p53CSV, a Novel p53-Inducible Gene Involved in the p53-Dependent Cell-Survival Pathway
Abstract
Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not fully understood. Here we report isolation of a novel p53 target gene, designated p53-inducible cell-survival factor (p53CSV). p53CSV contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced apoptosis, whereas overexpression protected cells from apoptosis caused by DNA damage. p53CSV is induced significantly when cells have a low level of genotoxic stresses, but not when DNA damage is severe. p53CSV can modulate apoptotic pathways through interaction with Hsp70 that probably inhibits activity of apoptosis protease activating factor-1. Our results imply that under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival.
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The p53 target TRIAP1 encodes for an inhibitor of apoptosis.
“Although many p53 target genes encode for apoptosis-promoting proteins, the p53 target TRIAP1 encodes for an inhibitor of apoptosis.189”
From Census and evaluation of p53 target genes (2017) · cites this paper as [189]
Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works
Lindquist, S., & Craig, E. A. (1988) · Annual Review of Genetics · doi:10.1146/annurev.ge.22.120188.003215 · Cited by 5,304 · see citing works
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works
Beere, H. M., Wolf, B. B., Cain, K., Mosser, D. D., Mahboubi, A., Kuwana, T., Tailor, P., Morimoto, R. I., Cohen, G. M., & Green, D. R. (2000) · Nature Cell Biology · doi:10.1038/35019501 · Cited by 1,513 · see citing works
Yin, X.-M., Oltvai, Z., & Korsmeyer, S. (1994) · Nature · doi:10.1038/369321a0 · Cited by 1,383 · see citing works
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Joza, N. A., Susín, S. A., Daugas, É., Stanford, W. L., Cho, S. K., Li, C. Y. J., Sasaki, T., Elia, A., Cheng, H.-Y. M., Ravagnan, L., et al. (2001) · Nature · doi:10.1038/35069004 · Cited by 1,365 · see citing works
The complexity of p53 modulation: emerging patterns from divergent signalsPreprint
Giaccia, A. J., & Kastan, M. B. (1998) · Genes & Development · doi:10.1101/gad.12.19.2973 · Cited by 1,303 · see citing works
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,288 · see citing works
Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works
Self-citationThe coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
Goldstein, J. C., Waterhouse, N. J., Juin, P. P., Evan, G. I., & Green, D. R. (2000) · Nature Cell Biology · doi:10.1038/35004029 · Cited by 1,073 · see citing works
(1999) · PubMed · Cited by 1,030 · see citing works
Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972 · see citing works
Database of p53 gene somatic mutations in human tumors and cell lines.
Hollstein, M. C., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sørlie, T., Hovig, E. J., Smith‐Sørensen, B., Montesano, R., & Harris, C. C. (1994) · Europe PMC (PubMed Central) · Cited by 860 · see citing works
Heat-shock protein 70 antagonizes apoptosis-inducing factor
Ravagnan, L., Gurbuxani, S. K., Susín, S. A., Maisse, C., Daugas, É., Zamzami, N., Mak, T. W., Jäättelä, M., Penninger, J. M., Garrido, C., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-839 · Cited by 859 · see citing works
Negative regulation of the Apaf-1 apoptosome by Hsp70
Saleh, A., Srinivasula, S. M., Balkir, L., Robbins, P. D., & Alnemri, E. S. (2000) · Nature Cell Biology · doi:10.1038/35019510 · Cited by 823 · see citing works
Hsp70 exerts its anti‐apoptotic function downstream of caspase‐3‐like proteases
Jäättelä, M., Wissing, D., Kokholm, K., Kallunki, T., & Egeblad, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6124 · Cited by 679 · see citing works
NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint
Zhao, J., Kennedy, B. K., Lawrence, B. D., Barbie, D. A., Matera, A. G., Fletcher, J. A., & Harlow, E. (2000) · Genes & Development · doi:10.1101/gad.827700 · Cited by 665 · see citing works
Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint
Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 631 · see citing works
Escaping Cell Death: Survival Proteins in Cancer
Jäättelä, M. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4455 · Cited by 608 · see citing works
Saleh, A., Srinivasula, S. M., Acharya, S., Fishel, R. A., & Alnemri, E. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17941 · Cited by 495 · see citing works
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
Qin, H., Srinivasula, S. M., Wu, G., Fernandes‐Alnemri, T., Alnemri, E. S., & Shi, Y. (1999) · Nature · doi:10.1038/21124 · Cited by 421 · see citing works
Heat shock proteins: regulators of stress response and apoptosis
Afshin Samali, A., & Orrenius, S. (1998) · Cell Stress and Chaperones · doi:10.1054/csac.1998.0129 · Cited by 316 · see citing works
Identification by cDNA microarray of genes involved in ovarian carcinogenesis.
Ono, K., Tanaka, T., Tsunoda, T., Kitahara, O., Kihara, C., Okamoto, A., Ochiai, K., Takagi, T., & Nakamura, Y. (2000) · PubMed · Cited by 307 · see citing works
Self-citationp53‐mediated induction of Cox‐2 counteracts p53‐ or genotoxic stress‐induced apoptosis
Han, J. A., Kim, J., Ongusaha, P. P., Hwang, D. H., Ballou, L. R., Mahale, A., Aaronson, S. A., & Lee, S. W. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf591 · Cited by 215 · see citing works
Ongusaha, P. P., Kim, J., Fang, L., Wong, T. W., Yancopoulos, G. D., Aaronson, S. A., & Lee, S. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg129 · Cited by 198 · see citing works
Isolation of p53‐target genes and their functional analysis
Nakamura, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03163.x · Cited by 169 · see citing works
Self-citationStrategies for manipulating the p53 pathway in the treatment of human cancer
Hupp, T. R., Lane, D. P., & Ball, K. L. (2000) · Biochemical Journal · doi:10.1042/bj3520001 · Cited by 148 · see citing works
Arbiser, J. L. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2003.09.013 · Cited by 42 · see citing works
Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya
Brunt, S. A., Perdew, G. H., Toft, D. O., & Silver, J. C. (1998) · Cell Stress and Chaperones · doi:10.1379/1466-1268(1998)003 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance
Neophytou, C. M., Trougakos, I. P., Erin, N., & Papageorgis, P. (2021) · Cancers · doi:10.3390/cancers13174363 · Cited by 376 · see citing works
Apaf-1: Regulation and function in cell death
Shakeri, R., Kheirollahi, A., & Davoodi, J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.02.001 · Cited by 313 · see citing works
Mitochondrial lipid trafficking
Tatsuta, T., Scharwey, M., & Langer, T. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.011 · Cited by 286 · see citing works
Transcriptomic responses to heat stress and bleaching in the elkhorn coral Acropora palmata
DeSalvo, M. K., Sunagawa, S., Voolstra, C. R., & Medina, M. (2009) · Marine Ecology Progress Series · doi:10.3354/meps08372 · Cited by 236 · see citing works
Potting, C., Tatsuta, T., König, T., Haag, M., Wai, T., Aaltonen, M. J., & Langer, T. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.008 · Cited by 212 · see citing works
Exploring the multiple roles of guardian of the genome: P53
Feroz, W., & Sheikh, A. M. A. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00089-x · Cited by 161 · see citing works
Yu, K., Ganesan, K., Tan, L. K., Laban, M., Wu, J., Zhao, X. D., Li, H., Leung, C. H., Zhu, Y., Wei, C. L., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000129 · Cited by 155 · see citing works
The transcription factor p53: Not a repressor, solely an activator.
Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153 · see citing works
Triggers, cascades, and endpoints: connecting the dots of coral bleaching mechanisms
Helgoe, J., Davy, S. K., Weis, V. M., & Rodríguez‐Lanetty, M. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13042 · Cited by 148 · see citing works
Milan, M., Pauletto, M., Patarnello, T., Bargelloni, L., Marin, M. G., & Matozzo, V. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.10.007 · Cited by 146 · see citing works
Modjtahedi, N., Tokatlidis, K., Dessen, P., & Kroemer, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.004 · Cited by 122 · see citing works
Genome-wide analysis of eukaryotic twin CX9C proteins
Cavallaro, G. (2010) · Molecular BioSystems · doi:10.1039/c0mb00058b · Cited by 103 · see citing works
Lacombe, J., Chao Sima, A., Amundson, S. A., & Zenhausern, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198851 · Cited by 99 · see citing works
ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport
Sassano, M. L., Felipe‐Abrio, B., & Agostinis, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.988014 · Cited by 93 · see citing works
Ånensen, N., Oyan, A. M., Bourdon, J., Kalland, K. H., Bruserud, Ø., & Gjertsen, B. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1970 · Cited by 92 · see citing works
Miliara, X., Garnett, J. A., Tatsuta, T., Ali, F. A., Baldie, H., Pérez‐Dorado, I., Simpson, P. J., Yagüe, E., Langer, T., & Matthews, S. (2015) · EMBO Reports · doi:10.15252/embr.201540229 · Cited by 77 · see citing works
Niu, P., Liu, L., Gong, Z., Tan, H., Wang, F., Yuan, J., Feng, Y., Wei, Q., Tanguay, R. M., & Wu, T. (2006) · Cell Stress and Chaperones · doi:10.1379/csc-175r.1 · Cited by 75 · see citing works
Beattie, M. C., Chen, H., Fan, J., Papadopoulos, V., Miller, P. S., & Zirkin, B. R. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.107052 · Cited by 68 · see citing works
At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity
Rizzotto, D., Englmaier, L., & Villunger, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910883 · Cited by 66 · see citing works
Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies
Shen, J., Wang, Q., Mao, Y., Gao, W., & Duan, S. (2023) · MedComm · doi:10.1002/mco2.288 · Cited by 66 · see citing works
Andrysík, Z., Kim, J., Tan, A. C., & Espinosa, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.014 · Cited by 65 · see citing works
Yildirimman, R., Brolén, G., Vilardell, M., Eriksson, G., Synnergren, J., Gmuender, H., Kamburov, A., Ingelman‐Sundberg, M., Castell, J. V., Lahoz, A., et al. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr225 · Cited by 63 · see citing works
Chai, L., Yang, Y., Yang, H., Zhao, Y., & Wang, H. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124902 · Cited by 60 · see citing works
Hearnes, J. M., Mays, D. J., Schavolt, K. L., Tang, L., Jiang, X. J., & Pietenpol, J. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10148-10158.2005 · Cited by 57 · see citing works
Felix, R. S., Colleoni, G. W. B., Caballero, O. L., Yamamoto, M., Almeida, M. S. S., Andrade, V. C. C., Chauffaille, M. D. L. L. F., Silva, W. A., Begnami, M. D., Soares, F. A., et al. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.12.022 · Cited by 55 · see citing works
Li, Y., Tang, X.-R., He, Q., Yang, X., Ren, X., Wen, X., Zhang, J., Wang, Y., Liu, N., & Ma, J. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006183 · Cited by 55 · see citing works
Nedelcu, A. M. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9201-1 · Cited by 51 · see citing works
Hsieh, P.-C., Chang, J.-C., Sun, W.-T., Hsieh, S.-C., Wang, M.-C., & Ff, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210304 · Cited by 50 · see citing works
Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance
Adams, C. E., Cazzanelli, G., Rasul, S., Hitchinson, B., Hu, Y., Coombes, R. C., Raguz, S., & Yagüe, E. (2015) · Oncology Reports · doi:10.3892/or.2015.3988 · Cited by 45 · see citing works
The Structure of a Gene Co-Expression Network Reveals Biological Functions Underlying eQTLs
Vialaneix, N., Liaubet, L., Laurent, T., Cherel, P., Gamot, A., & SanCristobal, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060045 · Cited by 42 · see citing works
MicroRNA-18a inhibits ovarian cancer growth via directly targeting TRIAP1 and IPMK
Liu, P., Qi, X., Bian, C., Yang, F., Lin, X., Zhou, S., Xie, C., Zhao, X., & Yi, T. (2017) · Oncology Letters · doi:10.3892/ol.2017.5961 · Cited by 36 · see citing works
Ketteler, J., Panic, A., Reis, H., Wittka, A., Maier, P., Herskind, C., Yagüe, E., Jendrossek, V., & Klein, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030348 · Cited by 31 · see citing works
Yan, W., & Chen, X. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0996 · Cited by 31 · see citing works
Changes in gravitational force cause changes in gene expression in the lens of developing zebrafish
Shimada, N., & Moorman, S. J. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20901 · Cited by 30 · see citing works
The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis
Shao, Z., Yang, W.-D., Qiu, H., He, Z.-H., Lu, M.-R., Shen, Q., Ding, J., Zheng, J., & Bai, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06740-4 · Cited by 26 · see citing works
Alves, V. L. F., de Oliveira, M. B., Zanatta, D. B., Strauss, B. E., & Colleoni, G. W. B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.03.011 · Cited by 25 · see citing works
Liu, Y., Wang, X. B., Wang, J., Wang, J., Duan, C., & Wang, J. (2022) · Viruses · doi:10.3390/v14020402 · Cited by 23 · see citing works
Eugênio, A. I. P., Alves, V. L. F., de Oliveira, M. B., Fernando, R. C., Zanatta, D. B., Strauss, B. E., Silva, M. R. R., Porcionatto, M. A., & Colleoni, G. W. B. (2017) · Oncotarget · doi:10.18632/oncotarget.22815 · Cited by 22 · see citing works
Jian, J., Xu, X., Li, W., & Wang, G. (2020) · Biochemical Genetics · doi:10.1007/s10528-020-10009-8 · Cited by 20 · see citing works
Dombkowski, A. A., Sultana, Z., Craig, D. B., & Jamil, H. M. (2011) · Cancer Informatics · doi:10.4137/cin.s6631 · Cited by 19 · see citing works
Singh, P. K., Kumar, R., Sharma, A. K., Arora, R., Chawla, R., Jain, S. K., & Sharma, R. K. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409343589 · Cited by 19 · see citing works
Metabolic sensing by p53: Keeping the balance between life and death
Tolstonog, G. V., & Deppert, W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007945107 · Cited by 17 · see citing works
Moreno‐Villanueva, M., Zhang, Y., Feiveson, A. H., Mistretta, B., Pan, Y., Chatterjee, S. S., Wu, W., Clanton, R., Nelman-Gonzalez, M. A., Krieger, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092316 · Cited by 17 · see citing works
Howell, M., Green, R. J., Killeen, A., WEDDERBURN, L., Picascio, V., Rabionet, A., Peng, Z., Larina, M., Xue, B., Kurgan, L., et al. (2012) · Journal of Biological Systems · doi:10.1142/s0218339012400086 · Cited by 17 · see citing works
Tang, X.-T., & Tamborindeguy, C. (2019) · Infection and Immunity · doi:10.1128/iai.00242-19 · Cited by 16 · see citing works
Tian-mei, Z. (2019) · Chemotherapy · doi:10.1159/000501633 · Cited by 16 · see citing works
Liu, H., Yang, M., Zhang, Y., Yang, Z., Chen, Z., Xie, Y., Peng, B., & Cai, L. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01909-9 · Cited by 15 · see citing works
Zhang, J., Cong, R., Zhao, K., Wang, Y., Song, N., & Gu, M. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.06.47 · Cited by 14 · see citing works
A functional screen for genes involved in Xenopus pronephros development
Kyuno, J., Massé, K. L., & Jones, E. A. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.03.001 · Cited by 14 · see citing works
Qian, Y., Sun, X., Wang, X., Xin, Y., Fan, M., Zhong, J., Pei, Z., & Guo, J. (2021) · Journal of Diabetes Research · doi:10.1155/2021/5477941 · Cited by 13 · see citing works
Liu, Y., Yang, N., Peng, X., Liu, G., Zhong, H., & Liu, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109254 · Cited by 12 · see citing works
Proteolytic Control of Lipid Metabolism
Sam, P. N., Avery, E., & Claypool, S. M. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00695 · Cited by 12 · see citing works
Tamilzhalagan, S., Muthuswami, M., Periasamy, J., Lee, M. H., Rha, S. Y., Tan, P. B. O., & Ganesan, K. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.02.010 · Cited by 11 · see citing works
Nedara, K., Reinhardt, C., Lebraud, E., Arena, G., Gracia, C., Buard, V., Pioche‐Durieu, C., Castelli, F. A., Colsch, B., Bénit, P., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.958155 · Cited by 10 · see citing works
Singh, P. K., Kumar, R., Sharma, A. K., Arora, R., Jain, S. K., & Sharma, R. K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080250 · Cited by 10 · see citing works
Rosales, M., Rodríguez‐Ulloa, A., Pérez, G. V., Besada, V., Soto, T., Ramos, Y., González, L. J., Zettl, K., Wiśniewski, J. R., Yang, K., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.834814 · Cited by 9 · see citing works
Structural comparison of yeast and human intra-mitochondrial lipid transport systems
Miliara, X., & Matthews, S. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150264 · Cited by 7 · see citing works
Biochemical characterization of stallion prostasomes and comparison to their human counterparts
Ronquist, G. K., Ek, B., Ronquist, G., Morrell, J. M., Carlsson, L. M. S., & Larsson, A. O. (2013) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2013.822612 · Cited by 7 · see citing works
Pawełkowicz, M. E., Wojcieszek, M., Osipowski, P., Krzywkowski, T., Pląder, W., & Przybecki, Z. (2016) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2249061 · Cited by 7 · see citing works
Modelling the p53 gene regulatory network.
Brewer, D. S. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 7 · see citing works
Balasco, N., Modjtahedi, N., Monti, A., Ruvo, M., Vitagliano, L., & Doti, N. (2025) · Molecules · doi:10.3390/molecules30102117 · Cited by 5 · see citing works
MIA40 circumvents the folding constraints imposed by TRIAP1 function
Pujols, J., Fornt‐Suñé, M., Gil-García, M., Bartolomé-Nafría, A., Canals, F., Cerofolini, L., Teilum, K., Banci, L., Esperante, S., & Ventura, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108268 · Cited by 4 · see citing works
Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest
Pavani, M., Chiroli, E., Cancrini, C., Groß, F., Bonaiuti, P., Villa, S., Giavazzi, F., Matafora, V., Bachi, A., Fava, L. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112215 · Cited by 3 · see citing works
Wang, B., Zuo, Z., Lv, F., Zhao, L., Du, M., & Gao, Y. (2017) · Open Life Sciences · doi:10.1515/biol-2017-0023 · Cited by 3 · see citing works
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC–MS/MS following sulforaphane exposure
Watson, G. W., Wickramasekara, S. I., Maier, C. S., Williams, D. E., Dashwood, R. H., & Ho, E. (2015) · EuPA Open Proteomics · doi:10.1016/j.euprot.2015.08.002 · Cited by 2 · see citing works
TRIAP1 (TP53 regulated inhibitor of apoptosis 1)
Alves, V. A. F., Felix, R., Vettore, A. L., & Colleoni, G. W. B. (2012) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/46029 · Cited by 1 · see citing works
The role of iHsp70 in myogenic stem cell resistance
Bironaitė, D., & Gal, J. (2010) · Biologija · doi:10.2478/v10054-010-0007-2
Modeling p53 transcriptional regulation
Riley, T. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t31836rn
Kısakürek, A. F. (2011) · Sabanci University
- Authors
- Park, W.-R., & Nakamura, Y.
- Affiliations
- Institute of Medical Science, The University of Tokyo (JP)
- Medical University of South Carolina (US)
- ORCID
- Nakamura, Yusuke
- Venue
- Cancer Research
- Published
- 2005-02-15
- Volume
- 65
- Issue
- 4
- Pages
- 1197-1206
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2123005692
- Cited by
- 72
- References
- 31
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 9 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- p53 target genes, apoptosis, DNA damage response, genotoxic stress, HSP70, Apaf-1, p53 binding sites, gene expression regulation, siRNA knockdown
- MeSH terms
- Amino Acid Sequence, Cell Survival, DNA Damage, Enzyme Activation, Humans, Molecular Sequence Data, Proteins, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, HSP70 Heat-Shock Proteins, Caspases, HCT116 Cells, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Caspase 9, Apoptotic Protease-Activating Factor 1, Caspase Inhibitors
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