Cited by 110Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsCancer, Lipids, and Metabolism

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The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse

Hursting, Stephen D., Nunez, Nomeli P., Varticovski, Lyuba, Vinson, Charles·2007·Cancer Research

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Abstract

Current dogma suggests that the positive correlation between obesity and cancer is driven by white adipose tissue that accompanies obesity, possibly through excess secretion of adipokines. Recent studies in fatless A-Zip/F1 mice, which have undetectable adipokine levels but display accelerated tumor formation, suggest that adipokines are not required for the enhanced tumor development. The A-Zip/F-1 mice are also diabetic and display elevated circulating levels of other factors frequently associated with obesity (insulin, insulin-like growth factor-1, and proinflammatory cytokines) and activation of several signaling pathways associated with carcinogenesis. In view of this information, the risk factors underlying the obesity-cancer link need to be revisited. We postulate that the pathways associated with insulin resistance and inflammation, rather than adipocyte-derived factors, may represent key prevention and therapeutic targets for disrupting the obesity-cancer link. [Cancer Res 2007;67(6):2391–3]

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Authors: Hursting, S. D., Nunez, N. P., Varticovski, L., & Vinson, C.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
1Division of Nutritional Sciences, University of Texas, Austin, Texas;
3Laboratory of Human Carcinogenesis and
National Institutes of Health (US)
ORCID: Hursting, Stephen D.
Varticovski, Lyuba
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2007-03-15
Volume: 67
Issue: 6
Pages: 2391-2393
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-06-4237
OpenAlex: W2155243001
Cited by: 110
References: 20
Citations by year: 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 15
FWCI: 7.34
Type: journal article
Language: en
Open access: closed
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01co12400-79-0-22)
National Cancer Institute (N01CO12400)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: obesity, cancer, adipokines, white adipose tissue, tumor formation, insulin resistance, inflammation, insulin-like growth factor I, inflammatory cytokines
MeSH terms: Animals, Disease Models, Animal, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Mammary Neoplasms, Experimental, Neoplasms, Obesity, Signal Transduction, Mice

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The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse

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