Effector functions of NLRs in the intestine: innate sensing, cell death, and disease

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

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Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Inflammasomes: Guardians of the Body

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Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

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Integrating cell-signalling pathways with NF-κB and IKK function

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A microbial symbiosis factor prevents intestinal inflammatory disease

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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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Inflammatory bowel disease

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Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

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Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

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Interactions between commensal intestinal bacteria and the immune system

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Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Lysosomal membrane permeabilization in cell death

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

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Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

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The apoptosome: Signalling platform of cell death

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

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The NLR Gene Family: A Standard Nomenclature

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Inflammatory Caspases

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

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The Nalp3 inflammasome is essential for the development of silicosis

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Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

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Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Honor thy symbionts

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Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

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Homeostasis and Inflammation in the Intestine

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NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

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Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

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The inflammasome: a danger sensing complex triggering innate immunity

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

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War and peace at mucosal surfaces

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Influenza virus activates inflammasomes via its intracellular M2 ion channel

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NALP1 in Vitiligo-Associated Multiple Autoimmune Disease

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Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

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NLRX1 is a regulator of mitochondrial antiviral immunity

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An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

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Nod2 is required for the regulation of commensal microbiota in the intestine

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Plant disease resistance protein signaling: NBS–LRR proteins and their partners

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Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

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Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

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A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

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Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

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Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

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Toll‐like receptor 2‐dependent bacterial sensing does not occur via peptidoglycan recognition

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Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells

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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

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Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

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Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

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NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

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