Cited by 72Cancer-related Molecular PathwaysCell death mechanisms and regulationHeat shock proteins research

p53CSV, a Novel p53-Inducible Gene Involved in the p53-Dependent Cell-Survival Pathway

Park, Woong-Ryeon, Nakamura, Yusuke·2005·Cancer Research

Abstract

Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not fully understood. Here we report isolation of a novel p53 target gene, designated p53-inducible cell-survival factor (p53CSV). p53CSV contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced apoptosis, whereas overexpression protected cells from apoptosis caused by DNA damage. p53CSV is induced significantly when cells have a low level of genotoxic stresses, but not when DNA damage is severe. p53CSV can modulate apoptotic pathways through interaction with Hsp70 that probably inhibits activity of apoptosis protease activating factor-1. Our results imply that under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival.

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Registry

Crossref · 10.1158/0008-5472.can-04-3339

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32 of 32 references verified0 citation errors · 0 not checkable

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  • The p53 target TRIAP1 encodes for an inhibitor of apoptosis.

    “Although many p53 target genes encode for apoptosis-promoting proteins, the p53 target TRIAP1 encodes for an inhibitor of apoptosis.189”

    From Census and evaluation of p53 target genes (2017) · cites this paper as [189]

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Authors
Park, W.-R., & Nakamura, Y.
Affiliations
  • Institute of Medical Science, The University of Tokyo (JP)
  • Medical University of South Carolina (US)
Venue
Cancer Research
Published
2005-02-15
Volume
65
Issue
4
Pages
1197-1206
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2123005692
Cited by
72
References
31
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 9 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 3
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
p53 target genes, apoptosis, DNA damage response, genotoxic stress, HSP70, Apaf-1, p53 binding sites, gene expression regulation, siRNA knockdown
MeSH terms
Amino Acid Sequence, Cell Survival, DNA Damage, Enzyme Activation, Humans, Molecular Sequence Data, Proteins, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, HSP70 Heat-Shock Proteins, Caspases, HCT116 Cells, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Caspase 9, Apoptotic Protease-Activating Factor 1, Caspase Inhibitors

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