The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse
Abstract
Current dogma suggests that the positive correlation between obesity and cancer is driven by white adipose tissue that accompanies obesity, possibly through excess secretion of adipokines. Recent studies in fatless A-Zip/F1 mice, which have undetectable adipokine levels but display accelerated tumor formation, suggest that adipokines are not required for the enhanced tumor development. The A-Zip/F-1 mice are also diabetic and display elevated circulating levels of other factors frequently associated with obesity (insulin, insulin-like growth factor-1, and proinflammatory cytokines) and activation of several signaling pathways associated with carcinogenesis. In view of this information, the risk factors underlying the obesity-cancer link need to be revisited. We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link. [Cancer Res 2007;67(6):2391–3]
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“Elevated inflammatory proteins in obese individuals [1] suggest that inflammation may play a determinant role in connecting obesity to metabolic, hepatic and cardiovascular diseases [2], and to some cancers [3].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [3]
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Cites
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Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330
Lee, J. A. H. (1986) · JAMA · doi:10.1001/jama.1986.03370120114036 · Cited by 2,252
Targeting the PI3K-Akt pathway in human cancer
Luo, J., Manning, B. D., & Cantley, L. C. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00248-4 · Cited by 1,290
El‐Serag, H. B., Hampel, H., & Javadi, F. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2005.12.007 · Cited by 831
Life without white fat: a transgenic mousePreprint
Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776
Self-citationBråkenhielm, E., Veitonmäki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T., & Cao, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308671100 · Cited by 736
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Metabolic Transformation of Normal Human Melanocytes Under Extracellular Stimuli
Demidem, A., Morvan, D., Steyaert, J. M., Israël, M., & Schwartz, L. H. (2012) · HAL
Normal Human Melanocytes Exposed to Chronic Insulin and Glucose
Morvan, D., Steyaert, J. M., Schwartz, L. H., Maurice, & Demidem, A. (2012)
20. A growing risk in a growing population: obesity's impact on leukemia incidence and survival
Orgel, E. (2016) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-822-3_20
The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment
Chang, J., & Dudley, A. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-39147-2_6
Effect of Antrodia cinnamomea Powder on Obesity in High-Fat Diet-Induced Rats
张, 晓. (2017) · Hans Journal of Food and Nutrition Science · doi:10.12677/hjfns.2017.64031
Ahmed, F. (2009) · CRC Press eBooks · doi:10.1201/9781420066029.ch17
The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms
Gallagher, E. J., Neel, B. A., Antoniou, I. M., & LeRoith, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_36-1
Neuhouser, M. L., Till, C., Kristal, A. R., Goodman, P. J., Hoque, A. M., Platz, E. A., Hsing, A. W., Albanes, D., Parnes, H. L., & Pollak, M. (2023) · doi:10.1158/1940-6207.c.6544538
Codimension-1,2 bifurcation analysis of glucose model with obesity effect
Rabo, M. M. A., Mahmoud, G. M., Aly, S., & Abed‐Elhameed, T. M. (2024) · International Journal of Biomathematics · doi:10.1142/s1793524524500463
Vascular Targeting of Adipose Tissue
Salameh, A., & Kolonin, M. G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_15
Metadata
- Authors
- Hursting, S. D., Nunez, N. P., Varticovski, L., & Vinson, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- 1Division of Nutritional Sciences, University of Texas, Austin, Texas;
- 3Laboratory of Human Carcinogenesis and
- National Institutes of Health (US)
- Venue
- Cancer Research
- Published
- 2007-03-15
- Volume
- 67
- Issue
- 6
- Pages
- 2391-2393
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2155243001
- Cited by
- 110
- References
- 20
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 15
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01co12400-79-0-22)
- National Cancer Institute (N01CO12400)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- obesity, cancer, adipokines, white adipose tissue, tumor formation, insulin resistance, inflammation, insulin-like growth factor I, inflammatory cytokines
- MeSH terms
- Animals, Disease Models, Animal, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Mammary Neoplasms, Experimental, Neoplasms, Obesity, Signal Transduction, Mice
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