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Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study
Open accessAbstract
Background. The aim of the present study was to assess the effects of lavender oil inhalation on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in healthy male adults. The mechanism was investigated by the action on oxytocin single neurons in the hypothalamus of rodents. Methods. The participants (n = 7) were aged 20–40 years. After randomisation, they received an inhaled dose of lavender oil or distilled water for 20 min. They received the other treatment after a washout period of one week. We assessed the outcomes using the Self‐Rating Depression Scale, State‐Trait Anxiety Inventory, and self‐rated unidimensional Visual Analogue Scale for depression; anxiety; and hunger, thirst, and appetite, respectively. Blood pressure, pulse rate, and cortisol concentration in the peripheral blood were assessed before and after inhalation. In the rodent study (n = 4), oxytocin single neurons were isolated from the mouse hypothalamus. Intracellular Ca 2+ concentration in the oxytocin neurons isolated from the hypothalamus was measured following direct administration of lavender oil. Results. Seven participants completed the study. Lavender inhalation decreased Self‐Rating Depression Scale score and systolic and diastolic blood pressure. Ex vivo administration of lavender oil increased intracellular Ca 2+ concentration in the hypothalamic oxytocin neurons. Conclusions. Lavender oil might be a useful therapy for stress relief, and its mechanism of action may include activation of the central oxytocin neurons.
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Exposure to lavender fragrance leads to activation of oxytocin neurons in PVN.
“Recently, Ogata et al. (2020) were able to show that exposure to lavender fragrance led to an activation of oxytocin neurons in PVN.”
From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Ogata et al. (2020)
The Animal Studies results (section 3.2) show that lavender oil increased activity in oxytocin-positive neurons isolated from the mouse PVN. They do not show that exposure to lavender fragrance activated those neurons in vivo; the Discussion (section 4) presents that link as a possibility rather than a demonstrated result. (LLM, conf=0.88)
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Metadata
- Authors
- Ogata, K., Ataka, K., Suzuki, H., Yagi, T., Okawa, A., Fukumoto, T., Zhang, B., Nakata, M., Yada, T., & Asakawa, A.
- Affiliations
- Kagoshima University (JP)
- Jichi Medical University (JP)
- Corresponding author
- Asakawa, Akihiro
- ORCID
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 2020
- Issue
- 1
- Pages
- 5418586-5418586
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC7376415
- OpenAlex
- W3042676064
- Cited by
- 29
- References
- 41
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 2 · 2021: 6 · 2020: 1
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (16H06404)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- lavender essential oil, depressive mood, anxiety, oxytocin neurons, hypothalamus, intracellular calcium, blood pressure, cortisol, stress reduction, essential oils
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