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Cited by 125Wnt/β-catenin signaling in development and cancerFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer

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Amado, Nathália G., Fonseca, Bárbara F., Cerqueira, Débora M., Neto, Vivaldo Moura, Abreu, José G.·2011·Life Sciences
DOI 10.1016/j.lfs.2011.05.003
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Abstract

Flavonoids are polyphenolic compounds found throughout the plant kingdom. They occur in every organ but are usually concentrated in leaves and flowers. During the last two decades, in vitro and in vivo studies demonstrated that flavonoids have inhibitory effects on human diseases through targeting of multiple cellular signaling components. Wnt/β-catenin signaling regulates proliferation, differentiation and fate specification in developmental stages and controls tissue homeostasis in adult life. For these reasons, this pathway has received great attention in the last years as potential pathway involved in distinct Human pathologies. In this review we discuss the emerging potential mechanisms for flavonoids on Wnt/β-catenin signaling in cancer and possible investigation strategies to understand flavonoids mode of action on this signaling pathway.

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  • A second meta-analysis found no significant effects from soy on breast density, also considered a surrogate of breast cancer risk.

    “A second meta analysis similarly found no significant effects from soy on breast density, also considered a surrogate of breast cancer risk [183].”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [183]

    The 'Cancer targeting by flavonoids' section discusses soy-derived genistein and possible breast-cancer-preventive activity, but not breast density. Searches for a soy meta-analysis and mammographic density found no passage reporting an effect on breast density or identifying it as a surrogate for breast cancer risk. Page numbers were not available in our copy. (LLM, conf=0.72)

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Cited by

Sorted by citations

Authors
Amado, N. G., Fonseca, B. F., Cerqueira, D. M., Neto, V. M., & Abreu, J. G.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
Corresponding author
Abreu, José G.
ORCID
Venue
Life Sciences
Publisher
Elsevier BV
Published
2011-10
Volume
89
Issue
15-16
Pages
545-554
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/j.lfs.2011.05.003
OpenAlex
W2047995701
Cited by
125
References
4
Citations by year
2026: 3 · 2025: 10 · 2024: 13 · 2023: 5 · 2022: 12 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 5
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • FAPERJ (Cientista do Nosso Estado)
  • CNPq
  • CAPES
  • National Institute of Technology for Translational Neuroscience
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
flavonoids, Wnt/β-catenin signaling, cancer, polyphenols, signaling pathway modulation, tumor cell proliferation, tissue homeostasis, mechanism of action
MeSH terms
Animals, Flavonoids, Humans, Neoplasms, Plants, Signal Transduction, Wnt Proteins, beta Catenin

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