The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.
Lipid metabolism reprogramming and its potential targets in cancer
Open accessAbstract
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element‐binding proteins (SREBPs), a family of membrane‐bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. Recent studies have revealed that SREBPs are highly up‐regulated in various cancers and promote tumor growth. SREBP cleavage‐activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis. Targeting altered lipid metabolic pathways has become a promising anti‐cancer strategy. This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.
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Metabolism of Amino Acids in Cancer
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Self-citationThe role of lipid metabolic reprogramming in tumor microenvironment
Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W. (2023) · Theranostics · doi:10.7150/thno.82920 · Cited by 270
Targeting T cell metabolism in the tumor microenvironment: an anti‐cancer therapeutic strategy
Yin, Z., Bai, L., Li, W., Zeng, T., Tian, H., & Cui, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1409-3 · Cited by 133
Cellular landscaping of cisplatin resistance in cervical cancer
Bhattacharjee, R., Dey, T., Kumar, L., Kar, S., Sarkar, R., Ghorai, M., Malik, S., Jha, N. K., Vellingiri, B., Kesari, K. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113345 · Cited by 93
Metadata
- Authors
- Cheng, C., Geng, F., Cheng, X., & Guo, D.
- Venue
- Cancer Communications
- Published
- 2018-05-21
- Volume
- 38
- Issue
- 1
- Pages
- 1-14
- ISSN
- 1000-467X (ISSN-L)
- 2523-3548
- OpenAlex
- W2805393256
- Cited by
- 850
- References
- 269
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- gold
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