HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Open accessAbstract
Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypoxic tumor cells evade innate immune recognition through up-regulation of CD47, which interacts with SIRPα on macrophages to block phagocytosis.
“hypoxic tumor cells evade innate immune recognition through the up-regulation of CD47, a cell surface molecule that interacts with signal regulatory protein alpha (SIRP α) on the surface of macrophages to block phagocytosis”
From Hypoxic control of metastasis (2016) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
7 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309 · see citing works
RetractedSamanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421438111 · Cited by 460 · see citing works
Self-citationRetractedRETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
Lee, K., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909353106 · Cited by 451 · see citing works
Self-citationRetractedZhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.365 · Cited by 326 · see citing works
Self-citationRetractedRETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296 · see citing works
Self-citationRetractedProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252 · see citing works
Self-citationRetractedGilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321510111 · Cited by 184 · see citing works
Self-citationRetractedPD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Györffy, B., Lanczky, A., Eklund, A. C., Denkert, C., Budczies, J., Li, Q., & Szallasi, Z. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0674-9 · Cited by 4,169 · see citing works
Ginestier, C., Hur, M., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C., Liu, S.-L., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,121 · see citing works
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413 · see citing works
Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works
Self-citationMajeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752 · see citing works
Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,667 · see citing works
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578 · see citing works
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473 · see citing works
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
Pennacchietti, S., Michieli, P., Galluzzo, M., Mazzone, M., Giordano, S., & Comoglio, P. M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00085-0 · Cited by 1,311 · see citing works
Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231 · see citing works
Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148 · see citing works
Baccelli, I., Schneeweiß, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bäuerle, T., Wallwiener, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2576 · Cited by 1,050 · see citing works
Integrin-associated protein (CD47) and its ligands
Brown, E. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01906-1 · Cited by 880 · see citing works
Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776 · see citing works
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
Liu, X., Pu, Y., Cron, K. R., Deng, L., Kline, J. P., Frazier, W. A., Xu, H., Peng, H., Fu, Y., & Xu, M. M. (2015) · Nature Medicine · doi:10.1038/nm.3931 · Cited by 770 · see citing works
Detection and Characterization of Tumor Hypoxia Using pO <sub>2</sub> Histography
Vaupel, P., Höckel, M., & Mayer, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1628 · Cited by 728 · see citing works
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
Conley, S. J., Gheordunescu, E., Kakarala, P., Newman, B., Korkaya, H., Heath, A. N., Clouthier, S. G., & Wicha, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018866109 · Cited by 663 · see citing works
Chan, K. S., Espinosa, Í., Chao, M. P., Wong, D. J., Ailles, L., Diehn, M., Gill, H. S., Presti, J. C., Chang, H. Y., van de Rijn, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906549106 · Cited by 658 · see citing works
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Hatfield, S. M., Kjaergaard, J., Lukashev, D., Schreiber, T. H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1260 · Cited by 600 · see citing works
Hoffmann, P. R., deCathelineau, A. M., Ogden, C. A., Leverrier, Y., Bratton, D. L., Daleke, D. L., Ridley, A. J., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108080 · Cited by 541 · see citing works
The hypoxic tumor microenvironment: A driving force for breast cancer progression
Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works
Self-citationHIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Mathieu, J., Zhang, Z., Zhou, W., Wang, A. J., Heddleston, J. M., Pinna, C. M. A., Hubaud, A., Stadler, B., Choi, M. P., Bar, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3320 · Cited by 510 · see citing works
Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410041111 · Cited by 493 · see citing works
Self-citationHistological and molecular types of breast cancer: is there a unifying taxonomy?
Weigelt, B., & Reis-Filho, J. S. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.166 · Cited by 461 · see citing works
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113483108 · Cited by 437 · see citing works
Self-citationGOBO: Gene Expression-Based Outcome for Breast Cancer Online
Ringnér, M., Fredlund, E., Häkkinen, J., Borg, Å., & Staaf, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017911 · Cited by 421 · see citing works
Noman, M. Z., Hasmim, M., Messai, Y., Terry, S., Kiéda, C., Janji, B., & Chouaı̈b, S. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00207.2015 · Cited by 405 · see citing works
Liao, D., Corle, C., Seagroves, T. N., & Johnson, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2701 · Cited by 339 · see citing works
Chia, S., Bramwell, V. H. C., Tu, D., Shepherd, L. E., Jiang, S., Vickery, T. L., Mardis, E. R., Leung, S. C. Y., Ung, K., Pritchard, K. I., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0286 · Cited by 301 · see citing works
Lu, H., Samanta, D., Xiang, L., Zhang, H., Hu, H., Chen, I., Bullen, J. W., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513433112 · Cited by 271 · see citing works
Self-citationProgrammed cell removal: a new obstacle in the road to developing cancer
Chao, M. P., Majeti, R., & Weissman, I. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3171 · Cited by 246 · see citing works
Hiraga, T., Kizaka-Kondoh, S., Hirota, K., Hiraoka, M., & Yoneda, T. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2355 · Cited by 242 · see citing works
Chaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 241 · see citing works
Self-citationInhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms
Cioffi, M., Trabulo, S. M. D., Hidalgo, M. M., Costello, E., Greenhalf, W., Erkan, M., Kleeff, J. H., Sáinz, B., & Heeschen, C. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1399 · Cited by 228 · see citing works
Chaturvedi, P., Gilkes, D. M., Takano, N., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406655111 · Cited by 226 · see citing works
Self-citationSchito, L., Rey, S., Tafani, M., Zhang, H., Wong, C. C.-L., Russo, A., Russo, M. A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214019109 · Cited by 224 · see citing works
Self-citationLee, T. K., Cheung, V. C. H., Lu, P., Lau, E. Y.-T., Ma, S., Tang, K. H., Tong, M., Lo, J. H. T., & Ng, I. O. (2014) · Hepatology · doi:10.1002/hep.27070 · Cited by 213 · see citing works
Dunn, L. K., Mohammad, K. S., Fournier, P. G. J., McKenna, C. R., Davis, H. W., Niewolna, M., Peng, X. H., Chirgwin, J. M., & Guise, T. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006896 · Cited by 212 · see citing works
Lo, J. H. T., Lau, E. Y.-T., Ching, R. H. H., Cheng, B. Y.-L., Ma, M. K. F., Ng, I. O., & Lee, T. K. (2015) · Hepatology · doi:10.1002/hep.27859 · Cited by 199 · see citing works
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response
Sitkovsky, M. V. (2009) · Trends in Immunology · doi:10.1016/j.it.2008.12.002 · Cited by 192 · see citing works
Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69244 · Cited by 181 · see citing works
Self-citationHypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer
Krishnamachary, B., Penet, M., Nimmagadda, S., Mironchik, Y., Raman, V., Solaiyappan, M., Semenza, G. L., Pomper, M. G., & Bhujwalla, Z. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044078 · Cited by 132 · see citing works
Self-citationXiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget · doi:10.18632/oncotarget.2997 · Cited by 119 · see citing works
Self-citationXiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H., & Semenza, G. L. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1102-5 · Cited by 114 · see citing works
Self-citationGene expression and hypoxia in breast cancer
Favaro, E., Lord, S., Harris, A. L., & Buffa, F. M. (2011) · Genome Medicine · doi:10.1186/gm271 · Cited by 88 · see citing works
Baccelli, I., Stenzinger, A., Vogel, V., Pfitzner, B. M., Klein, C., Wallwiener, M., Scharpff, M., Saini, M., Holland‐Letz, T., Sinn, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2385 · Cited by 86 · see citing works
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells
Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H., & Semenza, G. L. (2015) · Oncotarget · doi:10.18632/oncotarget.4190 · Cited by 73 · see citing works
Self-citationKershaw, M. H., & Smyth, M. J. (2013) · Science · doi:10.1126/science.1241716 · Cited by 39 · see citing works
Wu, X., Liu, X., Zhu, X., & Tang, C. (2007) · Shock · doi:10.1097/01.shk.0000246901.58068.a8 · Cited by 37 · see citing works
Gong, Y., Tan, W., Lin, J. M., Huang, M., Wood, C. G., & Wu, X. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-4640 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Vaupel P, Höckel M, Mayer A (2007) Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 9(8):1221-1235.
Cited by
Sorted by citations
Targeting macrophages: therapeutic approaches in cancer
Cassetta, L., & Pollard, J. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.169 · Cited by 2,057 · see citing works
Therapeutic Targeting of the Tumor Microenvironment
Bejarano, L., Jordão, M. J. C., & Joyce, J. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1808 · Cited by 1,672 · see citing works
Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works
Zhang, C., Samanta, D., Lu, H., Bullen, J. W., Zhang, H., Chen, I., He, X., & Semenza, G. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602883113 · Cited by 977 · see citing works
Self-citationHypoxia-Inducible Factors: Master Regulators of Cancer Progression
Schito, L., & Semenza, G. L. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.016 · Cited by 962 · see citing works
Self-citationPhagocytosis checkpoints as new targets for cancer immunotherapy
Feng, M., Jiang, W., Kim, B. Y. S., Zhang, C. C., Fu, Y., & Weissman, I. L. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0183-z · Cited by 914 · see citing works
Self-citationThe role of HIF in immunity and inflammation
McGettrick, A. F., & O’Neill, L. A. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.002 · Cited by 768 · see citing works
The CD47-SIRPα Immune Checkpoint
Logtenberg, M. E. W., Scheeren, F. A., & Schumacher, T. N. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.011 · Cited by 750 · see citing works
Hypoxia-inducible factors: cancer progression and clinical translation
Wicks, E. E., & Semenza, G. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159839 · Cited by 600 · see citing works
Self-citationCancer Stem Cells: The Architects of the Tumor Ecosystem
Prager, B. C., Xie, Q., Bao, S., & Rich, J. N. (2019) · Cell stem cell · doi:10.1016/j.stem.2018.12.009 · Cited by 587 · see citing works
The CD47‐SIRPα signaling axis as an innate immune checkpoint in cancer
Matlung, H. L., Szilagyi, K., Barclay, N., & van den Berg, T. K. (2017) · Immunological Reviews · doi:10.1111/imr.12527 · Cited by 563 · see citing works
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Wu, Q., Li, Y., Nepovimová, E., Heger, Z., Wu, W., Kuča, K., & Adam, V. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01292-6 · Cited by 494 · see citing works
Targeting CD47 for cancer immunotherapy
Jiang, Z., Sun, H., Yu, J., Tian, W., & Song, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01197-w · Cited by 349 · see citing works
The Role of the Extracellular Matrix in Cancer Stemness
Nallanthighal, S., Heiserman, J. P., & Cheon, D.-J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00086 · Cited by 344 · see citing works
Wang, B., Zhao, Q., Zhang, Y., Liu, Z., Zheng, Z., Liu, S., Meng, L., Xin, Y., & Jiang, X. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01820-7 · Cited by 315 · see citing works
Immunogenic effects of chemotherapy-induced tumor cell death
Wang, Y., Fletcher, R., Yu, J., & Zhang, L. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.05.003 · Cited by 316 · see citing works
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works
Samanta, D., Park, Y., Ni, X., Li, H., Zahnow, C. A., Gabrielson, E., Pan, F., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718197115 · Cited by 302 · see citing works
Self-citationEmerging phagocytosis checkpoints in cancer immunotherapy
Liu, Y., Wang, Y., Yang, Y., Weng, L., Wu, Q., Zhang, J., Zhao, P., Fang, L., Shi, Y., & Wang, P. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01365-z · Cited by 287 · see citing works
The role of hypoxia‐inducible factor 1 in tumor immune evasion
Li, Y., Wu, W., Wang, X., Fang, L., Adam, V., Nepovimová, E., Wu, Q., & Kuča, K. (2020) · Medicinal Research Reviews · doi:10.1002/med.21771 · Cited by 268 · see citing works
Functions of Immune Checkpoint Molecules Beyond Immune Evasion
Zhang, Y., & Zheng, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3266-5_9 · Cited by 267 · see citing works
Zhang, C., Zhi, W. I., Lu, H., Samanta, D., Chen, I., Gabrielson, E., & Semenza, G. L. (2016) · Oncotarget · doi:10.18632/oncotarget.11743 · Cited by 261 · see citing works
Self-citationEmerging roles of aerobic glycolysis in breast cancer
Wu, Z., Wu, J., Zhao, Q., Fu, S., & Jin, J. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02187-8 · Cited by 260 · see citing works
Hypoxia as a driver of resistance to immunotherapy
Kopecka, J., Salaroglio, I. C., Pérez-Ruiz, E., Sarmento‐Ribeiro, A. B., Saponara, S., Rivas, J. D. L., & Riganti, C. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100787 · Cited by 252 · see citing works
Hypoxia: Signaling the Metastatic Cascade
Rankin, E. B., Nam, J.-M., & Giaccia, A. J. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.05.006 · Cited by 240 · see citing works
Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment
Liu, G., Rui, W., Zhao, X., & Lin, X. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00655-2 · Cited by 241 · see citing works
Betancur, P. A., Abraham, B., Yiu, Y. Y., Willingham, S., Khameneh, F., Zarnegar, M. A., Kuo, A. H., McKenna, K., Kojima, Y., Leeper, N., et al. (2017) · Nature Communications · doi:10.1038/ncomms14802 · Cited by 221 · see citing works
Tumor hypoxia: From basic knowledge to therapeutic implications
Liao, C., Liu, X., Zhang, C., & Zhang, Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.011 · Cited by 223 · see citing works
Self-citationNoman, M. Z., Hasmim, M., Lequeux, A., Xiao, M., Duhem, C., Chouaı̈b, S., Berchem, G., & Janji, B. (2019) · Cells · doi:10.3390/cells8091083 · Cited by 215 · see citing works
Spatially fractionated radiation therapy: History, present and the future
Yan, W.-S., Khan, M. K., Wu, X.-D., Simone, C., Fan, J.-J., Gressen, E., Zhang, X., Limoli, C., Bahig, H., Tubin, S., et al. (2019) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2019.10.004 · Cited by 210 · see citing works
HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies
Zhao, Y., Xing, C., Deng, Y., Ye, C., & Peng, H. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.039 · Cited by 214 · see citing works
CD47/SIRPα pathway mediates cancer immune escape and immunotherapy
Jia, X., Yan, B., Tian, X., Liu, Q., Jin, J., Shi, J., & Hou, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60782 · Cited by 205 · see citing works
Li, Y., Patel, S. P., Roszik, J., & Qin, Y. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01591 · Cited by 197 · see citing works
Hypoxia-inducible factors and innate immunity in liver cancer
Yuen, V. W., & Wong, C. C. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137553 · Cited by 182 · see citing works
The Immunology of Hormone Receptor Positive Breast Cancer
Goldberg, J., Pastorello, R., Vallius, T., Davis, J. A., Cui, Y. X., Agudo, J., Waks, A. G., Keenan, T. E., McAllister, S. S., Tolaney, S. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674192 · Cited by 175 · see citing works
Wang, S., Wu, Q., Chen, T., Su, R., Pan, C., Qian, J., Huang, H., Yin, S., Xie, H., Zhou, L., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.011 · Cited by 167 · see citing works
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
Lu, H., Chen, I., Shimoda, L. A., Park, Y., Zhang, C., Tran, L., Zhang, H., & Semenza, G. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.001 · Cited by 168 · see citing works
Self-citationKabakov, A. E., & Yakimova, A. O. (2021) · Cancers · doi:10.3390/cancers13051102 · Cited by 155 · see citing works
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer
Zhao, H., Wang, J., Kong, X., Li, E., Liu, Y., Du, X., Kang, Z., Tang, Y. C., Kuang, Y., Yang, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep29719 · Cited by 152 · see citing works
CD47–SIRPα-targeted therapeutics: status and prospects
Maute, R. L., Xu, J., & Weissman, I. L. (2022) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2022.100070 · Cited by 152 · see citing works
Dheilly, E., Moine, V., Broyer, L., Salgado-Pires, S., Johnson, Z., Papaioannou, A., Cons, L., Calloud, S., Majocchi, S., Nelson, R. J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.11.006 · Cited by 146 · see citing works
Bian, Z., Shi, L., Guo, Y.-L., Lv, Z., Tang, C., Niu, S., Tremblay, A., Venkataramani, M., Culpepper, C. D., Li, L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521069113 · Cited by 139 · see citing works
Tumor microenvironment-mediated chemoresistance in breast cancer
Velaei, K., Samadi, N., Brazvan, B., & Rad, J. S. (2016) · The Breast · doi:10.1016/j.breast.2016.09.002 · Cited by 138 · see citing works
Role of Fcγ receptors in HER2-targeted breast cancer therapy
Musolino, A., Gradishar, W. J., Rugo, H. S., Nordstrom, J. L., Rock, E. P., Arnaldez, F. I., & Pegram, M. D. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003171 · Cited by 138 · see citing works
CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells
Lupia, M., Angiolini, F., Bertalot, G., Freddi, S., Sachsenmeier, K. F., Chisci, E., Kutryb-Zając, B. A., Confalonieri, S., Smolenski, R. T., Giovannoni, R., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.009 · Cited by 135 · see citing works
Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy
Zheng, Z., Su, J., Bao, X., Wang, H., Bian, C., Zhao, Q., & Jiang, X. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1247268 · Cited by 135 · see citing works
Augustin, R. C., Delgoffe, G. M., & Najjar, Y. G. (2020) · Cancers · doi:10.3390/cancers12123802 · Cited by 130 · see citing works
Lequeux, A., Noman, M. Z., Xiao, M., Van Moer, K., Hasmim, M., Benoit, A., Bosseler, M., Viry, E., Arakelian, T., Berchem, G., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01846-x · Cited by 129 · see citing works
Role of hypoxia in cellular senescence
Gao, H., Nepovimová, E., Heger, Z., Valko, M., Wu, Q., Kuča, K., & Adam, V. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106841 · Cited by 130 · see citing works
Maintenance of redox homeostasis by hypoxia-inducible factors
Samanta, D., & Semenza, G. L. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.022 · Cited by 127 · see citing works
Self-citationLan, J., Lu, H., Samanta, D., Salman, S., Lü, Y., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809695115 · Cited by 127 · see citing works
Self-citationHypoxic tumor microenvironment: Implications for cancer therapy
Roy, S., Kumaravel, S., Sharma, A., Duran, C. L., Bayless, K. J., & Chakraborty, S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220934038 · Cited by 127 · see citing works
Immune checkpoint inhibitor combinations: Current efforts and important aspects for success
Kon, E., & Benhar, I. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.07.004 · Cited by 121 · see citing works
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells
Kim, H., Lin, Q., Glazer, P. M., & Yun, Z. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-0944-8 · Cited by 122 · see citing works
Immunogenic cell death in colon cancer prevention and therapy
Ruan, H., Leibowitz, B. J., Zhang, L., & Yu, J. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23183 · Cited by 122 · see citing works
Boreel, D. F., Span, P. N., Heskamp, S., Adema, G. J., & Bussink, J. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3913 · Cited by 117 · see citing works
Lequeux, A., Noman, M. Z., Xiao, M., Sauvage, D., Van Moer, K., Viry, E., Bocci, I., Hasmim, M., Bosseler, M., Berchem, G., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.021 · Cited by 117 · see citing works
Tsao, L.-C., Crosby, E. J., Trotter, T. N., Agarwal, P., Hwang, B.-J., Acharya, C. R., Shuptrine, C. W., Wang, T., Wei, J.-P., Yang, X. Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131882 · Cited by 117 · see citing works
Regulation of CD47 expression in cancer cells
Huang, C.-Y., Ye, Z.-H., Huang, M., & Lu, J. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100862 · Cited by 119 · see citing works
Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia
Phung, C. D., Tran, T. H., Pham, L. M., Nguyen, H. T., Jeong, J., Yong, C. S., & Kim, J. O. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.029 · Cited by 115 · see citing works
Brooks, J. M., de Menezes, A. N., Ibrahim, M., Archer, L., Lal, N., Bagnall, C. J., von Zeidler, S. V., Valentine, H. R., Spruce, R. J., Batis, N., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3314 · Cited by 109 · see citing works
Putting the brakes on phagocytosis: “don't-eat-me” signaling in physiology and disease
Kelley, S. M., & Ravichandran, K. S. (2021) · EMBO Reports · doi:10.15252/embr.202152564 · Cited by 110 · see citing works
Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity
Terry, S., Buart, S., & Chouaı̈b, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01625 · Cited by 111 · see citing works
Hu, H., Cheng, R., Wang, Y., Wang, X., Wu, J., Kong, Y., Zhan, S., Zhou, Z., Zhu, H., Yu, R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153470 · Cited by 110 · see citing works
Self-citationCD133, Selectively Targeting the Root of Cancer
Schmohl, J., & Vallera, D. A. (2016) · Toxins · doi:10.3390/toxins8060165 · Cited by 109 · see citing works
Kaur, S., ELKAHLOUN, A. G., SINGH, S. P., Chen, Q., Meerzaman, D. M., Song, T., Manu, N., Wu, W., Mannan, P., Garfield, S. H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7100 · Cited by 108 · see citing works
Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy
Ma, Z., Wang, L. Z., Cheng, J.-T., Lam, S. T., Ma, X., Xiang, X., Wong, A. L., Goh, B. C., Gong, Q., Sethi, G., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7935 · Cited by 102 · see citing works
Current Progresses and Challenges of Immunotherapy in Triple-Negative Breast Cancer
Mediratta, K., El‐Sahli, S., D’Costa, V. M., & Wang, L. (2020) · Cancers · doi:10.3390/cancers12123529 · Cited by 102 · see citing works
Targeting CD47 in Sézary syndrome with SIRPαFc
Johnson, L. D. S., Banerjee, S., Kruglov, O., Viller, N. N., Horwitz, S. M., Lesokhin, A. M., Zain, J. M., Querfeld, C., Chen, R., Okada, C. Y., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018030577 · Cited by 99 · see citing works
Hypoxia-driven intratumor heterogeneity and immune evasion
Terry, S., Engelsen, A. S. T., Buart, S., El‐Sayed, W., Venkatesh, G. H., & Chouaı̈b, S. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.07.004 · Cited by 100 · see citing works
Liu, Y., Wu, J., Huang, W., Weng, S., Wang, B., Chen, Y., & Wang, H. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02366-0 · Cited by 98 · see citing works
Engineering macrophages to phagocytose cancer cells by blocking the CD47/SIRPɑ axis
Yang, H., Shao, R., Huang, H., Wang, X., Rong, Z., & Lin, Y. (2019) · Cancer Medicine · doi:10.1002/cam4.2332 · Cited by 95 · see citing works
Liu, X., Xie, P., Hao, N., Zhang, M., Liu, Y., Liu, P., Semenza, G. L., He, J., & Zhang, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2109144118 · Cited by 93 · see citing works
Self-citationMitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis
Wu, H., Wang, T., Liu, Y., Li, X., Xu, S., Wu, C., Zou, H., Cao, M., Jin, G., Lang, J., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01768-8 · Cited by 91 · see citing works
Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity
Terry, S., Zaarour, R. F., Venkatesh, G. H., Francis, A., El‐Sayed, W., Buart, S., Bravo, P. E., Thiery, J., & Chouaı̈b, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103044 · Cited by 86 · see citing works
Regulation of cancer stem cells in triple negative breast cancer
Fultang, N., Chakraborty, M., & Peethambaran, B. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.106 · Cited by 95 · see citing works
Mahara, S., Lee, P. L., Feng, M., Tergaonkar, V., Chng, W. J., & Yu, Q. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602079113 · Cited by 87 · see citing works
CD47: the next checkpoint target for cancer immunotherapy
Feng, R., Hai, Z., Xu, J., & Shen, C. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103014 · Cited by 86 · see citing works
Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade
Choi, Y., Seok, S. H., Yoon, H. Y., Ryu, J. H., & Kwon, I. C. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115306 · Cited by 89 · see citing works
Role of hypoxia inducible factor-1 in cancer stem cells (Review)
Zhang, Q., Han, Z., Zhu, Y., Chen, J., & Li, W. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11655 · Cited by 86 · see citing works
Elanany, M. M., Mostafa, D., & Hamdy, N. Μ. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121997 · Cited by 85 · see citing works
Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy
Khouzam, R. A., Venkatesh, G. H., Zaarour, R. F., Chamseddine, A. N., Francis, A., Buart, S., Terry, S., & Chouaı̈b, S. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.01.003 · Cited by 82 · see citing works
Recent Advances in Cancer Stem Cell-Targeted Immunotherapy
Badrinath, N., & Yoo, S. Y. (2019) · Cancers · doi:10.3390/cancers11030310 · Cited by 83 · see citing works
Deshmukh, S. K., Srivastava, S. K., Poosarla, T., Dyess, D. L., Holliday, N. P., Singh, A. P., & Singh, S. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.68 · Cited by 83 · see citing works
Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma
Grégoire, H., Roncali, L., Rousseau, A., Chérel, M., Delneste, Y., Jeannin, P., Hindré, F., & Garcion, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00368 · Cited by 72 · see citing works
Deciphering the role of CD47 in cancer immunotherapy
Liu, Y., Weng, L., Wang, Y., Zhang, J., Wu, Q., Zhao, P., Shi, Y., Wang, P., & Fang, L. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.10.009 · Cited by 83 · see citing works
Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia
Huang, X., Zhuang, J., Chung, S. W., Huang, B., Halpert, G., Negrón, K., Sun, X., Yang, J., Oh, Y., Hwang, P. M., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b05399 · Cited by 82 · see citing works
Noman, M. Z., Moer, K. V., Marani, V., Gemmill, R. M., Tranchevent, L.-C., Azuaje, F. J., Muller, A., Chouaı̈b, S., Thiery, J. P., Berchem, G., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1345415 · Cited by 79 · see citing works
3D culture technologies of cancer stem cells: promising ex vivo tumor models
Zhang, C., Yang, Z., Dong, D.-L., Jang, T., Knowles, J. C., Kim, H., Jin, G., & Xuan, Y. (2020) · Journal of Tissue Engineering · doi:10.1177/2041731420933407 · Cited by 79 · see citing works
Self-citationTumor cell-associated immune checkpoint molecules – Drivers of malignancy and stemness
Marcucci, F., Rumio, C., & Corti, A. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.10.006 · Cited by 80 · see citing works
Artificial Natural Killer Cells for Specific Tumor Inhibition and Renegade Macrophage Re‐Education
Zou, M., Liu, W., Gao, F., Bai, X., Chen, H., Zeng, X., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201904495 · Cited by 76 · see citing works
Radiotherapy: An immune response modifier for immuno-oncology
Martino, M. D., Daviaud, C., & Vanpouille‐Box, C. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101474 · Cited by 76 · see citing works
You, L., Zhao, Y., Kuča, K., Wang, X., Olekšák, P., Chrienová, Ž., Nepovimová, E., Jacevic, V. M., Wu, Q., & Wu, W. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03030-2 · Cited by 77 · see citing works
The development of small-molecule inhibitors targeting CD47
Yu, W., Ye, Z.-H., Chen, X., Shi, J.-J., & Lu, J. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.003 · Cited by 74 · see citing works
Li, Y., Lu, S., Xu, Y., Qiu, C., Jin, C., Wang, Y., Liu, Z., & Kong, B. (2017) · PubMed Central · Cited by 74 · see citing works
Warburg effect, lactate dehydrogenase, and radio/chemo-therapy efficacy
Koukourakis, M. I., & Giatromanolaki, A. N. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1490041 · Cited by 73 · see citing works
The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy
Li, Z., Li, Y., Gao, J., Fu, Y., Hua, P., Jing, Y., Cai, M., Wang, H., & Tong, T. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119150 · Cited by 73 · see citing works
(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2018.11.001 · Cited by 71 · see citing works
Self-citationHypoxia-Induced Phenotypes that Mediate Tumor Heterogeneity
Qian, J., & Rankin, E. B. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12734-3_3 · Cited by 71 · see citing works
Cellular Plasticity in Breast Cancer Progression and Therapy
Kong, D., Hughes, C. J., & Ford, H. L. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00072 · Cited by 67 · see citing works
- Authors
- Zhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L.
- Affiliations
- Johns Hopkins University (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-10-28
- Volume
- 112
- Issue
- 45
- Pages
- E6215-23
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4653179
- OpenAlex
- W1853160207
- Cited by
- 420
- References
- 62
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 62 · 2023: 46 · 2022: 57 · 2021: 48 · 2020: 52 · 2019: 29 · 2018: 31 · 2017: 17 · 2016: 21 · 2015: 1
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-09-25)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society (122437-RP-12-090-01-COUN)
- U.S. Department of Defense (W81XWH-12-1-0464)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- HIF-1, CD47, breast cancer, phagocytosis evasion, macrophages, cancer stem cells, hypoxia, transcriptional regulation, mammospheres, patient mortality, prognostic factors
- MeSH terms
- Analysis of Variance, Breast Neoplasms, Female, Humans, Luciferases, Phagocytosis, Neoplastic Stem Cells, Immunoblotting, Gene Expression Regulation, Neoplastic, DNA Primers, Tumor Escape, RNA, Small Interfering, Cell Line, Tumor, Chromatin Immunoprecipitation, Hypoxia-Inducible Factor 1, CD47 Antigen, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
