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Cited by 49Natural Antidiabetic Agents StudiesNatural Products and Biological ResearchPhytochemicals and Antioxidant Activities

Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats

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Ousaaid, Driss, Laaroussi, Hassan, Bakour, Meryem, ElGhouizi, Asmae, Aboulghazi, Abderrazak, Lyoussi, Badiaa, ElArabi, Ilham·2020·Journal of Diabetes Research
DOI 10.1155/2020/9284987PMC PMC7374219
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Abstract

The main objective of this study is to determine the effects of apple vinegar on the metabolic changes caused by hypercaloric diet in Wistar rats. Apple vinegar was first analyzed to find out the total acidity, the polyphenolic and flavonoid contents, the total antioxidant capacity, and the free radical scavenging activity. In vivo study on adult male and female Wistar rats was conducted by administering a drink containing either 10% D-glucose or water (control) for five weeks. Apple vinegar is administered daily by gavage (2 mL/kg) to rats fed D-glucose for 5 weeks. The results showed that the polyphenolic content in apple vinegar was 148.02±10.16 mg GAE/100 mL, flavonoid content was 22.93±0.73 QE/100 mL, and total antioxidant capacity was 13.4±0.47 mg AAE/100 mL. Free radical IC 50 apple vinegar scavenging activity (DPPH) was 0.74±0.154 μ L/mL. The total acidity was (3.24±0.02 mg AAE/100 mL). The treatment during five weeks with D-glucose leads to increased plasma glucose, lipid profile, hepatic enzyme levels, urea, and creatinine. Simultaneous treatment with apple vinegar improves the parameters studied. These results clearly show that the daily consumption of vinegar can reduce the rise in blood sugar and lipid profile induced by hypercaloric diet in rats. Therefore, the use of apple vinegar would have a very beneficial effect in the prevention of metabolic disorders caused by high-caloric food.

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  • Administration of fruits vinegar prevents diabetes.

    “The beneficial antihyperglycemic effects of FsV are partitioned as follows:”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [16]

    The Results (§3.2.2; page unavailable) show that apple vinegar prevented the rise in blood glucose seen in glucose-fed rats, and the Conclusion (§5; page unavailable) describes promising protection against diet-induced metabolic changes. The paper studied apple vinegar in rats, not fruit vinegars generally, and did not establish that vinegar prevents diabetes. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Acetic acid is the main acid of vinegar that can ameliorate metabolic disorders and disease markers.

    “The aforementioned features revealed that acetic acid is the main acid of vinegar that can ameliorate metabolic disorders and ameliorate disease markers [16,18,22,63,64,65,66,67,68,69,70,71].”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [16]

    The Discussion (page not provided) calls acetic acid a major component of vinegar and suggests it contributes to glucose-related effects. The Abstract and Conclusion (pages not provided) report improvements in metabolic markers in hypercaloric-fed rats given apple vinegar, but do not establish that acetic acid itself caused those broader improvements; the Conclusion also suggests flavonoids might be responsible. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Administration of apple vinegar at a dose of 2 mL daily by gavage for five weeks decreases the risk of developing persistent hyperglycemia induced by a hypercaloric diet.

    “Recently, the administration of apple vinegar at a dose of 2 mL daily by gavage for five weeks decreases the risk of developing persistent hyperglycemia induced by a hypercaloric diet [16].”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [16]

    The Methods (section 2.4) describe daily gavage for five weeks in rats given 10% D-glucose, and the Results (section 3.2.2) report lower blood glucose in the vinegar-treated group. But the dose was 2 mL/kg, not 2 mL, and the study measured glucose after five weeks rather than the risk of developing persistent hyperglycemia. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Administration of apple vinegar curbs the installation of hyperglycemia and hyperlipidemia induced by hypercaloric diet enriched in d-glucose in male and female rats.

    “Previously, it is shown that the administration of apple vinegar curbs the installation of hyperglycemia and hyperlipidemia induced by hypercaloric fed enriched in d-glucose in male and female rats [16].”

    From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [16]

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Authors
Ousaaid, D., Laaroussi, H., Bakour, M., ElGhouizi, A., Aboulghazi, A., Lyoussi, B., & ElArabi, I.
Affiliations
  • Sidi Mohamed Ben Abdellah University (MA)
  • Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, Fez, Morocco
Corresponding author
Ousaaid, Driss
ORCID
Venue
Journal of Diabetes Research
Publisher
Wiley
Published
2020-07-13
Volume
2020
Pages
1-7
ISSN
  • 2314-6745 (ISSN-L)
  • 2314-6753
DOI
10.1155/2020/9284987
PMC
PMC7374219
OpenAlex
W3042918561
Cited by
49
References
46
Citations by year
2026: 4 · 2025: 5 · 2024: 14 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 1
FWCI
4.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Diabetes Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
apple cider vinegar, hypercaloric diet, hyperglycemia, hyperlipidemia, D-glucose, polyphenols, flavonoids, antioxidant capacity, free radical scavenging, lipid profile, liver enzymes, metabolic disorders, diabetes prevention
MeSH terms
Animals, Blood Glucose, Body Weight, Female, Hyperglycemia, Hyperlipidemias, Lipids, Liver, Male, Treatment Outcome, Rats, Wistar, Oxidative Stress, Acetic Acid, Malus, Rats

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