The role of the gut microbiome in colorectal cancer: Where are we? Where are we going?
Abstract
Microbiome (microbiota) is a community of all microorganisms inhabiting a specific site of the body, including pathogens, which distinguishes it from the physiological microflora. Intestinal dysbiosis plays a key role in the development of colorectal cancer. In the process of carcinogenesis, inflammation, immune response, and toxic metabolites play a significant role. Specific species of bacteria might affect the risk of colorectal cancer and growth of tumor already present. Assessment of changes in the intestinal microbiome during the development and progression of colorectal cancer might create a simple diagnostic tool, a useful biomarker, or might influence treatment strategies in colorectal cancer patients. Analysis of the gut microbiome provides the potential to develop noninvasive diagnostic tests that would be useful as new protective markers of colorectal cancer, prognostic markers in already present colorectal cancer, and predictive markers of response to treatment, especially immunotherapy.
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Specific species of bacteria may affect both the risk of colorectal cancer and the growth of existing tumors.
“The study found that specific species of bacteria may affect both the risk of colorectal cancer and the growth of existing tumors [66].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [66]
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- Authors
- Wieczorska, K., Stolarek, M., & Stec, R.
- Affiliations
- Medical University of Warsaw (PL)
- Corresponding author
- Stec, Rafał
- ORCID
- Stec, Rafał
- Venue
- Clinical Colorectal Cancer
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 19
- Issue
- 1
- Pages
- 5-12
- ISSN
- 1533-0028 (ISSN-L)
- OpenAlex
- W2960881484
- Cited by
- 50
- References
- 67
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 8
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Colorectal Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, colorectal cancer, gut dysbiosis, carcinogenesis, inflammation, immune response, bacterial metabolites, tumor markers, non-invasive diagnosis, prognostic factors, predictive biomarkers, immunotherapy response
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Immune Checkpoint Inhibitors, Animals, Colon, Combined Modality Therapy, Disease Models, Animal, Feces, Humans, Immunotherapy, Inflammation, Intestinal Mucosa, Prognosis, Rectum, Colorectal Neoplasms, Treatment Outcome, Disease Progression, Probiotics, Carcinogenesis, Dysbiosis
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