The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
Open accessAbstract
One of the fundamental principles of pharmacology is that most drugs have side effects. Although considerable attention is paid to detrimental side effects, drugs can also have beneficial side effects. Given the time and expense of drug development, it would be particularly exciting if a systematic method could be applied to reveal all of the activities, including the unappreciated actions, of a potential drug. The present study takes the first step along this path. An activity-based proteomics strategy was used to simultaneously identify targets and screen for their inhibitors in prostate cancer. Orlistat, a Food and Drug Administration-approved drug used for treating obesity, was included in this screen. Surprisingly, we find a new molecular target and a potential new application for Orlistat. Orlistat is a novel inhibitor of the thioesterase domain of fatty acid synthase, an enzyme strongly linked to tumor progression. By virtue of its ability to inhibit fatty acid synthase, Orlistat halts tumor cell proliferation, induces tumor cell apoptosis, and inhibits the growth of PC-3 tumors in nude mice.
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Cites
A N EW A PPROACH TO D ECODING L IFE : Systems Biology
Ideker, T., Galitski, T., & Hood, L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.343 · Cited by 1,664
Activity-based protein profiling: The serine hydrolases
Liu, Y., Patricelli, M. P., & Cravatt, B. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14694 · Cited by 1,133
Fatty acid synthase, a proficient multifunctional enzyme
Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 820
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
Kuhajda, F. P. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00266-x · Cited by 788
Fatty acid synthesis: a potential selective target for antineoplastic therapy
Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705 · cited 2×
“This conclusion is also strongly supported by reports in the literature showing that FAS is misregulated in tumors (13) and that c75, an antagonist of the ketoacyl synthase domain, has antitumor activity (8, 20, 22).”
MethodEpoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
Greenbaum, D., Medzihradszky, K. F., Burlingame, A., & Bogyo, M. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00014-4 · Cited by 581
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., & Townsend, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3450 · Cited by 567
Profiling Serine Hydrolase Activities in Complex Proteomes
Kidd, D., Liu, Y., & Cravatt, B. F. (2001) · Biochemistry · doi:10.1021/bi002579j · Cited by 368
Alo, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C., & Di Tondo, U. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960201)77:3<474::aid-cncr8>3.0.co;2-k · Cited by 313
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
Gansler, T. S., Hardman, W., Hunt, D. A., Schaffel, S., & Hennigar, R. A. (1997) · Human Pathology · doi:10.1016/s0046-8177(97)90177-5 · Cited by 287
Cited by
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
The multifaceted roles of fatty acid synthesis in cancer
Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651
Lipid metabolism reprogramming and its potential targets in cancer
Cheng, C., Geng, F., Cheng, X., & Guo, D. (2018) · Cancer Communications · doi:10.1186/s40880-018-0301-4 · Cited by 850
Lipid metabolism in cancer: New perspectives and emerging mechanisms
Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 758
Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Van Veldhoven, P. P., Waltregny, D., Daniëls, V. W., Machiels, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3871 · Cited by 721
Metadata
- Authors
- Kridel, S. J., Axelrod, F., Rozenkrantz, N., & Smith, J. W.
- Venue
- Cancer Research
- Published
- 2004-03-15
- Volume
- 64
- Issue
- 6
- Pages
- 2070-2075
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2062785709
- Cited by
- 607
- References
- 30
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kridel, S. J., Axelrod, F., Rozenkrantz, N., & Smith, J. W. (2004). Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity. Cancer Research. https://doi.org/10.1158/0008-5472.can-03-3645
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