Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation‐Induced Migration and Invasion of Human Lung Cancer Cells
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Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of C entella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3). These compounds inhibited the ionizing radiation‐induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations. These results suggest that triterpenoids 1–3 isolated from C. asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non‐small‐cell lung cancer.
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Asiaticoside and madecassoside exhibit chemotherapeutic effects.
“exhibiting chemotherapeutic effects, 39”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [39]
Results and Discussion §3.1 reports anticancer activity for asiaticoside and describes its inhibition of cancer-cell migration and invasion. The paper lists madecassoside as a constituent of Centella asiatica in the Introduction, but the anticancer findings concern madecassic acid, a different compound. It therefore does not support the claimed effect for madecassoside. (LLM, conf=0.88)
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Cites
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21551 · Cited by 20,160 · see citing works
Non-small cell lung cancer: current treatment and future advances
Zappa, C., & Mousa, S. A. (2016) · Translational Lung Cancer Research · doi:10.21037/tlcr.2016.06.07 · Cited by 1,944 · see citing works
Lung cancer: Biology and treatment options
Lemjabbar‐Alaoui, H., Hassan, O. U., Yang, Y., & Buchanan, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.08.002 · Cited by 1,024 · see citing works
Anand, U., Jacobo-Herrera, N. J., Altemimi, A. B., & Lakhssassi, N. (2019) · Metabolites · doi:10.3390/metabo9110258 · Cited by 871 · see citing works
Pharmacological review on Centella asiatica: A potential herbal cure-all
Gohil, K., Patel, J. A., & Gajjar, A. (2010) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.78519 · Cited by 666 · see citing works
Role of metabolism in cancer cell radioresistance and radiosensitization methods
Tang, L. M., Wei, F., Wu, Y., He, Y., Shi, L., Xiong, F., Gong, Z., Guo, C. J., Li, X., Deng, H., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0758-7 · Cited by 413 · see citing works
Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban
James, J. T., & Dubery, I. A. (2009) · Molecules · doi:10.3390/molecules14103922 · Cited by 399 · see citing works
Radiation therapy to a primary tumor accelerates metastatic growth in mice.
Camphausen, K. A., Moses, M. A., Beecken, W.-D. C., Khan, M. K., Folkman, J., & O’Reilly, M. S. (2001) · PubMed · Cited by 258 · see citing works
Babu, T. D., Kuttan, G., & Padikkala, J. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01284-k · Cited by 217 · see citing works
Meeran, M. F. N., Goyal, S. N., Suchal, K., Sharma, C., Patil, C. R., & Ojha, S. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00892 · Cited by 199 · see citing works
Natural Products and Synthetic Analogs as a Source of Antitumor Drugs
Sharifi‐Rad, J., Ozleyen, A., Tumer, T. B., Adetunji, C. O., Omari, N. E., Balahbib, A., Taheri, Y., Bouyahya, A., Martorell, M., Martins, N. A., et al. (2019) · Biomolecules · doi:10.3390/biom9110679 · Cited by 198 · see citing works
Radiation-enhanced cell migration/invasion process: A review
Moncharmont, C., Lévy, A., Guy, J., Falk, A. T., Guilbert, M., Trone, J., Alphonse, G., Gilormini, M., Ardail, D., Toillon, R., et al. (2014) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.05.006 · Cited by 181 · see citing works
Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A. (1994) · Planta Medica · doi:10.1055/s-2006-959434 · Cited by 166 · cited 1× · see citing works
“Asiatic acid and its derivatives possess a broad spectrum of pharmacological activities, such as anticancer [6–8], wound healing [9, 10], antiinflammatory [10, 11], antidiabetic [12], hepatoprotective [13, 14], and neuroprotective activities [15, 16].”
BackgroundEffects of radiation on metastasis and tumor cell migration
Vilalta, M., Rafat, M., & Graves, E. E. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2210-5 · Cited by 158 · see citing works
Jung, C., Kim, E. M., Park, J. K., Hwang, S., Moon, S., Kim, W., & Um, H. (2013) · Oncology Reports · doi:10.3892/or.2013.2381 · Cited by 112 · see citing works
Self-citationCENTELLA ASIATICA (L.): A PLANT WITH IMMENSE MEDICINAL POTENTIAL BUT THREATENED
Singh, S., Gautam, A., Sharma, A., & Batra, A. (2010) · Cited by 103 · see citing works
Dong, S.-H., Liu, Y., Wei, F., Tan, H., & Han, Z.-D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.005 · Cited by 89 · see citing works
FUNCTIONAL PROPERTIES OF CENTELLA ASIATICA (L.): A REVIEW
S.Vasantharuba, P. B., Premalatha, S., & Arumugam, T. (2012) · Cited by 88 · see citing works
Zhi-min, Q., Ci, X., Huang, J., Liu, Q., Yu, Q., Zhou, J., & Deng, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.067 · Cited by 83 · see citing works
Bcl‐X L and STAT3 mediate malignant actions of γ‐irradiation in lung cancer cells
Ho, J., Kang, G. Y., Lee, S., Kim, J., Bae, I. H., Hwang, S., & Um, H. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01552.x · Cited by 82 · see citing works
Self-citationTriterpenoid Saponins from Symplocos lancifolia
Acebey-Castellon, I. L., Voutquenne‐Nazabadioko, L., Mai, H. D. T., Roseau, N., Bouthagane, N., Muhammad, D., Magrex-Debar, É. L., Gangloff, S. C., Litaudon, M., Sévenet, T., et al. (2011) · Journal of Natural Products · doi:10.1021/np100502y · Cited by 75 · see citing works
Two new flavonoids from Centella asiatica (Linn.)
Subban, R., Veerakumar, A., Manimaran, R., Hashim, K. M., & Balachandran, I. (2008) · Journal of Natural Medicines · doi:10.1007/s11418-008-0229-0 · Cited by 70 · see citing works
Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke
Lee, J., Park, H. A., Kwon, O., Jang, Y.-G., Kim, J. Y., Choi, B. K., Lee, H. J., Lee, S.-W., Paik, J., Oh, S., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.07.010 · Cited by 64 · see citing works
Self-citationNeuroprotective effect of asiatic acid against spinal cord injury in rats
Jiang, W., Li, M., He, F., Bian, Z., He, Q., Wang, X., Yao, W., & Zhu, L. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.004 · Cited by 64 · see citing works
Biocatalyzed Generation of Molecular Diversity: Selective Modification of the Saponin Asiaticoside
Monti, D., Candido, A., Silva, M. M., Vladimír Křen, A., Riva, S., & Danieli, B. (2005) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.200505047 · Cited by 44 · see citing works
Du, Q., Jerz, G., Chen, P., & Winterhalter, P. (2004) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200025707 · Cited by 41 · see citing works
Li, Y., Huihan, W., Zhang, R., Guojun, Z., Ying, Y., & Zhuogang, L. (2019) · Medical Science Monitor · doi:10.12659/msm.913397 · Cited by 37 · see citing works
Lu, Y., Liu, S., Wang, Y., Wang, D., Gao, J., & Zhu, L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.06.010 · Cited by 36 · see citing works
Jung, C., Han, A., Chung, H., Ha, I., & Um, H. (2018) · Natural Product Research · doi:10.1080/14786419.2018.1484460 · Cited by 31 · see citing works
Self-citationGajbhiye, N., Makasana, J., Saha, A., Patel, I., & Jat, R. S. (2016) · Chromatographia · doi:10.1007/s10337-016-3089-x · Cited by 28 · see citing works
Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation.
Zhang, H., Zhang, M., Tao, Y., Wang, G., & Xia, B. (2014) · PubMed · Cited by 19 · see citing works
Swapna, K., Uddandrao, V. V. S., Parim, B., Ravindarnaik, R., Suresh, P., Ponnusamy, P., Balakrishnan, S., Vadivukkarasi, S., Harishankar, N., Kallamadi, P. R., et al. (2019) · Comparative Clinical Pathology · doi:10.1007/s00580-019-02955-6 · Cited by 16 · see citing works
Ternchoocheep, K., Surangkul, D., & Ysothonsreekul, S. (2017) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2017.01.012 · Cited by 15 · see citing works
Kang, A.-R., Cho, J., Lee, N.-G., Song, J. Y., Hwang, S., Lee, D.-H., Um, H., & Park, J. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134584 · Cited by 10 · see citing works
Essential Oil Profiling of Centella asiatica (L.) Urb.-A Medicinally Important Herb
Francis, S. C., & Thomas, M. T. (2016) · South Indian Journal of Biological Sciences · doi:10.22205/sijbs/2016/v2/i1/100387 · Cited by 9 · see citing works
Lee, S. H., Han, A., Kang, U., Kim, J., Seo, E. K., & Jung, C. (2020) · Natural Product Communications · doi:10.1177/1934578x20915036 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [18]Srivastava R. Shukla Y. N. Kumar S. Chemistry and pharmacology of Centella asiatica: a review Journal of Medicinal and Aromatic Plants 1997 19 1049 1056
Cited by
Sorted by citations
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer
Yang, L., & Wang, Z. (2021) · Biomedicines · doi:10.3390/biomedicines9060689 · Cited by 104 · see citing works
Tripathy, S., Verma, D. K., Thakur, M., Chakravorty, N., Sıngh, S., & Srivastav, P. P. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101864 · Cited by 54 · see citing works
Huang, C.-F., Hung, T., Yang, S., Tsai, Y.-L., Yang, J.-T., Lin, C., & Hsieh, Y. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154036 · Cited by 31 · see citing works
Kim, Y.-R., Han, A., Kim, J., & Jung, C. (2021) · Biomedicines · doi:10.3390/biomedicines9080954 · Cited by 24 · see citing works
Self-citationSwargiary, G., & Mani, S. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.013 · Cited by 19 · see citing works
Khatua, A., Prasad, A., Behuria, H. G., Patel, A. K., Singh, M. K., Madhavan, Y., Saravanan, M., & Meena, R. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212855 · Cited by 18 · see citing works
Holistic View of TCM on Cancer Integrative Therapy
Zhang, Z., & Zhu, M. (2023) · Future Integrative Medicine · doi:10.14218/fim.2023.00048 · Cited by 18 · see citing works
Yasmin, R., Gogoi, S., Bora, J., Chakraborty, A., Dey, S., Ghaziri, G., Bhattacharjee, S., & Singh, L. H. (2023) · Journal of Cancer Prevention · doi:10.15430/jcp.2023.28.3.77 · Cited by 18 · see citing works
Kim, S. Y., Shin, M., Kim, G. J., Kwon, H., Lee, M. J., Han, A., Nam, J., Jung, C., Kang, K. S., & Choi, H. (2021) · Marine Drugs · doi:10.3390/md19080465 · Cited by 14 · see citing works
Self-citation(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac131.017 · Cited by 12 · see citing works
Manmuan, S., Tubtimsri, S., Chaothanaphat, N., Issaro, N., Tantisira, M. H., & Manmuan, P. (2024) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_81_23 · Cited by 8 · see citing works
Samaratunga, R., Kantono, K., Kam, R., Gannabathula, S., & Hamid, N. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17277 · Cited by 8 · see citing works
Investigation on the incidence and risk factors of lung cancer among Chinese hospital employees
Chen, Z., Chen, Z., Kang, J., Chu, X., Fu, R., Zhang, J., Qi, Y., Chen, J., Lin, J., Jiang, B., et al. (2022) · Thoracic Cancer · doi:10.1111/1759-7714.14549 · Cited by 6 · see citing works
Rashedi, S., Heydari, P., Kharazi, A. Z., Varshosaz, J., & Sheikholeslam, M. (2025) · Polymer Engineering and Science · doi:10.1002/pen.27158 · Cited by 5 · see citing works
Jin, Y., Li, J., Ding, L., Zhao, Q., Song, Y., Li, G., Ji, J., Ni, Y., & Hu, Q. (2021) · Molecular & Cellular Toxicology · doi:10.1007/s13273-021-00174-1 · Cited by 4 · see citing works
Malaysian herbs as potential natural resources of anticancer drugs: From folklore to discovery
Ismail, F., Zakaria, Y., Hassan, N. F. N., & Isa, M. (2022) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2022.030.1.06 · Cited by 3 · see citing works
Tran, T. T. P., Pham, N. T., Nguyen, N. X., Tran, C. V., Tran, L. V., Nguyen, L. T., Nguyen, D. T., Huynh, N. T. N., Nguyen, T. L., Be, Y. T. H., et al. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-q9vvc · Cited by 3 · see citing works
Pham, V. K., Le, T. T. H., Hua, N. M., Pham, S. H., Hoang, V. H., Nguyen, T. K. O., & Nguyen, P. H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118839 · Cited by 2 · see citing works
Ramya, H., Ravikumar, K. S., Ajith, T. A., Zuhara, K. F., & Janardhanan, K. K. (2023) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2023050169 · Cited by 1 · see citing works
Varshney, A. C., & Sarethy, I. P. (2026) · Water Resources · doi:10.1134/s009780782560024x · Cited by 1 · see citing works
Adekilekun, H. A., Omodamiro, O. D., Achi, N. K., Tijani, B. A., Oyewusi, H. A., Omodamiro, R. M., Oladipo, O. O., Oyeyemi, B. F., Odoma, S., & Hamed, A. A. (2026) · Oncology and Translational Medicine · doi:10.1097/ot9.0000000000000132 · Cited by 1 · see citing works
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer
Vasudeva, K., Chaturvedi, P., Khan, R., Sahu, P., & Munshi, A. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_271-1
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer
Vasudeva, K., Chaturvedi, P., Khan, R., Sahu, P., & Munshi, A. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_271
Berezutskiy, M. A., Дурнова, Н. А., Романтеева, Ю. В., Шереметьева, А. С., Komarova, E. E., Matvienko, U. A., & Zenina, I. V. (2022) · Современные проблемы науки и образования · doi:10.17513/spno.32108
Kurup, R., Nair, A. N. S., & Baby, S. (2023) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2023.2287113
Formulation and characterisation of emulsion combining several herbal extracts
Agustinisari, I., Gusmaini, G., Harimurti, N., Sembiring, B. B., & Iriani, E. S. (2026) · AIP conference proceedings · doi:10.1063/5.0334525
Suntivich, R., Malaphong, C., Chaiyen, P., Leartsakulpanich, U., & Maenpuen, S. (2026) · ACS Omega · doi:10.1021/acsomega.6c04697
- Authors
- Han, A.-R., Lee, S., Han, S., Lee, Y. J., Kim, J.-B., Seo, E. K., & Jung, C.-H.
- Affiliations
- Korea Atomic Energy Research Institute (KR)
- Jaseng Medical Foundation (KR)
- Ewha Womans University (KR)
- Corresponding author
- Seo, Eun Kyoung
- Jung, Chan-Hun
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 2020
- Issue
- 1
- Pages
- 3683460-3683460
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC7532382
- OpenAlex
- W3088710776
- Cited by
- 28
- References
- 37
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 9 · 2021: 5
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2017R1C1B2006273)
- Korea Atomic Energy Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Centella asiatica, triterpenoids, asiatic acid, madecassic acid, asiaticoside, ionizing radiation, radiotherapy enhancement, lung cancer, tumor cell migration, tumor invasion, A549 cells, non-small cell lung cancer, natural products
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