Cited by 283Immune Response and InflammationGut microbiota and healthNF-κB Signaling Pathways

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

Open access

Chen, Grace Y., Shaw, Michael H., Redondo, Gloria, Núñez, Gabriel·2008·Cancer Research

DOI 10.1158/0008-5472.can-08-2061PMC PMC2804847

Open this paper in CoChat — free account Open PDF

Abstract

There is growing evidence that the host innate immune system has a critical role in regulating carcinogenesis, but the specific receptors involved and the importance of their interaction with commensal bacteria need to be elucidated. Two major classes of innate immune receptors, the Toll-like receptors and Nod-like receptors, many of which are upstream of nuclear factor-kappaB, are involved in the detection of intestinal bacteria. The Toll-like receptors have been implicated in promoting colon tumorigenesis, but the role of Nod-like receptors in regulating tumorigenesis remains unclear. Using an established mouse model system of colitis-associated colon tumorigenesis, we show that Nod1 deficiency results in the increased development of both colitis-associated and Apc tumor suppressor-related colon tumors. In the absence of Nod1 signaling, there is a greater disruption of the intestinal epithelial cell barrier due to chemically induced injury as manifested by increased surface epithelial apoptosis early on during chemically induced colitis and increased intestinal permeability. The increased intestinal permeability is associated with enhanced inflammatory cytokine production and epithelial cell proliferation in Nod1-deficient mice as compared with wild-type mice. Depletion of the gut microbiota suppressed tumor development in Nod1-deficient mice, thus highlighting a link between the commensal bacteria within the intestine and the host innate immune Nod1 signaling pathway in the regulation inflammation-mediated colon cancer development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-08-2061

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
A cytokine-mediated link between innate immunity, inflammation, and cancer
Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,834

Show all 45 references

Sorted by citations

Items 101–200 of 283

The role of the gut microbiome in colorectal cancer: Where are we? Where are we going?
Wieczorska, K., Stolarek, M., & Stec, R. (2020) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2019.07.006 · Cited by 50
The Role of the Gut Microbiome in Colorectal Cancer
Chen, G. (2018) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0037-1602239 · Cited by 49
Self-citation
Risk of cancer in patients with constipation
Sundbøll, J., Thygesen, S. K., Veres, K., Liao, D., Zhao, J., Gregersen, H. N., & Sørensen, H. T. (2019) · Clinical Epidemiology · doi:10.2147/clep.s205957 · Cited by 47
Manipulating Liver Bile Acid Signaling by Nanodelivery of Bile Acid Receptor Modulators for Liver Cancer Immunotherapy
Ji, G., Si, X., Dong, S., Xu, Y., Li, M., Yang, B., Tang, Z., Fang, X., Huang, L., Song, W., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01360 · Cited by 47
Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences
M’Koma, A. E., Moses, H. L., & Adunyah, S. E. (2011) · International Journal of Colorectal Disease · doi:10.1007/s00384-011-1137-4 · Cited by 46
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation
Pellegrini, E., Signor, L., Singh, S. P., Erba, E. B., & Cusack, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177161 · Cited by 45
Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease
Corridoni, D., Chapman, T., Ambrose, T., & Simmons, A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00032 · Cited by 45
Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway
Zou, Y., Li, C., Fu, Y., JiZe, X.-P., Zhao, Y., Peng, X., Wang, J., Yin, Z., Li, Y., Song, X., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124689 · Cited by 44
Altering the Microbiome Inhibits Tumorigenesis in a Mouse Model of Oviductal High-Grade Serous Carcinoma
Chen, L., Zhai, Y., Wang, Y., Fearon, E. R., Núñez, G., Inohara, N., & Cho, K. R. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0106 · Cited by 44
Therapeutic targeting of NOD1 receptors
Moreno, L., & Gatheral, T. L. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12300 · Cited by 44
Molecular Pathways Underlying IBD-Associated Colorectal Neoplasia: Therapeutic Implications [RETRACTED]
Goel, G., Kandiel, A., Achkar, J. P., & Lashner, B. A. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.51 · Cited by 43
Retracted
TREM-1 inhibition attenuates inflammation and tumor within the colon
Zhou, J., Chai, F., Lu, G. X., Hang, G., Chen, C., Chen, X., & Shi, J. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.009 · Cited by 43
Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production
Zhan, Y., Seregin, S. S., Chen, J., & Chen, G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501822 · Cited by 43
Self-citation
NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions
Sharma, N., & Jha, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2123-8 · Cited by 41
NOD1 in the interplay between microbiota and gastrointestinal immune adaptations
Fernández-García, V., González-Ramos, S., Martín‐Sanz, P., del Portillo, F. G., Laparra, J. M., & Boscá, L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105775 · Cited by 41
Inflammation in sporadic colorectal cancer.
Moossavi, S., & Bishehsari, F. (2012) · PubMed · Cited by 41
Harnessing the untapped potential of nucleotide‐binding oligomerization domain ligands for cancer immunotherapy
Nabergoj, S., Mlinarič‐Raščan, I., & Jakopin, Ž. (2018) · Medicinal Research Reviews · doi:10.1002/med.21557 · Cited by 39
Circadian influence on the microbiome improves heart failure outcomes
Mistry, P., Reitz, C. J., Khatua, T. N., Rasouli, M., Oliphant, K., Young, M. E., Allen‐Vercoe, E., & Martino, T. A. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.09.006 · Cited by 38
Effector functions of NLRs in the intestine: innate sensing, cell death, and disease
Yeretssian, G. (2012) · Immunologic Research · doi:10.1007/s12026-012-8317-3 · Cited by 37
Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach
Haque, S., Raina, R., Afroze, N., Hussain, A., Alsulimani, A., Singh, V., Mishra, B. N., Kaul, S., & Kharwar, R. N. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.024 · Cited by 35
Severe Defects in the Macrophage Barrier to Gut Microflora in Inflammatory Bowel Disease and Colon Cancer
Rubio‐Terres, C., & Schmidt, P. T. (2018) · Anticancer Research · doi:10.21873/anticanres.12664 · Cited by 34
Advances in Modeling the Immune Microenvironment of Colorectal Cancer
Yoon, P., Piccolo, N. D., Shirure, V. S., Peng, Y., Kirane, A., Canter, R. J., Fields, R. C., George, S. C., & Gholami, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.614300 · Cited by 33
Role of Microbiome in Modulating Immune Responses in Cancer
Bose, M., & Mukherjee, P. (2019) · Mediators of Inflammation · doi:10.1155/2019/4107917 · Cited by 32
HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer
Liu, X., Ma, H., Fei, L., Jiang, M., Xia, M., Bai, L., Pi, X., Chen, S., & Yu, L. (2020) · Infectious Agents and Cancer · doi:10.1186/s13027-020-0272-3 · Cited by 32
Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
Iyer, K., Erkert, L., & Becker, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1228283 · Cited by 31
Review: Mouse models of inflammatory bowel disease--insights into the mechanisms of inflammation-associated colorectal cancer.
Mladenova, D. N., & Kohonen‐Corish, M. R. J. (2012) · PubMed · Cited by 31
Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model
Fan, X., Ding, X., & Zhang, Q.-Y. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.002 · Cited by 31
The Microbiome and Its Implications in Cancer Immunotherapy
Choudhry, H. (2021) · Molecules · doi:10.3390/molecules26010206 · Cited by 31
Microbial recognition regulates intestinal epithelial growth in homeostasis and disease
Ferguson, M., & Foley, E. (2021) · FEBS Journal · doi:10.1111/febs.15910 · Cited by 31
Toll-interacting Protein Modulates Colitis Susceptibility in Mice
Maillard, M. H., Bega, H., Uhlig, H. H., Barnich, N., Grandjean, T., Chamaillard, M., Michetti, P., & Velin, D. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000006 · Cited by 30
Thymosin α1 protects from CTLA-4 intestinal immunopathology
Renga, G., Bellet, M. M., Pariano, M., Gargaro, M., Stincardini, C., D’Onofrio, F., Mosci, P., Brancorsini, S., Bartoli, A., Goldstein, A. L., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000662 · Cited by 30
Epithelial sensing of microbiota-derived signals
Eshleman, E. M., & Alenghat, T. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00124-w · Cited by 30
Intratumoral microbiota: new frontiers in tumor immunity
Zhang, Z., Liao, Y., & Tang, D. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac063 · Cited by 30
Insights into the role of the intestinal microbiota in colon cancer
Oke, S., & Martín, A. (2017) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x17694832 · Cited by 30
The Impact of the Gut Microbiome on Colorectal Cancer
Maisonneuve, C., Irrazábal, T., Martín, A., Girardin, S. E., & Philpott, D. J. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050240 · Cited by 30
Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis
Wu, Y., Wu, C., Che, Y., Zhang, T., Dai, C., Nguyễn, A. D., Duan, K., Huang, Y., Li, N., Zhou, H., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.891429 · Cited by 29
D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism
Seki, N., Kimizuka, T., Gondo, M., Yamaguchi, G., Sugiura, Y., Akiyama, M., Yakabe, K., Uchiyama, J., Higashi, S., Haneda, T., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104838 · Cited by 29
NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression.
Wang, X., Jiang, W., Duan, N., Qian, Y., Zhou, Q., Ye, P., Jiang, H., Bai, Y., Zhang, W., & Wang, W. (2014) · Europe PMC (PubMed Central) · Cited by 28
Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases
Zhou, Z., Ding, M., Huang, L., Gilkeson, G. S., Lang, R., & Jiang, W. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.09.005 · Cited by 27
PSMA7 Directly Interacts with NOD1 and Regulates its Function
Yang, L., Tang, Z., Zhang, H., Kou, W., Lu, Z., Li, X., Li, Q., & Miao, Z. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350113 · Cited by 27
Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli
Sahu, U., Choudhury, A., Parvez, S., Biswas, S., & Kar, S. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.27 · Cited by 26
The role of innate immune signals in antitumor immunity
Jinushi, M. (2012) · OncoImmunology · doi:10.4161/onci.1.2.18495 · Cited by 26
The E3 Ligase RNF34 is a Novel Negative Regulator of the NOD1 Pathway
Zhang, R., Zhao, J., Song, Y., Wang, X., Wang, L., Xu, J., Song, C. H., & Liu, F. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362972 · Cited by 25
Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Immune System, and Bile Acids
Gupta, B., Rai, R. P., Oertel, M., & Raeman, R. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1748037 · Cited by 24
Role of NOD1 and ALPK1/TIFA Signalling in Innate Immunity Against Helicobacter pylori Infection
Ying, L., & Ferrero, R. L. (2019) · Current topics in microbiology and immunology · doi:10.1007/978-3-030-15138-6_7 · Cited by 24
NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet
González-Ramos, S., Paz-García, M., Fernández-García, V., Portune, K. J., Acosta-Medina, E. F., Sanz, Y., Castrillo, A., Martín‐Sanz, P., Obregón, M.-J., & Boscá, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-69295-2 · Cited by 24
Inflammatory Bowel Diseases and Inflammasome
Kim, J. M. (2011) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2011.58.6.300 · Cited by 24
The Microbiome and Colorectal Neoplasia: Environmental Modifiers of Dysbiosis
Turner, N. D., Ritchie, L. E., Bresalier, R. S., & Chapkin, R. S. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0346-0 · Cited by 23
NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system.
Antosz, H., & Osiak, M. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1992 · Cited by 22
Microbes and Colorectal Cancer: Is There a Relationship?
Uronis, J. M., & Jobin, C. (2009) · Current Oncology · doi:10.3747/co.v16i4.472 · Cited by 22
Rodent Intestinal Epithelial Carcinogenesis
Ward, J. M., & Treuting, P. M. (2013) · Toxicologic Pathology · doi:10.1177/0192623313505156 · Cited by 22
How Gut Microbiota Are Shaped by Pattern Recognition Receptors in Colitis and Colorectal Cancer
Qing, F., Xie, T., Xie, L., Guo, T., & Liu, Z. (2022) · Cancers · doi:10.3390/cancers14153821 · Cited by 21
The innate immune signaling in cancer and cardiometabolic diseases: Friends or foes?
Wang, W., Zhang, Y., Yang, L., & Li, H. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.06.004 · Cited by 21
Gut Immunity: A NOD to the Commensals
Chen, G., & Núñez, G. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.027 · Cited by 20
Self-citation
Salutaxel, a Conjugate of Docetaxel and a Muramyl Dipeptide (MDP) Analogue, Acts as Multifunctional Prodrug That Inhibits Tumor Growth and Metastasis
Wen, X., Zheng, P., Ma, Y., Ou, Y., Huang, W., Li, S., Liu, S., Zhang, X., Wang, Z., Zhang, Q., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01407 · Cited by 20
NOD1 modulates IL-10 signalling in human dendritic cells
Neuper, T., Ellwanger, K., Schwarz, H., Kufer, T. A., Duschl, A., & Horejs‐Hoeck, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00691-x · Cited by 19
Horizontal Gene Transfers with or without Cell Fusions in All Categories of the Living Matter
Sinkovics, J. G. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0782-5_2 · Cited by 19
Interaction of bacteria and stem cells in health and disease
O’Rourke, F., & Kempf, V. A. J. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz003 · Cited by 18
Remote Control of Intestinal Tumorigenesis by Innate Immunity
Sécher, T., Gaillot, O., Ryffel, B., & Chamaillard, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3401 · Cited by 17
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation
Overcast, G. R., Meibers, H. E., Eshleman, E. M., Saha, I., Waggoner, L., Patel, K. N., Jain, V. G., Haslam, D. B., Alenghat, T., VanDussen, K. L., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20212523 · Cited by 16
The correlation between gut and intra-tumor microbiota and PDAC: Etiology, diagnostics and therapeutics
Qian, J., Zhang, X., Wei, B., Tang, Z., & Zhang, B. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188943 · Cited by 16
Nod-like receptors in head and neck squamous cell carcinoma
Millrud, C. R., Kvarnhammar, A. M., Tajti, J., Munck‐Wikland, E., Uddman, R., & Cardell, L. (2013) · Acta Oto-Laryngologica · doi:10.3109/00016489.2013.831476 · Cited by 16
Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines
Ladaycia, A., Loretz, B., Passirani, C., Lehr, C., & Lepeltier, É. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.015 · Cited by 17
Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease
Stroo, I., Butter, L. M., Claessen, N., Teske, G. J., Rubino, S. J., Girardin, S. E., Florquin, S., & Leemans, J. C. (2012) · Biology Open · doi:10.1242/bio.2012554 · Cited by 16
Transcription Profiling of NOD-like Receptors in the Human Cornea with Disease
Oh, J. Y., Ko, J. H., Ryu, J. S., Lee, H. J., Kim, M. K., & Wee, W. R. (2016) · Ocular Immunology and Inflammation · doi:10.3109/09273948.2015.1130844 · Cited by 16
Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy
Li, Z., Rana, I., Park, G. T., Lee, J., Park, C. E., & Nam, J. (2023) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-023-00633-y · Cited by 14
The Function and Molecular Mechanism of Commensal Microbiome in Promoting Malignant Progression of Lung Cancer
Wang, H., Hu, J., Wu, J., Ji, P., Shang, A., & Li, D. (2022) · Cancers · doi:10.3390/cancers14215394 · Cited by 14
Debug Your Bugs – How NLRs Shape Intestinal Host-Microbe Interactions
Lipinski, S., & Rosenstiel, P. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00479 · Cited by 14
Nucleotide‐binding oligomerization domain 2 ( NOD 2) activation induces apoptosis of human oral squamous cell carcinoma cells
Yoon, H., Ahn, M., Kwon, S., Kim, D., Lee, J., & Yoon, J. (2015) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12354 · Cited by 12
Effector responses of bovine blood neutrophils against Escherichia coli: Role of NOD1/NF-κB signalling pathway
Tan, X., Wei, L.-J., Fan, G.-J., Jiang, Y.-N., & Yu, X. (2015) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2015.08.010 · Cited by 12
Involvement of Nucleotide-Binding and Oligomerization Domain-Like Receptors in the Intestinal Injury of Severe Acute Pancreatitis in Rats
Xu, S., Wei, S., Guo, Y., Cui, D.-L., & Yao, J.-F. (2018) · Pancreas · doi:10.1097/mpa.0000000000000977 · Cited by 12
Nucleotide-Binding Domain Leucine-Rich Repeat Containing Proteins and Intestinal Microbiota: Pivotal Players in Colitis and Colitis-Associated Cancer Development
Prossomariti, A., Sokol, H., & Ricciardiello, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01039 · Cited by 12
NOD1 and NOD2 Are Potential Therapeutic Targets for Cancer Immunotherapy
Wang, D. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/2271788 · Cited by 11
Retracted
Microbiome profile associated with malignant pleural effusion
Shojaee, S., Sharma, A., Gottel, N., Sanchez, T. M., Gilbert, J. A., & Rahman, N. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232181 · Cited by 11
Role of Gut Microbiome and Enteric Bacteria in Gallbladder Cancer
Sharma, J., Huda, F., Naithani, M., Singh, S. K., Kumar, N., & Basu, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104404 · Cited by 10
Integrated analysis of intestinal microbiota and host gene expression in colorectal cancer patients
Chen, Y., Si, H., Bao, B., Li, S., Teng, D., Yang, Y., Hu, S., Xu, Y., & Du, X. (2022) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001596 · Cited by 10
Mechanism of inflammasomes in cancer and targeted therapies
Gu, Q., Zou, J., Zhou, Y. Y., & Deng, Q. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1133013 · Cited by 10
NOD-like receptors mediate homeostatic intestinal epithelial barrier function: promising therapeutic targets for inflammatory bowel disease
Zhou, F., Zhang, G. D., Tan, Y., Hu, S. A., Tang, Q., & Pei, G. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231176889 · Cited by 10
Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract
Spanou, E., Kalisperati, P., Pateras, I. S., Papalampros, A., Barbouti, A., Tzioufas, A. G., Kotsinas, A., & Sougioultzis, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00065 · Cited by 10
Innate Immune Stimulation in Cancer Therapy
Duewell, P., Heidegger, S. M., & Kobold, S. (2019) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2018.12.002 · Cited by 10
Tumor Necrosis Factor-α–Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer
Lou, Y., Song, M., Han, M., Zhong, J., Tian, X., Ren, Y., Song, Y., Duan, L., Zhao, P., Song, X., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0666 · Cited by 10
Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
Spring, J., Khan, A. A., Lara, S., O’Grady, K., Wilks, J. C., Gurbuxani, S. K., Erickson, S. A., Fischbach, M. A., Jacobson, A. N., Chervonsky, A. V., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111341 · Cited by 10
The microbiome, its molecular mechanisms and its potential as a therapeutic strategy against colorectal carcinogenesis (Review)
Baliou, S., Adamaki, M., Spandidos, D. A., Kyriakopoulos, A. M., Christodoulou, I., & Zoumpourlis, V. C. (2018) · World Academy of Sciences Journal · doi:10.3892/wasj.2018.6 · Cited by 11
An 11-gene signature for the prediction of systemic recurrences in colon adenocarcinoma
Cai, J., Huang, X., Li, X.-L., Qin, S., Rong, Y., Chen, X., Weng, J., Zou, Y., & Lin, X. (2021) · Gastroenterology report · doi:10.1093/gastro/goab023 · Cited by 9
Role of the NOD1/NF-κB pathway on bovine neutrophil responses to crude lipopolysaccharide
Wei, L.-J., Tan, X., Fan, G.-J., Jiang, Y.-N., & Shah, Q. A. (2016) · The Veterinary Journal · doi:10.1016/j.tvjl.2016.02.006 · Cited by 9
Nutrition, Immunity, and Cancer
Ghaedi, E., Rezaei, N., & Mahmoudi, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_12 · Cited by 9
Microbiota-associated mechanisms in colorectal cancer
González, A., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.05.002 · Cited by 8
Presume Why Probiotics May Not Provide Protection in Inflammatory Bowel Disease through an Azoxymethane and Dextran Sodium Sulfate Murine Model
Hu, M., Lian, W., Wang, F., Yang, C., Huang, W., Yang, J., Chen, I., & Yang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179689 · Cited by 8
NOD1 cooperates with HAX ‐1 to promote cell migration in a RIPK2‐ and NF‐ĸB ‐independent manner
Hezinger, L., Bauer, S., Ellwanger, K., Piotrowsky, A., Biber, F., Venturelli, S., & Kufer, T. A. (2023) · FEBS Journal · doi:10.1111/febs.16912 · Cited by 8
Antibiotic induced adipose tissue browning in C57BL/6 mice: An association with the metabolic profile and the gut microbiota
Panda, S. S., Behera, B., Ghosh, R., Bagh, B., & Aich, P. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122473 · Cited by 8
The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice
Ono, J., Shime, H., Takaki, H., Takashima, K., Funami, K., Yoshida, S., Takeda, Y., Matsumoto, M., Kasahara, M., & Seya, T. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0387-z · Cited by 7
Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients
Zhang, J., Yin, X., Wang, H., Fang, T., Gao, J., Zhu, Z., Li, C., Wang, Y., Wang, X., Lu, Z., et al. (2023) · Cancer Control · doi:10.1177/10732748231202466 · Cited by 7
Clinical immunology Gene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression
Słotwiński, R., Dąbrowska, A., Lech, G., Słodkowski, M., & Słotwińska, S. M. (2014) · Central European Journal of Immunology · doi:10.5114/ceji.2014.47736 · Cited by 7
NOD1 activation promotes cell apoptosis in papillary thyroid cancer
Bai, N., Liu, C., Zhang, X., Cheng, Y., & Hou, D. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.153880 · Cited by 7
NOD1 deficiency promotes inflammation via autophagic degradation of ASK1
Kimura, Y., Kimura, M., Miura, N. N., Yoshino, Y., & Kono, H. (2025) · Communications Biology · doi:10.1038/s42003-025-08213-6 · Cited by 6
Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer
Yang, X., Zhang, K., Xia, L., & Li, J. (2026) · iMetaMed · doi:10.1002/imm3.70030 · Cited by 5
Role of the Microbiome in Malignancy
Godley, F. A., Shogan, B. D., & Hyman, N. (2023) · Surgical Infections · doi:10.1089/sur.2023.028 · Cited by 5
Data driven linear algebraic methods for analysis of molecular pathways: Application to disease progression in shock/trauma
McGuire, M. F., Iyengar, M. S., & Mercer, D. (2011) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2011.12.002 · Cited by 5
Prognostic and onco-immunological value of immune-related eRNAs-driven genes in lung adenocarcinoma
Wu, X., Zhao, X., Chao Hui, Z. H. O. U., Wei, N., Xu, Z., & Zhang, X. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05687-5 · Cited by 4
Antibiotic Cocktail: An Excellent Tool to Probe Physiology by Perturbing Gut Microbiota: A Mice Model
Panda, S. S., Pattnaik, T., & Aich, P. (2025) · Current Microbiology · doi:10.1007/s00284-025-04409-5 · Cited by 4

Authors: Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G.
Affiliations: University of Michigan (US)
2Pathology,
ORCID: Chen, Grace Y.
Shaw, Michael H.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2008-12-15
Volume: 68
Issue: 24
Pages: 10060-10067
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-08-2061
PMC: PMC2804847
OpenAlex: W1990955264
Cited by: 261
References: 45
Citations by year: 2026: 4 · 2025: 8 · 2024: 6 · 2023: 15 · 2022: 18 · 2021: 33 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 22 · 2012: 18
FWCI: 3.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: University of Michigan
National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007517)
National Cancer Institute (K08CA133185, T32CA009357)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 61707, R01DK061707)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: NOD1, NOD-like receptors, innate immunity, colitis-associated colorectal cancer, APC tumor suppressor, intestinal epithelial barrier, intestinal permeability, epithelial apoptosis, inflammatory cytokines, gut microbiota, commensal bacteria, chemically induced colitis, carcinogenesis
MeSH terms: Animals, Azoxymethane, Colitis, Colonic Neoplasms, Female, Immunity, Innate, Intestines, Male, Mice, Inbred C57BL, Receptors, Immunologic, RNA, Messenger, Specific Pathogen-Free Organisms, Cytokines, Dextran Sulfate, Genes, APC, Chemokines, Mice, Nod1 Signaling Adaptor Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks