Helicobacter pylori Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway In vitro and In vivo

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790 · see citing works

Pathogenesis of <i>Helicobacter pylori</i> Infection

Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526 · see citing works

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,809 · see citing works

Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China

Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T., Feng, R. E., Lai, K. C., Hu, W. H. C., Yuen, S. T., Leung, S. Y., et al. (2004) · JAMA · doi:10.1001/jama.291.2.187 · Cited by 1,436 · see citing works

Oncogenic mechanisms of the Helicobacter pylori CagA protein

Hatakeyama, M. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1433 · Cited by 756 · see citing works

Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003) · Science · doi:10.1126/science.1081919 · Cited by 739 · see citing works

Helicobacter infection and gastric neoplasia

Peek, R. M., & Crabtree, J. E. (2005) · The Journal of Pathology · doi:10.1002/path.1868 · Cited by 549 · see citing works

Activation of β-catenin by carcinogenic Helicobacter pylori

Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U. S., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L. S., Perez-Perez, G. I., Hatakeyama, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504927102 · Cited by 479 · see citing works

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474 · see citing works

c‐Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs

Stein, M., Bagnoli, F., Halenbeck, R., Rappuoli, R., Fantl, W. J., & Covacci, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02781.x · Cited by 439 · see citing works

Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

Jiang, Z., Mak, T. W., Sen, G. C., & Li, X. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308496101 · Cited by 388 · see citing works

Grb2 Is a Key Mediator of Helicobacter pylori CagA Protein Activities

Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R., & Sasakawa, C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00681-0 · Cited by 367 · see citing works

<i>Helicobacter pylori</i> CagA protein targets the c-Met receptor and enhances the motogenic response

Churin, Y., Al-Ghoul, L., Kepp, O., Meyer, T. F., Birchmeier, W., & Naumann, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208039 · Cited by 354 · see citing works

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells

Kanda, N., Seno, H., Konda, Y., Marusawa, H., Kanai, M., Nakajima, T., Kawashima, T., Nanakin, A., Sawabu, T., Uenoyama, Y., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207606 · Cited by 302 · see citing works

Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors

Franco, A. T., Johnston, E., Krishna, U. S., Yamaoka, Y., Israel, D. A., Nagy, T. A., Wroblewski, L. E., Piazuelo, M. B., Correa, P., & Peek, R. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-0824 · Cited by 278 · see citing works

CD25+/Foxp3+ T Cells Regulate Gastric Inflammation and Helicobacter pylori Colonization In Vivo

Rad, R., Brenner, L., Bauer, S., Schwendy, S., Layland, L. E., da Costa, C. P., Reindl, W., Dossumbekova, A., Friedrich, M., Saur, D., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.001 · Cited by 272 · see citing works

Mucosal FOXP3 -Expressing CD4 + CD25 high Regulatory T Cells in Helicobacter pylori -Infected Patients

Lundgren, A., Strömberg, E., Sjöling, Å., Lindholm, C., Enarsson, K., Edebo, A., Johnsson, E., Suri‐Payer, E., Larsson, P., Rudin, A., et al. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.523-531.2005 · Cited by 268 · see citing works

Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells

Bagnoli, F., Buti, L., Tompkins, L. S., Covacci, A., & Amieva, M. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502598102 · Cited by 267 · see citing works

Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase

Li, X.-X., Commane, M., Burns, C., Vithalani, K. K., Cao, Z.-D., & Stark, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4643 · Cited by 253 · see citing works

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling

Regis, G., Pensa, S., Boselli, D., Novelli, F., & Poli, V. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.06.004 · Cited by 237 · see citing works

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130

Judd, L. M., Alderman, B. M., Howlett, M., Shulkes, A., Dow, C., Moverley, J., Grail, D., Jenkins, B. J., Ernst, M., & Giraud, A. S. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.066 · Cited by 180 · see citing works

STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis

Judd, L. M., Bredin, K., Kalantzis, A., Jenkins, B. J., Ernst, M., & Giraud, A. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.018 · Cited by 127 · see citing works

Augmented gp130‐mediated cytokine signalling accompanies human gastric cancer progression

Cb, J., Judd, L. M., Menheniott, T. R., Kronborg, I., Dow, C., Yeomans, N. D., Boussioutas, A., Robb, L. G., & Giraud, A. (2007) · The Journal of Pathology · doi:10.1002/path.2218 · Cited by 117 · see citing works

Roles of Interleukin‐6 in Activation of STAT Proteins and Recruitment of Neutrophils duringEscherichia coliPneumonia

Jones, M. R., Quinton, L. J., Simms, B. T., Lupa, M. M., Kogan, M. S., & Mizgerd, J. P. (2006) · The Journal of Infectious Diseases · doi:10.1086/499312 · Cited by 104 · see citing works

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Chatterjee, M., Hönemann, D., Lentzsch, S., Bommert, K., Sers, C., Herrmann, P., Mathas, S., Dörken, B., & Bargou, R. C. (2002) · Blood · doi:10.1182/blood-2002-01-0102 · Cited by 100 · see citing works

Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense

Kao, J. Y., Rathinavelu, S., Eaton, K. A., Bai, L., Zavros, Y. L., Takami, M. S., Pierzchala, A., & Merchant, J. L. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00139.2005 · Cited by 85 · see citing works

Membrane-associated STAT3 and PY-STAT3 in the Cytoplasm

Shah, M., Patel, K., Mukhopadhyay, S., Xu, F., Guo, G. G., & Sehgal, P. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508527200 · Cited by 75 · see citing works

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.

Stuhlmann-Laeisz, C., Lang, S., Chalaris, A., Krzysztof, P., Enge, S., Eichler, J., Klingmüller, U., Samuel, M., Ernst, M., Rose-John, S., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-12-1129 · Cited by 71 · see citing works

IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections.

Gregory, S. H., Wing, E. J., Danowski, K. L., van Rooijen, N., Dyer, K. F., & Tweardy, D. (1998) · Journal of Immunology · doi:10.4049/jimmunol.160.12.6056 · Cited by 59 · see citing works

STAT3 activation in macrophages following infection with Salmonella.

Lin, T., & Bost, K. (2004) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2004.07.039 · Cited by 37 · see citing works

Helicobacter pylori Disrupts STAT1-Mediated Gamma Interferon-Induced Signal Transduction in Epithelial Cells

Mitchell, D. J., Huynh, H. Q., Ceponis, P. J. M., Jones, N. L., & Sherman, P. M. (2003) · Infection and Immunity · doi:10.1128/iai.72.1.537-545.2004 · Cited by 36 · see citing works

Helicobacter pylori Infection Interferes with Epithelial Stat6-Mediated Interleukin-4 Signal Transduction Independent of cagA , cagE , or VacA

Ceponis, P. J. M., McKay, D. M., Menaker, R. J., Galindo‐Mata, E., & Jones, N. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.2035 · Cited by 22 · see citing works

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works

Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works

Gut Microbiota and Cancer: From Pathogenesis to Therapy

Vivarelli, S., Salemi, R., Candido, S., Falzone, L., Santagati, M., Stefani, S., Torino, F., Banna, G. L., Tonini, G., & Libra, M. (2019) · Cancers · doi:10.3390/cancers11010038 · Cited by 586 · see citing works

Multifaceted link between cancer and inflammation

Sethi, G., Shanmugam, M. K., Ramachandran, L., Kumar, A. P., & Tergaonkar, V. (2011) · Bioscience Reports · doi:10.1042/bsr20100136 · Cited by 334 · see citing works

Helicobacter pylori and gastric cancer: mechanisms and new perspectives

Duan, Y., Xu, Y., Dou, Y., & Xu, D. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01654-2 · Cited by 311 · see citing works

S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites

Deng, J., Liu, Y., Lee, H., Herrmann, A., Zhang, W., Zhang, C., Shen, S., Priceman, S. J., Kujawski, M., Pal, S. K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.039 · Cited by 252 · see citing works

Dual Roles for Immunity in Gastrointestinal Cancers

Ferrone, C. R., & Dranoff, G. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.27.9992 · Cited by 242 · see citing works

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

Yong, X., Tang, B., Li, B., Xie, R., Hu, C.-J., Luo, G., Qin, Y., Dong, H. F., & Yang, S. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0111-0 · Cited by 236 · see citing works

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Becht, É., Giraldo, N. A., Germain, C., de Reyniès, A., Laurent‐Puig, P., Zucman‐Rossi, J., Dieu‐Nosjean, M., Sautès‐Fridman, C., & Fridman, W. H. (2016) · Advances in immunology · doi:10.1016/bs.ai.2015.12.002 · Cited by 213 · see citing works

lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy

Wu, Q., Ma, J., Wei, J., Meng, W., Wang, Y., & Shi, M. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.10.011 · Cited by 196 · see citing works

A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease

Jones, K. R., Whitmire, J. M., & Merrell, D. S. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00115 · Cited by 190 · see citing works

Collateral damage: Insights into bacterial mechanisms that predispose host cells to cancer

Gagnaire, A., Nadel, B., Raoult, D., Neefjes, J., & Gorvel, J.-P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.171 · Cited by 189 · see citing works

Inflammation and cancer: What a surgical oncologist should know

Dupré, A., & Malik, H. (2018) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2018.02.209 · Cited by 184 · see citing works

Helicobacter pylori Infection, Oncogenic Pathways and Epigenetic Mechanisms in Gastric Carcinogenesis

Ding, S., Goldberg, J. B., & Hatakeyama, M. (2010) · Future Oncology · doi:10.2217/fon.10.37 · Cited by 169 · see citing works

Transcription Factors in Cancer Development and Therapy

Vishnoi, K., Viswakarma, N., Rana, A., & Rana, B. (2020) · Cancers · doi:10.3390/cancers12082296 · Cited by 167 · see citing works

Helicobacter pylori CagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells

Lee, I. O., Kim, J., Choi, Y. J., Pillinger, M. H., Kim, S.-Y., Blaser, M. J., & Lee, Y. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.111054 · Cited by 132 · see citing works

The Hyaluronic Acid Receptor CD44 Coordinates Normal and Metaplastic Gastric Epithelial Progenitor Cell Proliferation

Khurana, S. S., Riehl, T. E., Moore, B. D., Fassan, M., Rugge, M., Romero–Gallo, J., Noto, J. M., Peek, R. M., Stenson, W. F., & Mills, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445551 · Cited by 125 · see citing works

The Human Gastric PathogenHelicobacter pyloriand Its Association with Gastric Cancer and Ulcer Disease

Bauer, B., & Meyer, T. F. (2011) · Ulcers · doi:10.1155/2011/340157 · Cited by 113 · see citing works

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

Tegtmeyer, N., Neddermann, M., Asche, C. I., & Backert, S. (2017) · Molecular Microbiology · doi:10.1111/mmi.13707 · Cited by 111 · see citing works

CagA-mediated pathogenesis of Helicobacter pylori

Tohidpour, A. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.005 · Cited by 100 · see citing works

Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10

Jaslow, S. L., Gibbs, K. D., Fricke, W. F., Wang, L., Pittman, K. J., Mammel, M. K., Thaden, J. T., Fowler, V. G., Hammer, G. E., Elfenbein, J. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.072 · Cited by 90 · see citing works

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors

Backert, S., & Tegtmeyer, N. (2017) · Toxins · doi:10.3390/toxins9040115 · Cited by 95 · see citing works

Targeting STAT3 in gastric cancer

Giraud, A. S., Menheniott, T. R., & Judd, L. M. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.709238 · Cited by 92 · see citing works

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells

Zhang, G., Tsang, C. M., Deng, W., Yip, Y. L., Lui, V. W. Y., Wong, S. C. C., Cheung, A. L. M., Hau, P. M., Zeng, M., Lung, M. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062284 · Cited by 93 · see citing works

Metaplasia in the Stomach—Precursor of Gastric Cancer?

Kinoshita, H., Hayakawa, Y., & Koike, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102063 · Cited by 89 · see citing works

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine

Stein, M., Ruggiero, P., Rappuoli, R., & Bagnoli, F. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00328 · Cited by 88 · see citing works

Gut Microbiota and Breast Cancer: The Dual Role of Microbes

Álvarez‐Mercado, A. I., Cano, A. D. V., Fernández, M. F., & Fontana, L. (2023) · Cancers · doi:10.3390/cancers15020443 · Cited by 88 · see citing works

Helicobacter pylori Cytotoxin-Associated Gene A Impairs Human Dendritic Cell Maturation and Function through IL-10–Mediated Activation of STAT3

Kaebisch, R., Mejías‐Luque, R., Prinz, C., & Gerhard, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302476 · Cited by 86 · see citing works

Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses

Asano, N., Imatani, A., Watanabe, T., Fushiya, J., Kondo, Y., Jin, X., Ara, N., Uno, K., Iijima, K., Koike, T., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2272 · Cited by 86 · see citing works

STAT3 activation in infection and infection-associated cancer

Lu, R., Zhang, Y., & Sun, J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.023 · Cited by 85 · see citing works

Pathogenesis of Helicobacter pylori Infection

Costa, A. C., Figueiredo, C., & Touati, E. (2009) · Helicobacter · doi:10.1111/j.1523-5378.2009.00702.x · Cited by 80 · see citing works

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

Katsha, A. M., Arras, J., Soutto, M., Belkhiri, A., & El-Rifai, W. M. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.05.012 · Cited by 74 · see citing works

Helicobacter pylori Activates IL‐6‐STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

Piao, J., Lee, H. G., Kim, S., Kim, D., Han, H., Ngo, H., Park, S., Woo, J., Lee, J., Na, H., et al. (2016) · Helicobacter · doi:10.1111/hel.12298 · Cited by 73 · see citing works

Gastric cancer: genome damaged by bugs

Zhao, Y., Zhang, J., Cheng, A. S. L., Yu, J. Q., To, K. F., & Kang, W. (2020) · Oncogene · doi:10.1038/s41388-020-1241-4 · Cited by 73 · see citing works

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation

Lee, K. S., Kalantzis, A., Jackson, C. B., O’Connor, L., Murata‐Kamiya, N., Hatakeyama, M., Judd, L. M., Giraud, A. S., & Menheniott, T. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030786 · Cited by 67 · see citing works

Helicobacter pylori Inhibits Dendritic Cell Maturation via Interleukin-10-Mediated Activation of the Signal Transducer and Activator of Transcription 3 Pathway

Rizzuti, D., Ang, M., Sokollik, C., Wu, T., Abdullah, M., Greenfield, L. K., Fattouh, R., Reardon, C., Tang, M., Diao, J., et al. (2014) · Journal of Innate Immunity · doi:10.1159/000368232 · Cited by 67 · see citing works

The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives

Wei, X., Wang, F., Tan, P., Huang, H., Wang, Z., Xie, J., Wang, L., Liu, D., & Hu, Z. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107148 · Cited by 68 · see citing works

Nucleotide Oligomerization Domain 1 Enhances IFN-γ Signaling in Gastric Epithelial Cells during Helicobacter pylori Infection and Exacerbates Disease Severity

Allison, C. C., Ferrand, J., McLeod, L., Hassan, M., Kaparakis‐Liaskos, M., Grubman, A., Bhathal, P. S., Dev, A. T., Sievert, W., Jenkins, B. J., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200591 · Cited by 63 · see citing works

Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer

Xiong, H., Du, W., Wang, J., Wang, Y., Tang, J. T., Hong, J., & Fang, J. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0869-0 · Cited by 63 · see citing works

Cytokine signalling via gp130 in gastric cancer

Howlett, M., Menheniott, T. R., Judd, L. M., & Giraud, A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.07.009 · Cited by 62 · see citing works

Induction of Fibroblast Growth Factor Receptor 4 by Helicobacter pylori via Signal Transducer and Activator of Transcription 3 With a Feedforward Activation Loop Involving SRC Signaling in Gastric Cancer

Zhang, X. Y., Soutto, M., Chen, Z., Bhat, N. S., Zhu, S., Eissmann, M. F., Ernst, M., Lu, H., Peng, D., Xu, Z., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.016 · Cited by 56 · see citing works

MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7

Geng, Y., LU, X., Wu, X., Li, X., Wang, X., & Xu, J. (2016) · Oncology Reports · doi:10.3892/or.2016.4572 · Cited by 56 · see citing works

Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-XL, Leading to Apoptosis in Gastric Epithelial Cells

Matsumoto, A., Isomoto, H., Nakayama, M., Hisatsune, J., Nishi, Y., Nakashima, Y., Matsushima, K., Kurazono, H., Nakao, K., Hirayama, T., et al. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1420-1 · Cited by 52 · see citing works

Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis

Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y., MIYAMOTO, K., Nakamura, I., Ohki, S., Koyama, Y., et al. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.210 · Cited by 52 · see citing works

Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells

Park, B., Lim, J. W., & Kim, H. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.07.010 · Cited by 51 · see citing works

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer

Yeh, C., Chang, L.-Y., Lin, S., Chou, J., Hsieh, H., Zeng, L.-H., Chuang, S.-Y., Wang, H.-W., Dittner, C., Lin, C.-Y., et al. (2016) · Scientific Reports · doi:10.1038/srep31690 · Cited by 50 · see citing works

Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation

Idowu, S., Bertrand, P. P., & Walduck, A. K. (2022) · Helicobacter · doi:10.1111/hel.12891 · Cited by 46 · see citing works

Homeostasis in Infected Epithelia: Stem Cells Take the Lead

Pitsouli, C., Apidianakis, Y., & Perrimon, N. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.10.001 · Cited by 46 · see citing works

Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach

Piao, J., Kim, S., Kim, D.-H., Park, J. H., Park, S., Han, H.-J., Na, H., Yoon, K., Lee, H., Kim, N., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72594-3 · Cited by 44 · see citing works

MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking

Peng, H., Hsiao, J., Chou, S.-T., Hsu, Y.-M., Wu, G.-H., Shieh, Y., & Shiah, S. (2020) · Neoplasia · doi:10.1016/j.neo.2020.08.005 · Cited by 43 · see citing works

Special Licorice Extracts Containing Lowered Glycyrrhizin and Enhanced Licochalcone A Prevented Helicobacter pylori‐Initiated, Salt Diet‐Promoted Gastric Tumorigenesis

Park, J., Park, S., Hong, K., Han, Y., Jang, S., Kim, E., & Hahm, K. (2014) · Helicobacter · doi:10.1111/hel.12121 · Cited by 42 · see citing works

A positive feedback loop between STAT3 and cyclooxygenase‐2 gene may contribute to Helicobacter pylori‐associated human gastric tumorigenesis

Xiong, H., Du, W., Sun, T., Lin, Y., Wang, J., Hong, J., & Fang, J. (2013) · International Journal of Cancer · doi:10.1002/ijc.28539 · Cited by 41 · see citing works

CD24 mediates gastric carcinogenesis and promotes gastric cancer progression via STAT3 activation

Wang, Y., Wang, J., Kong, X., Sun, T., Chen, H., Hong, J., & Fang, J. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0949-9 · Cited by 39 · see citing works

Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer

Zhao, J., Dong, Y., Kang, W., Go, M. Y. Y., TONG, J. H. M., Ng, E. K., Chiu, P. W. Y., Cheng, A. S. L., To, K. F., Sung, J. J. �., et al. (2014) · Oncoscience · doi:10.18632/oncoscience.62 · Cited by 39 · see citing works

NF-kB-dependent activation of STAT3 by H. pylori is suppressed by TFF1

Soutto, M., Bhat, N. S., Khalafi, S., Zhu, S., Poveda, J., Garcia-Buitrago, M. T., Zaika, A. I., & El-Rifai, W. M. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02140-2 · Cited by 37 · see citing works

Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer

Peng, Y., Lei, X., Yang, Q., Zhang, G., He, S., Wang, M., Ling, R., Zheng, B., He, J., Chen, X., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01167-5 · Cited by 34 · see citing works

STAT3: a critical component in the response toHelicobacter pyloriinfection

Menheniott, T. R., Judd, L. M., & Giraud, A. S. (2015) · Cellular Microbiology · doi:10.1111/cmi.12518 · Cited by 33 · see citing works

Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection

Liu, Y. G., Teng, Y., Cheng, P., Kong, H., Lv, P. Y., Mao, F.-Y., Wu, X. L., Hao, C.-J., Chen, W., Yang, S., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201802016rr · Cited by 31 · see citing works

Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism

Zhang, W., Cui, N., Ye, J., Yang, B., Sun, Y., & Kuang, H. (2022) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.11.003 · Cited by 31 · see citing works

α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells

Choi, J. H., Cho, S. O., & Kim, H. (2015) · Yonsei Medical Journal · doi:10.3349/ymj.2016.57.1.260 · Cited by 31 · see citing works

Protective effects of an electrophilic metabolite of docosahexaenoic acid on UVB-induced oxidative cell death, dermatitis, and carcinogenesis

Kim, S. H., Lee, S. E., Kim, S., Fang, X., Hur, J., Sözen, E., Özer, N. K., Kim, K. P., & Surh, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102666 · Cited by 30 · see citing works

Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity

Bhattacharjee, A., Sahoo, O. S., Sarkar, A., Bhattacharya, S., Chowdhury, R., Kar, S., & Mukherjee, O. (2024) · Infection · doi:10.1007/s15010-023-02159-9 · Cited by 30 · see citing works

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment

He, P., Miao, Y., Sun, Y., Bian, A., Jin, W., Chen, H., Ye, J., He, J., Peng, Y., Gu, H., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00413 · Cited by 29 · see citing works

Constitutive STAT3 serine phosphorylation promotes Helicobacter-mediated gastric disease.

Balic, J., Saad, M., Dawson, R. E., West, A. J., McLeod, L., West, A., D'Costa, K., Deswaerte, V., Dev, A., Sievert, W., et al. (2020) · American Journal of Pathology · doi:10.1016/j.ajpath.2020.01.021 · Cited by 25 · see citing works

Bidirectional regulation between TMEFF2 and STAT3 may contribute to H elicobacter pylori‐associated gastric carcinogenesis

Sun, T., Tang, J., Du, W., Zhao, H., Zhao, G., Yang, S., Chen, H., Hong, J., & Fang, J. (2014) · International Journal of Cancer · doi:10.1002/ijc.29061 · Cited by 27 · see citing works

Inflammation and Cancer

Beatty, P. L., Cascio, S., & Finn, O. J. (2017) · Wiley eBooks · doi:10.1002/9781118468869.ch4 · Cited by 27 · see citing works

IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis

Yu, B., de Vos, D., Guo, X., Peng, S., Xie, W., Peppelenbosch, M. P., Fu, Y., & Fuhler, G. M. (2024) · Neoplasia · doi:10.1016/j.neo.2024.100981 · Cited by 26 · see citing works

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer

Yang, J., Hu, Y., Zhang, B., Liang, X., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.881396 · Cited by 26 · see citing works

Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop

Xu, T., Xie, M., Jing, X., Jiang, H., Wu, X., Wang, X., & Shu, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03933-x · Cited by 26 · see citing works

Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori

Jang, S., Hansen, L. M., Su, H., Solnick, J. V., & Cha, J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044721 · Cited by 25 · see citing works

Gene Expression Profiling in Gastric Mucosa from Helicobacter pylori-Infected and Uninfected Patients Undergoing Chronic Superficial Gastritis

Yang, Z., Chen, W.-W., & Wang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033030 · Cited by 25 · see citing works

IL-22 Negatively Regulates Helicobacter pylori-Induced CCL20 Expression in Gastric Epithelial Cells

Chen, J.-P., Wu, M., Kuo, S., & Liao, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097350 · Cited by 24 · see citing works

Repressed TGF-β signaling through CagA-Smad3 interaction as pathogenic mechanisms of Helicobacter pylori-associated gastritis

Nguyen, T. T., Kim, S., Park, J. M., Hahm, K. B., & Lee, H.-J. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-38 · Cited by 22 · see citing works

Dietary intake of walnut prevented Helicobacter pylori-associated gastric cancer through rejuvenation of chronic atrophic gastritis

Park, J. M., Han, Y. M., Park, Y. J., & Hahm, K. B. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-103 · Cited by 21 · see citing works

Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe–gastric epithelial cells cross-talk

Chiariotti, L., Angrisano, T., Keller, S., Florio, E., Affinito, O., Pallante, P., Perrino, C., Pero, R., & Lembo, F. (2013) · Medical Microbiology and Immunology · doi:10.1007/s00430-013-0301-6 · Cited by 20 · see citing works

Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction

Park, J. M., An, J. M., Han, Y. M., Surh, Y., Hwang, S. J., Kim, S., & Hahm, K. B. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-89 · Cited by 20 · see citing works

Regulation of RKIP Function by Helicobacter pylori in Gastric Cancer

Moen, E. L., Wen, S., Anwar, T., Cross-Knorr, S., Brilliant, K. E., Birnbaum, F. A., Rahaman, S., Sedivy, J. M., Moss, S. F., & Chatterjee, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037819 · Cited by 20 · see citing works

Campylobacter jejuni-Mediated Induction of CC and CXC Chemokines and Chemokine Receptors in Human Dendritic Cells

Hu, L., Bray, M. D., Geng, Y., & Kopecko, D. J. (2012) · Infection and Immunity · doi:10.1128/iai.00129-12 · Cited by 19 · see citing works

Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection

Mejías‐Luque, R., Lozano‐Pope, I., Wanisch, A., Heikenwälder, M., Gerhard, M., & Obonyo, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-43417-x · Cited by 18 · see citing works

rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population

Yuan, K.-X., Liu, H., Huang, L., Ren, X., Liu, J., Dong, X.-Q., Tian, W.-J., & Jia, Y.-H. (2014) · BioMed Research International · doi:10.1155/2014/527918 · Cited by 22 · see citing works

Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells

Zhou, J., Xie, Y., Zhao, Y., Wang, S., & Li, Y. (2011) · Gastric Cancer · doi:10.1007/s10120-011-0044-2 · Cited by 17 · see citing works

Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer

Wei, K., Chou, J., Chen, Y.-C., Jin, H., Chuang, Y., Wu, C., & Chan, M. W. Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218338 · Cited by 17 · see citing works

Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice

Yan, D., Jobe, F., Hutchison, R. E., & Mohi, G. (2015) · Leukemia · doi:10.1038/leu.2015.116 · Cited by 17 · see citing works

The Interplay Between Helicobacter pylori and Suppressors of Cytokine Signaling ( SOCS ) Molecules in the Development of Gastric Cancer and Induction of Immune Response

Jafarzadeh, A., Jafarzadeh, Z., Nemati, M., & Yoshimura, A. (2024) · Helicobacter · doi:10.1111/hel.13105 · Cited by 17 · see citing works

Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation

Ishii, Y., Shibata, W., Sugimori, M., Kaneta, Y., Kanno, M., Sato, T. A., Sue, S., Kameta, E., Kaneko, H., Irie, K., et al. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/9050715 · Cited by 16 · see citing works

Ready, STAT3, Go! Bacteria in the race for M2 macrophage polarisation

Panagi, I., & Thurston, T. L. M. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102285 · Cited by 15 · see citing works

Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori

Pandey, A., Tripathi, S. C., Shukla, S., Mahata, S., Vishnoi, K., Misra, S. P., Misra, V., MITRA, S. P., Dwivedi, M., & Bharti, A. C. (2018) · Cancer Reports · doi:10.1002/cnr2.1004 · Cited by 13 · see citing works

Gastric Cancer and Microbiota: Exploring the Microbiome’s Role in Carcinogenesis and Treatment Strategies

Lazăr, D. C., Chiriac, S. D., Drăghici, G. A., Moacă, E.-A., Faur, A. C., Avram, M. F., Turi, V., Nicolin, M.-R., Goldiș, A., Salehi, M. A., et al. (2025) · Life · doi:10.3390/life15070999 · Cited by 13 · see citing works

The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications

Huang, L., Jiang, C., Yan, M., Wan, W., Li, S., Xiang, Z., & Wu, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1413266 · Cited by 13 · see citing works

A single nucleotide polymorphism in the 3′-UTR ofSTAT3regulates its expression and reduces risk of pancreatic cancer in a Chinese population

Zhu, B., Zhu, Y., Lou, J., Ke, J., Zhang, Y., Li, J., Gong, Y., Yang, Y., Tian, J., Peng, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11607 · Cited by 12 · see citing works

Helicobacter pylori-induced aberrant methylation of ID4 mediated by DNMT3B drives gastric cancer progression via DEC1-SHH signaling pathway

Luan, M., Zhu, W., Feng, Z., Jing, F., Xing, Y., Ma, X., Wang, Y., Ning, B., & Jia, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08042-9 · Cited by 11 · see citing works

Regulation of GKN1 expression in gastric carcinogenesis: A problem to resolve (Review)

Alarc�n‐Mill�n, J., Martínez-Carrillo, D. N., Peralta-Zaragoza, Ó., & Fernández‐Tilapa, G. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4843 · Cited by 11 · see citing works

Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line

Luo, J., Bai, L., Tao, J., Wen, Y. J., Li, M., Zhu, Y., Luo, S., Pu, G., & Ma, L. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01151-7 · Cited by 11 · see citing works

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Haley, K. P., Blanz, E. J., & Gaddy, J. A. (2014) · Journal of Visualized Experiments · doi:10.3791/52122 · Cited by 11 · see citing works

Polymorphisms inInterleukin-6-6331 Influences the Susceptibility of a Chinese Population to Gastric Cancer

Yu, J. Q., Jia, Y., Cheung, K. F., Zeng, Z., Tian, L., Wang, S., Hu, P., & Sung, J. J. �. (2011) · Cancer Investigation · doi:10.3109/07357907.2011.605411 · Cited by 9 · see citing works

Surreptitious manipulation of the human host byHelicobacter pylori

Israel, D. A., & Peek, R. M. (2010) · Gut Microbes · doi:10.4161/gmic.1.2.11991 · Cited by 9 · see citing works

H. pylori induces the expression of Hath1 in gastric epithelial cells via interleukin‐8/STAT3 phosphorylation while suppressing Hes1

Zhang, X., Yang, Y., Zhu, R., Bai, J., Tian, Y., Li, X., Peng, Z., He, Y., Chen, L., Fang, D.-C., et al. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24248 · Cited by 9 · see citing works

CarcinogenicHelicobacter pyloriin gastric pre-cancer and cancer lesions: Association with tobacco-chewing

Pandey, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6860 · Cited by 9 · see citing works

The impact of multidimensional interactions among Helicobacter pylori infection, tumor microenvironment, and gut microbiota on gastric cancer immune response

Xiong, C., Chen, Z., Wu, X., Zhang, C., Yuan, Z., Wang, X., Xiao, Z., Chen, Y., Deng, S., Wu, X., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178401 · Cited by 8 · see citing works

Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer

Zhao, J., Dong, Y., Kang, W., Go, M. Y. Y., TONG, J. H. M., Ng, E. K., Chiu, P. W. Y., Cheng, A. S. L., To, K. F., Sung, J. J. �., et al. (2014) · Oncoscience · doi:10.18632/oncoscience.62 · Cited by 39 · see citing works

Helicobacter pylori Activates IL‐6‐STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

Piao, J., Lee, H. G., Kim, S., Kim, D., Han, H., Ngo, H., Park, S., Woo, J., Lee, J., Na, H., et al. (2016) · Helicobacter · doi:10.1111/hel.12298 · Cited by 73 · see citing works

M1635 Helicobacter pylori CagA Cytotoxin Stimulates Inappropriate STAT3 Activation in Gastric Epithelial Cells By a Phosphorylation Dependent Mechanism

Menheniott, T. R., Jackson, C. B., Murata‐Kamiya, N., Hatakeyama, M., & Giraud, A. S. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)61805-3

Mechanism of Helicobacter pylori Induced Gastric Cancer: Role of the Signal Transducer and Activator of Transcription Pathway

Bronte-Tinkew, D. M. (2010) · Library and Archives Canada (Government of Canada)

Abstract 2592: Helicobacter pylori induces phosphorylation of STAT3 Tyr705 and Ser727 in human gastric epithelial cells.

Piao, J., Lee, H.-G., Ji, H.-G., Han, H.-J., Ngo, H. K. C., Kim, D., Kim, S., Lee, S., & Surh, Y. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-2592