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Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
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Abstract
Hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. The transcription factor hypoxia-inducible factor-1 (HIF-1) is a major regulator of adaptation to hypoxia and is implicated in the malignant progression of cancers. Here, we studied whether hypoxia and HIF-1 expression contribute to the development of bone metastases using a well-characterized animal model of bone metastasis in MDA-MB-231 human breast cancer cells. To study the role of hypoxia in bone metastases, we tested the effects of the fusion protein (TOP3), the oxygen-dependent degradation domain of HIF-1α fused with HIV-TAT, and procaspase-3. TOP3 selectively induced apoptosis in hypoxic tumor cells in vitro and significantly reduced bone metastases in vivo. We next examined the role of HIF-1 in bone metastases by establishing MDA-MB-231 cells overexpressing constitutively active or dominant-negative HIF-1α (MDA/CA-HIF or MDA/DN-HIF, respectively). Bone metastases of MDA/CA-HIF were significantly increased with elevated number of CD31-positive blood vessels. In contrast, bone metastases were significantly reduced in MDA/DN-HIF. Because the progression of osteolytic bone metastases is due in part to the imbalance between bone formation and bone resorption, we examined the effects of hypoxia and HIF-1 on the differentiation of osteoblasts and osteoclasts. Hypoxia and CA-HIF overexpression markedly inhibited osteoblastic differentiation, whereas hypoxia increased osteoclast-like cell formation. In conclusion, these results suggest that tumor-associated hypoxia and HIF-1 expression promote the progression of bone metastases in breast cancer. Our results also suggest that hypoxia and HIF-1 lead to the development of osteolytic bone metastases by suppressing osteoblast differentiation and promoting osteoclastogenesis. [Cancer Res 2007;67(9):4157–63]
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“Insights from a transgenic mouse model of metastatic breast cancer (Liao et al., 2007) and xenograft models of breast cancer (Hiraga et al., 2007;Lu et al., 2010) also point to HIF-1α as a critical regulator of metastasis.”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Hiraga et al., 2007
In the citing paper
“whereas inactivation of HIF decreases the metastatic potential of tumor cells”
From Hypoxic control of metastasis (2016) · cites this paper as [43]
In the citing paper
“In experimental models, overexpression of HIF in tumor cells promotes metastasis”
From Hypoxic control of metastasis (2016) · cites this paper as [43]
In the citing paper
“Compared to an empty vector subclone, expression of a constitutively active or dominant negative form of HIF-1α increased or decreased, respectively, the tumor area and blood vessel density in long bone sections [32].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [32]
In the citing paper
“Because BCCs were injected directly into the circulation, these studies do not provide compelling evidence that HIF-1 is required for spontaneous metastasis from breast to bone as opposed to a more limited requirement for bone colonization by circulating tumor cells.”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [32]
In the citing paper
“The bone metastases that formed after injection of MDA-MB-231 cells contained hypoxic regions and exposure of spleen cells to hypoxia in vitro inhibited osteoblast differentiation and stimulated osteoclast differentiation [32].”
From The hypoxic tumor microenvironment: A driving force for breast cancer progression (2016) · cites this paper as [32]
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Cites
1 retracted
Kasuno, K., Takabuchi, S., Fukuda, K., Kizaka‐Kondoh, S., Yodoi, J., Adachi, T., Semenza, G. L., & Hirota, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308197200 · Cited by 226
Self-citationRetractedTargeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
Metastasis to bone: causes, consequences and therapeutic opportunities
Mundy, G. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc867 · Cited by 2,816
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418
(1999) · PubMed · Cited by 2,204
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505
Cited by
Sorted by citations
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712
The impact of O2 availability on human cancer
Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2540 · Cited by 1,365
Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340
Cancer to bone: a fatal attraction
Weilbaecher, K. N., Guise, T. A., & McCauley, L. K. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3055 · Cited by 1,325
Subtypes of Breast Cancer Show Preferential Site of Relapse
Smid, M., Wang, Y., Zhang, Y., Sieuwerts, A. M., Yu, J. X., Klijn, J. G. M., Foekens, J. A., & Martens, J. W. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5644 · Cited by 827
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“, 2007) and xenograft models of breast cancer (Hiraga et al., 2007; Lu et al., 2010) also point to HIF-1α as a critical regulator of metastasis.”
BackgroundRohwer, N., & Cramer, T. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.03.001 · Cited by 632
The hypoxic tumor microenvironment: A driving force for breast cancer progression
Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535
New developments and novel therapeutic perspectives for vitamin C
Li, Y., & Schellhorn, H. E. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2171 · Cited by 508
Zhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520032112 · Cited by 420
Bone metastasis: mechanisms, therapies, and biomarkers
Clézardin, P., Coleman, R., Puppo, M., Ottewell, P. D., Bonnelye, E., Paycha, F., Confavreux, C. B., & Holen, I. (2020) · Physiological Reviews · doi:10.1152/physrev.00012.2019 · Cited by 442
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Evaluation of HIF-1 inhibitors as anticancer agents
Semenza, G. L. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.08.006 · Cited by 363
Hypoxia-driven pathways in bone development, regeneration and disease
Maes, C., Carmeliet, G., & Schipani, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.36 · Cited by 307
RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
RetractedThe mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α
Tosatto, A., Sommaggio, R., Kummerow, C., Bentham, R. B., Blacker, T. S., Berecz, T., Duchen, M. R., Rosato, A., Bogeski, I., Szabadkai, G., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606255 · Cited by 264
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252
RetractedHypoxia: Signaling the Metastatic Cascade
Rankin, E. B., Nam, J.-M., & Giaccia, A. J. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.05.006 · Cited by 249
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M. E., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6203 · Cited by 229
Liang, X., Chen, M., Bhattarai, P., Hameed, S., & Dai, Z. (2020) · ACS Nano · doi:10.1021/acsnano.0c05617 · Cited by 222
Dunn, L. K., Mohammad, K. S., Fournier, P. G. J., McKenna, C. R., Davis, H. W., Niewolna, M., Peng, X. H., Chirgwin, J. M., & Guise, T. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006896 · Cited by 212
Semenza, G. L. (2012) · Oncogene · doi:10.1038/onc.2012.578 · Cited by 208
Hypoxic Tumor Microenvironment and Cancer Cell Differentiation
Kim, Y., Lin, Q., Glazer, P. M., & Yun, Z. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167113 · Cited by 185
Sawant, A., Deshane, J. S., Jules, J., Lee, C. M., Harris, B. A., Feng, X., & Ponnazhagan, S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2202 · Cited by 183
Yang, D.-C., Yang, M., Tsai, C.-C., Huang, T.-F., Chen, Y., & Hung, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023965 · Cited by 185
Yang, L., Lin, C., Wang, L., Guo, H., & Wang, X. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.07.017 · Cited by 190
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Lee, S.-H., Golinska, M., & Griffiths, J. R. (2021) · Cells · doi:10.3390/cells10092371 · Cited by 169
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia
Díaz, B., Yuen, A., Iizuka, S., Higashiyama, S., & Courtneidge, S. A. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201209151 · Cited by 162
Autophagy regulates hypoxia‐induced osteoclastogenesis through the HIF‐1α/BNIP3 signaling pathway
Zhao, Y., Chen, G., Zhang, W., Xu, N., Zhu, J., Jia, J., Sun, Z., Wang, Y., & Zhao, Y. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.22768 · Cited by 156
The critical role of the bone microenvironment in cancer metastases
Casimiro, S., Guise, T. A., & Chirgwin, J. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.004 · Cited by 149
TGF-β in cancer and bone: Implications for treatment of bone metastases
Juárez, P., & Guise, T. A. (2010) · Bone · doi:10.1016/j.bone.2010.08.004 · Cited by 153
Ju, J. A., Godet, I., Ye, I. C., Byun, J., Jayatilaka, H., Lee, S. J., Xiang, L., Samanta, D., Lee, M., Wu, P.-H., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0338 · Cited by 128
Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget · doi:10.18632/oncotarget.2997 · Cited by 119
Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis
Knowles, H. J., & Athanasou, N. A. (2009) · The Journal of Pathology · doi:10.1002/path.2534 · Cited by 117
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Yang, J., Li, Q., Feng, Y., & Zeng, Y. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086891 · Cited by 142
Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells
Wang, K.-L., Hsia, S., Chan, C.-J., Chang, F.-Y., Huang, C., Bau, D., & Wang, P. S. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.756869 · Cited by 111
Bone Metastasis: Find Your Niche and Fit in
Zhang, W., Bado, I., Wang, H., Lo, H.-C., & Zhang, X. H.-F. (2019) · Trends in cancer · doi:10.1016/j.trecan.2018.12.004 · Cited by 110
Storti, P., Bolzoni, M., Donofrío, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., et al. (2013) · Leukemia · doi:10.1038/leu.2013.24 · Cited by 107
Zhang, J., Hu, Z., Horta, C. A., & Yang, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.002 · Cited by 106
Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness
Waning, D. L., & Guise, T. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1590 · Cited by 101
The role of TGF-β in bone metastasis: novel therapeutic perspectives
Buijs, J. T., Stayrook, K. R., & Guise, T. A. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.96 · Cited by 99
Bone metastasis: Interaction between cancer cells and bone microenvironment
Hiraga, T. (2019) · Journal of Oral Biosciences · doi:10.1016/j.job.2019.02.002 · Cited by 102
Self-citationTang, X., Zhang, Q., Shi, S., Yen, Y., Li, X., Zhang, Y., Zhou, K., & Le, A. D. (2009) · International Journal of Cancer · doi:10.1002/ijc.24710 · Cited by 95
Kizaka‐Kondoh, S., Itasaka, S., Zeng, L., Tanaka, S., Zhao, T., Takahashi, Y., Shibuya, K., Hirota, K., Semenza, G. L., & Hiraoka, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2267 · Cited by 92
Self-citationBone-Derived IGF Mediates Crosstalk between Bone and Breast Cancer Cells in Bony Metastases
Hiraga, T., Myoui, A., Hashimoto, N., Sasaki, A., Hata, K., Morita, Y., Yoshikawa, H., Rosen, C. J., Mundy, G. R., & Yoneda, T. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3061 · Cited by 90
Self-citationMicrofluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis
Mei, X., Middleton, K., Shim, D., Wan, Q., Xu, L., Ma, Y.-H. V., Devadas, D., Walji, N., Wang, L., Young, E. W. K., et al. (2019) · Integrative Biology · doi:10.1093/intbio/zyz008 · Cited by 92
The Endosteal Niche in Breast Cancer Bone Metastasis
Haider, M., Smit, D. J., & Taipaleenmäki, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00335 · Cited by 87
Knowles, H. J., & Athanasou, N. (2008) · The Journal of Pathology · doi:10.1002/path.2319 · Cited by 86
Lü, X., Yan, C. H., Yuan, M., Wei, Y., Hu, G., & Kang, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3739 · Cited by 91
Hypoxia and Bone Metastatic Disease
Johnson, R. W., Sowder, M. E., & Giaccia, A. J. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0378-8 · Cited by 92
Mechanisms governing metastatic dormancy in breast cancer
Dittmer, J. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.006 · Cited by 83
The HIF-1-active microenvironment: An environmental target for cancer therapy
Kizaka‐Kondoh, S., Tanaka, S., Harada, H., & Hiraoka, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.01.006 · Cited by 82
Self-citationA therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways
Podar, K., & Anderson, K. C. (2010) · Cell Cycle · doi:10.4161/cc.9.9.11358 · Cited by 82
Jiang, H.-L., Sun, H.-F., Gao, S.-P., Li, L.-D., Huang, S., Hu, X., Liu, S., Wu, J., Shao, Z., & Jin, W. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1630 · Cited by 82
RetractedLemma, S., Pompo, G. D., Porporato, P. E., Sboarina, M., Russell, S., Gillies, R. J., Baldini, N., Sonveaux, P., & Avnet, S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.030 · Cited by 80
Homing of Cancer Cells to the Bone
Mishra, A., Shiozawa, Y., Pienta, K. J., & Taichman, R. S. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0083-6 · Cited by 76
Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions
Lee, J. G., Shin, J. H., Shim, H. S., Lee, C. Y., Kim, D. J., Kim, Y. S., & Chung, K. S. (2015) · Respiratory Research · doi:10.1186/s12931-015-0285-4 · Cited by 75
TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases
Buijs, J. T., Stayrook, K. R., & Guise, T. A. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0075-6 · Cited by 76
Role of TGF-β in breast cancer bone metastases
Chiechi, A., Waning, D. L., Stayrook, K. R., Buijs, J. T., Guise, T. A., & Mohammad, K. S. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.410a4003 · Cited by 76
Immunohistochemical Detection of Changes in Tumor Hypoxia
Russell, J., Carlin, S., Burke, S. A., Wen, B., Yang, K., & Ling, C. C. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.12.004 · Cited by 70
Hypoxic Microenvironment and Metastatic Bone Disease
Hiraga, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113523 · Cited by 78
Self-citationBone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions
Papachristou, D. J., Basdra, E. K., & Papavassiliou, A. G. (2010) · Medicinal Research Reviews · doi:10.1002/med.20224 · Cited by 76
Li, X., & O’Donoghue, J. A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.037 · Cited by 72
Tumour oxygenation: implications for breast cancer prognosis
Rundqvist, H., & Johnson, R. S. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12091 · Cited by 71
SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation
Amir, S., Wang, R., Simons, J. W., & Mabjeesh, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808348200 · Cited by 70
Bendinelli, P., Maroni, P., Matteucci, E., Luzzati, A., Perrucchini, G. G., & Desiderio, M. A. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.03.002 · Cited by 66
Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy
Bhandari, P. N., Novikova, G., Goergen, C. J., & Irudayaraj, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20363-8 · Cited by 66
HIF targets in bone remodeling and metastatic disease
Johnson, R. W., Schipani, E., & Giaccia, A. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.02.002 · Cited by 65
Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice
Lee, S. Y., Park, K. H., Yu, H.-G., Kook, E., Song, W., Lee, G., Koh, J., Shin, H., Choi, J., Huh, Y. H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0054-y · Cited by 63
Implications of Hypoxia in Breast Cancer Metastasis to Bone
Gilkes, D. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101669 · Cited by 65
Conceição, F., Sousa, D. M., Loessberg-Zahl, J., Vollertsen, A. R., Neto, E., Søe, K., Paredes, J., Leferink, A., & Lamghari, M. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100219 · Cited by 63
Oxygen nanobubbles revert hypoxia by methylation programming
Bhandari, P. N., Cui, Y., Elzey, B. D., Goergen, C. J., Long, C. M., & Irudayaraj, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-08988-7 · Cited by 64
Altemus, M., Goo, L., Little, A. C., Yates, J. A., Cheriyan, H., Wu, Z.-F., & Merajver, S. D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220973 · Cited by 63
Bendinelli, P., Matteucci, E., Maroni, P., & Desiderio, M. A. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0548 · Cited by 60
Bone metastases: When and how lung cancer interacts with bone
Roato, I. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i2.149 · Cited by 62
Therapeutic targeting of hypoxia and hypoxia-inducible factor 1 alpha in multiple myeloma
Borsi, E., Terragna, C., Brioli, A., Tacchetti, P., Martello, M., & Cavo, M. (2014) · Translational research · doi:10.1016/j.trsl.2014.12.001 · Cited by 61
Fujimoto, D., Ueda, H., Shimizu, R., Kato, R., Otoshi, T., Kawamura, T., Tamai, K., Shibata, Y., Matsumoto, T., Nagata, K., et al. (2014) · Clinical & Experimental Metastasis · doi:10.1007/s10585-014-9648-3 · Cited by 59
CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription
Huang, S., Chi, Y., Qin, Y., Wang, Z., Xiu, B., Su, Y., Guo, R., Guo, L., Sun, H., Zeng, C., et al. (2018) · Theranostics · doi:10.7150/thno.22523 · Cited by 58
Chanda, D., Isayeva, T., Kumar, S., Hensel, J. A., Sawant, A., Ramaswamy, G., Siegal, G. P., Beatty, M. S., & Ponnazhagan, S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1938 · Cited by 58
Hyperbaric oxygen therapy suppresses osteoclast formation and bone resorption
Hadi, H. A., Smerdon, G. R., & Fox, S. W. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22443 · Cited by 54
Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden
Bohn, K. A., Adkins, C. E., Nounou, M. I., & Lockman, P. R. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00193 · Cited by 54
Hypoxic Signalling in Tumour Stroma
Laitala, A., & Erler, J. T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00189 · Cited by 55
Jennbacken, K., Welén, K., OLSSON, A. G., Axelsson, B., Törngren, M., Damber, J., & Leanderson, T. (2011) · The Prostate · doi:10.1002/pros.21495 · Cited by 53
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Zarrer, J., Haider, M., Smit, D. J., & Taipaleenmäki, H. (2020) · Biomolecules · doi:10.3390/biom10020337 · Cited by 54
Fang, J., & Xu, Q. (2014) · Clinical & Translational Oncology · doi:10.1007/s12094-014-1247-x · Cited by 52
Hypoxia induces RANK and RANKL expression by activating HIF-1α in breast cancer cells
Tang, Z.-N., Zhang, F., Tang, P., Qi, X., & Jiang, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.035 · Cited by 49
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Todd, V. M., & Johnson, R. W. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.004 · Cited by 51
Hiraga, T., & Nakamura, H. (2008) · International Journal of Cancer · doi:10.1002/ijc.23903 · Cited by 46
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Metadata
- Authors
- Hiraga, T., Kizaka-Kondoh, S., Hirota, K., Hiraoka, M., & Yoneda, T.
- Affiliations
- Matsumoto Dental University (JP)
- 3Department of Therapeutic Radiation Oncology, Kyoto University Graduate School of Medicine; and
- Kyoto University Hospital (JP)
- Kyoto University (JP)
- The University of Osaka (JP)
- Venue
- Cancer Research
- Published
- 2007-05-01
- Volume
- 67
- Issue
- 9
- Pages
- 4157-4163
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2047253593
- Cited by
- 242
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 15 · 2022: 15 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 19 · 2012: 10
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- tumor hypoxia, HIF-1, HIF-1α, breast cancer bone metastasis, osteolytic bone metastasis, oxygen-dependent degradation domain, procaspase-3, apoptosis, tumor angiogenesis, osteogenic differentiation, osteoclastogenesis, bone resorption, MDA-MB-231 cells
- MeSH terms
- Animals, Bone Neoplasms, Breast Neoplasms, Female, Humans, Indazoles, Mice, Inbred C3H, Mice, Nude, Recombinant Fusion Proteins, Transfection, Cell Hypoxia, Cell Line, Tumor, Mice, Hypoxia-Inducible Factor 1, alpha Subunit, Caspase 3
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