Cited by 220Cell Adhesion Molecules ResearchEffects of Radiation ExposurePI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

Open access

Park, Catherine C., Zhang, Hui J., Yao, Evelyn S., Park, Chong J., Bissell, Mina J.·2008·Cancer Research

DOI 10.1158/0008-5472.can-07-6390PMC PMC3719863

Open this paper in CoChat — free account Open PDF

Abstract

β1 Integrin signaling has been shown to mediate cellular resistance to apoptosis after exposure to ionizing radiation (IR). Other signaling molecules that increase resistance include Akt, which promotes cell survival downstream of β1 integrin signaling. We previously showed that β1 integrin inhibitory antibodies (e.g., AIIB2) enhance apoptosis and decrease growth in human breast cancer cells in three-dimensional laminin-rich extracellular matrix (lrECM) cultures and in vivo. Here, we asked whether AIIB2 could synergize with IR to modify Akt-mediated IR resistance. We used three-dimensional lrECM cultures to test the optimal combination of AIIB2 with IR treatment of two breast cancer cell lines, MCF-7 and HMT3522-T4-2, as well as T4-2 myr-Akt breast cancer colonies or HMT3522-S-1, which form normal organotypic structures in three-dimensional lrECM. Colonies were assayed for apoptosis and β1 integrin/Akt signaling pathways were evaluated using Western blot. In addition, mice bearing MCF-7 xenografts were used to validate the findings in three-dimensional lrECM. We report that AIIB2 increased apoptosis optimally post-IR by down-regulating Akt in breast cancer colonies in three-dimensional lrECM. In vivo, addition of AIIB2 after IR significantly enhanced tumor growth inhibition and apoptosis compared with either treatment alone. Remarkably, the degree of tumor growth inhibition using AIIB2 plus 2 Gy radiation was similar to that of 8 Gy alone. We previously showed that AIIB2 had no discernible toxicity in mice; here, its addition allowed for a significant reduction in the IR dose that was necessary to achieve comparable growth inhibition and apoptosis in breast cancer xenografts in vivo. [Cancer Res 2008;68(11):4398–405]

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-07-6390

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Integrin signaling
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483
Self-citation
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
Werb, Z., Tremble, P., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.877 · Cited by 1,057
Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
Damiano, J. S., Cress, A. E., Hazlehurst, L., Shtil, A. A., & Dalton, W. S. (1999) · Blood · doi:10.1182/blood.v93.5.1658 · Cited by 899
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Brognard, J., Clark, A. S., Ni, Y., & Dennis, P. A. (2001) · PubMed · Cited by 885
The Akt-mTOR tango and its relevance to cancer
Hay, N. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.008 · Cited by 826
β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00125-3 · Cited by 794
Self-citation
Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., & Bissell, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14821 · Cited by 653
Self-citation
Outcome at 8 Years After Breast-Conserving Surgery and Radiation Therapy for Invasive Breast Cancer: Influence of Margin Status and Systemic Therapy on Local Recurrence
Park, C. C., Mitsumori, M., Nixon, A. J., Recht, A., Connolly, J. L., Gelman, R. S., Silver, B., Hetelekidis, S., Abner, A. L., Harris, J. R., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1668 · Cited by 547
Self-citation
Radiation and the microenvironment – tumorigenesis and therapy
Barcellos‐Hoff, M. H., Park, C., & Wright, E. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1735 · Cited by 513
Self-citation
The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.
Hall, D. E., Reichardt, L. F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., & Damsky, C. H. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2175 · Cited by 376
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
Aoudjit, F., & Vuori, K. (2001) · Oncogene · doi:10.1038/sj.onc.1204554 · Cited by 336
β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo
Park, C. C., Zhang, H., Pallavicini, M., Gray, J. W., Baehner, F., Park, C. J., & Bissell, M. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3071 · Cited by 326
Self-citation
Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt
Kohn, A. D., Barthel, A., Kovacina, K. S., Boge, A., Wallach, B. J., Summers, S. A., Birnbaum, M. J., Scott, P., Lawrence, J. C., & Roth, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11937 · Cited by 304
A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium
Briand, P., PETERSEN, O. W., & van Deurs, B. (1987) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623578 · Cited by 241
Increased β1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer
Yao, E. S., Zhang, H., Chen, Y., Lee, B., Chew, K., Moore, D. A., & Park, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2768 · Cited by 227
Self-citation
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells
Liu, H. S., Radisky, D. C., Wang, F., & Bissell, M. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200306090 · Cited by 222
Self-citation
Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · University of North Texas Digital Library (University of North Texas) · doi:10.1016/s1535-6108%2802%2900125-3 · Cited by 208
Self-citation
Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and γ-irradiation
Damiano, J., Hazlehurst, L., & Dalton, W. (2001) · Leukemia · doi:10.1038/sj.leu.2402179 · Cited by 197
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002
Gupta, A., Cerniglia, G. J., Mick, R., Ahmed, M. S., Bakanauskas, V. J., Muschel, R. J., & McKenna, W. G. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(03)00214-1 · Cited by 184
Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines
Kim, I., Bae, S.-S., Fernandes, A., Wu, J., Muschel, R. J., McKenna, W. G., Birnbaum, M. J., & Bernhard, E. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0513 · Cited by 179
Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagen.
Tomaselli, K. J., Damsky, C. H., & Reichardt, L. F. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.3.1241 · Cited by 166
β1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury
Cordes, N., Seidler, J. F., Durzok, R., Geinitz, H., & Brakebusch, C. (2005) · Oncogene · doi:10.1038/sj.onc.1209164 · Cited by 155
Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.
Edwards, E., Geng, L., Tan, J., Onishko, H. M., Donnelly, E. F., & Hallahan, D. E. (2002) · PubMed · Cited by 152
ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through β1 integrin-dependent activation of PI3-kinase
Hodkinson, P. S., Elliott, T., Wong, W. S., Rintoul, R. C., MacKinnon, A. C., Haslett, C., & Sethi, T. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401849 · Cited by 144
Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels
Hallahan, D. E., Geng, L., Qu, S., Scarfone, C., Giorgio, T. D., Donnelly, E. F., Gao, X., & Clanton, J. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00238-6 · Cited by 134
Cell Adhesion-Mediated Radioresistance (CAM-RR) Extracellular Matrix-Dependent Improvement of Cell Survival in Human Tumor and Normal Cells in Vitro
Cordes, N., & Meineke, V. (2003) · Strahlentherapie und Onkologie · doi:10.1007/s00066-003-1074-4 · Cited by 130
Phosphatidylinositol 3-Kinase Inhibition by LY294002 Radiosensitizes Human Cervical Cancer Cell Lines
Lee, C. M., Fuhrman, C. B., Planelles, V., Peltier, M. R., Gaffney, D. K., Soisson, A. P., Dodson, M. K., Tolley, H. D., Green, C. L., & Zempolich, K. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1084 · Cited by 128
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Liang, K., Jin, W., Knuefermann, C., Schmidt, M., Mills, G. B., Ang, K. K., Milas, L., & Fan, Z. (2003) · PubMed · Cited by 110
It Takes a Tissue to Make a Tumor: Epigenetics, Cancer and the Microenvironment
Barcellos‐Hoff, M. H. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1011317009329 · Cited by 106
Activation of Bak and Bax through c-Abl-Protein Kinase Cδ-p38 MAPK Signaling in Response to Ionizing Radiation in Human Non-small Cell Lung Cancer Cells
Choi, S.-Y., Kim, M., Kang, C., Bae, S., Cho, C.-K., Soh, J., Kim, J., Kang, S., Chung, H. Y., Lee, Y., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512000200 · Cited by 93
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
Nakamura, J. L., Karlsson, A., Arvold, N. D., GOTTSCHALK, A. R., Pieper, R. O., Stokoe, D., & Haas-Kogan, D. A. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-004-1718-y · Cited by 90
Ionizing radiation induces up-regulation of functional β 1-integrin in human lung tumour cell lines in vitro
Cordes, N., Bläse, M., Meineke, V., & Beuningen, D. V. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000110117340 · Cited by 87
Ionizing radiation induces heritable disruption of epithelial cell interactions
Park, C. C., Henshall-Powell, R. L., Erickson, A., Talhouk, R., Parvin, B., Bissell, M. J., & Barcellos‐Hoff, M. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832185100 · Cited by 71
Self-citation
Irradiation induces increase of adhesion molecules and accumulation of β2-integrin-expressing cells in humans
Handschel, J. G., Prott, F., Sunderkötter, C. H., Metze, D., Meyer, U., & Joos, U. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00202-3 · Cited by 65
Radiation-Induced Increase in Expression of the α IIb β 3 Integrin in Melanoma Cells: Effects on Metastatic Potential
Onoda, J. M., Piechocki, M. P., & Honn, K. V. (1992) · Radiation Research · doi:10.2307/3578372 · Cited by 59
Differential Activation of the Phosphatidylinositol 3′-Kinase/Akt Survival Pathway by Ionizing Radiation in Tumor and Primary Endothelial Cells
Zingg, D., Riesterer, O., Fabbro, D., Glanzmann, C., Bodis, S. B., & Pruschy, M. N. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3369 · Cited by 54
Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways
Choi, J.-A., Park, M.-T., Kang, C.-M., Um, H., Bae, S., Lee, K.-H., Kim, T., Kim, J., Cho, C.-K., Lee, Y., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1206982 · Cited by 53
A mechanism of drug resistance to tamoxifen in breast cancer
Schafer, J. M., Bentrem, D. J., Takei, H., Gajdos, C., Badve, S., & Jordan, V. C. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00251-0 · Cited by 41
Cellular expression of integrin-? is of critical importance for inducing therapeutic angiogenesis by cell implantation
Li, T., Ito, H., HAYASHI, M., Furutani, A., Matsuzaki, M., & Hamano, K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.019 · Cited by 36
The role of β1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance
Morozevich, G. E., Kozlova, N. I., Preobrazhenskaya, M. E., Ушакова, Н. А., Eltsov, I. A., Shtil, A. A., & Berman, A. E. (2006) · Biochemistry (Moscow) · doi:10.1134/s000629790605004x · Cited by 30
Interactions of the integrin subunit β1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival
Seidler, J., Durzok, R., Brakebusch, C., & Cordes, N. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.018 · Cited by 25

Sorted by citations

The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144
Tumor microenvironment and therapeutic response
Wu, T., & Dai, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.01.043 · Cited by 1,802
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,584
Self-citation

See all 220

Authors: Park, C. C., Zhang, H. J., Yao, E. S., Park, C. J., & Bissell, M. J.
Affiliations: University of California, San Francisco (US)
Lawrence Berkeley National Laboratory (US)
ORCID: Park, Catherine C.
Bissell, Mina J.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2008-06-01
Volume: 68
Issue: 11
Pages: 4398-4405
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-07-6390
PMC: PMC3719863
OpenAlex: W1968324001
Cited by: 220
References: 43
Citations by year: 2026: 6 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 9 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 20 · 2013: 19 · 2012: 18
FWCI: 8.20
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
University of North Texas Digital Library (University of North Texas) (submittedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders: U.S. Department of Defense (DE-AC02-05CH11231)
U.S. Department of Energy (-AC02-05CH11231, DE-AC03-?, AC03-76SF00098, DEAC03-76SF00098, 05CH11231, DE AC02 05CH11231, DE-AC02-)
National Institutes of Health (DE-AC02–05CH11231, NIH P50, DE-AC03- 76SF00098)
University of California, San Francisco
National Cancer Institute (R01CA124891, CA64786-09, CA-58207, R37CA064786, P50CA058207, R01CA064786, CA CA58207-08, DE-AC02-05CH11231)
Biological and Environmental Research (05CH11231, DE-AC02 − 05CH11231, AC02-05CH11231)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: beta1 integrin, radiotherapy, breast cancer, Akt signaling, radioresistance (biology), apoptosis, MCF-7 xenografts, tumor growth inhibition, radiosensitization
MeSH terms: Breast, Breast Neoplasms, Cell Line, Cell Separation, Humans, Transplantation, Heterologous, Blotting, Western, Treatment Outcome, Apoptosis, Microscopy, Confocal, Integrin beta1, In Situ Nick-End Labeling, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks