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Cited by 133Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model OrganismsTryptophan and brain disorders

The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.

The Role of Immunosenescence in Neurodegenerative Diseases

Open access
Costantini, Erica, D’Angelo, Chiara, Reale, Marcella·2018·Mediators of Inflammation
DOI 10.1155/2018/6039171PMC PMC5863336
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Abstract

Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in the number of circulating monocytic and dendritic cells, thymic involution, T cell polyfunctionality, or production of proinflammatory cytokines, and are defined as immunosenescence. Inflammatory functions are increased with age, causing the chronic low-grade inflammation, referred to as inflamm-aging, that contribute, together with immunosenescence, to neurodegenerative diseases. In this review, we discuss the link between the immune and nervous systems and how the immunosenescence and inflamm-aging can contribute to neurodegenerative diseases.

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Figure 1 Schematic representation of immune cell age-related changes, leading to inflamm-aging, neurodegeneration, and neuroinflammation.
Figure 1 Schematic representation of immune cell age-related changes, leading to inflamm-aging, neurodegeneration, and neuroinflammation.CC BY · PubMed Central
Figure 2 Immune activation in neurodegenerative diseases and healthy brain. The neurodegeneration is accompanied by immunosenescence and inflamm-aging. During aging, neuronal cells modify their morphology, and their overactivation leads to IL-6 and TNF-α abnormal production. The immune cells penetrate the damaged BBB and causes a further increase in proinflammatory cytokines, modulating, in turn, neuronal dysfunction.
Figure 2 Immune activation in neurodegenerative diseases and healthy brain. The neurodegeneration is accompanied by immunosenescence and inflamm-aging. During aging, neuronal cells modify their morphology, and their overactivation leads to IL-6 and TNF-α abnormal production. The immune cells penetrate the damaged BBB and causes a further increase in proinflammatory cytokines, modulating, in turn, neuronal dysfunction.CC BY · PubMed Central
Figure 3 Advantages and disadvantages of an inflammatory response. Phagocytosis eliminates the debris of dead or dying cells, thereby reducing the likelihood of further cell loss through the release of toxic agents. Cytokines and growth factors may help damaged neurons to survive and promote repair. Chronic inflammation can lead to the injury or death of neurons.
Figure 3 Advantages and disadvantages of an inflammatory response. Phagocytosis eliminates the debris of dead or dying cells, thereby reducing the likelihood of further cell loss through the release of toxic agents. Cytokines and growth factors may help damaged neurons to survive and promote repair. Chronic inflammation can lead to the injury or death of neurons.CC BY · PubMed Central

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Research works printed but not linked: 3

  1. 2017, European Journal of Neurology, 25, 59
  2. 2001, Archives of Neurology Journal, 86, 83
  3. 2016, Archives of Medical Science, 8, 2

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Metadata

Authors
Costantini, E., D’Angelo, C., & Reale, M.
Affiliations
University of Chieti-Pescara (IT)
Corresponding author
Reale, Marcella
ORCID
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2018
Volume
2018
Pages
1-12
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
DOI
10.1155/2018/6039171
PMC
PMC5863336
OpenAlex
W2792949361
Cited by
133
References
126
Citations by year
2026: 9 · 2025: 20 · 2024: 9 · 2023: 16 · 2022: 15 · 2021: 28 · 2020: 19 · 2019: 13 · 2018: 4
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
immunosenescence, neurodegenerative diseases, inflammaging, aging, low-grade inflammation, innate immune system, adaptive immunity, thymic involution, T cell polyfunctionality, inflammatory cytokines, dendritic cells, monocytic cells, neuroinflammation
MeSH terms
Immunosenescence, Animals, Dendritic Cells, Humans, Immunity, Innate, Neurodegenerative Diseases

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