Antihypertensive Effects of Acetic Acid and Vinegar on Spontaneously Hypertensive Rats
Abstract
To clarify the possibility of a preventive effect of dietary vinegar on blood pressure, long-term administration of vinegar or the acetic acid to SHR was examined. As a result, it was observed that acetic acid itself, the main component of vinegar, significantly reduced both blood pressure (p<0.05) and renin activity (p<0.01) compared to controls given no acetic acid or vinegar, as well as vinegar. There were no significant differences in angiotensin I-converting enzyme activity in various organs. As for the mechanism of this function, it was suggested that this reduction in blood pressure may be caused by the significant reduction in renin activity and the subsequent decrease in angiotensin II. From this study, it was also suggested that the antihypertensive effect of vinegar is mainly due to the acetic acid in it.
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Vinegar prevents angiotensin-converting enzymes and reduced blood pressure in spontaneously hypertensive rats.
“It has been proven that vinegar prevents angiotensin-converting enzymes and reduced blood pressure in spontaneously hypertensive rats [95,118].”
From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [95]
The paper reports that rice vinegar reduced blood pressure in spontaneously hypertensive rats (Discussion, p. 4). But it expressly says there was no influence on organ ACE activity and suggests that the reduction was mediated by decreased renin activity rather than ACE inhibition (Discussion, p. 4). (LLM, conf=0.91)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredAcetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels.
“It has been shown that the acetic acid downregulates the expression of lipogenic genes through the activation of AMPK, subsequently inducing diminution of fatty acid synthase and Acetyl-CoA carboxylase levels [95,96].”
From Fruits Vinegar: Quality Characteristics, Phytochemistry, and Functionality (2021) · cites this paper as [95]
The Discussion (pp. 4–5) addresses acetic acid’s possible blood-pressure effect through reduced renin activity, not regulation of lipogenic genes. Searches of our copy for AMPK, fatty acid synthase, and acetyl-CoA carboxylase found no passage addressing the claimed mechanism. (LLM, conf=0.76)
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- Authors
- KONDO, S., TAYAMA, K., TSUKAMOTO, Y., IKEDA, K., & YAMORI, Y.
- Affiliations
- Central Research Institute (IN)
- Kyoto University (JP)
- ORCID
- YAMORI, Yukio
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01
- Volume
- 65
- Issue
- 12
- Pages
- 2690-2694
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2028589790
- Semantic Scholar
- be6c615842cc2d427571fc0d2ca875bb0d9ef11f
- Cited by
- 179
- References
- 16
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 13 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- vinegar, acetic acid, antihypertensive effect, spontaneously hypertensive rats, blood pressure, renin activity, angiotensin II, angiotensin-converting enzyme
- MeSH terms
- Animals, Antihypertensive Agents, Body Weight, Drinking Behavior, Feeding Behavior, Male, Rats, Inbred SHR, Renin, Acetic Acid, Rats
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