Organosulfur Compounds and their Health Promoting Effects
Petropoulos, S. A., Gioia, F. D., & Ntatsi, G. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170111100531 · Cited by 88 · see citing works
Ried, K. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8374 · Cited by 81 · see citing works
Self-citationCicero, A. F. G., Grassi, D., Tocci, G., Galletti, F., Borghi, C., & Ferri, C. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-0296-6 · Cited by 79 · see citing works
Okoro, B. C., Dokunmu, T. M., Okafor, E., Taiwo, I., Israel, E. N., Olusegun, D. O., Bella-Omunagbe, M., Uche, M. E., Ugbogu, E. A., & Iweala, E. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100273 · Cited by 84 · see citing works
Therapeutic effects of garlic in cardiovascular atherosclerotic disease
Sobenin, I. A., Myasoedova, V. A., Iltchuk, M., Zhang, D., & Orekhov, A. N. (2019) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(19)30088-3 · Cited by 70 · see citing works
Nutraceuticals and blood pressure control: a European Society of Hypertension position document
Borghi, C., Tsioufis, K. P., Agabiti‐Rosei, E., Burnier, M., Cicero, A. F. G., Clement, D. L., Coca, A., Desideri, G., Grassi, G. M., Lović, D. B., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002353 · Cited by 67 · see citing works
Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis
Kirichenko, T. V., Sukhorukov, V. N., Markin, A. M., Nikiforov, N. G., Liu, P., Sobenin, I. A., Tarasov, V. V., Orekhov, A. N., & Aliev, G. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00403 · Cited by 63 · see citing works
Hsu, C., Hou, C., Chang‐Chien, G., Lin, S., & Tain, Y. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001116 · Cited by 62 · see citing works
Therapeutic opportunities of edible antiviral plants for COVID-19
Patel, B. M., Sharma, S., Nair, N., Majeed, J., Goyal, R. K., & Dhobi, M. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04084-7 · Cited by 63 · see citing works
Ozma, M. A., Abbasi, A., Rezaee, M. A., Hosseini, H., Hosseinzadeh, N., Sabahi, S., Noori, S. M. A., Sepordeh, S., Khodadadi, E., Lahouty, M., et al. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2100417 · Cited by 64 · see citing works
Kalhotra, P., Chittepu, V. C. S. R., Osorio-Revilla, G. I., & Gallardo‐Velázquez, T. (2020) · Biomolecules · doi:10.3390/biom10020305 · Cited by 64 · see citing works
Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
Yang, Z., Li, X., Luo, W., Zhu, J., Zhao, J., Wang, M., Sang, L.-X., Chang, B., & Wang, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.903259 · Cited by 57 · see citing works
Samoisy, A. K., & Mahomoodally, M. F. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.06.036 · Cited by 57 · see citing works
Role of hydrogen sulfide in health and disease
Jin, Y., Yuan, H., Liu, Y., Zhu, Y., Wang, Y., Liang, X., Gao, W., Ren, Z., Ji, X., & Wu, D. (2024) · MedComm · doi:10.1002/mco2.661 · Cited by 54 · see citing works
Azizah, N., Halimah, E., Puspitasari, I. M., & Hasanah, A. N. (2021) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s289156 · Cited by 51 · see citing works
Aumeeruddy, M. Z., & Mahomoodally, M. F. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.09.008 · Cited by 50 · see citing works
A Review of Medicinal Plants in Cardiovascular Disorders: Benefits and Risks
Naveed, M., Majeed, F., Taleb, A., Zubair, H. M., Shumzaid, M., Farooq, M. A., Baig, M. M. F. A., Abbas, M., Saeed, M., & Li, C. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500147 · Cited by 48 · see citing works
Anti-hypertensive medicinal plants and their mode of action
Rawat, P., Singh, P. K., & Kumar, V. (2016) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2016.06.001 · Cited by 47 · see citing works
Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases
Vergallo, C. (2020) · Nanomaterials · doi:10.3390/nano10061232 · Cited by 47 · see citing works
Nutraceuticals: Reviewing their Role in Chronic Disease Prevention and Management
Bergamin, A., Mantzioris, E., Cross, G., Deo, P., Garg, S., & Hill, A. M. (2019) · Pharmaceutical Medicine · doi:10.1007/s40290-019-00289-w · Cited by 47 · see citing works
Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics
Liu, M., Wu, L., Montaut, S., & Yang, G. (2016) · Prostate Cancer · doi:10.1155/2016/8108549 · Cited by 44 · see citing works
Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins
Hsu, C., & Tain, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051438 · Cited by 44 · see citing works
Venkatakrishnan, K., Chiu, H., & Wang, C. (2020) · Food & Function · doi:10.1039/d0fo00357c · Cited by 43 · see citing works
Valls, R. M., Companys, J., Calderón-Pérez, L., Salamanca-Gonzalez, P., Pla‐Pagà, L., Sandoval-Ramírez, B. A., Bueno, A., Puzo, J., Crescenti, A., Bas-Prior, J. M. D., et al. (2022) · Nutrients · doi:10.3390/nu14030405 · Cited by 41 · see citing works
Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease
Chen, C., Cheng, M., Hsu, C., & Tain, Y. (2023) · Metabolites · doi:10.3390/metabo13060688 · Cited by 41 · see citing works
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway
Aquila, G., Marracino, L., Martino, V., Calabria, D., Campo, G. C., Caliceti, C., & Rizzo, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5470470 · Cited by 41 · see citing works
Sangouni, A. A., Alizadeh, M., Jamalzehi, A., & Parastouei, K. (2021) · Phytotherapy Research · doi:10.1002/ptr.7146 · Cited by 40 · see citing works
Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses
Cicero, A. F. G., & Colletti, A. (2015) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-015-0081-8 · Cited by 39 · see citing works
Liu, Y., Liu, Q. L., Liu, Y., Ju, F., Ma, Q., & He, Q. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111619 · Cited by 39 · see citing works
Chan, Q. M., Wren, G., Lau, C. E., Ebbels, T. M. D., Gibson, R., Loo, R. L., Aljuraiban, G. S., Posma, J. M., Dyer, A. R., Steffen, L. M., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac067 · Cited by 38 · see citing works
Capítulo 3 - Avaliação Clínica e Complementar
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160153 · Cited by 36 · see citing works
Al‐Obaidi, J. R., Alobaidi, K. H., Al-Taie, B. S., Wee, D. H.-S., Hussain, H., Jambari, N. N., Ahmad-Kamil, E. I., & Ariffin, N. S. (2021) · Sustainability · doi:10.3390/su13073671 · Cited by 36 · see citing works
Organosulfur Compounds as Nutraceuticals
Goncharov, N. V., Orekhov, A. N., Voitenko, N., Уколов, А. И., Jenkins, R. O., & Авдонин, П. П. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00041-3 · Cited by 35 · see citing works
Shaikh, K. A., Kinninger, A., Cherukuri, L., Birudaraju, D., Nakanishi, R., Almeida, S. O., Jayawardena, E., Shekar, C., Flores, F. R., Hamal, S. A., et al. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8371 · Cited by 34 · see citing works
Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cells
DeLeon, E. R., Gao, Y., Huang, E. S., & Olson, K. R. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00061.2016 · Cited by 33 · see citing works
Piragine, E., & Calderone, V. (2020) · Phytotherapy Research · doi:10.1002/ptr.6923 · Cited by 33 · see citing works
Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
Hsu, C., & Tain, Y. (2021) · Antioxidants · doi:10.3390/antiox10020247 · Cited by 33 · see citing works
Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications
Sleiman, C., Daou, R., Hazzouri, A. A., Hamdan, Z., Ghadieh, H. E., Harbieh, B., & Romani, M. (2024) · Nutrients · doi:10.3390/nu16172895 · Cited by 30 · see citing works
Sahidur, M. R., Islam, S., & Jahurul, M. H. A. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100353 · Cited by 30 · see citing works
Capítulo 14 – Crise Hipertensiva
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160164 · Cited by 30 · see citing works
Sholikhah, E. N., Mustofa, M. K., Nugrahaningsih, D. A. A., Yuliani, F. S., Purwono, S., Sugiyono, S., Widyarini, S., Ngatidjan, N., Jumina, J., Santosa, D., et al. (2020) · BioMed Research International · doi:10.1155/2020/8609364 · Cited by 26 · see citing works
Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis
Renieris, G., Droggiti, D.-E., Katrini, K., Koufargyris, P., Gkavogianni, T., Karakike, E., Antonakos, N., Damoraki, G., Karageorgos, A., Sabracos, L., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009473 · Cited by 26 · see citing works
Jain, M., Patil, N., Mohammed, A., & Hamzah, Z. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70152 · Cited by 25 · see citing works
Antiatherosclerotic and Cardioprotective Effects of Time-Released Garlic Powder Pills
Карагодин, В. П., Sobenin, I. A., & Orekhov, A. N. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612822666151112153351 · Cited by 24 · see citing works
7th Brazilian Guideline of Arterial Hypertension: Chapter 6 - Non-pharmacological treatment
Malachias, M., Franco, R., Forjaz, C., Pierin, A., Gowdak, M., Klein, M., & Matsudo, V. K. R. (2016) · The Scientific Electronic Library Online (Fundação de Amparo à Pesquisa do Estado de São Paulo) · Cited by 21 · see citing works
Hamal, S. A., Cherukuri, L., Birudaraju, D., Matsumoto, S., Kinninger, A., Chaganti, B. T., Flores, F. R., Shaikh, K. A., Roy, S. K., & Budoff, M. J. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8377 · Cited by 21 · see citing works
Prieto, J. M., Graham, L., Alkhabbaz, O., & Mazzari, A. L. D. A. (2023) · Plants · doi:10.3390/plants12030623 · Cited by 21 · see citing works
Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway
Shi, G., Li, X., Wang, W., Hou, L., Yin, L., & Wang, L. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01215-x · Cited by 20 · see citing works
Capítulo 9 - Hipertensão Arterial na gestação
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Poli‐de‐Figueiredo, C. E., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160159 · Cited by 21 · see citing works
Soleimani, D., Moosavian, S. P., Zolfaghari, H., & Paknahad, Z. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2307 · Cited by 19 · see citing works
Allithiamine Alleviates Hyperglycaemia-Induced Endothelial Dysfunction
Bíró, A., Markovics, A., Fazekas, M. É., Fidler, G., Szalóki, G., Paholcsek, M., Lukács, J., Stündl, L., & Remenyik, J. (2020) · Nutrients · doi:10.3390/nu12061690 · Cited by 18 · see citing works
Herbs and Spices - New Advances
Ivanišová, E. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104270 · Cited by 17 · see citing works
Organosulfur compounds as nutraceuticals
Goncharov, N. V., Belinskaia, D. A., Уколов, А. И., Jenkins, R. O., & Avdonin, P. V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00054-9 · Cited by 17 · see citing works
Rad, S. Z. K., Javadi, B., Hayes, A. W., & Karimi, G. (2019) · Europe PMC (PubMed Central) · doi:10.22038/ajp.2019.12233 · Cited by 17 · see citing works
Baik, J. S., Min, J. H., Ju, S., Ahn, J.-M., Ko, S., Chon, H. S., Kim, M. S., & Shin, Y. (2022) · Nutrients · doi:10.3390/nu14245238 · Cited by 17 · see citing works
Martelli, A., Bianca, R. D. D. V., Cirino, G., Sorrentino, R., Calderone, V., & Bucci, M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106947 · Cited by 16 · see citing works
Flow Cytometry and Light Scattering Technique in Evaluation of Nutraceuticals
Викторович, М. И., Kudryavtsev, I. V., Серебрякова, М. К., Trulioff, A. S., Gambaryan, S. P., Sudnitsyna, J. S., Khmelevskoy, D., Voitenko, N., Авдонин, П. П., Jenkins, R. O., et al. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00024-3 · Cited by 16 · see citing works
Grman, M., Nasim, M. J., Leontiev, R., Mišák, A., Jakusova, V., Ondriaš, K., & Jacob, C. (2017) · Antioxidants · doi:10.3390/antiox6010014 · Cited by 16 · see citing works
Hashemi, S. A., Ghorbanoghli, S., Manouchehri, A., & Hatkehlouei, M. B. (2019) · AIMS Agriculture and Food · doi:10.3934/agrfood.2019.2.386 · Cited by 16 · see citing works
Preparation of S-allyl cysteine-enriched garlic by two-step processing
Chen, Y., Lee, C.-H., Chen, Y., Wu, J., Tsai, M., Cheng, K., & Hsieh, C. (2020) · LWT · doi:10.1016/j.lwt.2020.109130 · Cited by 15 · see citing works
Zilbeyaz, K., Öztekіn, A., & Kutluana, E. G. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116194 · Cited by 15 · see citing works
The powerful story against cardiovascular diseases: Dietary factors
Kisioglu, B., & Nergiz‐Unal, R. (2017) · Food Reviews International · doi:10.1080/87559129.2017.1410172 · Cited by 15 · see citing works
Mohammadi, S., Mazloomi, S. M., Niakousari, M., Far, Z. G., Azadi, A., Yousefinejad, S., Jafari, P., & Faghih, S. (2022) · Phytotherapy Research · doi:10.1002/ptr.7421 · Cited by 14 · see citing works
Capítulo 6 - Tratamento não medicamentoso
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160156 · Cited by 14 · see citing works
Tain, Y., Hou, C., Chang‐Chien, G., Lin, S., & Hsu, C. (2022) · Nutrients · doi:10.3390/nu14214624 · Cited by 13 · see citing works
Vila-Nova, T. M. S., Barbosa, K. B. F., Freire, A. R. S., Cintra, D. E., Silva, D. G., Rodrigues, T. M. D. A., Costa, B. M., & Aragao, L. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105931 · Cited by 13 · see citing works
Nutraceutical Bioactive Compounds Promote Healthspan Counteracting Cardiovascular Diseases
Malaguti, M., Angeloni, C., & Hrelia, S. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1080107 · Cited by 13 · see citing works
Kroll, J. L., Werchan, C. A., Reeves, A. G., Bruemmer, K. J., Lippert, A. R., & Ritz, T. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.05.023 · Cited by 13 · see citing works
Foods of the Mediterranean diet: Garlic and Mediterranean legumes
Medori, M. C., Naureen, Z., Bonetti, G., Velluti, V., Aquilanti, B., Matera, G., Iaconelli, A., & Bertelli, M. (2022) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2022.63.2s3.2741 · Cited by 12 · see citing works
Vahed, H., & Jafri, S. B. (2016) · Journal of Antivirals & Antiretrovirals · doi:10.4172/jaa.1000129 · Cited by 12 · see citing works
Role of Nutraceuticals in the Prevention and Treatment of Hypertension and Cardiovascular Diseases
Alves, Q. L., Barbosa, C. S., & Silva, D. F. (2019) · Journal of Hypertension and Management · doi:10.23937/2474-3690/1510037 · Cited by 12 · see citing works
Medicinal Plants Used as Galactagogues
Bekoe, E. O., Kitcher, C., Mireku-Gyimah, N. A., Schwinger, G., & Frempong, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82199 · Cited by 11 · see citing works
Introduction to Nutraceuticals and Pharmaceuticals
Trifković, K. T., & Benković, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816450-1.00001-5 · Cited by 11 · see citing works
Hu, B., Hu, H., Pu, C., Wei, Z., Wang, Q., & Kuang, H. (2022) · Natural Product Research · doi:10.1080/14786419.2022.2047045 · Cited by 11 · see citing works
Ahmed, M., Hwang, J. H., Ali, M. N., Al-Ahnoumy, S., & Han, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.926449 · Cited by 11 · see citing works
Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
Chauhan, A. P. S., Dewali, S., Pathak, V. M., Bisht, S. S., Chauhan, R., Kaur, D., Tuli, H. S., Haque, S., & Ahmad, F. (2025) · Discover Oncology · doi:10.1007/s12672-025-02591-3 · Cited by 11 · see citing works
Capítulo 10 - Hipertensão na Criança e no Adolescente
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160160 · Cited by 9 · see citing works
Luikham, S., & Bhattacharyya, J. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2315594 · Cited by 9 · see citing works
Chiu, H., Venkatakrishnan, K., & Wang, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00020-2 · Cited by 9 · see citing works
Safety and Toxicity Evaluation of Nutraceuticals in Animal Models
Goncharov, N. V., Sobolev, V. E., Terpilowski, M. A., Korf, E. A., & Jenkins, R. O. (2019) · Springer eBooks · doi:10.1007/978-3-030-04624-8_48 · Cited by 8 · see citing works
Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders
Ahangar‐Sirous, R., Poudineh, M., Ansari, A., Nili, A., Dana, S. M. M. A., Nasiri, Z., Hosseini, Z., Karami, D., Mokhtari, M., & Deravi, N. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210927101257 · Cited by 8 · see citing works
Plant Secondary Metabolites as Nutraceuticals
Nirmala, L., Amma, Z. D. P. P., & Jalaj, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-5136-9_11 · Cited by 8 · see citing works
Jimoh, O. A., Nwachukwu, C. U., Abosede, O. O., & Samuel, T. O. (2023) · Translational Animal Science · doi:10.1093/tas/txad106 · Cited by 12 · see citing works
Nemzer, B. V., & Kalita, D. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.109774 · Cited by 7 · see citing works
The potency of black garlic as anti-atherosclerotic: Mechanisms of action and the prospectively
Saryono, S., & Proverawati, A. (2019) · AIP conference proceedings · doi:10.1063/1.5097496 · Cited by 7 · see citing works
Natural Foods and Indian herbs of cardiovascular interest
Mohiuddin, A. K. (2019) · Pharmacy & Pharmacology International Journal · doi:10.15406/ppij.2019.07.00235 · Cited by 8 · see citing works
- Authors
- Ried, K., & Fakler, P.
- Affiliations
- National Institute of Integrative Medicine (AU)
- Corresponding author
- Ried, Karin
- ORCID
- Ried, Karin
- Venue
- Integrated Blood Pressure Control
- Publisher
- Informa UK Limited
- Published
- 2014-12
- Volume
- 7
- Pages
- 71
- ISSN
- 1178-7104 (ISSN-L)
- PMC
- PMC4266250
- OpenAlex
- W1987743550
- Cited by
- 198
- References
- 137
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 13 · 2023: 21 · 2022: 25 · 2021: 31 · 2020: 20 · 2019: 19 · 2018: 5 · 2017: 13 · 2016: 18 · 2015: 5
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Integrated Blood Pressure Control (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- garlic, hypertension, blood pressure reduction, aged garlic extract, S-allylcysteine, polysulfides, hydrogen sulfide, nitric oxide, endothelial function, vasodilation, smooth muscle relaxation, sulfur deficiency, organosulfur compounds, dietary factors, genetic factors
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