The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Expression of Wnt-5a Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion
Open accessAbstract
Wnt-5a is a representative ligand that activates a β-catenin-independent pathway in the Wnt signaling. Although abnormal activation of β-catenin-dependent pathway is often observed in human cancer, the relationship between β-catenin-independent pathway and tumorigenesis is not clear. We sought to clarify how Wnt-5a is involved in aggressiveness of gastric cancer. Abnormal expression of Wnt-5a was observed in 71 of 237 gastric cancer cases by means of immunohistochemistry. The positivity of Wnt-5a expression was correlated with advanced stages and poor prognosis of gastric cancer. Wnt-5a had the abilities to stimulate cell migration and invasion in gastric cancer cells. Wnt-5a activated focal adhesion kinase and small GTP-binding protein Rac, both of which are known to play a role in cell migration. Cell migration, membrane ruffling, and turnover of paxillin were suppressed in Wnt-5a knockdown cells. Furthermore, anti-Wnt-5a antibody suppressed gastric cancer cell migration. These results suggest that Wnt-5a stimulates cell migration by regulating focal adhesion complexes and that Wnt-5a is not only a prognostic factor but also a good therapeutic target for gastric cancer. (Cancer Res 2006; 66(21): 10439-48)
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Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
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Focal adhesion kinase: the first ten years
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Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
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Cited by
WNT signalling pathways as therapeutic targets in cancer
Anastas, J. N., & Moon, R. T. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3419 · Cited by 1,911
Signaling pathways and therapeutic interventions in gastric cancer
Lei, Z.-N., Teng, Q.-X., Tian, Q., Chen, W., Xie, Y., Wu, K., Zeng, Q., Zeng, L., Pan, Y., Chen, Z.-S., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01190-w · Cited by 322
Convergence between Wnt-β-catenin and EGFR signaling in cancer
Hu, T., & Li, C. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-236 · Cited by 291
WNT as a Driver and Dependency in Cancer
Parsons, M. J., Tammela, T., & Dow, L. E. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0190 · Cited by 257
Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer
Amado, N. G., Fonseca, B. F., Cerqueira, D. M., Neto, V. M., & Abreu, J. G. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.003 · Cited by 125
Metadata
- Authors
- Kurayoshi, M., Oue, N., Yamamoto, H., Kishida, M., Inoue, A., Asahara, T., Yasui, W., & Kikuchi, A.
- Venue
- Cancer Research
- Published
- 2006-11-01
- Volume
- 66
- Issue
- 21
- Pages
- 10439-10448
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2099011309
- Cited by
- 451
- References
- 41
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kurayoshi, M., Oue, N., Yamamoto, H., Kishida, M., Inoue, A., Asahara, T., Yasui, W., & Kikuchi, A. (2006). Expression of Wnt-5a Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion. Cancer Research. https://doi.org/10.1158/0008-5472.can-06-2359
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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