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Cited by 83Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomaliesPeripheral Neuropathies and Disorders

Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment

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Meldgaard, Theresa, Olesen, Søren Schou, Farmer, Adam D., Krogh, Klaus, Wendel, Anne Astrid, Brock, Birgitte, Drewes, Asbjørn Mohr, Brock, Christina·2018·Journal of Diabetes Research
DOI 10.1155/2018/3827301PMC PMC6165592
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Abstract

The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a “molecule to mechanism” approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.

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  • Risk correlates for DGP include long disease duration, poor glycemic control, presence of other diabetic complications (especially peripheral and autonomic neuropathy), prior bariatric surgery, and female sex.

    “Risk correlates include long disease duration [8, 11, 12], poor glycemic control [3, 13], presence of other diabetic complications (especially peripheral and autonomic neuropathy) [4, 13], prior bariatric surgery [14, 15], and female sex [16, 17]”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [12]

    Clinical Aspects links gastroparesis symptom severity to diabetes duration and poor glycaemic control, but it does not establish that either increases the risk of developing gastroparesis. Emerging Techniques discusses autonomic neuropathy and peripheral nerve degeneration in adults with diabetes and GI symptoms, not as demonstrated risk correlates for gastroparesis. The passages do not support prior bariatric surgery or female sex as risk correlates. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Meldgaard, T., Olesen, S. S., Farmer, A. D., Krogh, K., Wendel, A. A., Brock, B., Drewes, A. M., & Brock, C.
Affiliations
  • Aalborg University Hospital (DK)
  • Queen Mary University of London (GB)
  • Aarhus University Hospital (DK)
  • Steno Diabetes Center Copenhagen (DK)
Corresponding author
Brock, Christina
ORCID
Venue
Journal of Diabetes Research
Publisher
Wiley
Published
2018-09-16
Volume
2018
Pages
1-12
ISSN
  • 2314-6745 (ISSN-L)
  • 2314-6753
DOI
10.1155/2018/3827301
PMC
PMC6165592
OpenAlex
W2890761517
Cited by
83
References
7
Citations by year
2026: 12 · 2025: 5 · 2024: 10 · 2023: 21 · 2022: 11 · 2021: 10 · 2020: 6 · 2019: 8
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Diabetes Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by)
Funders
  • Novo Nordisk Scandinavia AS (10-092786)
  • Innovation Fund Denmark (10-092786)
  • Aalborg University (10-092786)
  • Novo Nordisk Foundation (10-092786)
  • University Hospitals of North Midlands (10-092786)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
diabetic enteropathy, diabetic gastroparesis, enteric nervous system, diabetic neuropathy, gastrointestinal motility disorders, neuroinflammation, diabetic microvascular complications, patient-reported outcome measures, treatment options
MeSH terms
Diabetic Neuropathies, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Enteric Nervous System

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