The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Role of Macrophage Inhibitory Cytokine-1 in Tumorigenesis and Diagnosis of Cancer
Open accessAbstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Growth differentiation factor 15 (GDF15), also called macrophage inhibitory cytokine-1, is associated with numerous biological processes and diseases including cancer, cardiovascular disease, and obesity [[199], [200], [201], [202]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [199]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180
Self-citationPhosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α
Campbell, R., Bhat-Nakshatri, P., Patel, N., Constantinidou, D., Ali, S., & Nakshatri, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010840200 · Cited by 880
Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum
Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503
Self-citationBaek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C., & Eling, T. E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.901 · Cited by 402
Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers
Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274
Self-citationMIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation
Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H.-P., & Breit, S. N. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.1.2 · Cited by 266
Self-citationMIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.
Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B., & Breit, S. N. (2003) · PubMed · Cited by 265
Self-citationLi, P.-X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., & Klamut, H. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909580199 · Cited by 254
Activin receptor–like kinase 1 is implicated in the maturation phase of angiogenesis
Lamouille, S., Mallet, C., Feige, J., & Bailly, S. (2002) · Blood · doi:10.1182/blood.v100.13.4495 · Cited by 211
Albertoni, M., Shaw, P. H., Nozaki, M., Godard, S., Tenan, M., Hamou, M., Fairlie, W. D., Breit, S. N., Paralkar, V. M., de Tribolet, N., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205610 · Cited by 180
Self-citationBottner, M. B., Suter‐Crazzolara, C., Schober, A., & Unsicker, K. (1999) · Cell and Tissue Research · doi:10.1007/s004410051337 · Cited by 180
Liu, T., Bauskin, A. R., Zaunders, J. J., Brown, D. A., Pankhurst, S., Russell, P. J., Breit, S. N., & Panhurst, S. (2003) · PubMed · Cited by 174
Self-citationBaek, S. J., Kim, J., Moore, S. M., Lee, S., Martinez, J. M., & Eling, T. E. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.005108 · Cited by 162
Lee, D. H., Yang, Y. D., Lee, S. J., Kim, K. Y., Koo, T. H., Shin, S. M., Song, K. S., Lee, Y. H., Kim, Y. J., Lee, J. J., et al. (2003) · PubMed · Cited by 161
Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation.
Yang, H. S., Filipovic, Z., Brown, D. A., Breit, S. N., & Vassilev, L. T. (2003) · PubMed · Cited by 157
Self-citationBauskin, A. R., Brown, D. A., Junankar, S. R., Rasiah, K., Eggleton, S. A., Hunter, M. I., Liu, T., Smith, D., Kuffner, T., Pankhurst, G. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3827 · Cited by 154
Self-citationSchober, A., Bottner, M. B., Strelau, J., Kinscherf, R., Bonaterra, G. A., Barth, M., Schilling, L., Fairlie, W. D., Breit, S. N., & Unsicker, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1333 · Cited by 151
Self-citationH6D Polymorphism in Macrophage-Inhibitory Cytokine-1 Gene Associated With Prostate Cancer
Lindmark, F., Zheng, S. L., Wiklund, F. E., Bensen, J. T., Bälter, K. A., Chang, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D. A., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh227 · Cited by 120
Brown, D. A., Stephan, C., Ward, R. L., Law, M. G., Hunter, M., Bauskin, A. R., Amin, J., Jung, K., Diamandis, E. P., Hampton, G. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1331 · Cited by 109
Self-citationde Wit, N. J. W., Rijntjes, J., Diepstra, J. H. S., Kuppevelt, T. H. V., Weidle, U. H., Ruiter, D. J., & van Muijen, G. N. P. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602612 · Cited by 97
Cheung, P. K., Woolcock, B. W., Adomat, H. H., Sutcliffe, M., Bainbridge, T. C., Jones, E. C., Webber, D. L., Κinahan, T. J., Sadar, M. D., Gleave, M. E., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1216 · Cited by 95
Yamaguchi, K., Lee, S., Eling, T. E., & Baek, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408796200 · Cited by 94
Nakamura, T., Scorilas, A., Stephan, C., Yousef, G. M., Kristiansen, G., Jung, K., & Diamandis, E. P. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600869 · Cited by 88
Ferrari, N., Pfeffer, U., Dell’Eva, R., Ambrosini, C., Noonan, D. M., & Albini, A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2210 · Cited by 75
Kim, J., Baek, S. J., Sali, T. M., & Eling, T. E. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0201 · Cited by 64
Modlich, O., Prisack, H.-B., Munnes, M., Audretsch, W., & Bojar, H. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1031 · Cited by 64
Graichen, R., Liu, D., Sun, Y., Lee, K., & Lobie, P. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109931200 · Cited by 61
Research works printed but not linked: 1
- Liu T, Bauskin AR, Zaunders J, et al. MIC-1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res 2003; 63: 5034–40.
Cited by
Sorted by citations
Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1677 · Cited by 612
Self-citationRiker, A. I., Enkemann, S. A., Fodstad, Ø., Liu, S., Ren, S., Morris, C. G., Xi, Y., Howell, P., Metge, B. J., Samant, R. S., et al. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-13 · Cited by 525
Adela, R., & Banerjee, S. K. (2015) · Journal of Diabetes Research · doi:10.1155/2015/490842 · Cited by 474
Promiscuity and specificity in BMP receptor activation
Mueller, T. D., & Nickel, J. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.02.043 · Cited by 302
Metadata
- Authors
- Bauskin, A. R., Brown, D. A., Kuffner, T., Johnen, H., Luo, X. W., Hunter, M., & Breit, S. N.
- Affiliations
- UNSW Sydney (AU)
- Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia
- Venue
- Cancer Research
- Published
- 2006-05-15
- Volume
- 66
- Issue
- 10
- Pages
- 4983-4986
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2020474446
- Cited by
- 251
- References
- 27
- Citations by year
- 2025: 8 · 2024: 13 · 2023: 14 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 12
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- MIC-1, TGF-beta superfamily, carcinogenesis, cancer diagnosis, tumor microenvironment, tumor progression, tumor invasion
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Biomarkers, Tumor, Cytokines, Growth Differentiation Factor 15
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
