The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence
Open accessAbstract
The stress-activated kinase p38 plays key roles in tumor suppression and induction of tumor cell dormancy. However, the mechanisms behind these functions remain poorly understood. Using computational tools, we identified a transcription factor (TF) network regulated by p38α/β and required for human squamous carcinoma cell quiescence in vivo. We found that p38 transcriptionally regulates a core network of 46 genes that includes 16 TFs. Activation of p38 induced the expression of the TFs p53 and BHLHB3, while inhibiting c-Jun and FoxM1 expression. Furthermore, induction of p53 by p38 was dependent on c-Jun down-regulation. Accordingly, RNAi down-regulation of BHLHB3 or p53 interrupted tumor cell quiescence, while down-regulation of c-Jun or FoxM1 or overexpression of BHLHB3 in malignant cells mimicked the onset of quiescence. Our results identify components of the regulatory mechanisms driving p38-induced cancer cell quiescence. These may regulate dormancy of residual disease that usually precedes the onset of metastasis in many cancers. [Cancer Res 2009;69(14):5664–72]
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Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
ASPP Proteins Specifically Stimulate the Apoptotic Function of p53
Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., & Wagner, E. F. (2006) · Genes & Development · doi:10.1101/gad.390506 · Cited by 232
Cited by
Bragado, P., Estrada, Y., Parikh, F., Krause, S., Capobianco, C., Farina, H. G., Schewe, D. M., & Aguirre-Ghiso, J. A. (2013) · Nature Cell Biology · doi:10.1038/ncb2861 · Cited by 503
Self-citationEMT, CTCs and CSCs in tumor relapse and drug-resistance
Mitra, A., Mishra, L., & Li, S. (2015) · Oncotarget · doi:10.18632/oncotarget.4037 · Cited by 465
NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes
Sosa, M. S., Parikh, F., Maia, A. G., Estrada, Y., Bosch, A., Bragado, P., Ekpin, E., George, A., Zheng, Y., Lam, H.-M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7170 · Cited by 355
Self-citationFluegen, G., Avivar-Valderas, A., Wang, Y., Padgen, M. R., Williams, J. K., Nobre, A. R., Calvo, V., Cheung, J. F., Bravo-Cordero, J. J., Entenberg, D., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3465 · Cited by 336
Self-citationA tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy
Di Martino, J. S., Nobre, A. R., Mondal, C., Taha, I., Farias, E. F., Fertig, E. J., Naba, A., Aguirre-Ghiso, J. A., & Bravo-Cordero, J. J. (2021) · Nature Cancer · doi:10.1038/s43018-021-00291-9 · Cited by 322
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Metadata
- Authors
- Adam, A. P., George, A., Schewe, D., Bragado, P., Iglesias, B. V., Ranganathan, A. C., Kourtidis, A., Conklin, D. S., & Aguirre-Ghiso, J. A.
- Venue
- Cancer Research
- Published
- 2009-07-15
- Volume
- 69
- Issue
- 14
- Pages
- 5664-5672
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1971481045
- Cited by
- 168
- References
- 4
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Adam, A. P., George, A., Schewe, D., Bragado, P., Iglesias, B. V., Ranganathan, A. C., Kourtidis, A., Conklin, D. S., & Aguirre-Ghiso, J. A. (2009). Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence. Cancer Research. https://doi.org/10.1158/0008-5472.can-08-3820
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