Cited by 340Proteoglycans and glycosaminoglycans researchProtease and Inhibitor MechanismsMechanisms of cancer metastasis

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Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective

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Götte, Martin, Yip, George W.·2006·Cancer Research

DOI 10.1158/0008-5472.can-06-1464

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Abstract

Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. (Cancer Res 2006; 66(21): 10233-7)

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Authors: Götte, M., & Yip, G. W.
Affiliations: 1Department of Obstetrics and Gynecology, Münster University Hospital, Münster, Germany and
National University of Singapore (SG)
ORCID: Yip, George W.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2006-11-01
Volume: 66
Issue: 21
Pages: 10233-10237
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-06-1464
OpenAlex: W2134709252
Cited by: 340
References: 58
Citations by year: 2026: 3 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 20 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 22 · 2016: 22 · 2015: 19 · 2014: 25 · 2013: 28 · 2012: 24
FWCI: 1.57
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: heparanase, hyaluronic acid, CD44, breast cancer, glycosaminoglycans, tumor microenvironment, tumor stroma, metastasis, tumor progression, angiogenesis, tumor cell proliferation, cell migration and invasion, prognostic factors, therapeutic target
MeSH terms: Heparanase, Breast Neoplasms, Female, Glucuronidase, Humans, Hyaluronic Acid, Neoplasm Invasiveness, Hyaluronan Receptors, Cell Proliferation

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Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective

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