CoChat
Sign Up
Cited by 248Heavy Metal Exposure and ToxicityTrace Elements in HealthHeavy metals in environment

A Review of Metal Exposure and Its Effects on Bone Health

Open access
Rodríguez, Juliana, Mandalunis, Patricia Mónica·2018·Journal of Toxicology
DOI 10.1155/2018/4854152PMC PMC6323513
Open this paper in CoChat — free accountOpen PDF

Abstract

The presence of metals in the environment is a matter of concern, since human activities are the major cause of pollution and metals can enter the food chain and bioaccumulate in hard and soft tissues/organs, which results in a long half-life of the metal in the body. Metal intoxication has a negative impact on human health and can alter different systems depending on metal type and concentration and duration of metal exposure. The present review focuses on the most common metals found in contaminated areas (cadmium, zinc, copper, nickel, mercury, chromium, lead, aluminum, titanium, and iron, as well as metalloid arsenic) and their effects on bone tissue. Both the lack and excess of these metals in the body can alter bone dynamics. Long term exposure and short exposure to high concentrations induce an imbalance in the bone remodeling process, altering both formation and resorption and leading to the development of different bone pathologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2018/4854152

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The bone diseases associated with Al exposure are osteoporosis, osteomalacia, rickets, exostosis, osteodystrophy and osteitis fibrosa.

    “The bone diseases associated with Al exposure are osteoporosis, osteomalcia, rickets, exostosis, osteodystrophy and osteitis fibrosa (Sherrard et al., 1985; Chappard et al., 2016; Rodríguez and Mandalunis, 2018; Klein, 2019).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Rodríguez and Mandalunis, 2018

    Section 2.6 (Aluminum; page unavailable) links aluminum poisoning to renal osteodystrophy, osteomalacia, and osteoporosis. It reports aluminum in the bone of patients with exostosis, but does not say aluminum exposure causes exostosis. It does not identify rickets or osteitis fibrosa as aluminum-associated diseases. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 136

  1. [1]Cai L. Huang L. Zhou Y. Heavy metal concentrations of agricultural soils and vegetables from Dongguan, Guangdong Journal of Geographical Sciences 2010 20 1 121 134 2-s2.0-75849150462 10.1007/s11442-010-0121-1 · DOI
  2. [2]Celik H. Celik N. Kocyigit A. Dikilitas M. The relationship between plasma aluminum content, lymphocyte DNA damage, and oxidative status in persons using aluminum containers and utensils daily Clinical Biochemistry 2012 45 18 1629 1633 2-s2.0-84870675258 10.1016/j.clinbiochem.2012.08.010 22981396 · DOI
  3. [3]Garg V. K. Yadav P. Mor S. Singh B. Pulhani V. Heavy metals bioconcentration from soil to vegetables and assessment of health risk caused by their ingestion Biological Trace Element Research 2014 157 3 256 265 2-s2.0-84896735943 10.1007/s12011-014-9892-z 24464601 · DOI
  4. [4]Leung A. O. W. Duzgoren-Aydin N. S. Cheung K. C. Wong M. H. Heavy metals concentrations of surface dust from e-waste recycling and its human health implications in southeast China Environmental Science & Technology 2008 42 7 2674 2680 10.1021/es071873x 2-s2.0-41649095956 18505015 · DOI
  5. [5]Guo Y. Huo X. Li Y. Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in China Science of the Total Environment 2010 408 16 3113 3117 2-s2.0-77953720399 10.1016/j.scitotenv.2010.04.018 20451954 · DOI
  6. [6]Weidenhamer J. D. Miller J. Guinn D. Pearson J. Bioavailability of cadmium in inexpensive jewelry Environmental Health Perspectives 2011 119 7 1029 1033 2-s2.0-79960069373 10.1289/ehp.1003011 21377949 PMC3222974 · DOI
  7. [8]Shi Z. Taylor A. W. Riley M. Byles J. Liu J. Noakes M. Association between dietary patterns, cadmium intake and chronic kidney disease among adults Clinical Nutrition 2018 37 1 276 284 2-s2.0-85009738437 10.1016/j.clnu.2016.12.025 28094058 · DOI
  8. [9]Messner B. Bernhard D. Cadmium and cardiovascular diseases: Cell biology, pathophysiology, and epidemiological relevance BioMetals 2010 23 5 811 822 2-s2.0-78349307799 10.1007/s10534-010-9314-4 20213268 · DOI
  9. [10]Nawrot T. S. Staessen J. A. Roels H. A. Cadmium exposure in the population: From health risks to strategies of prevention BioMetals 2010 23 5 769 782 2-s2.0-78349309172 10.1007/s10534-010-9343-z 20517707 · DOI
  10. [11]Nordberg G. Fowler B. Nordbergt M. Handbook on the Toxicology of Metals 2014 61 4th Academic Press
  11. [12]Trakulsrichai S. Kosanyawat N. Atiksawedparit P. Clinical characteristics of zinc phosphide poisoning in Thailand Therapeutics and Clinical Risk Management 2017 13 335 340 2-s2.0-85015728944 10.2147/TCRM.S129610 28352183 PMC5360397 · DOI
  12. [13]El Idrissi A. van Berkel L. Bonekamp N. E. Dalemans D. J. Z. van der Heyden M. A. G. The toxicology of zinc chloride smoke producing bombs and screens Clinical Toxicology 2017 55 3 167 174 2-s2.0-85010867682 10.1080/15563650.2016.1271125 28074704 · DOI
  13. [14]Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Copper 2004 Atlanta, GA, USA Department of Health and Human Services, Public Health Service https://www.atsdr.cdc.gov/toxprofiles/tp132.pdf 10.4135/9781452240121 · DOI
  14. [15]Klein C. Costa M. Handbook on the Toxicology of Metals 2007 3th Academic Press
  15. [16]Duda-Chodak A. Błaszczyk U. The impact of nickel on human health Journal of Elementology 2008 13 4 685 696 2-s2.0-77949807209
  16. [17]Berlin M. Zalups R. K. Fowler B. A. Nordberg G. F. Fowler A. B. Nordberg M. Friberg L. T. Mercury, in Handbook on the Toxicology of Metals 2007 3rd chapter 33 New York, NY, USA Elsevier
  17. [18]Syversen T. Kaur P. The toxicology of mercury and its compounds Journal of Trace Elements in Medicine and Biology 2012 26 4 215 226 2-s2.0-84868198333 10.1016/j.jtemb.2012.02.004 22658719 · DOI
  18. [19]Mahaffey K. R. Clickner R. P. Bodurow C. C. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000 Environmental Health Perspectives 2004 112 5 562 570 2-s2.0-7944226409 10.1289/ehp.6587 15064162 PMC1241922 · DOI
  19. [20]Bernhoft R. A. Mercury toxicity and treatment: a review of the literature Journal of Environmental and Public Health 2012 2012 10 460508 10.1155/2012/460508 PMC3253456 22235210 · DOI
  20. [21]Maqbool F. Niaz K. Hassan F. I. Khan F. Abdollahi M. Immunotoxicity of mercury: Pathological and toxicological effects Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews 2017 35 1 29 46 2-s2.0-85013389503 10.1080/10590501.2016.1278299 28055311 · DOI
  21. [22]Rice K. M. Walker E. M. Jr. Wu M. Gillette C. Blough E. R. Environmental mercury and its toxic effects Journal of Preventive Medicine & Public Health 2014 47 2 74 83 2-s2.0-84899432882 10.3961/jpmph.2014.47.2.74 24744824 PMC3988285 · DOI
  22. [25]Remy L. L. Byers V. Clay T. Reproductive outcomes after non-occupational exposure to hexavalent chromium, Willits California, 1983-2014 Environmental Health 2017 16 1 10.1186/s12940-017-0222-8 PMC5340004 28264679 · DOI
  23. [26]Sun H. Brocato J. Costa M. Oral Chromium Exposure and Toxicity Current Environmental Health Reports 2015 2 3 295 303 2-s2.0-84993505419 10.1007/s40572-015-0054-z 26231506 PMC4522702 · DOI
  24. [27]Assi M. A. Hezmee M. N. M. Haron A. W. Sabri M. Y. M. Rajion M. A. The detrimental effects of lead on human and animal health Veterinary World 2016 9 6 660 671 2-s2.0-84976568920 10.14202/vetworld.2016.660-671 27397992 PMC4937060 · DOI
  25. [28]Järup L. Hazards of heavy metal contamination British Medical Bulletin 2003 68 1 167 182 10.1093/bmb/ldg032 2-s2.0-3242774357 14757716 · DOI · Paper page
  26. [29]Dongre N. N. Suryakar A. N. Patil A. J. Hundekari I. A. Devarnavadagi B. B. Biochemical effects of lead exposure on battery manufacture workers with reference to blood pressure, calcium metabolism and bone mineral density Indian Journal of Clinical Biochemistry 2013 28 1 65 70 2-s2.0-84872677330 10.1007/s12291-012-0241-8 24381424 PMC3547442 · DOI
  27. [30]Gambelunghe A. Sallsten G. Borné Y. Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort Environmental Research 2016 149 157 163 2-s2.0-84968853353 10.1016/j.envres.2016.05.015 27208466 · DOI
  28. [31]Vorvolakos T. Arseniou S. Samakouri M. There is no safe threshold for lead exposure: Α literature review Psychiatrike = Psychiatriki 2016 27 3 204 214 2-s2.0-85017089795 10.22365/jpsych.2016.273.204 27837574 · DOI
  29. [32]Priest N. D. The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: Review and study update Journal of Environmental Monitoring 2004 6 5 375 403 2-s2.0-2642534671 10.1039/b314329p 15152306 · DOI
  30. [33]Stahl T. Falk S. Rohrbeck A. Migration of aluminum from food contact materials to food—a health risk for consumers? Part I of III: exposure to aluminum, release of aluminum, tolerable weekly intake (TWI), toxicological effects of aluminum, study design, and methods Environmental Sciences Europe 2017 29 1 2-s2.0-85017513884 PMC5388732 28458989
  31. [34]Taiyi J. Berlin M. Handbook on the Toxicology of Metals 2014 4th Chapter 57 Academic Press
  32. [35]Jia P. Xu Y. J. Zhang Z. L. Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species Journal of Orthopaedic Research 2012 30 11 1843 1852 2-s2.0-84867233063 10.1002/jor.22133 22570238 · DOI
  33. [36]Guggenbuhl P. Brissot P. Loréal O. Haemochromatosis: The bone and the joint Best Practice & Research Clinical Rheumatology 2011 25 5 649 664 2-s2.0-82955174678 10.1016/j.berh.2011.10.014 22142745 · DOI
  34. [37]Fowler B. A. Chou C. H. S. J. Jones D R. L. Jr. Chen C. J. Handbook on the Toxicology of Metals 2014 28 4th Chapter 28 Academic Press
  35. [38]Bhattacharya S. Medicinal plants and natural products in amelioration of arsenic toxicity: A short review Pharmaceutical Biology 2017 55 1 349 354 2-s2.0-85015355760 10.1080/13880209.2016.1235207 27931138 PMC6130623 · DOI
  36. [39]Shea J. E. Miller S. C. Skeletal function and structure: implications for tissue-targeted therapeutics Advanced Drug Delivery Reviews 2005 57 7 945 957 10.1016/j.addr.2004.12.017 2-s2.0-18844421096 15876397 · DOI
  37. [40]Cao J. Venton L. Sakata T. Halloran B. P. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice Journal of Bone and Mineral Research 2003 18 2 270 277 10.1359/jbmr.2003.18.2.270 2-s2.0-0037302038 12568404 · DOI · Paper page
  38. [41]Maly I. P. Eppler E. Müller-Gerbl M. High metabolic activity of tissue-nonspecific alkaline phosphatase not only in young but also in adult bone as demonstrated using a new histochemical detection protocol General and Comparative Endocrinology 2018 258 109 118 2-s2.0-85020209880 10.1016/j.ygcen.2017.05.008 28502741 · DOI
  39. [42]Nisse C. Tagne-Fotso R. Howsam M. Richeval C. Labat L. Leroyer A. Blood and urinary levels of metals and metalloids in the general adult population of Northern France: The IMEPOGE study, 2008–2010 International Journal of Hygiene and Environmental Health 2017 220 2 341 363 2-s2.0-85007439545 10.1016/j.ijheh.2016.09.020 27931767 · DOI
  40. [44]Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Nickel 2005 Atlanta, GA, USA Department of Health and Human Services, Public Health Service 10.4135/9781452240121 · DOI
  41. [45]Bocca B. Bena A. Pino A. Human biomonitoring of metals in adults living near a waste-to-energy incinerator in ante-operam phase: Focus on reference values and health-based assessments Environmental Research 2016 148 338 350 2-s2.0-84963904701 10.1016/j.envres.2016.04.013 27107710 · DOI
  42. [46]Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Aluminum 2008 Atlanta, GA, USA Department of Health and Human Services, Public Health Service 37983316
  43. [47]Abass K. Koiranen M. Mazej D. Arsenic, cadmium, lead and mercury levels in blood of Finnish adults and their relation to diet, lifestyle habits and sociodemographic variables Environmental Science and Pollution Research 2017 24 2 1347 1362 2-s2.0-84992221645 10.1007/s11356-016-7824-5 27778267 · DOI
  44. [48]Engström A. Michaëlsson K. Vahter M. Julin B. Wolk A. Åkesson A. Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women Bone 2012 50 6 1372 1378 2-s2.0-84860835477 10.1016/j.bone.2012.03.018 22465267 · DOI
  45. [49]Wallin M. Barregard L. Sallsten G. Low-Level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: the mros sweden study Journal of Bone and Mineral Research 2016 31 4 732 741 10.1002/jbmr.2743 2-s2.0-84952684460 26572678 PMC4832374 · DOI
  46. [50]Kazantzis G. Cadmium, osteoporosis and calcium metabolism BioMetals 2004 17 5 493 498 2-s2.0-17944380456 10.1023/B:BIOM.0000045727.76054.f3 15688852 · DOI
  47. [51]Åkesson A. Bjellerup P. Lundh T. Cadmium-induced effects on bone in a population-based study of women Environmental Health Perspectives 2006 114 6 830 834 2-s2.0-33745018112 10.1289/ehp.8763 16759980 PMC1480481 · DOI
  48. [52]Bernard A. Cadmium & its adverse effects on human health Indian Journal of Medicine Research 2008 128 4 557 564 19106447
  49. [53]Chen X. Zhu G. Jin T. Lei L. Liang Y. Bone mineral density is related with previous renal dysfunction caused by cadmium exposure Environmental Toxicology and Pharmacology 2011 32 1 46 53 2-s2.0-79957836519 10.1016/j.etap.2011.03.007 21787729 · DOI
  50. [54]Johri N. Jacquillet G. Unwin R. Heavy metal poisoning: the effects of cadmium on the kidney BioMetals 2010 23 5 783 792 10.1007/s10534-010-9328-y 2-s2.0-78349306576 20354761 · DOI
  51. [55]Brzóska M. M. Moniuszko-Jakoniuk J. Low-level exposure to cadmium during the lifetime increases the risk of osteoporosis and fractures of the lumbar spine in the elderly: Studies on a rat model of human environmental exposure Toxicological Sciences 2004 82 2 468 477 2-s2.0-10044236465 10.1093/toxsci/kfh275 15375291 · DOI
  52. [56]Brzóska M. M. Moniuszko-Jakoniuk J. Disorders in bone metabolism of female rats chronically exposed to cadmium Toxicology and Applied Pharmacology 2005 202 1 68 83 2-s2.0-10044289149 10.1016/j.taap.2004.06.007 15589978 · DOI
  53. [57]Chen X. Zhu G. Jin T. Gu S. Xiao H. Qiu J. Cadmium induces differentiation of RAW264.7 cells into osteoclasts in the presence of RANKL Food and Chemical Toxicology 2011 49 9 2392 2397 2-s2.0-79960844956 10.1016/j.fct.2011.06.053 21723911 · DOI
  54. [58]Rodríguez J. Mandalunis P. M. Effect of cadmium on bone tissue in growing animals Experimental and Toxicologic Pathology 2016 68 7 391 397 2-s2.0-85006427790 10.1016/j.etp.2016.06.001 27312893 · DOI
  55. [59]Chen X. Zhu G. Gu S. Jin T. Shao C. Effects of cadmium on osteoblasts and osteoclasts in vitro Environmental Toxicology and Pharmacology 2009 28 2 232 236 2-s2.0-67650263453 10.1016/j.etap.2009.04.010 21784008 · DOI
  56. [60]Chen X. Zhu G. Jin T. Cadmium stimulates the osteoclastic differentiation of RAW264.7 Cells in presence of osteoblasts Biological Trace Element Research 2012 146 3 349 353 2-s2.0-84862570449 10.1007/s12011-011-9256-x 22076734 · DOI
  57. [61]Papa V. Bimonte V. M. Wannenes F. The endocrine disruptor cadmium alters human osteoblast-like Saos-2 cells homeostasis in vitro by alteration of Wnt/β-catenin pathway and activation of caspases Journal of Endocrinological Investigation 2015 38 12 1345 1356 2-s2.0-84946067923 10.1007/s40618-015-0380-x 26335301 · DOI
  58. [62]Oliveira H. Monteiro C. Pinho F. Pinho S. Ferreira de Oliveira J. M. P. Santos C. Cadmium-induced genotoxicity in human osteoblast-like cells Mutation Research - Genetic Toxicology and Environmental Mutagenesis 2014 775-776 38 47 2-s2.0-84912043819 10.1016/j.mrgentox.2014.10.002 25435354 · DOI
  59. [63]Hu K.-H. Li W.-X. Sun M.-Y. Cadmium induced apoptosis in MG63 cells by increasing ROS, activation of p38 MAPK and inhibition of ERK 1/2 pathways Cellular Physiology and Biochemistry 2015 36 2 642 654 2-s2.0-84929678192 10.1159/000430127 25998312 · DOI
  60. [64]Choi Y.-H. Hu H. Mukherjee B. Miller J. Park S. K. Environmental cadmium and lead exposures and hearing loss in U.S. adults: The National Health and Nutrition Examination Survey, 1999 to 2004 Environmental Health Perspectives 2012 120 11 1544 1550 2-s2.0-84868572431 10.1289/ehp.1104863 22851306 PMC3556613 · DOI
  61. [65]Yuan G. Dai S. Yin Z. Toxicological assessment of combined lead and cadmium: Acute and sub-chronic toxicity study in rats Food and Chemical Toxicology 2014 65 260 268 2-s2.0-84893020103 10.1016/j.fct.2013.12.041 24394482 · DOI
  62. [66]Chen X. Wang K. Wang Z. Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population Bone 2014 63 76 80 2-s2.0-84896137752 10.1016/j.bone.2014.02.017 24607944 · DOI
  63. [67]Morais S. Sousa J. P. Fernandes M. H. Carvalho G. S. In vitro biomineralization by osteoblast-like cells I. Retardation of tissue mineralization by metal salts Biomaterials 1998 19 1-3 13 21 2-s2.0-0031812308 10.1016/S0142-9612(97)00149-X 9678845 · DOI
  64. [68]Kanaji A. Orhue V. Caicedo M. S. Cytotoxic effects of cobalt and nickel ions on osteocytes in vitro Journal of Orthopaedic Surgery and Research 2014 9 1, article no. 91 2-s2.0-84908103289 10.1186/s13018-014-0091-6 25288055 PMC4194407 · DOI
  65. [69]Suzuki N. Yamamoto M. Watanabe K. Kambegawa A. Hattori A. Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: The scale is a good model for the evaluation of heavy metals in bone metabolism Journal of Bone and Mineral Metabolism 2004 22 5 439 446 2-s2.0-4544252856 10.1007/s00774-004-0505-3 15316864 · DOI
  66. [70]Yachiguchi K. Sekiguchi T. Nakano M. Effects of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone Zoological Science 2014 31 5 330 337 2-s2.0-84900852899 10.2108/zs130265 24832906 · DOI
  67. [71]Abd El-Aziz G. S. El-Fark M. M. O. Saleh H. A. M. The prenatal toxic effect of methylmercury on the development of the appendicular skeleton of rat fetuses and the protective role of vitamin E Anatomical Record 2012 295 6 939 949 10.1002/ar.22485 2-s2.0-84860918303 22549941 · DOI
  68. [72]Sankaramanivel S. Jeyapriya R. Hemalatha D. Djody S. Arunakaran J. Srinivasan N. Effect of chromium on vertebrae, femur and calvaria of adult male rats Human & Experimental Toxicology 2006 25 6 311 318 2-s2.0-33745972891 10.1191/0960327105ht627oa 16866188 · DOI
  69. [73]De Lucca R. C. Dutrey P. L. Villarino M. E. Ubios A. M. Effect of different doses of hexavalent chromium on mandibular growth and tooth eruption in juvenile Wistar rats Experimental and Toxicologic Pathology 2009 61 4 347 352 2-s2.0-67249161660 10.1016/j.etp.2008.10.001 19042111 · DOI
  70. [74]Shah K. M. Quinn P. D. Gartland A. Wilkinson J. M. Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells Journal of Orthopaedic Research 2015 33 1 114 121 2-s2.0-84911874462 10.1002/jor.22729 25251692 · DOI
  71. [75]Shah K. M. Wilkinson J. M. Gartland A. Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro Journal of Orthopaedic Research 2015 33 11 1663 1670 2-s2.0-84942835540 10.1002/jor.22932 25929464 · DOI
  72. [76]Andrews R. E. Shah K. M. Wilkinson J. M. Gartland A. Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health Bone 2011 49 4 717 723 10.1016/j.bone.2011.06.007 2-s2.0-80052292468 21689801 · DOI
  73. [77]Flora G. Gupta D. Tiwari A. Toxicity of lead: a review with recent updates Interdisciplinary Toxicology 2012 5 2 47 58 10.2478/v10102-012-0009-2 2-s2.0-84873957737 23118587 PMC3485653 · DOI
  74. [78]Gulson B. Taylor A. Eisman J. Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations Bone 2016 89 40 51 2-s2.0-84973167303 10.1016/j.bone.2016.05.005 27233973 · DOI
  75. [79]Skerfving S. Bergdahl I. Handbook on the Toxicology of Metals 2007 3th Chapter 31
  76. [80]Wong A. K. Beattie K. A. Bhargava A. Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women Bone 2015 79 58 64 10.1016/j.bone.2015.05.010 25986335 PMC5092152 · DOI
  77. [81]Carmouche J. J. Puzas J. E. Zhang X. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency Environmental Health Perspectives 2005 113 6 749 755 2-s2.0-20844463259 10.1289/ehp.7596 15929899 PMC1257601 · DOI
  78. [82]Shukla R. Bornschein R. L. Dietrich K. N. Fetal and infant lead exposure: Effects on growth in stature Pediatrics 1989 84 4 604 612 2-s2.0-0024456999 2780121
  79. [83]Cen S. Y. Qu T. F. Wu J. Study on correlation between blood lead level and living environment in infants with growth retardation Journal of Clinical Pediatrics 2004 22 464 46
  80. [84]Olchowik G. Widomska J. Tomaszewski M. Gospodarek M. Tomaszewska M. Jagiełło-Wójtowicz E. The influence of lead on the biomechanical properties of bone tissue in rats Annals of Agricultural and Environmental Medicine 2014 21 2 278 281 2-s2.0-84902318866 10.5604/1232-1966.1108591 24959776 · DOI
  81. [85]Conti M. I. Terrizzi A. R. Lee C. M. Effects of lead exposure on growth and bone biology in growing rats exposed to simulated high altitude Bulletin of Environmental Contamination and Toxicology 2012 88 6 1033 1037 2-s2.0-84862820285 10.1007/s00128-012-0602-2 22456729 · DOI
  82. [86]Monir A. U. Gundberg C. M. Yagerman S. E. The effect of lead on bone mineral properties from female adult C57/BL6 mice Bone 2010 47 5 888 894 2-s2.0-77957756432 10.1016/j.bone.2010.07.013 20643234 PMC3386851 · DOI
  83. [87]Beier E. E. Sheu T.-J. Dang D. Heavy metal ion regulation of gene expression: Mechanisms by which lead inhibits osteoblastic bone-forming activity through modulation of the Wnt/β-catenin signaling pathway The Journal of Biological Chemistry 2015 290 29 18216 18226 2-s2.0-84937408385 10.1074/jbc.M114.629204 25975268 PMC4505064 · DOI
  84. [88]Ma Y. Fu D. Liu Z. Effect of lead on apoptosis in cultured rat primary osteoblasts Toxicology & Industrial Health 2012 28 2 136 146 2-s2.0-84859025352 10.1177/0748233711407956 21712424 · DOI
  85. [89]Lv X.-H. Zhao D.-H. Cai S.-Z. Autophagy plays a protective role in cell death of osteoblasts exposure to lead chloride Toxicology Letters 2015 239 2 131 140 2-s2.0-84943629237 10.1016/j.toxlet.2015.09.014 26383630 · DOI
  86. [90]González-Riola J. Hernández E. R. Escribano A. Effect of lead on bone and cartilage in sexually mature rats: A morphometric and histomorphometry study Environmental Research 1997 74 1 91 93 2-s2.0-0030870513 10.1006/enrs.1997.3760 9339220 · DOI
  87. [91]Hicks D. G. O'Keefe R. J. Reynolds K. J. Effects of lead on growth plate chondrocyte phenotype Toxicology and Applied Pharmacology 1996 140 1 164 172 2-s2.0-0030248153 10.1006/taap.1996.0209 8806882 · DOI
  88. [92]Nebeker H. G. Coburn J. W. Aluminum and renal osteodystrophy. Annual Review of Medicine 1986 37 79 95 2-s2.0-0022566861 10.1146/annurev.me.37.020186.000455 3085581 · DOI
  89. [93]Crisponi G. Fanni D. Gerosa C. The meaning of aluminium exposure on human health and aluminium-related diseases Biomolecular Concepts 2013 4 1 77 87 2-s2.0-84876588231 10.1515/bmc-2012-0045 25436567 · DOI
  90. [94]Chappard D. Bizot P. Mabilleau G. Hubert L. Aluminum and bone: Review of new clinical circumstances associated with Al3+ deposition in the calcified matrix of bone Morphologie 2016 100 329 95 105 2-s2.0-84952685243 10.1016/j.morpho.2015.12.001 26762722 · DOI · Paper page
  91. [95]Aaseth J. Boivin G. Andersen O. Osteoporosis and trace elements - An overview Journal of Trace Elements in Medicine and Biology 2012 26 2-3 149 152 2-s2.0-84862525397 10.1016/j.jtemb.2012.03.017 22575536 · DOI
  92. [96]Chappard D. Mabilleau G. Moukoko D. Aluminum and iron can be deposited in the calcified matrix of bone exostoses Journal of Inorganic Biochemistry 2015 152 174 179 2-s2.0-84949514330 10.1016/j.jinorgbio.2015.09.008 26404568 · DOI
  93. [97]Li X. Hu C. Zhu Y. Sun H. Li Y. Zhang Z. Effects of aluminum exposure on bone mineral density, mineral, and trace elements in rats Biological Trace Element Research 2011 143 1 378 385 2-s2.0-80054761023 10.1007/s12011-010-8861-4 20886309 · DOI
  94. [98]Sun X. Wang H. Huang W. Inhibition of bone formation in rats by aluminum exposure via Wnt/Β-catenin pathway Chemosphere 2017 176 1 7 2-s2.0-85013786894 10.1016/j.chemosphere.2017.02.086 28249195 · DOI
  95. [99]Zhang F. Sun X. Yu H. Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats BioMetals 2017 30 1 143 150 2-s2.0-84996956352 10.1007/s10534-016-9982-9 27885436 · DOI · Paper page
  96. [100]Yang X. Huo H. Xiu C. Inhibition of osteoblast differentiation by aluminum trichloride exposure is associated with inhibition of BMP-2/Smad pathway component expression Food and Chemical Toxicology 2016 97 120 126 2-s2.0-84986576823 10.1016/j.fct.2016.09.004 27600293 · DOI
  97. [101]Zhu Y. Xu F. Yan X. The suppressive effects of aluminum chloride on the osteoblasts function Environmental Toxicology and Pharmacology 2016 48 125 129 2-s2.0-84992744147 10.1016/j.etap.2016.10.009 27771505 · DOI
  98. [102]Song M. Huo H. Cao Z. Han Y. Gao L. Aluminum trichloride inhibits the rat osteoblasts mineralization in vitro Biological Trace Element Research 2017 175 1 186 193 10.1007/s12011-016-0761-9 2-s2.0-85008223204 27260532 · DOI
  99. [103]Degeratu C. N. Mabilleau G. Cincu C. Chappard D. Aluminum inhibits the growth of hydroxyapatite crystals developed on a biomimetic methacrylic polymer Journal of Trace Elements in Medicine and Biology 2013 27 4 346 351 2-s2.0-84884595158 10.1016/j.jtemb.2013.05.004 23867705 · DOI
  100. [104]Grenón M. S. Robledo J. Ibáñez J. C. Sánchez H. J. Titanium diffusion in shinbone of rats with osseointegrated implants Journal of Microscopy 2016 264 2 182 188 10.1111/jmi.12428 27239053 · DOI
  101. [105]Wennerberg A. Ide-Ektessabi A. Hatkamata S. Titanium release from implants prepared with different surface roughness: An in vitro and in vivo study Clinical Oral Implants Research 2004 15 5 505 512 2-s2.0-12144252348 10.1111/j.1600-0501.2004.01053.x 15355391 · DOI
  102. [106]Mine Y. Makihira S. Nikawa H. Impact of titanium ions on osteoblast-, osteoclast- and gingival epithelial-like cells Journal of Prosthodontic Research 2010 54 1 1 6 2-s2.0-70449707206 10.1016/j.jpor.2009.07.003 19733525 · DOI
  103. [107]Wachi T. Shuto T. Shinohara Y. Matono Y. Makihira S. Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption Toxicology 2015 327 1 9 2-s2.0-84910014981 10.1016/j.tox.2014.10.016 25446332 · DOI
  104. [108]Zhu W.-Q. Ming P.-P. Qiu J. Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts Journal of Applied Toxicology 2018 38 824 833 2-s2.0-85041125825 29377205
  105. [109]Liao H. Wurtz T. Li J. Influence of titanium ion on mineral formation and properties of osteoid nodules in rat calvaria cultures Journal of Biomedical Materials Research Part B: Applied Biomaterials 1999 47 2 220 227 2-s2.0-0032857236 10.1002/(SICI)1097-4636(199911)47:2<220::AID-JBM12>3.0.CO;2-9 10449633 · DOI
  106. [110]Yanming B. I. Van De Motter R. R. Ragab A. A. Goldberg V. M. Anderson J. M. Greenfield E. M. Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts The Journal of Bone & Joint Surgery 2001 83 4 501 508 2-s2.0-0035074458 11315778
  107. [111]Sun S. X. Guo H. H. Zhang J. Yu B. Sun K. N. Jin Q. H. BMP-2 and titanium particles synergistically activate osteoclast formation Brazilian Journal of Medical and Biological Research 2014 47 6 461 469 2-s2.0-84901664474 10.1590/1414-431X20132966 24820069 PMC4086172 · DOI
  108. [112]Valenti L. Varenna M. Fracanzani A. L. Rossi V. Fargion S. Sinigaglia L. Association between iron overload and osteoporosis in patients with hereditary hemochromatosis Osteoporosis International 2009 20 4 549 555 2-s2.0-62149108646 10.1007/s00198-008-0701-4 18661088 · DOI · Paper page
  109. [113]Skordis N. Toumba M. Bone disease in thalassaemia major: recent advances in pathogenesis and clinical aspects Pediatric endocrinology reviews: PER 2011 8 300 306 2-s2.0-80052324985 21705982
  110. [114]Rossi F. Perrotta S. Bellini G. Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels Haematologica 2014 99 12 1876 1884 2-s2.0-84919343513 10.3324/haematol.2014.104463 25216685 PMC4258755 · DOI
  111. [115]Marcucci G. Brandi M. L. Rare causes of osteoporosis Clinical Cases in Mineral and Bone Metabolism 2015 12 2 151 156 2-s2.0-84945587098 26604941 PMC4625772
  112. [116]Tsay J. Yang Z. Ross F. P. Bone loss caused by iron overload in a murine model: Importance of oxidative stress Blood 2010 116 14 2582 2589 2-s2.0-77957747011 10.1182/blood-2009-12-260083 20554970 PMC2953890 · DOI
  113. [117]Wang X. Chen B. Sun J. Iron-induced oxidative stress stimulates osteoclast differentiation via NF-κB signaling pathway in mouse model Metabolism - Clinical and Experimental 2018 83 167 176 2-s2.0-85043461785 10.1016/j.metabol.2018.01.005 29378199 · DOI · Paper page
  114. [118]Mandalunis P. M. Ubios A. M. Experimental renal failure and iron overload: a histomorphometric study in rat tibia Toxicologic Pathology 2005 33 3 398 403 10.1080/01926230590935826 2-s2.0-18144387931 15805079 · DOI
  115. [119]Yuang Y. Xu F. Cao Y. Iron accumulation leads to bone loss by inducing mesenchymal stem cells apoptosis through the activation of caspase 3 Biological Trace Element Research 2018 29948914
  116. [120]Isidori A. Borin L. Elli E. Iron toxicity – Its effect on the bone marrow Blood Reviews 2018 10.1016/j.blre.2018.04.004 29699840 · DOI
  117. [121]Jia P. Xu Y. J. Zhang Z. L. Li K. Zhang W. Yang H. Ferric ion could facilitate osteoclast differentiation and bone resoption through the production of reactive oxygen species Journal of Orthopaedic Research Month 2012 1 10 22570238
  118. [122]Balogh E. Tolnai E. Nagy B. Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016 1862 9 1640 1649 10.1016/j.bbadis.2016.06.003 2-s2.0-84973487274 27287253 · DOI
  119. [123]Zhao G.-Y. Zhao L.-P. He Y.-F. A comparison of the biological activities of human osteoblast hFOB1.19 between iron excess and iron deficiency Biological Trace Element Research 2012 150 1-3 487 495 2-s2.0-84870681571 10.1007/s12011-012-9511-9 23054865 · DOI
  120. [124]Messer J. G. Kilbarger A. K. Erikson K. M. Kipp D. E. Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures Bone 2009 45 5 972 979 2-s2.0-70349282987 10.1016/j.bone.2009.07.073 19643212 · DOI
  121. [125]He Y. Ma Y. Gao C. Iron overload inhibits osteoblast biological activity through oxidative stress Biological Trace Element Research 2013 152 2 292 296 10.1007/s12011-013-9605-z 23334864 · DOI
  122. [126]Guggenbuhl P. Filmon R. Mabilleau G. Baslé M. F. Chappard D. Iron inhibits hydroxyapatite crystal growth in vitro Metabolism - Clinical and Experimental 2008 57 7 903 910 2-s2.0-44949213071 10.1016/j.metabol.2008.02.004 18555830 · DOI
  123. [127]Dani S. U. Osteoresorptive arsenic intoxication Bone 2013 53 2 541 545 2-s2.0-84873715245 10.1016/j.bone.2013.01.017 23337042 · DOI
  124. [128]Lever J. H. Paget's disease of bone in Lancashire and arsenic pesticide in cotton mill wastewater: A speculative hypothesis Bone 2002 31 3 434 436 2-s2.0-0036755763 10.1016/S8756-3282(02)00833-5 12231419 · DOI
  125. [129]Griz L. Caldas G. Bandeira C. Assunção V. Bandeira F. Paget's disease of bone Arquivos Brasileiros de Endocrinologia & Metabologia 2006 50 4 814 822 2-s2.0-33751243011 10.1590/S0004-27302006000400026 17117306 · DOI
  126. [130]Dumlu A. Yalcinkaya S. Olgac V. Güvercin M. Osteomyelitis due to arsenic trioxide use for tooth deviatlizaion International Endodontic Journal 2007 40 4 317 322 2-s2.0-33947391706 10.1111/j.0143-2885.2007.01230.x 17298410 · DOI
  127. [131]Marty M. Noirrit-Esclassan E. Diemer F. Arsenic trioxide-induced osteo-necrosis treatment in a child: mini-review and case report European Archives of Paediatric Dentistry 2016 17 5 419 422 2-s2.0-84989291110 10.1007/s40368-016-0250-z 27613404 · DOI
  128. [132]Yavuz M. S. Şimşek Kaya G. Yalçin E. Aras M. H. Mandibular bone necrosis caused by use of arsenic paste during endodontic treatment: Two case reports International Endodontic Journal 2008 41 7 633 637 2-s2.0-44949086751 10.1111/j.1365-2591.2008.01406.x 18479373 · DOI
  129. [133]Chen G. Sung P.-T. Gingival and localized alveolar bone necrosisrelated to the use of arsenic trioxidepaste-Two case reports Journal of the Formosan Medical Association 2014 113 3 187 190 2-s2.0-84895872298 10.1016/j.jfma.2012.07.023 24630037 · DOI
  130. [134]Odstrcil A. D. C. A. Carino S. N. Ricci J. C. D. Mandalunis P. M. Effect of arsenic in endochondral ossification of experimental animals Experimental and Toxicologic Pathology 2010 62 3 243 249 10.1016/j.etp.2009.04.001 2-s2.0-77952890199 19447590 · DOI
  131. [135]Hu Y.-C. Cheng H.-L. Hsieh B.-S. Huang L.-W. Huang T.-C. Chang K.-L. Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function Bone 2012 50 6 1406 1415 2-s2.0-84860841588 10.1016/j.bone.2012.03.012 22465848 · DOI
  132. [136]Wu C.-T. Lu T.-Y. Chan D.-C. Tsai K.-S. Yang R.-S. Liu S.-H. Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats Environmental Health Perspectives 2014 122 6 559 565 2-s2.0-84901780082 10.1289/ehp.1307832 24531206 PMC4050517 · DOI
  133. [137]Cai B. Meng F. Zhu S. Arsenic trioxide induces the apoptosis in bone marrow mesenchymal stem cells by intracellular calcium signal and caspase-3 pathways Toxicology Letters 2010 193 2 173 178 10.1016/j.toxlet.2010.01.001 20079407 · DOI
  134. [138]Tang C.-H. Chiu Y.-C. Huang C.-F. Chen Y.-W. Chen P.-C. Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress Toxicology and Applied Pharmacology 2009 241 2 173 181 2-s2.0-70350212786 10.1016/j.taap.2009.08.011 19695276 · DOI
  135. [139]Chiu P. R. Hu Y. C. Hsieh B. S. Osteoblasts active the Nrf2 signalling pathway in response to arsenic trioxide treatment International Journal of Biochemistry & Cell Biology 2016 79 327 336 27592447
  136. [140]Zofkova I. Davis M. Blahos J. Trace elements have beneficial, as well as detrimental effects on bone homeostasis Physiological Research 2017 66 3 391 402 2-s2.0-85019483629 28248532

Cited by

Sorted by citations

Authors
Rodríguez, J., & Mandalunis, P. M.
Affiliations
Universidad de Buenos Aires (AR)
Corresponding author
Rodríguez, Juliana
ORCID
Venue
Journal of Toxicology
Publisher
Wiley
Published
2018-12-23
Volume
2018
Pages
1-11
ISSN
  • 1687-8191 (ISSN-L)
  • 1687-8205
DOI
10.1155/2018/4854152
PMC
PMC6323513
OpenAlex
W2906453444
Cited by
248
References
1
Citations by year
2026: 15 · 2025: 26 · 2024: 34 · 2023: 36 · 2022: 44 · 2021: 36 · 2020: 37 · 2019: 18 · 2016: 1
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Toxicology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Keywords
metal exposure, bone health, metal toxicity, cadmium, zinc, copper, nickel, mercury, chromium, lead, aluminum, titanium, iron, arsenic, bioaccumulation, bone remodeling, bone formation, bone resorption, bone pathology, environmental pollution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review