Cited by 50Gut microbiota and healthColorectal Cancer Treatments and StudiesClostridium difficile and Clostridium perfringens research

The role of the gut microbiome in colorectal cancer: Where are we? Where are we going?

Wieczorska, Karina, Stolarek, Małgorzata, Stec, Rafał·2020·Clinical Colorectal Cancer

Abstract

Microbiome (microbiota) is a community of all microorganisms inhabiting a specific site of the body, including pathogens, which distinguishes it from the physiological microflora. Intestinal dysbiosis plays a key role in the development of colorectal cancer. In the process of carcinogenesis, inflammation, immune response, and toxic metabolites play a significant role. Specific species of bacteria might affect the risk of colorectal cancer and growth of tumor already present. Assessment of changes in the intestinal microbiome during the development and progression of colorectal cancer might create a simple diagnostic tool, a useful biomarker, or might influence treatment strategies in colorectal cancer patients. Analysis of the gut microbiome provides the potential to develop noninvasive diagnostic tests that would be useful as new protective markers of colorectal cancer, prognostic markers in already present colorectal cancer, and predictive markers of response to treatment, especially immunotherapy.

Integrity signals

Registry

Crossref · 10.1016/j.clcc.2019.07.006

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Specific species of bacteria may affect both the risk of colorectal cancer and the growth of existing tumors.

    “The study found that specific species of bacteria may affect both the risk of colorectal cancer and the growth of existing tumors [66].”

Cites

Flagged first, then by citations

1 of the 67 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Wieczorska, K., Stolarek, M., & Stec, R.
Affiliations
Medical University of Warsaw (PL)
Corresponding author
Stec, Rafał
Venue
Clinical Colorectal Cancer
Publisher
Elsevier BV
Published
2020-03
Volume
19
Issue
1
Pages
5-12
ISSN
1533-0028 (ISSN-L)
OpenAlex
W2960881484
Cited by
50
References
67
Citations by year
2026: 1 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 8
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Colorectal Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Keywords
gut microbiota, colorectal cancer, gut dysbiosis, carcinogenesis, inflammation, immune response, bacterial metabolites, tumor markers, non-invasive diagnosis, prognostic factors, predictive biomarkers, immunotherapy response
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Immune Checkpoint Inhibitors, Animals, Colon, Combined Modality Therapy, Disease Models, Animal, Feces, Humans, Immunotherapy, Inflammation, Intestinal Mucosa, Prognosis, Rectum, Colorectal Neoplasms, Treatment Outcome, Disease Progression, Probiotics, Carcinogenesis, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review