Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis
Abstract
Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.
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Enhancement of wound healing, particularly angiogenesis, might be due to stimulation of collagen I and increased production of FGF and VEGF, via activation of the TβR2 kinase-independent pathway.
“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
The favourable effect of C. asiatica on wound healing is observed with quicker wound contraction, probably owing to stimulation of fibronectin and collagen I synthesis and matrix remodelling.
“This favourable effect is observed with a quicker wound contraction, probably owing to the stimulation of fibronectin [69] and collagen I synthesis [21,31] and matrix remodelling [31].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [31]
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Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
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Effect of Asiaticoside on 99mTc-Tetrofosmin and 99mTc-Sestamibi Uptake in MCF-7 Cells
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“Many studies have reported a positive correlation between the administration of asiaticoside and antitumor activity (30), inhibition of DNA synthesis (33), therapeutic interventions for many human cancer types (34,35), and protection of the liver from damage.”
BackgroundThe Identification of New Triterpenoids in Eucalyptus globulus Wood
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A Convergent Synthesis of the Triterpene Saponin Asiaticoside
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Current Concepts in Scar Evolution and Control
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Biological potential of an ethanolic extract from “Mela Rosa Marchigiana” pulp callus culture
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- Authors
- Bonte, F., Dumas, M., Chaudagne, C., & Meybeck, A.
- Affiliations
- LVMH (France) (FR)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-04
- Volume
- 60
- Issue
- 02
- Pages
- 133-135
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1996838400
- Cited by
- 166
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 12 · 2021: 15 · 2020: 15 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiatic acid, madecassic acid, asiaticoside, ursane triterpenoids, collagen I synthesis, human dermal fibroblasts, vitamin C, sugar moiety
- MeSH terms
- Adult, Carbohydrate Sequence, Cells, Cultured, Collagen, Humans, Molecular Sequence Data, Terpenes, Triterpenes, Pentacyclic Triterpenes
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